Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus
Hormonal treatments that combine the use of Gonadotropin Releasing Hormone (GnRH) and Prostaglandin F2α (PGF2α) have been able to synchronize estrus and ovulation in dairy cows and buffaloes, but in heifers the results have been very variable, reporting dispersion in estrus, persistence of follicles...
- Autores:
-
Ortega Barrios, Laura Vanessa
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Córdoba
- Repositorio:
- Repositorio Institucional Unicórdoba
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicordoba.edu.co:ucordoba/7392
- Acceso en línea:
- https://repositorio.unicordoba.edu.co/handle/ucordoba/7392
- Palabra clave:
- Cosynch
Folículos
Hormonas
IATF
Tasa de preñez
Cosynch
Follicles
Hormones
IATF
Pregnancy rate
- Rights
- openAccess
- License
- Copyright Universidad de Córdoba, 2023
id |
UCORDOBA2_e78c818193ce1cc19ee6d84e2000037c |
---|---|
oai_identifier_str |
oai:repositorio.unicordoba.edu.co:ucordoba/7392 |
network_acronym_str |
UCORDOBA2 |
network_name_str |
Repositorio Institucional Unicórdoba |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
title |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
spellingShingle |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus Cosynch Folículos Hormonas IATF Tasa de preñez Cosynch Follicles Hormones IATF Pregnancy rate |
title_short |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
title_full |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
title_fullStr |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
title_full_unstemmed |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
title_sort |
Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicus |
dc.creator.fl_str_mv |
Ortega Barrios, Laura Vanessa |
dc.contributor.advisor.none.fl_str_mv |
Salgado Otero, Roger Daniel |
dc.contributor.author.none.fl_str_mv |
Ortega Barrios, Laura Vanessa |
dc.subject.proposal.spa.fl_str_mv |
Cosynch Folículos Hormonas IATF Tasa de preñez |
topic |
Cosynch Folículos Hormonas IATF Tasa de preñez Cosynch Follicles Hormones IATF Pregnancy rate |
dc.subject.keywords.eng.fl_str_mv |
Cosynch Follicles Hormones IATF Pregnancy rate |
description |
Hormonal treatments that combine the use of Gonadotropin Releasing Hormone (GnRH) and Prostaglandin F2α (PGF2α) have been able to synchronize estrus and ovulation in dairy cows and buffaloes, but in heifers the results have been very variable, reporting dispersion in estrus, persistence of follicles and low ovulation rates1. Therefore, in order to reduce the variability of these results, protocols have been created in combination with progesterone release devices; in this regard, the P4-Cosynch treatment that combines the use of Progesterone (P4) with GnRH and PGF2α, which has given good results in the synchronization of cows and heifers of dairy and beef breeds, stands out. According to ASOCEBÚ data, 95% of the Colombian cattle population is zebu or has zebu genetics. Therefore, this study could contribute to the dynamization of productive processes and to the increase of the breeding stock. Considering the above, the objective of this study was to evaluate the effect of GnRH hormone in fixed-term artificial insemination protocols on the fertility of Bos taurus indicus heifers. For the study, 158 clinically healthy Brahman cyclic and acyclic heifers with a body condition score of four were synchronized. The experimental treatments corresponded to six protocols that included the following hormones GnRH-PGF2-GnRH (T1 and T2), DIBGnRH-PGF2-GnRH (T3 and T4) and DIB-GnRH-PGF2-eCG-GnRH (T5 and T6). The animals were assessed for preovulatory follicle size by ultrasonography using an ALOKA Co., Ltd. UST-5820-5 equipped with a 5MHz linear translator, the screen was split in 2B mode, the image was frozen with the Freeze option, and the variables were analyzed by Chi-square test of independence and comparison of proportions between two populations. With the synchronization protocols, a total pregnancy rate of 10.7% (T1), 16.6% (T2) 36.8% (T3) 41.9% (T4) 38.7% (T5) and 27.68% (T6) was obtained. The effect (P= 0.0803) between treatments was found when comparing pregnancy proportions, it was found that T1 and T2 were statistically equal (p>0.05). The same happened with treatments T3, T4, T5 and T6, but differences (p≤0.05) were found between treatments T1 and T2 when compared with treatments T3, T4, T5 and T6. On the other hand, there were no differences (P ≥ 0.05), in the average preovulatory follicle size being these 10.28; 11.21 and 11.77 mm for heifers synchronized with treatments 1-2, 3-4 and 5-6, respectively. The use of GnRH hormone in combination with progesterone in Cosynch protocol significantly improves pregnancy rates in Bos indicus heifers, compared to the traditional Cosynch protocol. |
publishDate |
2023 |
dc.date.accessioned.none.fl_str_mv |
2023-06-26T18:39:49Z |
dc.date.available.none.fl_str_mv |
2023-06-26T18:39:49Z |
dc.date.issued.none.fl_str_mv |
2023-06-24 |
dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_71e4c1898caa6e32 |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.content.spa.fl_str_mv |
Text |
format |
http://purl.org/coar/resource_type/c_7a1f |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unicordoba.edu.co/handle/ucordoba/7392 |
url |
https://repositorio.unicordoba.edu.co/handle/ucordoba/7392 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.rights.spa.fl_str_mv |
Copyright Universidad de Córdoba, 2023 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.creativecommons.spa.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
rights_invalid_str_mv |
Copyright Universidad de Córdoba, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.faculty.spa.fl_str_mv |
Facultad de Medicina Veterinaria y Zootecnia |
dc.publisher.place.spa.fl_str_mv |
Berástegui, Córdoba, Colombia |
dc.publisher.program.spa.fl_str_mv |
Medicina Veterinaria y Zootecnia |
institution |
Universidad de Córdoba |
bitstream.url.fl_str_mv |
http://172.16.14.198/bitstreams/4589d1c7-6d55-4443-98df-3d9c42087a21/download http://172.16.14.198/bitstreams/ba2e8da4-dabc-4567-a176-573e4eac35bd/download http://172.16.14.198/bitstreams/c19034cf-0cd8-4360-8de4-80a9564eb09b/download http://172.16.14.198/bitstreams/85684347-b1c0-4d41-9215-4c7768133c54/download http://172.16.14.198/bitstreams/e13efcdd-d630-4e7f-b093-5e4cd1cb7dab/download http://172.16.14.198/bitstreams/b886af28-0079-488f-8b63-d7101233fd92/download http://172.16.14.198/bitstreams/b90e8b81-eca2-4137-ba3e-1c2cb2eb49f8/download |
bitstream.checksum.fl_str_mv |
419120de5621b0483e4a83e736f91358 9acea1e9a1c4486c2000be0e3f9cf443 2f9959eaf5b71fae44bbf9ec84150c7a 841fff0068c644597a5c748dad73f4eb d301897f1c2aec9ca1ca7ee1eabb0d04 a6c8b62127a4b8a6366688a8e2d789e7 9775e2564a61427f7d4f14881ea84466 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Universidad de Córdoba |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1812173339738767360 |
spelling |
Salgado Otero, Roger Danielacf3a3ed-f3a9-4be7-9e66-789d5753d96b-1Ortega Barrios, Laura Vanessad44e1353-9301-4aa4-a082-c3a0b4b78643-12023-06-26T18:39:49Z2023-06-26T18:39:49Z2023-06-24https://repositorio.unicordoba.edu.co/handle/ucordoba/7392Hormonal treatments that combine the use of Gonadotropin Releasing Hormone (GnRH) and Prostaglandin F2α (PGF2α) have been able to synchronize estrus and ovulation in dairy cows and buffaloes, but in heifers the results have been very variable, reporting dispersion in estrus, persistence of follicles and low ovulation rates1. Therefore, in order to reduce the variability of these results, protocols have been created in combination with progesterone release devices; in this regard, the P4-Cosynch treatment that combines the use of Progesterone (P4) with GnRH and PGF2α, which has given good results in the synchronization of cows and heifers of dairy and beef breeds, stands out. According to ASOCEBÚ data, 95% of the Colombian cattle population is zebu or has zebu genetics. Therefore, this study could contribute to the dynamization of productive processes and to the increase of the breeding stock. Considering the above, the objective of this study was to evaluate the effect of GnRH hormone in fixed-term artificial insemination protocols on the fertility of Bos taurus indicus heifers. For the study, 158 clinically healthy Brahman cyclic and acyclic heifers with a body condition score of four were synchronized. The experimental treatments corresponded to six protocols that included the following hormones GnRH-PGF2-GnRH (T1 and T2), DIBGnRH-PGF2-GnRH (T3 and T4) and DIB-GnRH-PGF2-eCG-GnRH (T5 and T6). The animals were assessed for preovulatory follicle size by ultrasonography using an ALOKA Co., Ltd. UST-5820-5 equipped with a 5MHz linear translator, the screen was split in 2B mode, the image was frozen with the Freeze option, and the variables were analyzed by Chi-square test of independence and comparison of proportions between two populations. With the synchronization protocols, a total pregnancy rate of 10.7% (T1), 16.6% (T2) 36.8% (T3) 41.9% (T4) 38.7% (T5) and 27.68% (T6) was obtained. The effect (P= 0.0803) between treatments was found when comparing pregnancy proportions, it was found that T1 and T2 were statistically equal (p>0.05). The same happened with treatments T3, T4, T5 and T6, but differences (p≤0.05) were found between treatments T1 and T2 when compared with treatments T3, T4, T5 and T6. On the other hand, there were no differences (P ≥ 0.05), in the average preovulatory follicle size being these 10.28; 11.21 and 11.77 mm for heifers synchronized with treatments 1-2, 3-4 and 5-6, respectively. The use of GnRH hormone in combination with progesterone in Cosynch protocol significantly improves pregnancy rates in Bos indicus heifers, compared to the traditional Cosynch protocol.INTRODUCCIÓN 11. OBJETIVOS 31.1 OBJETIVO GENERAL 31.2 OBJETIVOS ESPECÍFICOS 32. MARCO TEÓRICO 42.1 PROTOCOLO COSYNCH 42.2 USO DE PROGESTERONA EN EL PROTOCOLO CO SYNCH (P4-COSYNCH) 42.3 USO DE LA ECG EN PROTOCOLOS DE IATF 53. MATERIALES Y MÉTODOS 73.1 TIPO DE ESTUDIO 73.2 LOCALIZACIÓN 73.3 POBLACIÓN Y MUESTRA 73.4 TECNICAS DE RECOLECCIÓN DE DATOS 73.4.1 Tratamiento Cosynch tradicional 83.4.2 Tratamiento Cosynch con progesterona 83.4.3 Tratamiento Cosynch con Progesterona y eCG 93.4.4 Ultrasonografía ovárica, respuesta ovulatoria y diagnóstico de preñez 93.5 ANALISIS ESTADÍSTICO 104. ASPECTOS ÉTICOS 115. RESULTADOS, DISCUCIÓN Y CONCLUSIONES 12BIBLIOGRAFÍA 19Los tratamientos hormonales que combinan el uso de la Hormona liberadora de Gonadotropina (GnRH) y Prostaglandina F2α (PGF2α) han logrado sincronizar el celo y la ovulación en vacas lecheras y búfalas, pero en novillas los resultados han sido muy variables, reportándose dispersiones en celo, persistencia de folículos y bajas tasas de ovulación1 . Por lo tanto, y en aras de disminuir la variabilidad de estos resultados se han creado protocolos en combinación con dispositivos de liberación de progesterona; al respecto se resalta el tratamiento P4-Cosynch que combina el uso de Progesterona (P4) con GnRH y PGF2α, el cual ha dado buenos resultados en la sincronización de vacas y novillas de razas lecheras y cárnicas. Puesto que según datos de ASOCEBÚ, el 95% de la población bovina colombiana es cebú o tiene genética cebuina. Por lo cual este estudio podría contribuir en la dinamización de procesos productivos y al aumento del pie de cría. Teniendo en cuenta lo anterior, el objetivo de este estudio fue evaluar el efecto de la hormona GnRH en protocolos de inseminación artificial a término fijo sobre la fertilidad de novillas Bos taurus indicus. Para el estudio se sincronizaron 158 novillas cíclicas y acíclicas de la raza Brahman clínicamente sanas y con un puntaje de condición corporal de cuatro. Los tratamientos experimentales correspondieron a seis protocolos que incluyeron las siguientes hormonas GnRH-PGF2-GnRH (T1 y T2), DIB-GnRH-PGF2-GnRH (T3 y T4) y DIB-GnRHPGF2-eCG-GnRH (T5 y T6). A los animales se les evaluó el tamaño del folículo preovulatorio por medio de ultrasonografía utilizando un ecógrafo ALOKA Co., Ltda. UST5820-5 equipado con un traductor lineal de 5MHz, la pantalla fue dividida en modo 2B, la imagen fue congelada con la opción Freeze, y las variables fueron analizadas mediante prueba de independencia de Chí cuadrado y comparación de proporciones entre dos poblaciones. Con los protocolos de sincronización se obtuvo una tasa de preñez total de 10,7 %(T1), 16,6% (T2) 36,8% (T3) 41,9 %(T4) 38,7% (T5) y 27,68% (T6). Se encontró efecto (P= 0.0803) entre los tratamientos al realizar la comparación de proporciones de preñez, se encontró que el T1 y T2 fueron estadísticamente iguales (p>0.05). Igualmente sucedió con los tratamientos T3, T4, T5 y T6, pero se encontró diferencias (p≤0.05) entre los tratamientos T1 y T2 al compararlos con los tratamientos T3, T4, T5 y T6. Por su parte, no hubo diferencias (P ≥ 0,05), en el promedio del tamaño de folículo preovulatorio siendo éstos 10,28; 11,21 y 11,77 mm para las novillas sincronizadas con los tratamientos 1-2, 3-4 y 5-6, respectivamente. El uso de la hormona GnRH en combinación con progesterona en protocolo Cosynch mejora significativamente las tasas de preñez en novillas Bos indicus, en comparación al protocolo Cosynch tradicional.PregradoMédico(a) Veterinario(a) y ZootecniaTrabajos de Investigación y/o Extensiónapplication/pdfspaCopyright Universidad de Córdoba, 2023https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Efecto de la GnRh en protocolos de sincronización sobre la fertilidad de novillas Bos taurus indicusTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/coar/version/c_71e4c1898caa6e32CosynchFolículosHormonasIATFTasa de preñezCosynchFolliclesHormonesIATFPregnancy rateFacultad de Medicina Veterinaria y ZootecniaBerástegui, Córdoba, ColombiaMedicina Veterinaria y Zootecnia1. Barreiros T, et al. Dynamics of follicular growth and progesterone concentrations in cyclic and anestrous suckling Nelore cows (Bos indicus) treated with progesterone, equine chorionic gonadotropin, or temporary calf removal. Theriogenology. 2014. 81, 651-656. Disponible en: https://ezproxyucor.unicordoba.edu.co:2054/science/article/pii/S0093691X130052322. González P. Uso de anabólicos en la producción ganadera y sus efectos en la salud de las personas. Biblioteca del congreso nacional de Chile. 2017. Disponible en: https://www.camara.cl/verDoc.aspx?prmID=121769&prmTIPO=DOCUMENTOCOMISION3. Vázquez S. Evaluación de dos protocolos de sincronización del estro y la ovulación en ganado de carne raza Nelore. 2019.4. Colazo M y Ambrose D. Neither duration of progesterone insert nor initial GnRH treatment affect pregnancy per timed-insemination in dairy heifers subjected to a Co-synch protocol. Theriogenology. 2011. 76:578-588. Disponible en: https://doi.org/10.1016/j.theriogenology.2011.03.0135. Gómez C, et al. Evaluación de la introducción de un dispositivo de progesterona (CIDR) en un protocolo Cosynch en ganado vacuno lechero. XVII jornadas sobre producción animal. 2017. 371-373.6. Bilbao M, et al. Comparison between the 5-day cosynch and 7-day estradiol-based protocols for synchronization of ovulation and timed artificial insemination in suckled BOS taurus BEEF cows. Theriogenology. 2019. 131: 72-78. https://doi.org/10.1016/j.theriogenology.2019.01.0277. Kasimanickam R, et al. Sire effect on the pregnancy outcome in beef cows synchronized with progesterone based Ovsynch and CO-Synch protocols. Animal Reproduction Science. 2008. 104, 1–8. Disponible en: https://ezproxyucor.unicordoba.edu.co:2054/science/article/pii/S0378432007000073#!8. Whittier W, et al. Fertility in Angus cross beef cows following 5-day CO-Synch þ CIDR or 7-day CO-Synch þ CIDR estrus synchronization and timed artificial insemination. Theriogenology. 2013, 80, 963–969. Disponible en: https://ezproxyucor.unicordoba.edu.co:2054/science/article/pii/S0093691X13002902#!9. Thomas J, et al. Delayed insemination of nonestrous cows improves pregnancy rates when using sex-sorted semen in timed artificial insemination of suckled beef cows. Journal of animal science. 2014. vol. 92, no 4, p. 1747-1752.10. Kasimanickam R, et al. Effect of the first GnRH and two doses of PGF2a in a 5-day progesterone-based CO-Synch protocol on heifer pregnancy. Theriogenology. 2014. 81, 797–804. Disponible en: https://ezproxyucor.unicordoba.edu.co:2054/science/article/abs/pii/S0093691X1400002811. Bó, Gabriel, et al. Implementacion de Programas de Inseminación Artificial en Rodeos de Cría de Argentina.VI Simposio Internacional de Reproducción Animal, Córdoba, Argentina. 200512. Sá filho M, et al. Equine chorionic gonadotropin improves the efficacy of a progestin-based fixed-time artificial insemination protocol in Nelore (Bos indicus) heifers, Animal Reproduction Science. 2010. 118, 182–187. Disponible en: https://ezproxyucor.unicordoba.edu.co:2054/science/article/abs/pii/S0378432009002619#!13. Maraña D, et al. Implementacion de Programa de Inseminación Artificial en Rodeos de Cría de Argentina. 2005. VI Simposio Internacional de Reproducción Animal, Córdoba, Argentina.14. Baruselli P S, et al. The use of hormonal treatments to improve reproductive performance of anestrous beef cattle in tropical climates. 2004. Anim Reprod Sci. 82-83: 479- 486. 200.15. Bó G y Cutaia L. Inseminación artificial a tiempo fijo en vacas lecheras. 2008; Instituto de Reproducción Animal Córdoba (IRAC), Córdoba, Argentina.16. Ferreira R, et al. Effect of different doses of equine chorionic gonadotropin on follicular and luteal dynamics and P/AI of high-producing Holstein cows. Animal reproduction Science. 2013. vol. 140, no 1-2, p. 26-33. Disponible en: https://ezproxyucor.unicordoba.edu.co:2054/science/article/abs/pii/S037843201300146217. Lowman B G, Scott N, Somerville S. Condition scoring beef cattle. The east of Scotland College of Agriculture. 1976. Bulletin Nº 6. Disponible en: https://scholar.google.es18. Innovación, T. E. Política de Ética de la Investigación, Bioética e Integridad Científica. Disponible en: https://minciencias.gov.co/sites/default/files/pdf_poltica.pdf19. Villa N, et al. Evaluación de cuatro protocolos de sincronización para inseminación a tiempo fijo en animales Bos indicus lactantes. 2007. Revista Cientifica Maracaibo, 17(5), 501-507. Disponible en: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0798-22592007000500010&lng=es&tlng=en.20. Bó G, et al. Alternative programs for synchronizing and resynchronizing ovulation in beef cattle. 2016. Theriogenology, 86(1), 388-396. Disponible en: https://doi.org/10.1016/j.theriogenology.2016.04.05321. Peel J, et al. Effect of 2, 4, and 5-hour intervals between 2 prostaglandin F2α injections administered with 5-day CO-Synch + CIDR protocol on pregnancy rate in beef cows. 2012. Animal Science, 28(6), 623-627. Disponible en: https://doi.org/10.15232/S1080-7446(15)30420-422. Ratzburg K, et al. Presynchronization with CIDR, with or without GnRH, prior to CO-Synch in beef heifers. 2020. Theriogenology, 146, 80-87. Disponible en: https://doi.org/10.1016/j.theriogenology.2020.02.00523. Martinez MF, et al. The use of progestins in regimens for fixed-time artificial insemination in beef cattle. 2002. Theriogenology, 57:1049-1059. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0093691X0100682324. Mihm M, et al. Association between the duration of dominance of the ovulatory follicle and pregnancy rate in beef heifers. 1994. J. Reprod. Fertil. 102: 123-130. Disponible en: https://rep.bioscientifica.com/view/journals/rep/102/1/jrf_102_1_016.xml25. Ahmad N, et al. Effect of persistent follicles on early embryonic losses in beef cows. 1995. Biology of Reproduction, 52, 1129–1135. Disponible en: https://academic.oup.com/biolreprod/article/52/5/1129/2761579?searchresult=126. Bao B, et al. Changes in messenger ribonucleic acid encoding luteinizing hormone receptor, cytochrome P450-side chain cleavage, and aromatase are associated with recruitment and selection of bovine ovarian follicles. 1997. Biology of Reproduction, 56(5), 1158-1168.27. Rawan A, et al. Insulin‐Like Growth Factor‐1 Regulates the Expression of Luteinizing Hormone Receptor and Steroid Production in Bovine Granulosa Cells. 2015. Reproduction in Domestic Animals, 50(2), 283-291.28. Lopes G, et al. Evaluation of reproductive and economic outcomes of dairy heifers inseminated at induced estrus or at fixed time after a 5-day or 7-day progesterone insert-based ovulation synchronization protocol. 2013. Journal Dairy Science, 96(3), 1612-1622. Disponible en: https://doi.org/10.3168/jds.2012-597129. Madureira G, et al. Progesterone-based timed AI protocols for Bos indicus cattle II: Reproductive outcomes of either EB or GnRH-type protocol, using or not GnRH at AI. 2020. Theriogenology, 145, 86-93. Disponible en: https://doi.org/10.1016/j.theriogenology.2020.01.03330. Bó G. Pursuit of a means of manipulating ovarian function in the cow: An adventure of serendipity, collaboration and friendship. 2020. Theriogenology, 150, 480-489. Disponible en: https://doi.org/10.1016/j.theriogenology.2020.03.01031. Oliveira L. Progesterone release profile and follicular development in Holstein cows receiving intravaginal progesterone devices. 2021. Theriogenology, 172, 207-215. Disponible en: https://doi.org/10.1016/j.theriogenology.2021.07.00132. Menchaca A, et al. How fertility can be improved in fixed-time AI programs in beef cattle. Proceedings X Symposium on Animal Reproduction (pp. 103-134). 2013. Institute of Animal Reproduction Cordoba (IRAC), Córdoba, Argentina. Disponible en: https://iracbiogen.com/wp-content/uploads/2021/06/RESUMEN-11-Simposio-Internacional-de-Reproduccion-Animal-2015.pdf33. Lopes I, et al. Effect of initial GnRH and time of insemination on reproductive performance in cyclic and acyclic beef heifers subjected to a 5-d Co-synch plus progesterone protocol. 2018. Theriogenology, 106, 39-45. Disponible en: https://doi.org/10.1016/j.theriogenology.2017.10.00134. Duica A. Efecto del diámetro del folículo ovulatorio, tamaño del cuerpo lúteo y perfiles de progesterona sobre la tasa de preñez en la hembra receptora de embriones bovinos. 2010. Universidad Nacional de Colombia Sede Bogotá Facultad de Medicina Veterinaria y Zootecnia.35. Palomino S, et al. Effects of follicular ablation and GnRH on synchronization of ovulation and conception rates in embryo recipient heifers. 2020. Animal Reproduction Sci. 221: 0378-4320. Disponible en: https://doi.org/10.1016/j.anireprosci.2020.10659636. Scandolo D, et al. Efficacy of estradiol or GnRH in combination with progesterone intravaginal devices to control the follicular wave dynamics and resulting fertility in lactating dairy cows. 2020. Animal Reproduction Science, 223, 0378-4320. Disponible en: https://doi.org/10.1016/j.anireprosci.2020.10664637. Guzmán F. Efecto del diámetro del folículo preovulatorio en el momento de la IATF y de la expresión de estro sobre la tasa de preñez en vacas Nelore con cría al pie. 2018. Instituto de reproducción animal Córdoba (IRAC), Córdoba, Argentina. Disponible en: http://hdl.handle.net/11086/657238. Gimenes L U, et al. Follicle deviation and ovulatory capacity in Bos indicus heifers. 2008. Theriogenology. 69, 852–858. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0093691X0800009539. Vasconcelos J, et al. Reduction in size of the ovulatory follicle reduces subsequent luteal size and pregnancy rate. 2001. Teriogenology, 56(2):307– 314. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0093691X0100565940. Busch D C, et al. Effect of ovulatory follicle size and expression of estrus on progesterone secretion in beef cows. 2008. Journal of animal science, 86(3):553–563. Disponible en: https://academic.oup.com/jas/article-abstract/86/3/553/4789053?redirectedFrom=fulltextPublicationORIGINALortegabarrioslaura.pdfortegabarrioslaura.pdfapplication/pdf843926http://172.16.14.198/bitstreams/4589d1c7-6d55-4443-98df-3d9c42087a21/download419120de5621b0483e4a83e736f91358MD51Formato de Autorización.pdfFormato de Autorización.pdfapplication/pdf542872http://172.16.14.198/bitstreams/ba2e8da4-dabc-4567-a176-573e4eac35bd/download9acea1e9a1c4486c2000be0e3f9cf443MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-814828http://172.16.14.198/bitstreams/c19034cf-0cd8-4360-8de4-80a9564eb09b/download2f9959eaf5b71fae44bbf9ec84150c7aMD53TEXTortegabarrioslaura.pdf.txtortegabarrioslaura.pdf.txtExtracted texttext/plain42393http://172.16.14.198/bitstreams/85684347-b1c0-4d41-9215-4c7768133c54/download841fff0068c644597a5c748dad73f4ebMD54Formato de Autorización.pdf.txtFormato de Autorización.pdf.txtExtracted texttext/plain127http://172.16.14.198/bitstreams/e13efcdd-d630-4e7f-b093-5e4cd1cb7dab/downloadd301897f1c2aec9ca1ca7ee1eabb0d04MD56THUMBNAILortegabarrioslaura.pdf.jpgortegabarrioslaura.pdf.jpgGenerated Thumbnailimage/jpeg4037http://172.16.14.198/bitstreams/b886af28-0079-488f-8b63-d7101233fd92/downloada6c8b62127a4b8a6366688a8e2d789e7MD55Formato de Autorización.pdf.jpgFormato de Autorización.pdf.jpgGenerated Thumbnailimage/jpeg10582http://172.16.14.198/bitstreams/b90e8b81-eca2-4137-ba3e-1c2cb2eb49f8/download9775e2564a61427f7d4f14881ea84466MD57ucordoba/7392oai:172.16.14.198:ucordoba/73922023-10-06 00:45:17.066https://creativecommons.org/licenses/by-nc-nd/4.0/Copyright Universidad de Córdoba, 2023open.accesshttp://172.16.14.198Repositorio Universidad de Córdobabdigital@metabiblioteca.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 |