Successful Object Encoding Induces Increased Directed Connectivity in Presymptomatic Early-Onset Alzheimer's Disease

ABSTRACT: Background: Recent studies report increases in neural activity in brain regions critical to episodic memory at preclinical stages of Alzheimer’s disease (AD). Although electroencephalography (EEG) is widely used in AD studies, given its non-invasiveness and low cost, there is a need to translate the findings in other neuroimaging methods to EEG. Objective: To examine how the previous findings using functional magnetic resonance imaging (fMRI) at preclinical stage in presenilin-1 E280A mutation carriers could be assessed and extended, using EEG and a connectivity approach. Methods: EEG signals were acquired during resting and encoding in 30 normal cognitive young subjects, from an autosomal dominant early-onset AD kindred from Antioquia, Colombia. Regions of the brain previously reported as hyperactive were used for connectivity analysis. Results: Mutation carriers exhibited increasing connectivity at analyzed regions. Among them, the right precuneus exhibited the highest changes in connectivity. Conclusion: Increased connectivity in hyperactive cerebral regions is seen in individuals, genetically-determined to develop AD, at preclinical stage. The use of a connectivity approach and a widely available neuroimaging technique opens the possibility to increase the use of EEG in early detection of preclinical AD.

• Autores: Ochoa Gómez, John Fredy; Alonso, Joan Francesc; Duque Grajales, Jon Edinson; Tobón Quintero, Carlos Andrés; Mañanas Villanueva, Miguel Ángel; Lopera Restrepo, Francisco Javier; Hernández Valdivieso, Alher Mauricio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2016
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/23066
• Acceso en línea: http://hdl.handle.net/10495/23066
• Palabra clave: Enfermedad de Alzheimer; Alzheimer Disease; Neuroimagen Funcional; Functional Neuroimaging; Presenilina-1; Presenilin-1; Electroencefalografía; Electroencephalography
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc/2.5/co/