Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
ABSTRACT: We have previously proposed that 17b -estradiol may be responsible in part for the decreased frequency of clinical paracoccidioidomycosis in females via a blocking of the initial morphological transformation necessary to initiate infection. Here we examined the course of infection in male...
- Autores:
-
Aristizabal Bernal, Beatriz Helena
Clemons X, Karl V
Cock Botero, Ana Maria
Stevens X, David A
Restrepo Moreno, Ángela
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2002
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/24123
- Acceso en línea:
- http://hdl.handle.net/10495/24123
- Palabra clave:
- Paracoccidioides
Estrógenos
Estrogens
Granuloma
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/2.5/co/
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oai:bibliotecadigital.udea.edu.co:10495/24123 |
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|
dc.title.spa.fl_str_mv |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
title |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
spellingShingle |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses Paracoccidioides Estrógenos Estrogens Granuloma |
title_short |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
title_full |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
title_fullStr |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
title_full_unstemmed |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
title_sort |
Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses |
dc.creator.fl_str_mv |
Aristizabal Bernal, Beatriz Helena Clemons X, Karl V Cock Botero, Ana Maria Stevens X, David A Restrepo Moreno, Ángela |
dc.contributor.author.none.fl_str_mv |
Aristizabal Bernal, Beatriz Helena Clemons X, Karl V Cock Botero, Ana Maria Stevens X, David A Restrepo Moreno, Ángela |
dc.subject.decs.none.fl_str_mv |
Paracoccidioides Estrógenos Estrogens Granuloma |
topic |
Paracoccidioides Estrógenos Estrogens Granuloma |
description |
ABSTRACT: We have previously proposed that 17b -estradiol may be responsible in part for the decreased frequency of clinical paracoccidioidomycosis in females via a blocking of the initial morphological transformation necessary to initiate infection. Here we examined the course of infection in male and female mice in relation to their hormonal status. After pulmonary infection with conidia, normal males showed progressive infection, whereas normal females restricted proliferation and progressive disease. In contrast, castrated animals exhibited lesser capacity to restrict disease progression. Castrated male mice reconstituted with 17b -estradiol initially restricted proliferation, but showed disease progression later in infection, whereas castrated female mice reconstituted with testosterone were unable to restrict disease. Quantitative histological analyses demonstrated that only normal male and castrated reconstituted mice developed granulomas, which decreased in number and size with time correlating with increasing numbers of CFU in the lungs. Greater numbers of chronic in ammatory foci did not correlate with higher CFU. These results further support a role for 17b -estradiol during early innate resistance of females to paracoccidioidomycosis. |
publishDate |
2002 |
dc.date.issued.none.fl_str_mv |
2002 |
dc.date.accessioned.none.fl_str_mv |
2021-11-15T20:12:04Z |
dc.date.available.none.fl_str_mv |
2021-11-15T20:12:04Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
dc.type.local.spa.fl_str_mv |
Artículo de investigación |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
1369-3786 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/24123 |
dc.identifier.doi.none.fl_str_mv |
10.1080/mmy.40.2.169.178 |
dc.identifier.eissn.none.fl_str_mv |
1460-2709 |
identifier_str_mv |
1369-3786 10.1080/mmy.40.2.169.178 1460-2709 |
url |
http://hdl.handle.net/10495/24123 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Med. Mycol. |
dc.rights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/2.5/co/ |
dc.rights.accessrights.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.creativecommons.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/2.5/co/ http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
dc.format.extent.spa.fl_str_mv |
10 |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Oxford University Press |
dc.publisher.group.spa.fl_str_mv |
Micología Médica y Experimental |
dc.publisher.place.spa.fl_str_mv |
Oxford, Inglaterra |
institution |
Universidad de Antioquia |
bitstream.url.fl_str_mv |
http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/1/RestrepoAngela2002_ExperimentalInfluence.pdf http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/2/license_rdf http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/3/license.txt |
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MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad de Antioquia |
repository.mail.fl_str_mv |
andres.perez@udea.edu.co |
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spelling |
Aristizabal Bernal, Beatriz HelenaClemons X, Karl VCock Botero, Ana MariaStevens X, David ARestrepo Moreno, Ángela2021-11-15T20:12:04Z2021-11-15T20:12:04Z20021369-3786http://hdl.handle.net/10495/2412310.1080/mmy.40.2.169.1781460-2709ABSTRACT: We have previously proposed that 17b -estradiol may be responsible in part for the decreased frequency of clinical paracoccidioidomycosis in females via a blocking of the initial morphological transformation necessary to initiate infection. Here we examined the course of infection in male and female mice in relation to their hormonal status. After pulmonary infection with conidia, normal males showed progressive infection, whereas normal females restricted proliferation and progressive disease. In contrast, castrated animals exhibited lesser capacity to restrict disease progression. Castrated male mice reconstituted with 17b -estradiol initially restricted proliferation, but showed disease progression later in infection, whereas castrated female mice reconstituted with testosterone were unable to restrict disease. Quantitative histological analyses demonstrated that only normal male and castrated reconstituted mice developed granulomas, which decreased in number and size with time correlating with increasing numbers of CFU in the lungs. Greater numbers of chronic in ammatory foci did not correlate with higher CFU. These results further support a role for 17b -estradiol during early innate resistance of females to paracoccidioidomycosis.COL001370910application/pdfengOxford University PressMicología Médica y ExperimentalOxford, Inglaterrainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc/4.0/Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responsesParacoccidioidesEstrógenosEstrogensGranulomaMed. Mycol.Medical Mycology169178402ORIGINALRestrepoAngela2002_ExperimentalInfluence.pdfRestrepoAngela2002_ExperimentalInfluence.pdfArtículo de investigaciónapplication/pdf519607http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/1/RestrepoAngela2002_ExperimentalInfluence.pdf7986a691e0285fcb1a6e094c9c95efc2MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8933http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/2/license_rdfc0c92b0ffc8b7d22d9cf56754a416a76MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/24123oai:bibliotecadigital.udea.edu.co:10495/241232022-04-22 10:21:55.966Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |