Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

ABSTRACT: Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.

• Autores: Navas Navas, María Cristina; Suárez Mellado, Iris; Carreño Vanegas, Andrea Fernanda; Uribe Yunda, Diego Fernando; Ríos Ocampo, Wilson Alfredo; Cortés Mancera, Fabián Mauricio; Martel, Ghyslaine; Vieco, Beatriz; Lozano, Diana; Jiménez, Carlos; Gouas, Doriane; Osorio, Germán; Hoyos Duque, Sergio Iván; Restrepo, Juan C.; Correa Arango, Gonzalo; Jaramillo, Sergio; Lopez, Rocío; Bravo, Luis E.; Arbeláez Montoya, María Patricia; Scoazec, Jean Y.; Abedi Ardekani, Behnoush; Santella, Regina M.; Chemin, Isabelle; Hainaut, Pierre
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2011
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/26156
• Acceso en línea: http://hdl.handle.net/10495/26156
• Palabra clave: Biomarcadores; Biomarkers; Hepatitis B; Hepatitis C; Genes p53; Genes, p53
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/