Viral recognition by the innate immune system : the role of pattern recognition receptors
ABSTRACT: Pattern recognition receptors are the main sensors of the innate immune response. Their function is to recognize pathogen-associated molecular patterns, which are molecules essential for the survival of microbial pathogens, but are not produced by the host. The recognition of pathogen-asso...
- Autores:
-
Torres Pedraza, Silvia Mayerli
Betancur Medina, Juan Guillermo
Urcuqui Inchima, Silvio
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2010
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/32315
- Acceso en línea:
- https://hdl.handle.net/10495/32315
- Palabra clave:
- Inmunidad Innata
Immunity, Innate
Receptores Toll-Like
Toll-Like Receptors
Citocinas
Cytokines
Receptores de Reconocimiento de Patrones
Receptors, Pattern Recognition
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| dc.title.alternative.spa.fl_str_mv |
Reconocimiento viral por el sistema inmune innato : papel de los receptores de reconocimiento de patrones |
| title |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| spellingShingle |
Viral recognition by the innate immune system : the role of pattern recognition receptors Inmunidad Innata Immunity, Innate Receptores Toll-Like Toll-Like Receptors Citocinas Cytokines Receptores de Reconocimiento de Patrones Receptors, Pattern Recognition |
| title_short |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| title_full |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| title_fullStr |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| title_full_unstemmed |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| title_sort |
Viral recognition by the innate immune system : the role of pattern recognition receptors |
| dc.creator.fl_str_mv |
Torres Pedraza, Silvia Mayerli Betancur Medina, Juan Guillermo Urcuqui Inchima, Silvio |
| dc.contributor.author.none.fl_str_mv |
Torres Pedraza, Silvia Mayerli Betancur Medina, Juan Guillermo Urcuqui Inchima, Silvio |
| dc.subject.decs.none.fl_str_mv |
Inmunidad Innata Immunity, Innate Receptores Toll-Like Toll-Like Receptors Citocinas Cytokines Receptores de Reconocimiento de Patrones Receptors, Pattern Recognition |
| topic |
Inmunidad Innata Immunity, Innate Receptores Toll-Like Toll-Like Receptors Citocinas Cytokines Receptores de Reconocimiento de Patrones Receptors, Pattern Recognition |
| description |
ABSTRACT: Pattern recognition receptors are the main sensors of the innate immune response. Their function is to recognize pathogen-associated molecular patterns, which are molecules essential for the survival of microbial pathogens, but are not produced by the host. The recognition of pathogen-associated molecular patterns by pattern recognition receptors leads to the expression of cytokines, chemokines, and co-stimulatory molecules that eliminate pathogens, such as viruses, for the activation of antigen presenting cells and for the activation of specific adaptive immunity. Among the most thoroughly studied pattern recognition receptors implicated in viral infections, there are the toll-like receptors (TLRs) and the RNA helicase-type retinoic acid-inducible gene-1 receptors [or RIG-like receptors (RLRs)]. Moreover, other proteins such as PKR, 2’-5’ OAS, and ADAR also act as effector proteins in antiviral responses. The identification and characterization of pattern recognition receptors have contributed to our knowledge of the role of innate immunity in viral infections and has led us to better understand host-pathogen interactions. The most recent findings concerning the role of TLRs and RLRs in viral infections, the molecular mechanisms of viral ligand recognition through pattern recognition receptors, and the activation of their signaling pathways are discussed in this review. |
| publishDate |
2010 |
| dc.date.issued.none.fl_str_mv |
2010 |
| dc.date.accessioned.none.fl_str_mv |
2022-11-24T21:56:03Z |
| dc.date.available.none.fl_str_mv |
2022-11-24T21:56:03Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_dcae04bc |
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Artículo de revisión |
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Torres-Pedraza, S., Betancur, J., & Urcuqui-Inchima, S. (2011). Viral recognition by the innate immune system: the role of pattern recognition receptors. Colombia Médica, 41(4), 377-387. https://doi.org/10.25100/cm.v41i4.731 |
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0120-8322 |
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https://hdl.handle.net/10495/32315 |
| dc.identifier.doi.none.fl_str_mv |
10.25100/cm.v41i4.731 |
| dc.identifier.eissn.none.fl_str_mv |
1657-9534 |
| identifier_str_mv |
Torres-Pedraza, S., Betancur, J., & Urcuqui-Inchima, S. (2011). Viral recognition by the innate immune system: the role of pattern recognition receptors. Colombia Médica, 41(4), 377-387. https://doi.org/10.25100/cm.v41i4.731 0120-8322 10.25100/cm.v41i4.731 1657-9534 |
| url |
https://hdl.handle.net/10495/32315 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Colomb. Med. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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| dc.publisher.spa.fl_str_mv |
Universidad del Valle |
| dc.publisher.group.spa.fl_str_mv |
Inmunovirología |
| dc.publisher.place.spa.fl_str_mv |
Cali, Colombia |
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Universidad de Antioquia |
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Repositorio Institucional Universidad de Antioquia |
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andres.perez@udea.edu.co |
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Torres Pedraza, Silvia MayerliBetancur Medina, Juan GuillermoUrcuqui Inchima, Silvio2022-11-24T21:56:03Z2022-11-24T21:56:03Z2010Torres-Pedraza, S., Betancur, J., & Urcuqui-Inchima, S. (2011). Viral recognition by the innate immune system: the role of pattern recognition receptors. Colombia Médica, 41(4), 377-387. https://doi.org/10.25100/cm.v41i4.7310120-8322https://hdl.handle.net/10495/3231510.25100/cm.v41i4.7311657-9534ABSTRACT: Pattern recognition receptors are the main sensors of the innate immune response. Their function is to recognize pathogen-associated molecular patterns, which are molecules essential for the survival of microbial pathogens, but are not produced by the host. The recognition of pathogen-associated molecular patterns by pattern recognition receptors leads to the expression of cytokines, chemokines, and co-stimulatory molecules that eliminate pathogens, such as viruses, for the activation of antigen presenting cells and for the activation of specific adaptive immunity. Among the most thoroughly studied pattern recognition receptors implicated in viral infections, there are the toll-like receptors (TLRs) and the RNA helicase-type retinoic acid-inducible gene-1 receptors [or RIG-like receptors (RLRs)]. Moreover, other proteins such as PKR, 2’-5’ OAS, and ADAR also act as effector proteins in antiviral responses. The identification and characterization of pattern recognition receptors have contributed to our knowledge of the role of innate immunity in viral infections and has led us to better understand host-pathogen interactions. The most recent findings concerning the role of TLRs and RLRs in viral infections, the molecular mechanisms of viral ligand recognition through pattern recognition receptors, and the activation of their signaling pathways are discussed in this review.RESUMEN: Los receptores de reconocimiento de patrones (PRR) son los principales sensores de la respuesta inmune innata. Su función es reconocer moléculas indispensables para la sobrevivencia de los patógenos, conocidas como patrones moleculares asociados a patógenos (PAMP). El reconocimiento de los PAMP por los PRR conlleva a la expresión de citoquinas, quimioquinas, y moléculas coestimuladoras implicadas en la eliminación de patógenos como virus, en la activación de células presentadoras de antígenos y en la inducción de una inmunidad adaptativa específica. Entre los PRR mejor descritos y con implicaciones en infecciones virales se encuentran los receptores tipo toll (TLR) y receptores tipo RNA helicasas inducibles por ácido retinoico (RLR); además las proteínas efectoras PKR, 2 ́- 5 ́ OAS y ADAR también participan activamente en la respuesta antiviral. La descripción y caracterización de los PRR ha contribuido enormemente al entendimiento del papel dela respuesta inmune innata en las infecciones virales y han sido usados para comprender mejor las interacciones hospedero-patógenos. Se discuten en la presente revisión los más recientes conocimientos de los TLR y RLR, el mecanismo de reconocimiento de los virus vía PRRs y las vías de señalización activadas por dicho reconocimiento.COL001244411application/pdfengUniversidad del ValleInmunovirologíaCali, Colombiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVArtículo de revisiónhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/http://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-nd/4.0/Viral recognition by the innate immune system : the role of pattern recognition receptorsReconocimiento viral por el sistema inmune innato : papel de los receptores de reconocimiento de patronesInmunidad InnataImmunity, InnateReceptores Toll-LikeToll-Like ReceptorsCitocinasCytokinesReceptores de Reconocimiento de PatronesReceptors, Pattern RecognitionColomb. Med.Colombia Médica377387414Colombia. Ministerio de Ciencia, Tecnología e Innovacióngrid.433658.f111540820517-2.ORIGINALTorresSilvia_2010_ViralRecognitionInnateImmuneSystem.pdfTorresSilvia_2010_ViralRecognitionInnateImmuneSystem.pdfArtículo de revisiónapplication/pdf433696https://bibliotecadigital.udea.edu.co/bitstream/10495/32315/1/TorresSilvia_2010_ViralRecognitionInnateImmuneSystem.pdf4b2e5911a152fae71758ac479c9edb2eMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstream/10495/32315/2/license_rdfb88b088d9957e670ce3b3fbe2eedbc13MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstream/10495/32315/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5310495/32315oai:bibliotecadigital.udea.edu.co:10495/323152022-11-24 16:56:03.719Repositorio Institucional Universidad de Antioquiaandres.perez@udea.edu.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 |