Intestinal parasitic infection alters bacterial gut microbiota in children
ABSTRACT: The study of the burden that parasites can exert upon the bacterial gut microbiota was restricted by the available technologies and their costs. Currently, next-generation sequencing coupled with traditional methodologies allows the study of eukaryotic parasites (protozoa and helminths) an...
- Autores:
-
Toro Londoño, Miguel Ángel
Bedoya Urrego, Katherine
García Montoya, Gisela María
Galván Díaz, Ana Luz
Alzate Restrepo, Juan Fernando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/23305
- Acceso en línea:
- http://hdl.handle.net/10495/23305
- Palabra clave:
- Helmintiasis
Helminthiasis
Gusanos parásitos e intestinales
Worms, intestinal and parasitic
Niños
Children
Parásitos intestinales
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
id |
UDEA2_13de337d3629d9457396a7d4df77cda5 |
---|---|
oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/23305 |
network_acronym_str |
UDEA2 |
network_name_str |
Repositorio UdeA |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Intestinal parasitic infection alters bacterial gut microbiota in children |
title |
Intestinal parasitic infection alters bacterial gut microbiota in children |
spellingShingle |
Intestinal parasitic infection alters bacterial gut microbiota in children Helmintiasis Helminthiasis Gusanos parásitos e intestinales Worms, intestinal and parasitic Niños Children Parásitos intestinales |
title_short |
Intestinal parasitic infection alters bacterial gut microbiota in children |
title_full |
Intestinal parasitic infection alters bacterial gut microbiota in children |
title_fullStr |
Intestinal parasitic infection alters bacterial gut microbiota in children |
title_full_unstemmed |
Intestinal parasitic infection alters bacterial gut microbiota in children |
title_sort |
Intestinal parasitic infection alters bacterial gut microbiota in children |
dc.creator.fl_str_mv |
Toro Londoño, Miguel Ángel Bedoya Urrego, Katherine García Montoya, Gisela María Galván Díaz, Ana Luz Alzate Restrepo, Juan Fernando |
dc.contributor.author.none.fl_str_mv |
Toro Londoño, Miguel Ángel Bedoya Urrego, Katherine García Montoya, Gisela María Galván Díaz, Ana Luz Alzate Restrepo, Juan Fernando |
dc.subject.decs.none.fl_str_mv |
Helmintiasis Helminthiasis |
topic |
Helmintiasis Helminthiasis Gusanos parásitos e intestinales Worms, intestinal and parasitic Niños Children Parásitos intestinales |
dc.subject.lemb.none.fl_str_mv |
Gusanos parásitos e intestinales Worms, intestinal and parasitic Niños Children |
dc.subject.proposal.spa.fl_str_mv |
Parásitos intestinales |
description |
ABSTRACT: The study of the burden that parasites can exert upon the bacterial gut microbiota was restricted by the available technologies and their costs. Currently, next-generation sequencing coupled with traditional methodologies allows the study of eukaryotic parasites (protozoa and helminths) and its effects on the human bacterial gut microbiota diversity. This diversity can be altered by a variety of factors such as agediet, genetics and parasitic infections among others. The disturbances of the gut microbiota have been associated with a variety of illnesses. Children population in developing countries, are especially susceptible to parasitic infections because of the lack of proper sanitation and undernutrition, allowing both, the thriving of intestinal parasites and profound alteration of the gut microbiota. In this work, we have sampled the stool of 23 children from four different children’s care-centers in Medellin, Colombia, and we have identified the eukaryotic parasites by traditional and molecular methodologies coupled with microbial profiling using 16S rDNA sequencing. This mixed methodology approach has allowed us to establish an interesting relationship between Giardia intestinalis and helminth infection, having both effects upon the bacterial gut microbiota enterotypes, causing a switch from a type I to a type II enterotype upon infection. |
publishDate |
2019 |
dc.date.issued.none.fl_str_mv |
2019 |
dc.date.accessioned.none.fl_str_mv |
2021-10-20T17:57:27Z |
dc.date.available.none.fl_str_mv |
2021-10-20T17:57:27Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.citation.spa.fl_str_mv |
Toro-Londono MA, Bedoya-Urrego K, Garcia-Montoya GM, Galvan-Diaz AL, Alzate JF. 2019. Intestinal parasitic infection alters bacterial gut microbiota in children. PeerJ 7:e6200 http://doi.org/10.7717/peerj.6200 |
dc.identifier.issn.none.fl_str_mv |
2167-8359 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/23305 |
dc.identifier.doi.none.fl_str_mv |
10.7717/peerj.6200 |
identifier_str_mv |
Toro-Londono MA, Bedoya-Urrego K, Garcia-Montoya GM, Galvan-Diaz AL, Alzate JF. 2019. Intestinal parasitic infection alters bacterial gut microbiota in children. PeerJ 7:e6200 http://doi.org/10.7717/peerj.6200 2167-8359 10.7717/peerj.6200 |
url |
http://hdl.handle.net/10495/23305 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
PeerJ |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
dc.format.extent.spa.fl_str_mv |
23 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
PeerJ Inc. |
dc.publisher.group.spa.fl_str_mv |
Grupo de Parasitología Universidad de Antioquia Microbiología Ambiental |
dc.publisher.place.spa.fl_str_mv |
Corte Madera, Estados Unidos |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/23305/1/MiguelToro_2019_ParasiticBacterialchildren.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/23305/3/license.txt http://bibliotecadigital.udea.edu.co/bitstream/10495/23305/2/license_rdf |
bitstream.checksum.fl_str_mv |
f6933087e716e14316ac68cf5b664c62 8a4605be74aa9ea9d79846c1fba20a33 1646d1f6b96dbbbc38035efc9239ac9c |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
_version_ |
1812173122275639296 |
spelling |
Toro Londoño, Miguel ÁngelBedoya Urrego, KatherineGarcía Montoya, Gisela MaríaGalván Díaz, Ana LuzAlzate Restrepo, Juan Fernando2021-10-20T17:57:27Z2021-10-20T17:57:27Z2019Toro-Londono MA, Bedoya-Urrego K, Garcia-Montoya GM, Galvan-Diaz AL, Alzate JF. 2019. Intestinal parasitic infection alters bacterial gut microbiota in children. PeerJ 7:e6200 http://doi.org/10.7717/peerj.62002167-8359http://hdl.handle.net/10495/2330510.7717/peerj.6200ABSTRACT: The study of the burden that parasites can exert upon the bacterial gut microbiota was restricted by the available technologies and their costs. Currently, next-generation sequencing coupled with traditional methodologies allows the study of eukaryotic parasites (protozoa and helminths) and its effects on the human bacterial gut microbiota diversity. This diversity can be altered by a variety of factors such as agediet, genetics and parasitic infections among others. The disturbances of the gut microbiota have been associated with a variety of illnesses. Children population in developing countries, are especially susceptible to parasitic infections because of the lack of proper sanitation and undernutrition, allowing both, the thriving of intestinal parasites and profound alteration of the gut microbiota. In this work, we have sampled the stool of 23 children from four different children’s care-centers in Medellin, Colombia, and we have identified the eukaryotic parasites by traditional and molecular methodologies coupled with microbial profiling using 16S rDNA sequencing. This mixed methodology approach has allowed us to establish an interesting relationship between Giardia intestinalis and helminth infection, having both effects upon the bacterial gut microbiota enterotypes, causing a switch from a type I to a type II enterotype upon infection.COL0007506COL004018923application/pdfengPeerJ Inc.Grupo de Parasitología Universidad de AntioquiaMicrobiología AmbientalCorte Madera, Estados Unidosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by/4.0/Intestinal parasitic infection alters bacterial gut microbiota in childrenHelmintiasisHelminthiasisGusanos parásitos e intestinalesWorms, intestinal and parasiticNiñosChildrenParásitos intestinalesPeerJPeerJ1247ORIGINALMiguelToro_2019_ParasiticBacterialchildren.pdfMiguelToro_2019_ParasiticBacterialchildren.pdfArtículo de investigaciónapplication/pdf5577710http://bibliotecadigital.udea.edu.co/bitstream/10495/23305/1/MiguelToro_2019_ParasiticBacterialchildren.pdff6933087e716e14316ac68cf5b664c62MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/23305/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927http://bibliotecadigital.udea.edu.co/bitstream/10495/23305/2/license_rdf1646d1f6b96dbbbc38035efc9239ac9cMD5210495/23305oai:bibliotecadigital.udea.edu.co:10495/233052022-01-25 15:23:42.585Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |