Perfil metabólico en ovinos de pelo del departamento de Córdoba

With the purpose of establishing the metabolic profile in hair sheep in the department of Córdoba. 10 sheep were chosen between males and females of different productive stages, in optimal health conditions from 32 farms distributed in the department of Córdoba, blood samples were collected in order...

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Autores:
Román Zambrano, Nicole Estefanía
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2021
Institución:
Universidad de Córdoba
Repositorio:
Repositorio Institucional Unicórdoba
Idioma:
spa
OAI Identifier:
oai:repositorio.unicordoba.edu.co:ucordoba/4668
Acceso en línea:
https://repositorio.unicordoba.edu.co/handle/ucordoba/4668
Palabra clave:
Productividad
Nutrición
Metabolitos sanguíneos
Productivity
Nutrition
Blood metabolites
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openAccess
License
Copyright Universidad de Córdoba, 2021
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dc.title.spa.fl_str_mv Perfil metabólico en ovinos de pelo del departamento de Córdoba
title Perfil metabólico en ovinos de pelo del departamento de Córdoba
spellingShingle Perfil metabólico en ovinos de pelo del departamento de Córdoba
Productividad
Nutrición
Metabolitos sanguíneos
Productivity
Nutrition
Blood metabolites
title_short Perfil metabólico en ovinos de pelo del departamento de Córdoba
title_full Perfil metabólico en ovinos de pelo del departamento de Córdoba
title_fullStr Perfil metabólico en ovinos de pelo del departamento de Córdoba
title_full_unstemmed Perfil metabólico en ovinos de pelo del departamento de Córdoba
title_sort Perfil metabólico en ovinos de pelo del departamento de Córdoba
dc.creator.fl_str_mv Román Zambrano, Nicole Estefanía
dc.contributor.advisor.none.fl_str_mv Rúgeles Pinto, Clara Cecilia
dc.contributor.author.none.fl_str_mv Román Zambrano, Nicole Estefanía
dc.subject.proposal.spa.fl_str_mv Productividad
Nutrición
Metabolitos sanguíneos
topic Productividad
Nutrición
Metabolitos sanguíneos
Productivity
Nutrition
Blood metabolites
dc.subject.keywords.eng.fl_str_mv Productivity
Nutrition
Blood metabolites
description With the purpose of establishing the metabolic profile in hair sheep in the department of Córdoba. 10 sheep were chosen between males and females of different productive stages, in optimal health conditions from 32 farms distributed in the department of Córdoba, blood samples were collected in order to determine by spectrophotometry serum concentrations of total proteins, albumin, globulins, urea, urea nitrogen (BUN), glucose, total cholesterol and HDL, β-hydroxybutyrate, triglycerides, calcium, phosphorus and magnesium. The results of arithmetic means found were total proteins 6.16 ± 1.56 g / dL, albumin 3.41 ± 0.82 g / dL, globulins 2.77 ± 1.57 g / dL, urea 47.37 ± 12, 48 mg / dL, urea nitrogen 22.26 ± 5.87 mg / dL with respect to the protein metabolic profile; glucose 46.49 ± 26.16 mg / dL, cholesterol 66.56 ± 21.34 mg / L, triglycerides 52.74 ± 16.59 mg / dL, HDL cholesterol 36.14 ± 16.87 mg / dL, β - hydroxybutyrate 1.29 ± 0.78 mmol / Lt according to the energy metabolic profile and for the mineral metabolic profile calcium 3.49 ± 2.51 mg / dL, magnesium 1.80 ± 35mg / dL and phosphorus 10.14 ± 2.40 mg / dL. For each profile, significant differences were found between municipalities, productive stage and sex. It concludes by highlighting the importance of having reference concentration values, which globally evaluate the productive behavior of hair sheep in favor of strengthening the sheep-goat sector of the department and the country.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-10-12T22:04:25Z
dc.date.available.none.fl_str_mv 2021-10-12T22:04:25Z
dc.date.issued.none.fl_str_mv 2021-10-12
dc.type.spa.fl_str_mv Trabajo de grado - Pregrado
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dc.rights.spa.fl_str_mv Copyright Universidad de Córdoba, 2021
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dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina Veterinaria y Zootecnia
dc.publisher.place.spa.fl_str_mv Berástegui, Córdoba, Colombia
dc.publisher.program.spa.fl_str_mv Medicina Veterinaria y Zootecnia
institution Universidad de Córdoba
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spelling Rúgeles Pinto, Clara Cecilia4da19972-c7fb-4784-b7b7-92005fd120c8-1Román Zambrano, Nicole Estefanía660f4c5e-1e3d-407a-b573-e4a456bc6d3a-12021-10-12T22:04:25Z2021-10-12T22:04:25Z2021-10-12https://repositorio.unicordoba.edu.co/handle/ucordoba/4668With the purpose of establishing the metabolic profile in hair sheep in the department of Córdoba. 10 sheep were chosen between males and females of different productive stages, in optimal health conditions from 32 farms distributed in the department of Córdoba, blood samples were collected in order to determine by spectrophotometry serum concentrations of total proteins, albumin, globulins, urea, urea nitrogen (BUN), glucose, total cholesterol and HDL, β-hydroxybutyrate, triglycerides, calcium, phosphorus and magnesium. The results of arithmetic means found were total proteins 6.16 ± 1.56 g / dL, albumin 3.41 ± 0.82 g / dL, globulins 2.77 ± 1.57 g / dL, urea 47.37 ± 12, 48 mg / dL, urea nitrogen 22.26 ± 5.87 mg / dL with respect to the protein metabolic profile; glucose 46.49 ± 26.16 mg / dL, cholesterol 66.56 ± 21.34 mg / L, triglycerides 52.74 ± 16.59 mg / dL, HDL cholesterol 36.14 ± 16.87 mg / dL, β - hydroxybutyrate 1.29 ± 0.78 mmol / Lt according to the energy metabolic profile and for the mineral metabolic profile calcium 3.49 ± 2.51 mg / dL, magnesium 1.80 ± 35mg / dL and phosphorus 10.14 ± 2.40 mg / dL. For each profile, significant differences were found between municipalities, productive stage and sex. It concludes by highlighting the importance of having reference concentration values, which globally evaluate the productive behavior of hair sheep in favor of strengthening the sheep-goat sector of the department and the country.INTRODUCIÓN……………………………………………………………………… 91. OBJETIVOS………………………………………………………………………. 111.1 OBJETIVO GENERAL ………………………………………………………… 111.2 OBJETIVOS ESPECIFICOS……………………………………………………112. MARCO TEÓRICO………………………………………………………………..122.1.1 Perfil proteico…………………………………………………………………..132.1.3Perfil energético………………………………………………………………. 142.1.3 Perfil mineral ………………………………………………………………….153. MATERIALES Y MÉTODOS……………………………………………………..183.1 TIPO DE ESTUDIO……………………………………………………………...183.2 TIPO DE MUESTREO Y CALCULO DEL TAMAÑO DE LA MUESTRA…. 183.3 MANEJO DE LOS ANIMALES………………………………………………... 183.4 TOMA Y MANEJO DE MUESTRAS …………………………………………..193.5 PROCESAMIENTO DE LAS MUESTRAS……………………………………193.6 ANÁLISIS ESTADÍSTICO………………………………………………………194. ASPECTOS ÉTICOS……………………………………………………………..215. RESULTADOS Y DISCUSIÓN …………………………………………………..225.1 PERFIL PROTEICO……………………………………………………………..225.2 PERFIL ENERGETICO…………………………………………………………255.3 PERFIL MINERAL……………………………………………………………….286. CONCLUSIONES………………………………………………………………..317. RECOMENDACIONES …………………………………………………………32BLIBLIOGRAFIA……………………………………………………………………..33Con el propósito de establecer el perfil metabólico en ovinos de pelo en el departamento de Córdoba. Se eligieron 10 ovinos entre machos y hembras de diferentes etapas productivas, en óptimas condiciones de salud de 32 fincas repartidas en el departamento de Córdoba, se colectaron muestras de sangre con el fin de determinar mediante espectrofotometría concentraciones séricas de proteínas totales, albumina, globulinas, urea, nitrógeno ureico (BUN), Glucosa, Colesterol total y HDL, β- hidroxibutirato, triglicéridos, calcio, fosforo y magnesio. Los resultados de medias aritméticas encontradas proteínas totales 6,16±1,56 g/dL, albumina 3,41±0,82 g/dL, globulinas 2,77±1,57 g/dL, urea 47,37±12,48 mg/dL, nitrógeno ureico 22,26±5,87 mg/dL respecto al perfil metabólico proteico; glucosa 46,49±26,16 mg/dL, colesterol 66,56±21,34 mg/L, triglicéridos 52,74±16,59 mg/dL, colesterol HDL 36,14±16,87 mg/dL, β- hidroxibutirato 1,29±0,78 mmol/Lt de acuerdo al perfil metabólico energético y para el perfil metabólico mineral calcio 3,49±2,51 mg/dL, magnesio 1,80±35mg/dL y fósforo 10,14±2,40 mg/dL. Para cada perfil se encontró diferencias significativas entre municipios, etapa productiva y sexo. Se concluye, resaltando la importancia de contar con valores de concentraciones referentes, que se evalué de manera global, el comportamiento productivo de los ovinos de pelo en pro al fortalecimiento del sector ovino-caprino del departamento y el país.PregradoMédico(a) Veterinario(a) y ZootecniaTrabajo de Investigación y/o Extensiónapplication/pdfspaCopyright Universidad de Córdoba, 2021https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Perfil metabólico en ovinos de pelo del departamento de CórdobaTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1fTexthttps://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_71e4c1898caa6e32ProductividadNutriciónMetabolitos sanguíneosProductivityNutritionBlood metabolitesFacultad de Medicina Veterinaria y ZootecniaBerástegui, Córdoba, ColombiaMedicina Veterinaria y ZootecniaEspinal CF, Covaleda HM, Amézquita. JE. La cadena ovinos y caprinos en colombia. Min Agric y Desarro Rural Obs Agrocadenas Colomb [Internet]. 2006;(58):40. Available from: http://www.agrocadenas.gov.co agrocadenas@iica.intOquendo JG, Londoño LF, Pérez VM. El perfil metabólico como herramienta de monitoreo de la salud, la producción y la fertilidad en el hato lechero del Politécnico Colombiano Jaime Isaza Cadavid. Rev Lasallista Investig. 2013;10(1):38–48.Geffré A, Friedrichs K, Harr K, Concordet D, Trumel C, Braun JP. Reference values: A review. Vet Clin Pathol. 2009;38(3):288–98.Lo Fiego D.P., Belmonte A.M. MF. Caracterización morfoestructural de tres poblaciones de Ovino de Pelo Criollo Colombiano “OP. Arch Zootec [Internet]. 2017;66(254):287–99. Available from: http://www.uco.es/ucopress/az/index.php/az/article/view/2334/1547Espinal CF, Covaleda HM, Amézquita. JE. La Cadena Ovinos Y Caprinos En Colombia. Min Agric y Desarro Rural Obs Agrocadenas Colomb. 2006;(58):40.Reyes Sanclemente H, Alzate C. Caracterización ocupacional del subsector de especies menores en Colombia [Internet]. Servicio Nacional de Aprendizaje (SENA); 2007 [cited 2018 Nov 5]. 200 p. Available from: https://repositorio.sena.edu.co/handle/11404/2134#.W9-fZ8253pQ.mendeleyDiagnostico de los sistemas ovino caprino del departamento del cesar. Corpoica. 2018;Roubies N, Panousis N, Fytianou A, Katsoulos PD, Giadinis N, Karatzias H. Effects of age and reproductive stage on certain serum biochemical parameters of chios sheep under greek rearing conditions. J Vet Med Ser A Physiol Pathol Clin Med. 2006;53(6):277–81.Gonzales FH, Barcellos J, Ospina Patiño H, Ribeiro LA. Perfil metabólico em ruminantes: seu uso em nutricao e doencas nutricionais [Internet]. Biblioteca setorial da Facultadade de Medicina Veterinaria de UFRGS. 2000. 108 p. Available from: http://www6.ufrgs.br/favet/lacvet/restrito/pdf/perfil nutricional ruminantes.pdfZárate,R. Pedrozo R. Acosta R. Lara, M. Báez, M. González A. Perfiles metabólicos en ovejas Texel en los periodos de preservicio, último tercio de gestación e inicio de lactancia. Compend Ciencias Vet [Internet]. 2014;04 (02)(2226–1761):39–46. Available from: http://scielo.iics.una.py/pdf/ccv/v4n2/v4n2a07.pdfEvans GO. Animal Clinical Chemistry - a practice handbook for toxicologist and biomedical researchers. Secrond. Vol. 23, eJIFCCVol23No1pp005-010. Taylor & Francis Group; 2012. 308 p.Bartges J. New test for renal disease:what do they mean? J Exp Psychol. 2007;136(1):23–42.Aschenbach JR, Kristensen NB, Donkin SS, Hammon HM, Penner GB. Gluconeogenesis in dairy cows: The secret of making sweet milk from sour dough. IUBMB Life. 2010;62(12):869–77.Saborío-Montero A, Sánchez JM. Relación entre concentración sanguínea de β-hidroxibutirato e indicadores productivos, reproductivos y de salud en hatos Jersey y Holstein. Agron Costarric. 2016;40(1):41–50.NRC. Nutrient Requirements of Diary Cattle. Nutrient Requirements of Dairy Cattle. 2001. 401 p.King MW. themedicalbiochemistrypage.org/ [Internet]. 2020. Available from: https://themedicalbiochemistrypage.org/Turriza Chan JL, Castellanos Ruelas AF, Rosado Rubio GJ, Heredia y Aguilar M, Cabrera Torres E. Diagnóstico de la concentración mineral en tejido óseo de ovinos en pastoreo en el Estado de Yucatán, México. Agrociencia [Internet]. 2010;44(4):471–80. Available from: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-31952010000400007Martens H, Schweigel M. Pathophysiology of grass tetany and other hypomagnesemias. Implications for clinical management. Vet Clin North Am Food Anim Pract [Internet]. 2000;16(2):339–68. Available from: http://dx.doi.org/10.1016/S0749-0720(15)30109-2Perez AV, Avendaño Reyes L, Barajas Cruz R, Macias Cruz U, Correa Calderon A, Perez RV, et al. Parámetros bioquímicos y hematológicos en ovinos de pelo con y sin sombra bajo condiciones desérticas. Ecosistemas y Recur Agropecu [Internet]. 2018;5(14):259. Available from: http://era.ujat.mx/index.php/rera/article/view/1544Avellanet R, Cuenca R, Pastor J, Jordana J. Parametros hematologicos y bioquimicos clinicos en la raza ovina xisqueta. Arch Zootec. 2007;56:497–501.Maza Angulo L, Cardona Álvarez J, Vergara Garay O. Analisis del perfil metabolico de hembras ovinas criollas gestantes en condiciones de pastoreo extensivo. Rev Científica, FCU-LUZ [Internet]. 2011;XXI(4):335–9. Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Analysis+of+Metabolic+Profile+in+Pregnant+Creole+Sheep+in+Extensive+Grazing+Conditions#0Gonzalez Gonzalez NN, Gutierrez Gonzalez D, Garcia Lopez R, Fernandez Mayer A. Metabolitos sanguíneos en caprinos alimentados con mezclas integrales frescas con Moringa oleífera: Pennisetum purpureum Clon-OM22. Av en Investig Agropecu. 2015;19(3):25–36.Galván Doria C, Rugeles Pinto C, Vergara Garay Ó. Variation of Serum Levels of Glucose and Protein During the Day in Sheep of Different Sex. Rev Med Vet (Bogota) [Internet]. 2014;(28):57–66. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0122-93542014000200006Bustamante M de J, Maza Angulo L, Rugeles Pinto C, Simanca JC, Patiño M R, Vergara Garay Ó. Determinación Del Perfil metabólico Durante el Periodo Gestación-lactancia en Hembras ovinas De Pelo en Córdoba, Colombia. Rev Fac Cs Vets. 2016;57 (2):114–24.Rowlands GJ. A review of variations in the concentrations of metabolites in the blood of beef and dairy cattle associated with physiology, nutrition and disease, with particular reference to the interpretation of metabolic profiles. World Rev Nutr Diet. 1980;35:172–235.Osorio J, Barrera L, Pérez J. Comparación del perfil lipidico por sexo y edad en ovinos. Rev Med Vet Zoot. 62 (1), enero-junio;2015.Rueda G. Metabolitos sanguineos y proteicos asocioados alestado nutricional en ovejas criollas. Facultad de Medicina Veterinaria y Zootecnia, Maestria en salud y producción animal, Universidad Cooperativa de Colombia, Bucaramanga; 2019Brito MA, Diaz´Gonzalez.F, Ribeiro LA, Campos R, Lacerda L, Rick-Barbosa P, Bergmann G. Composição do sangue e do leite em ovinos leiteiros do sul do Brasil: variações na gestação e na lactação..Ciênc Rural, 2006; 36(3):942-948.Cardoso E, Oliveira D, Dourado A, Araujo C, Ortolani E, Brandão, F. Peso e condição corporal, contagem de OPG e perfil metabólico sanguíneo de ovelhas da raça Santa Inês no periparto, criadas na região da Baixada Litorânea do Estado do Rio de Janeiro. 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