Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses

ABSTRACT: We have previously proposed that 17b -estradiol may be responsible in part for the decreased frequency of clinical paracoccidioidomycosis in females via a blocking of the initial morphological transformation necessary to initiate infection. Here we examined the course of infection in male...

Full description

Autores:
Aristizabal Bernal, Beatriz Helena
Clemons X, Karl V
Cock Botero, Ana Maria
Stevens X, David A
Restrepo Moreno, Ángela
Tipo de recurso:
Article of investigation
Fecha de publicación:
2002
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/24123
Acceso en línea:
http://hdl.handle.net/10495/24123
Palabra clave:
Paracoccidioides
Estrógenos
Estrogens
Granuloma
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc/2.5/co/
id UDEA2_0cb5ac7cd5ad35f64bc0930c5fc23882
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/24123
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
title Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
spellingShingle Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
Paracoccidioides
Estrógenos
Estrogens
Granuloma
title_short Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
title_full Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
title_fullStr Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
title_full_unstemmed Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
title_sort Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responses
dc.creator.fl_str_mv Aristizabal Bernal, Beatriz Helena
Clemons X, Karl V
Cock Botero, Ana Maria
Stevens X, David A
Restrepo Moreno, Ángela
dc.contributor.author.none.fl_str_mv Aristizabal Bernal, Beatriz Helena
Clemons X, Karl V
Cock Botero, Ana Maria
Stevens X, David A
Restrepo Moreno, Ángela
dc.subject.decs.none.fl_str_mv Paracoccidioides
Estrógenos
Estrogens
Granuloma
topic Paracoccidioides
Estrógenos
Estrogens
Granuloma
description ABSTRACT: We have previously proposed that 17b -estradiol may be responsible in part for the decreased frequency of clinical paracoccidioidomycosis in females via a blocking of the initial morphological transformation necessary to initiate infection. Here we examined the course of infection in male and female mice in relation to their hormonal status. After pulmonary infection with conidia, normal males showed progressive infection, whereas normal females restricted proliferation and progressive disease. In contrast, castrated animals exhibited lesser capacity to restrict disease progression. Castrated male mice reconstituted with 17b -estradiol initially restricted proliferation, but showed disease progression later in infection, whereas castrated female mice reconstituted with testosterone were unable to restrict disease. Quantitative histological analyses demonstrated that only normal male and castrated reconstituted mice developed granulomas, which decreased in number and size with time correlating with increasing numbers of CFU in the lungs. Greater numbers of chronic in ammatory foci did not correlate with higher CFU. These results further support a role for 17b -estradiol during early innate resistance of females to paracoccidioidomycosis.
publishDate 2002
dc.date.issued.none.fl_str_mv 2002
dc.date.accessioned.none.fl_str_mv 2021-11-15T20:12:04Z
dc.date.available.none.fl_str_mv 2021-11-15T20:12:04Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.local.spa.fl_str_mv Artículo de investigación
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 1369-3786
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/24123
dc.identifier.doi.none.fl_str_mv 10.1080/mmy.40.2.169.178
dc.identifier.eissn.none.fl_str_mv 1460-2709
identifier_str_mv 1369-3786
10.1080/mmy.40.2.169.178
1460-2709
url http://hdl.handle.net/10495/24123
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Med. Mycol.
dc.rights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc/2.5/co/
dc.rights.accessrights.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/2.5/co/
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.format.extent.spa.fl_str_mv 10
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Oxford University Press
dc.publisher.group.spa.fl_str_mv Micología Médica y Experimental
dc.publisher.place.spa.fl_str_mv Oxford, Inglaterra
institution Universidad de Antioquia
bitstream.url.fl_str_mv http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/1/RestrepoAngela2002_ExperimentalInfluence.pdf
http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/2/license_rdf
http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/3/license.txt
bitstream.checksum.fl_str_mv 7986a691e0285fcb1a6e094c9c95efc2
c0c92b0ffc8b7d22d9cf56754a416a76
8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad de Antioquia
repository.mail.fl_str_mv andres.perez@udea.edu.co
_version_ 1812173255624097792
spelling Aristizabal Bernal, Beatriz HelenaClemons X, Karl VCock Botero, Ana MariaStevens X, David ARestrepo Moreno, Ángela2021-11-15T20:12:04Z2021-11-15T20:12:04Z20021369-3786http://hdl.handle.net/10495/2412310.1080/mmy.40.2.169.1781460-2709ABSTRACT: We have previously proposed that 17b -estradiol may be responsible in part for the decreased frequency of clinical paracoccidioidomycosis in females via a blocking of the initial morphological transformation necessary to initiate infection. Here we examined the course of infection in male and female mice in relation to their hormonal status. After pulmonary infection with conidia, normal males showed progressive infection, whereas normal females restricted proliferation and progressive disease. In contrast, castrated animals exhibited lesser capacity to restrict disease progression. Castrated male mice reconstituted with 17b -estradiol initially restricted proliferation, but showed disease progression later in infection, whereas castrated female mice reconstituted with testosterone were unable to restrict disease. Quantitative histological analyses demonstrated that only normal male and castrated reconstituted mice developed granulomas, which decreased in number and size with time correlating with increasing numbers of CFU in the lungs. Greater numbers of chronic in ammatory foci did not correlate with higher CFU. These results further support a role for 17b -estradiol during early innate resistance of females to paracoccidioidomycosis.COL001370910application/pdfengOxford University PressMicología Médica y ExperimentalOxford, Inglaterrainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTArtículo de investigaciónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc/4.0/Experimental Paracoccidioides brasiliensis infection in mice : influence of the hormonal status of the host on tissue responsesParacoccidioidesEstrógenosEstrogensGranulomaMed. Mycol.Medical Mycology169178402ORIGINALRestrepoAngela2002_ExperimentalInfluence.pdfRestrepoAngela2002_ExperimentalInfluence.pdfArtículo de investigaciónapplication/pdf519607http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/1/RestrepoAngela2002_ExperimentalInfluence.pdf7986a691e0285fcb1a6e094c9c95efc2MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8933http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/2/license_rdfc0c92b0ffc8b7d22d9cf56754a416a76MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://bibliotecadigital.udea.edu.co/bitstream/10495/24123/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/24123oai:bibliotecadigital.udea.edu.co:10495/241232022-04-22 10:21:55.966Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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