Características osteoconductoras de la hidroxiapatita sintética y la derivada de corales marinos injertadas en conejos. Análisis descriptivo

ABSTRACT: In this study we present the procedure to obtain synthetic hydroxyapatite (HA) from ammonium phosphate and calcium nitrate sources. Cellulose fibers were incorporated with the purpose to achieve a good crystallization of HA and combustion of the cellulose was performed in order to produce a porous-like material. The X-ray diffraction analysis (XRD) showed a high proportion of HA with small quantities of tricalcium and tetracalcium phosphates. Coral samples treated with ammonium phosphate by a hydrothermal procedure or coral samples pre-heated at 650 and 1000 °C submerged in ammonium phosphates and later on treated at 1050 °C by a pyrothermal procedure were also evaluated by XRD. The hydrothermal technique did not produce decomposition of the typical aragonite frame of the coral, whereas the pyrothermal technique did not produce any quantity of HA. Finally, a good integration of the HA was observed when HA was implanted to tibial bone in dogs; remodeling and reparation were optimal and evolved according to normal processes. However, the animals implanted with coralline showed necrosis, lysis and severe inflammatory reactions at the implantation sites. These results indicate that it is not possible obtain HA from coral under the experimental conditions here evaluated and that coralline did not behave as a good biocompatible material for implants.

• Autores: Riaño Benavides, Carlos Humberto; Echavarría Velásquez, Alejandro Iván; Gloria E., Ramírez J.; Escobar Luján, Iván Guillermo; Cardona, Jhon J.; Giraldo Ramírez, Adriana Estella
• Tipo de recurso: Article of investigation
• Fecha de publicación: 1999
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/7190
• Acceso en línea: http://hdl.handle.net/10495/7190
• Palabra clave: Conejos; Ortopedia
• Rights: openAccess
• License: Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)