Disseminated histoplasmosis: A comparative study between patients with acquired immunodeficiency syndrome and non-human immunodeficiency virus-infected individuals
ABSTRACT : We studied 52 patients with disseminated histoplasmosis, 30 with the acquired immunodeficiency syndrome (AIDS) (cohort 1) and 22 not co-infected with the human immunodeficiency virus (cohort 2). Demographic, clinical, laboratory, mycologic findings, as well as antifungal therapy and highl...
- Autores:
-
Tobón Orozco, Ángela María
Arango Arteaga, Myrtha
Bedout Gómez, Catalina de
Restrepo Moreno, Ángela
Agudelo Restrepo, Carlos Andrés
Rosero, Daniel Santiago
Ochoa Múnera, Juan Eugenio
Zuluaga Rodríguez, Alejandra
Sampedro, Jaime
Cano Restrepo, Luz Elena
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2005
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/20565
- Acceso en línea:
- http://hdl.handle.net/10495/20565
- Palabra clave:
- Histoplasmosis
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
Histoplasma
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/2.5/co/
| Summary: | ABSTRACT : We studied 52 patients with disseminated histoplasmosis, 30 with the acquired immunodeficiency syndrome (AIDS) (cohort 1) and 22 not co-infected with the human immunodeficiency virus (cohort 2). Demographic, clinical, laboratory, mycologic findings, as well as antifungal therapy and highly active antiretroviral (HAART), were analyzed. Skin lesions were significantly higher in cohort 1 than in cohort2(P 0.001). Anemia, leukopenia, and an elevated erythrocyte sedimentation rate were also more pronounced in cohort 1 than in cohort 2 (P < 0.001). Histoplasma capsulatum was isolated more often in cohort 1 than in cohort 2 (P < 0.05) patients, but antibodies to H.capsulatum were detected more frequently in cohort 2 than in cohort 1 (P < 0.05). Itraconazole treatment was less effective in cohort 1 than in cohort 2 (P 0.012). In cohort 1 patients, HAART improved response to antifungals when compared with individuals not given HAART (P 0.003), who exhibited higher mortality rates (P 0.025). Cohort 1 patients who were given dual antifungal and anti-retroviral therapies responded as well as the non-HIV patients in cohort 2, who were treated only with itraconazole. These results indicate the need to promote restoration of the immune system in patients with AIDS and histoplasmosis. |
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