Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos

Autores:: Monsalve B, Santiago
Gallego L, Vanessa
Molina, Victor Manuel
Rodas G, Juan

Tipo de recurso:: Article of journal

Fecha de publicación:: 2017

Institución:: Universidad de Córdoba

Repositorio:: Repositorio Institucional Unicórdoba

Idioma:: spa

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dc.title.spa.fl_str_mv	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
dc.title.translated.eng.fl_str_mv	Pharmacokinetics and adverse effects of doxycycline in the treatment of Ehrlichiosis: theoretical foundations for clinical trials in canines
title	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
spellingShingle	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos Blood chemistry Ehrlichia canis hematology pharmacokinetics tetracycline Ehrlichia canis farmacocinética hematología química sanguínea tetraciclina
title_short	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
title_full	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
title_fullStr	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
title_full_unstemmed	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
title_sort	Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos
dc.creator.fl_str_mv	Monsalve B, Santiago Gallego L, Vanessa Molina, Victor Manuel Rodas G, Juan
dc.contributor.author.spa.fl_str_mv	Monsalve B, Santiago Gallego L, Vanessa Molina, Victor Manuel Rodas G, Juan
dc.subject.eng.fl_str_mv	Blood chemistry Ehrlichia canis hematology pharmacokinetics tetracycline
topic	Blood chemistry Ehrlichia canis hematology pharmacokinetics tetracycline Ehrlichia canis farmacocinética hematología química sanguínea tetraciclina
dc.subject.spa.fl_str_mv	Ehrlichia canis farmacocinética hematología química sanguínea tetraciclina
publishDate	2017
dc.date.accessioned.none.fl_str_mv	2017-05-25 00:00:00 2022-07-01T21:00:36Z
dc.date.available.none.fl_str_mv	2017-05-25 00:00:00 2022-07-01T21:00:36Z
dc.date.issued.none.fl_str_mv	2017-05-25
dc.type.spa.fl_str_mv	Artículo de revista
dc.type.eng.fl_str_mv	Journal article
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dc.identifier.doi.none.fl_str_mv	10.21897/rmvz.1076
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dc.identifier.eissn.none.fl_str_mv	1909-0544
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dc.relation.references.spa.fl_str_mv	Aronson AL. Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 1980; 176(10):1061–8. Cunha, B.A. Sibley, C.M. Ristuccia AM. Doxyxycline. Ther Drug Monit 1982; 4(2):115. https://doi.org/10.1097/00007691-198206000-00001 Riond JL, Vaden SL, Riviere JE. Comparative Pharmacokinetics of Doxycycline in Cats and Dogs. J Vet Pharmacol Ther 1990; 13(4):415–24. https://doi.org/10.1111/j.1365-2885.1990.tb00797.x Barza M, Brown RB, Shanks C, Gamble C, Weinstein L. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs. Antimicrob Agents Chemother 1975; 8(6):713–20. https://doi.org/10.1128/AAC.8.6.713 Villaescusa A, García-Sancho M, Rodríguez-Franco F, Tesouro MÁ, Sainz Á. Effects of doxycycline on haematology, blood chemistry and peripheral blood lymphocyte subsets of healthy dogs and dogs naturally infected with Ehrlichia canis. Vet J 2015; 204(3):263–8. https://doi.org/10.1016/j.tvjl.2015.03.031 Von Wittenau, M.S. Yeary R. The excretion and distribution in body fluids of tetracyclines after intravenous administration to dogs. J Pharmacol Exp Ther 1963; 140(2):258–66. Neer TM, Breitschwerdt EB, Greene RT, Lappin MR. Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM. American College of Veterinary Internal Medicine. J Vet Intern Med 2002; 16(3):309–15. https://doi.org/10.1111/j.1939-1676.2002.tb02374.x Sumano H, Ocampo L. Tetraciclinas. Farmacología veterinaria. México: MC Graw Hill; 2006. Chambers HE. Inhibidores de la síntesis de proteína y otros antibacterianos. En: Laurence L. Brunton(Ed). Las Bases Farmacológicas de la Terapéutica. Undécima e. México: MC Graw Hill; 2008. Vicente D, Pérez-Trallero E. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002 Gutiérrez L, Velasco Z, Vázquez C, Vargas D, Sumano H. Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs. Acta Vet Scand 2012; 54(1):1. https://doi.org/10.1186/1751-0147-54-35 Deck DH, Winston LG. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones. In: Katzung BG, Masters SB, Trevor AJ (editor). Basic & clinical pharmacology. Vol 12. 2012. Schulz BS, Hupfauer S, Ammer H, Sauter-Louis C, Hartmann K. Suspected side effects of doxycycline use in dogs - a retrospective study of 386 cases. Vet Rec 2011; 169(9):229. https://doi.org/10.1136/vr.d4344 Bartlett JG, Bustetter LA, Gorbach SL, Andrew B. Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Flora 1975; 7(1):55–7. Little SE. Ehrlichiosis. In: Arthropod Borne Diseases. Springer International Publishing; 2017. https://doi.org/10.1007/978-3-319-13884-8_14 Perez M, Bodor M, Zhang C, Xiong Q, Rikihisa Y. Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela. Ann N Y Acad Sci 2006;1078:110–7. https://doi.org/10.1196/annals.1374.016 Bouza-mora L, Dolz G, Solórzano-morales A, Romero-zu JJ, Salazar-sánchez L, Labruna MB, et al. Novel genotype of Ehrlichia canis detected in samples of human blood bank donors in Costa Rica. Ticks Tick Borne Dis 2017; 8(1):36–40. https://doi.org/10.1016/j.ttbdis.2016.09.012 López, J. Rivera, M. Concha, J. C. Gatica, S. Loeffeholz, M. Barriga O. Ehrlichiosis humana en Chile: evidencia serológica. Rev Med Chil 2003; 131(1):67–70. https://doi.org/10.4067/S0034-98872003000100010 Vargas-Hernandez, G., André, M. R., Cendales, D. M., Sousa, K. C. M. D., Gonçalves, L. R., Rondelli., Zacarías-Machado, R., Tinucci-Costa M. Molecular detection of Anaplasma species in dogs in Colombia. Braz J Vet Parasitol 2016; 25(4):459–64. https://doi.org/10.1590/s1984-29612016066 Nair ADS, Cheng C, Ganta CK, Sanderson MW, Alleman R, Munderloh UG, et al. Comparative Experimental Infection Study in Dogs with Ehrlichia canis, E . chaffeensis, Anaplasma platys and A . phagocytophilum. PLoS One 2016;11(2):1–21. https://doi.org/10.1371/journal.pone.0148239 Miranda J, Mattar S. Molecular detection of Anaplasma sp. and ehrlichia sp. in ticks collected in domestical animals, Colombia. Trop Biomed 2015;32(4):726–35. Waner T, Harrus S, Jongejan F, Bark H, Keysary A. Cornelissen AWCA. Significance of serological testing for ehrlichial diseases in dogs with special emphasis on the diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis. Vet Parasitol 2001; 95(1):1–15. https://doi.org/10.1016/S0304-4017(00)00407-6 Casas EA. Seroprevalencia de la dirofilariosis y ehrlichiosis canina en tres distritos de Lima. Rev Inv Vet Peru 2003;14(1):43–8. Swann JW, Woods K, Wu Y, Glanemann B, Garden OA. Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia. PLoS One 2016; 11(2):1-18. https://doi.org/10.1371/journal.pone.0168296 Mccullough S. Immune-mediated hemolytic anemia : understanding the nemesis. Vet Clin North Am Small Anim Pr 2003; 33:1295–315. https://doi.org/10.1016/j.cvsm.2003.08.003 Ge, Y., Yin, H., Rikihisa, Y., Pan, W., & Yin H. Molecular Detection of Tick-Borne Rickettsiales in Goats and Sheep from Southeastern China. Vector-Borne Zoonotic Dis. 2016; 16(5):309–16. https://doi.org/10.1089/vbz.2015.1884 Karnezi D, Ceron JJ, Theodorou K, Leontides L, Siarkou VI, Martinez S, et al. Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. Vet Microbiol 2016; 184:59–63. https://doi.org/10.1016/j.vetmic.2016.01.007 Little SE. Ehrlichiosis and Anaplasmosis in Dogs and Cats. Vet Clin North Am - Small Anim Pract 2010; 40(6):1121–40. https://doi.org/10.1016/j.cvsm.2010.07.004 Rikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis : subversive manipulators of host cells. Nat Publ Gr 2010; 8(5):328–39. https://doi.org/10.1038/nrmicro2318 Kucuk A, Kabadere S, Tosun M, Koken T, Kinaci MK, Isikli B, et al. Protective effects of doxycycline in ischemia/reperfusion injury on kidney. J Physiol Biochem 2009; 65(2):183–91. https://doi.org/10.1007/BF03179069 Gabler, W.L. Creamer HR. Suppression of human neutrophil functions by tetracyclines. J Periodontal Res 1991; 26(1):52–8. https://doi.org/10.1111/j.1600-0765.1991.tb01626.x Griffin MO, Fricovsky E, Ceballos G, Villarreal F. Tetracyclines : a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol 2010; 299(3):C539-48. https://doi.org/10.1152/ajpcell.00047.2010 Frank JR, Breitschwerdt EB. A Retrospective Study of Ehrlichiosis in 62 Dogs from North Carolina and Virginia. J Vet Intern Med 1999; 13(3):194-201. https://doi.org/10.1111/j.1939-1676.1999.tb02178.x De Castro MB, Machado RZ, De Aquino LPCT, Alessi AC, Costa MT. Experimental acute canine monocytic ehrlichiosis: Clinicopathological and immunopathological findings. Vet Parasitol 2004; 119(1):73–86. https://doi.org/10.1016/j.vetpar.2003.10.012 Ismail N, Crossley EC, Stevenson HL, Walker DH. Relative Importance of T-Cell Subsets in Monocytotropic Ehrlichiosis : a Novel Effector Mechanism Involved in Ehrlichia -Induced Immunopathology in Murine Ehrlichiosis. Infect Immun 2007; 75(9):4608-4620. https://doi.org/10.1128/IAI.00198-07 Winslow GM, Yager E, Shilo K, Volk E, Reilly A, Chu FK. Antibody-Mediated Elimination of the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis during Active Infection. Infect Immun 2000; 68(4):2187-2195. https://doi.org/10.1128/IAI.68.4.2187-2195.2000 Harrus S, Waner T, Friedmann-morvinski D. Down-regulation of MHC class II receptors of DH82 cells, following infection with Ehrlichia canis. Vet Immunol Immunopathol 2003; 96(3-4):239-43. https://doi.org/10.1016/j.vetimm.2003.08.005 Wilson RC, Kemp DT, Kitzman J V., Goetsch DD. Pharmacokinetics of doxycycline in dogs. Can J Vet Res 1988; 52(1):12–4. Maurin M, Bakken JS, Dumler JS. Antibiotic susceptibilities of Anaplasma (Ehrlichia) phagocytophilum strains from various geographic areas in the United States. Antimicrob Agents Chemother 2003; 47(1):413–5. https://doi.org/10.1128/AAC.47.1.413-415.2003 Collins, S.P. Labelle, A.L. Dirikolu, L. Li, Z. Mitchell, M.A. Hamor RE. Tear film concentrations of doxycycline following oral administration in ophthalmologically normal dogs. J Am Vet Med Assoc 2016; 249(5):508–14. https://doi.org/10.2460/javma.249.5.508 Arciniegas-Ruiz SM, Gutiérrez-Olvera L, Bernad-Bernad MJ, Caballero-Chacón SDC, Vargas-Estrada D. Comparative pharmacokinetics of a new oral long-acting formulation of doxycycline hyclate: A canine clinical trial. Eur J Pharm Sci 2015; 80:9–15. https://doi.org/10.1016/j.ejps.2015.09.012 Vicente D, Pérez-Trallero E. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002 Armijo JA. Absorción, distribución y eliminación de los fármacos. In: editor. Farmacología humana. Barcelona: Masson S.A: 1997. Perez-Trallero E, Iglesias L. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002 Riond J, Riviere JE. Doxycycline binding to plasma albumin of several species. J Vet Pharmacol Ther 1989; 12(3):253-260. https://doi.org/10.1111/j.1365-2885.1989.tb00668.x Bidgood TL, Papich MG. Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs. Am J Vet Res 2003; 64(8):1040–6. https://doi.org/10.2460/ajvr.2003.64.1040 Passalidou, P. Giudicelli, H. Moreigne, M. Khalfi A. Un cas d'ulcère œsophagien secondaire à la prise de doxycycline. Arch Pédiatrie 2006; 13(1):90–1. https://doi.org/10.1016/j.arcped.2005.10.014 Michel, G. Mosser, J. Fauran AU. Serum kinetics of doxycycline polyphosphate in dogs. Eur J Drug Metab Pharmacokinet 1979; 1:43–48. https://doi.org/10.1007/BF03189398 Iqbal ZRY. Reisolation of Ehrlichia canis from Blood and Tissues of Dogs after Doxycycline Treatment. J Clin Microbiol 1994; 32(7):1644–9. Breitschwerdt EB, Hegarty BC, Hancock SI, Carolina N, Carolina N. Doxycycline Hyclate Treatment of Experimental Canine Ehrlichiosis Followed by Challenge Inoculation with Two Ehrlichia canis Strains. Antimicrob Agents Chemother 1998; 42(2): 362–368. McClure JC, Crothers ML, Schaefer JJ, Stanley PD, Needham GR, Ewing SA, et al. Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis. Antimicrob Agents Chemother 2010; 54(12):5012–20. https://doi.org/10.1128/AAC.01622-09 Chiers K, Weyens P, Deprez P, Heerden M van, Meulemans G, Baert K, et al. Lingual and pharyngeal paralysis due to acute doxycycline intoxication in veal calves. Vet Rec 2004;155(1):25–6. https://doi.org/10.1136/vr.155.1.25 Riond J, Riviere JE, Duckettt WM, Atkins CE. Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses and ponies. Equine Vet J 1992;24:41–5. https://doi.org/10.1111/j.2042-3306.1992.tb02777.x Schölkens, B. Gerhards, H. Lindner E. Circulatory effects of intravenously administered rolitetracycline and other tetracyclines in animal experiments. Arzneimittelforschung 1971; 24(3):312–7. Brouqui P, Raoult D. In vitro susceptibility of Ehrlichia sennetsu to antibiotics. Antimicrob Agents Chemother 1990; 34(8):1593–6. https://doi.org/10.1128/AAC.34.8.1593 Branger S, Rolain JM, Raoult D. Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR. Antimicrob Agents Chemother 2004; 48(12):4822–8. https://doi.org/10.1128/AAC.48.12.4822-4828.2004 Davoust B, Keundjian A, Rous V, Maurizi L, Parzy D. Validation of chemoprevention of canine monocytic ehrlichiosis with doxycycline. Vet Microbiol 2005;107(3–4):279–83. https://doi.org/10.1016/j.vetmic.2005.02.002
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spelling	Monsalve B, Santiago8e16ed3b-edcc-48be-b001-ed9a0dc18ee0-1Gallego L, Vanessa5167fbee-8d04-4d03-957c-f438408d14ba-1Molina, Victor Manuel1d4f27ef-073c-4e65-b863-29f37fc7ca8b-1Rodas G, Juan51959f32-acbf-47ba-a5fb-ddf1db3a203a-12017-05-25 00:00:002022-07-01T21:00:36Z2017-05-25 00:00:002022-07-01T21:00:36Z2017-05-250122-0268https://repositorio.unicordoba.edu.co/handle/ucordoba/589110.21897/rmvz.1076https://doi.org/10.21897/rmvz.10761909-0544application/pdfspaUniversidad de Córdobahttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://revistamvz.unicordoba.edu.co/article/view/1076Blood chemistryEhrlichia canishematologypharmacokineticstetracyclineEhrlichia canisfarmacocinéticahematologíaquímica sanguíneatetraciclinaFarmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninosPharmacokinetics and adverse effects of doxycycline in the treatment of Ehrlichiosis: theoretical foundations for clinical trials in caninesArtículo de revistaJournal articleinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREFhttp://purl.org/coar/version/c_970fb48d4fbd8a85Aronson AL. Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 1980; 176(10):1061–8.Cunha, B.A. Sibley, C.M. Ristuccia AM. Doxyxycline. Ther Drug Monit 1982; 4(2):115. https://doi.org/10.1097/00007691-198206000-00001Riond JL, Vaden SL, Riviere JE. Comparative Pharmacokinetics of Doxycycline in Cats and Dogs. J Vet Pharmacol Ther 1990; 13(4):415–24. https://doi.org/10.1111/j.1365-2885.1990.tb00797.xBarza M, Brown RB, Shanks C, Gamble C, Weinstein L. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs. Antimicrob Agents Chemother 1975; 8(6):713–20. https://doi.org/10.1128/AAC.8.6.713Villaescusa A, García-Sancho M, Rodríguez-Franco F, Tesouro MÁ, Sainz Á. Effects of doxycycline on haematology, blood chemistry and peripheral blood lymphocyte subsets of healthy dogs and dogs naturally infected with Ehrlichia canis. Vet J 2015; 204(3):263–8. https://doi.org/10.1016/j.tvjl.2015.03.031Von Wittenau, M.S. Yeary R. The excretion and distribution in body fluids of tetracyclines after intravenous administration to dogs. J Pharmacol Exp Ther 1963; 140(2):258–66.Neer TM, Breitschwerdt EB, Greene RT, Lappin MR. Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM. American College of Veterinary Internal Medicine. J Vet Intern Med 2002; 16(3):309–15. https://doi.org/10.1111/j.1939-1676.2002.tb02374.xSumano H, Ocampo L. Tetraciclinas. Farmacología veterinaria. México: MC Graw Hill; 2006.Chambers HE. Inhibidores de la síntesis de proteína y otros antibacterianos. En: Laurence L. Brunton(Ed). Las Bases Farmacológicas de la Terapéutica. Undécima e. México: MC Graw Hill; 2008.Vicente D, Pérez-Trallero E. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002Gutiérrez L, Velasco Z, Vázquez C, Vargas D, Sumano H. Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs. Acta Vet Scand 2012; 54(1):1. https://doi.org/10.1186/1751-0147-54-35Deck DH, Winston LG. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones. In: Katzung BG, Masters SB, Trevor AJ (editor). Basic & clinical pharmacology. Vol 12. 2012.Schulz BS, Hupfauer S, Ammer H, Sauter-Louis C, Hartmann K. Suspected side effects of doxycycline use in dogs - a retrospective study of 386 cases. Vet Rec 2011; 169(9):229. https://doi.org/10.1136/vr.d4344Bartlett JG, Bustetter LA, Gorbach SL, Andrew B. Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Flora 1975; 7(1):55–7.Little SE. Ehrlichiosis. In: Arthropod Borne Diseases. 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Vet Microbiol 2005;107(3–4):279–83. https://doi.org/10.1016/j.vetmic.2005.02.002https://revistamvz.unicordoba.edu.co/article/download/1076/pdfNúm. supl , Año 2017 : Revista MVZ Córdoba Volumen 22(Supl) Mayo 20176074supl606222Revista MVZ CórdobaPublicationOREORE.xmltext/xml2771https://repositorio.unicordoba.edu.co/bitstreams/b1c61c64-b079-4721-9fa6-72a003fcdfc4/download770e984f50ce8f706569e33bc47bec34MD51ucordoba/5891oai:repositorio.unicordoba.edu.co:ucordoba/58912023-10-06 00:46:15.022https://creativecommons.org/licenses/by-nc-sa/4.0/metadata.onlyhttps://repositorio.unicordoba.edu.coRepositorio Universidad de Córdobabdigital@metabiblioteca.com

Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos

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