Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia

Introduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.

• Autores: VILLEGAS, ROSSANA; FRANCO, CATALINA; RENDÓN, JAVIER; TORRES, JOSÉ; JARAMILLO, PATRICIA
• Tipo de recurso: Article of journal
• Fecha de publicación: 2016
• Institución: Universidad de Córdoba
• Repositorio: Repositorio Institucional Unicórdoba
• Idioma: spa
• OAI Identifier: oai:repositorio.unicordoba.edu.co:ucordoba/618
• Acceso en línea: https://repositorio.unicordoba.edu.co/handle/ucordoba/618
• Palabra clave: Monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometry
• Rights: openAccess
• License: Copyright Universidad de Córdoba, 2016