Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba
Debido a características biológicas y evolutivas, como la longevidad, supervivencia, grandes densidades de población, comportamiento de descanso y la capacidad de volar; los murciélagos son considerados como potenciales reservorios de patógenos zoonóticos en todo el mundo. Estudios recientes identif...
- Autores:
-
Bertel Pacheco, Valeria
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2024
- Institución:
- Universidad de Córdoba
- Repositorio:
- Repositorio Institucional Unicórdoba
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicordoba.edu.co:ucordoba/8370
- Acceso en línea:
- https://repositorio.unicordoba.edu.co/handle/ucordoba/8370
https://repositorio.unicordoba.edu.co
- Palabra clave:
- PCR convencional
Secuenciación
Anaplasma spp
Dirofilaria immitis
Murciélagos
Conventional PCR
Sequencing
Anaplasma spp
Dirofilaria immitis
Bats
- Rights
- embargoedAccess
- License
- Copyright Universidad de Córdoba, 2024
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| dc.title.spa.fl_str_mv |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| title |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| spellingShingle |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba PCR convencional Secuenciación Anaplasma spp Dirofilaria immitis Murciélagos Conventional PCR Sequencing Anaplasma spp Dirofilaria immitis Bats |
| title_short |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| title_full |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| title_fullStr |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| title_full_unstemmed |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| title_sort |
Identificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de Córdoba |
| dc.creator.fl_str_mv |
Bertel Pacheco, Valeria |
| dc.contributor.advisor.none.fl_str_mv |
Martínez Bravo, Caty Milena |
| dc.contributor.author.none.fl_str_mv |
Bertel Pacheco, Valeria |
| dc.contributor.jury.none.fl_str_mv |
Contreras Cogollo, Verónica Calderón Rangel, Alfonso |
| dc.subject.proposal.none.fl_str_mv |
PCR convencional Secuenciación Anaplasma spp Dirofilaria immitis Murciélagos |
| topic |
PCR convencional Secuenciación Anaplasma spp Dirofilaria immitis Murciélagos Conventional PCR Sequencing Anaplasma spp Dirofilaria immitis Bats |
| dc.subject.keywords.none.fl_str_mv |
Conventional PCR Sequencing Anaplasma spp Dirofilaria immitis Bats |
| description |
Debido a características biológicas y evolutivas, como la longevidad, supervivencia, grandes densidades de población, comportamiento de descanso y la capacidad de volar; los murciélagos son considerados como potenciales reservorios de patógenos zoonóticos en todo el mundo. Estudios recientes identificaron a los murciélagos como hospederos potenciales del filo de las proteobacterias y de nematodos filariales. El objetivo de este estudio fue determinar por medio de pruebas moleculares la presencia de ADN de Anaplasma spp. y Dirofilaria immitis en murciélagos del departamento de Córdoba. En este estudio se analizaron muestras de tejidos de murciélagos mediante detección del gen ARNr 16s de la familia Anaplasmataceae y el gen Citocromo oxidasa para Dirofilaria immitis. El 2,42% (5/206) muestras de bazo fueron positivas para el gen ARN 16s y el 26,34% (54/205) muestras de tejido de corazón para el gen (COX). Murciélagos del género Artibeus fueron los huéspedes con mayor presencia de infección por los distintos hemotrópicos. Se evidenció una coinfección en dos individuos de las especies Artibeus phaeotis y Phyllostomus hastatus, registrados en los municipios de Montelíbano y Moñitos, respectivamente. Nuestro estudio presenta la primera detección de D. immitis en murciélagos en el departamento de Córdoba. Factores como los cambios en el uso del suelo (agricultura, deforestación, urbanización, ganadería, etc.), se encontraron relacionados con la circulación de hemotrópicos con potencial zoonótico en murciélagos del departamento de Córdoba. Estos resultados fortalecen el esquema de salud unificada mediante la prevención y detección de enfermedades zoonóticas integrando la salud animal y el bienestar ecosistémico que sin duda repercute en el bienestar y salud humana. Palabras clave: PCR convencional, secuenciación, Anaplasma spp, Dirofilaria immitis, murciélagos. |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-10T22:52:22Z |
| dc.date.available.none.fl_str_mv |
2024-07-10T22:52:22Z 2025-07-10 |
| dc.date.issued.none.fl_str_mv |
2024-07-10 |
| dc.type.none.fl_str_mv |
Trabajo de grado - Pregrado |
| dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
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http://purl.org/coar/resource_type/c_7a1f |
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info:eu-repo/semantics/acceptedVersion |
| dc.type.content.none.fl_str_mv |
Text |
| format |
http://purl.org/coar/resource_type/c_7a1f |
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acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unicordoba.edu.co/handle/ucordoba/8370 |
| dc.identifier.instname.none.fl_str_mv |
Universidad de Córdoba |
| dc.identifier.reponame.none.fl_str_mv |
Repositorio Universidad de Córdoba |
| dc.identifier.repourl.none.fl_str_mv |
https://repositorio.unicordoba.edu.co |
| url |
https://repositorio.unicordoba.edu.co/handle/ucordoba/8370 https://repositorio.unicordoba.edu.co |
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Universidad de Córdoba Repositorio Universidad de Córdoba |
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spa |
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Litomosoides sp. (Filarioidea: Onchocercidae) Infection in Frugivorous Bats (Artibeus spp.): Pathological Features, Molecular Evidence, and Prevalence. Tropical medicine and infectious disease( PMC6631640). https://doi.org/ 10.3390/tropicalmed4020077 Renz, A., & Wenk, P. (1981). Intracellular development of the cotton-rat filaria Litomosoides carinii in the vector mite Ornithonyssus bacoti. Trans R Soc Trop Med Hyg(7268858), 166-8. https://doi.org/ 10.1016/0035-9203(81)90056-0 Rodríguez, I., Burri, C., Noda, A., Douet, V., & Gern, L. (2015). Multiplex PCR for molecular screening of Borrelia burgdorferi sensu lato, Anaplasma spp. and Babesia spp. Ann Agric Environ Med(26706969). https://doi.org/10.5604/12321966.1185767 Said, M. S., Tirthani, E., & Lesho, E. (2023). Animal Zoonotic Related Diseases. (34033321). https://www.ncbi.nlm.nih.gov/books/NBK570559/ Soares, L. A., Matias, I. C., Silva, S. S., Ramos, M. E., Silva, A. P., Barretto, M. L., Brasil, A. W., Silva, M. L., Galiza, G. J., & Maia, L. A. (2022). Parasitological, serological and molecular diagnosis of Dirofilaria immitis in dogs in Northeastern Brazil. Experimental Parasitology(108233). https://doi.org/https://doi.org/10.1016/j.exppara.2022.108233 Socolovschi, C., Kernif, T., Raoult, D., & Parola, P. (2012). Borrelia, Rickettsia, and Ehrlichia species in bat ticks, France,. Emerg Infect Dis(23171714). https://doi.org/10.3201/eid1812.111237. Upton, K., Sobotyk, C., Edwards, E., & Verocai, G. (2022). Dirofilaria immitis in an Asian small-clawed otter (Aonyx cinereus) from southeastern Louisiana, United States. Vet Parasitol Reg Stud Reports(35256129). https://doi.org/ 10.1016/j.vprsr.2022.100703 Upton, K., Sobotyk, C., Edwards, E., & Verocai, G. (2022). Dirofilaria immitis in an Asian small-clawed otter (Aonyx cinereus) from southeastern Louisiana, United States. Veterinary Parasitology, 29. https://doi.org/https://doi.org/10.1016/j.vprsr.2022.100703 Vega, R. L. (2009). Zoonosis emergentes y reemergentes y principios básicos de control de zoonosis. Medicina Veterinaria, 85-97. https://doi.org/https://ciencia.lasalle.edu.co/mv/vol1/iss17/7/ Vláschenko, A., Răileanu, C., Tauchman, O., Muzyka, D., Bohodista, V., Filatov, S., Rodenko, O., Tovstukha, I., & Silaghi, C. (2020). First data on bacteria associated with bat ectoparasites collected in Kharkiv oblast, Northeastern Ukraine. Parasit Vectors.(36434644). https://doi.org/ 10.1186/s13071-022-05582-3 Wicht, B., Yanagida, T., Scholz, T., Ito, A., Jiménez, J. A., & Brabec, J. (2010). Multiplex PCR for differential identification of broad tapeworms (Cestoda: Diphyllobothrium) infecting humans. J Clin Microbiol. https://doi.org/10.1128/JCM.00445-10 Williams, R. (1948). Studies on the life cycle of Litomosoides carinii, filariid parasite of the cotton rat, Sigmodon hispidus litoralis. Parasitol(18903614), 24-43 Younes, L., Barré-Cardi, H., Bedjaoui, S., Ayhan, N., Varloud, M., Mediannikov, O., Otranto, D., & Davoust, B. (2021). Dirofilaria immitis and Dirofilaria repens in mosquitoes from Corsica Island, France. Parasit Vectors(34446069). https://doi.org/ 10.1186/s13071-021-04931-y Zahn, A., Holzhaider, J., Kriner, E., Maier, A., & & Kayikcioglu, A. (2008). Foraging activity of Rhinolophus hipposideros on the island of Herrenchiemsee, Upper Bavaria. Mammalian Biology, 73, 222-229. |
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Martínez Bravo, Caty Milena10156dc8-ea2f-4f2f-952b-fdc32abf2131-1Bertel Pacheco, Valeria2acd44a3-7eb2-4b72-a9df-08f3d76a4f07-1Contreras Cogollo, Verónica2ff5ac5f-d4ea-439b-a6eb-b608370fde3a600Calderón Rangel, Alfonsode728744-ff95-4637-b2ec-975af9ce3e3b-12024-07-10T22:52:22Z2025-07-102024-07-10T22:52:22Z2024-07-10https://repositorio.unicordoba.edu.co/handle/ucordoba/8370Universidad de CórdobaRepositorio Universidad de Córdobahttps://repositorio.unicordoba.edu.coDebido a características biológicas y evolutivas, como la longevidad, supervivencia, grandes densidades de población, comportamiento de descanso y la capacidad de volar; los murciélagos son considerados como potenciales reservorios de patógenos zoonóticos en todo el mundo. Estudios recientes identificaron a los murciélagos como hospederos potenciales del filo de las proteobacterias y de nematodos filariales. El objetivo de este estudio fue determinar por medio de pruebas moleculares la presencia de ADN de Anaplasma spp. y Dirofilaria immitis en murciélagos del departamento de Córdoba. En este estudio se analizaron muestras de tejidos de murciélagos mediante detección del gen ARNr 16s de la familia Anaplasmataceae y el gen Citocromo oxidasa para Dirofilaria immitis. El 2,42% (5/206) muestras de bazo fueron positivas para el gen ARN 16s y el 26,34% (54/205) muestras de tejido de corazón para el gen (COX). Murciélagos del género Artibeus fueron los huéspedes con mayor presencia de infección por los distintos hemotrópicos. Se evidenció una coinfección en dos individuos de las especies Artibeus phaeotis y Phyllostomus hastatus, registrados en los municipios de Montelíbano y Moñitos, respectivamente. Nuestro estudio presenta la primera detección de D. immitis en murciélagos en el departamento de Córdoba. Factores como los cambios en el uso del suelo (agricultura, deforestación, urbanización, ganadería, etc.), se encontraron relacionados con la circulación de hemotrópicos con potencial zoonótico en murciélagos del departamento de Córdoba. Estos resultados fortalecen el esquema de salud unificada mediante la prevención y detección de enfermedades zoonóticas integrando la salud animal y el bienestar ecosistémico que sin duda repercute en el bienestar y salud humana. Palabras clave: PCR convencional, secuenciación, Anaplasma spp, Dirofilaria immitis, murciélagos.Due to biological and evolutionary characteristics such as longevity, survival, high population densities, resting behavior, and the ability to fly, bats are considered potential reservoirs of zoonotic pathogens worldwide. Recent studies have identified bats as potential hosts of the Proteobacteria phylum and filarial nematodes. The aim of this study was to determine, through molecular testing, the presence of DNA of Anaplasma spp. and Dirofilaria immitis in bats from the department of Córdoba. In this study, bat tissue samples were analyzed by detecting the 16s rRNA gene of the Anaplasmataceae family and the Cytochrome oxidase gene for Dirofilaria immitis. 2.42% (5/206) spleen samples were positive for the 16s rRNA gene and 26.34% (54/205) heart tissue samples for the (COX) gene. Bats of the genus Artibeus were the hosts with the highest presence of infection by the different hemotropics. A co-infection was evidenced in two individuals of the species Artibeus phaeotis and Phyllostomus hastatus, recorded in the municipalities of Montelíbano and Moñitos, respectively. Our study presents the first detection of D. immitis in bats in the department of Córdoba. Factors such as changes in land use (agriculture, deforestation, urbanization, livestock, etc.), were found to be related to the circulation of hemotropics with zoonotic potential in bats in the department of Córdoba. These results strengthen the unified health scheme through the prevention and detection of zoonotic diseases by integrating animal health and ecosystem well-being, which undoubtedly impacts human health and well-being. Keywords: Conventional PCR, sequencing, Anaplasma spp, Dirofilaria immitis, bats.1. INTRODUCCIÓN...92. OBJETIVOS...122.1. OBJETIVO GENERAL...122.2. OBJETIVOS ESPECÍFICOS...123. MARCO TEÓRICO Y ANTECEDENTES...133.1. Anaplasma spp. 133.1.1. Estado del arte...133.2. Dirofilaria spp...153.2.1. Estado del arte...163.3. Zoonosis como problema de salud pública...173.4. Antecedentes de los murciélagos como potenciales reservorios zoonóticos...194. MATERIALES Y MÉTODOS...224.1. Área de estudio...224.2. Muestreo en campo y toma de muestras...234.3. Protocolos de laboratorio...234.3.1. Extracción de ADN...234.3.2. Estandarización de protocolo para PCR...234.3.3. Revelación de productos por electroforesis...244.4. Secuenciación...254.5. Elaboración árbol filogenético...254.6. Georreferenciación...255. RESULTADOS Y DISCUSIÓN...265.1. Resultados para el cumplimiento del objetivo específico 1...265.1.1 Extracción de ácidos nucleicos...265.1.2. Ensayo de PCR por multiplexación para la detección molecular de ADN hemotrópicos...275.1.3. Estandarización de protocolo para la detección de ADN Anaplasma spp...285.1.4. Estandarización de protocolo para la detección de ADN Dirofilaria immitis...295.2. Resultados para el cumplimiento del objetivo específico 2...305.2.1. Detección de Anaplasma spp...305.2.2. Detección de Dirofilaria immitis...335.2.3. Análisis filogenéticos...365.3. Resultados para el cumplimiento del objetivo 3...376. CONCLUSIONES...417. RECOMENDACIONES...428. BIBLIOGRAFÍA...439. ANEXOS...53PregradoBiólogo(a)Trabajos de Investigación y/o Extensiónapplication/pdfspaUniversidad de CórdobaFacultad de Ciencias BásicasMontería, Córdoba, ColombiaBiologíaCopyright Universidad de Córdoba, 2024https://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfIdentificación molecular de ADN Anaplasma spp y Dirofilaria Immitis en murciélagos del departamento de CórdobaTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/acceptedVersionTextAlcantara, D. C., Ikeda, P., Souza, C. S., Mello, V. V., Torres, J. M., Lourenço, E. C., Bassini-Silva, R., Herrera, H. M., & Rosangela Zacarias Machado 2, D. M. (2022). Multilayer Networks Assisting to Untangle Direct and Indirect Pathogen Transmission in Bats. Microbial ecology(36166070), 1292-1306. https://doi.org/10.1007/s00248-022-02108-3Alfonso, E., & Goydadin, A. (2018). Molecular detection of Anaplasma phagocytophilum DNA in the lesser horseshoe bat (Rhinolophus hipposideros) guano. Epidemiol Infect(29843834), 1253-1258. https://doi.org/10.1017/S0950268818001279Alho, A., Marcelino, I., Colella, V., Flanagan, C., Silva, N., Correia, J., Latrofa, M., Otranto, D., & Madeira de Carvalho, L. (2017). Dirofilaria immitis in pinnipeds and a new host record. Parasit Vectors(PMC5347183). https://doi.org/10.1186/s13071-017-2073-0André, M. R., Ikeda, P., Lee, D. A., Amaral, R. B., Carvalho, L. A., Pinheiro, D. G., Torres, J. M., Mello, V. V., Rice, G., & Cer, R. (2023). Characterization of the bacterial microbiome of non-hematophagous bats and associated ectoparasites from Brazil. Front Microbiol(37928691). https://doi.org/10.3389/fmicb.2023.1261156Atif, F. A. (2016). 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Genetic diversity and molecular epidemiology of Anaplasma. Infect Genet Evol(28122249). https://doi.org/ 10.1016/j.meegid.2017.01.021Bolivar, A. M., Rojas, A., & Garcia-Lugo, P. (2013). PCR y PCR-Múltiple: parámetros críticos y protocolo de estandarización. Instituto de Inmunología Clínica, 3(1)(2244-7881), 25-33. https://doi.org/PPI201102ME3935Capelli, G., Genchi, C., Baneth, G., Bourdeau, P., Brianti, E., Cardoso, L., Danesi, P., Fuehrer, H.-P., Giannelli, A., Ionică, A. M., Maia, C., Modrý, D., Montarsi, F., Krücken, J., & Papadopoulos, E. (2018). Recent advances on Dirofilaria repens in dogs and humans in Europe. Parasit Vectors(30567586). https://doi.org/10.1186/s13071-018-3205-xCasiraghi, M., Anderson, T., Bandi, C., Bazzocchi, C., & Genchi, C. (2001). A phylogenetic analysis of filarial nematodes: Comparison with the phylogeny of Wolbachia endosymbionts. Parasitology, 93-103.CDC. (2019, Junio 27). Dirofilariasis. 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F., Lugaresi, C., Aguirre, N., Mangold, A., Moretta, R., Farber, M., & Mondillo, C. (2005). Detection of antibodies against Anaplasma marginale in milk using a recombinant MSP5 indirect ELISA. Vet Microbiol(15778035). https://doi.org/10.1016/j.vetmic.2004.12.026Dimkić, I., Fira, D., Janákiev, T., Kabic, J., Miloš, E., Nenadić, M., Unković, N., & Grbić, M. L. (2021). The microbiome of bat guano: for what is this knowledge important? Appl Microbiol Biotechnol(33512572), 1407-1419. https://doi.org/10.1007/s00253-021-11143Eraso-Cadena, M. P., Molina-Guzmán, L. P., Cardona, X., Cardona-Arias, J. A., Ríos-Osorio, L. A., & Gutierrez-Builes, L. A. (2018). Serological evidence of exposure to some zoonotic microorganisms in cattle and humans with occupational exposure to livestock in Antioquia, Colombia. Cad Saude Publica(30329003). https://doi.org/ 10.1590/0102-311X00193617Ferreira, C., Afonso, A., Calado, M., Maurício, I., Margarida, A., Alho, Meireles, J., Carvalho, L. M., & Belo, S. (2017). Molecular characterization of Dirofilaria spp. circulating in Portugal. Parasit Vectors(28526036). https://doi.org/10.1186/s13071-017-2180-yFlorez, A. A., Martinez, A. R., & Pinilla, J. C. (2020). Prevalence of Dirofilaria immitis in shelter dogs in Bucaramanga metropolitan area, Colombia. Veterinary Parasitology, 22(100489). https://doi.org/https://ezproxyucor.unicordoba.edu.co:2129/10.1016/j.vprsr.2020.100489García, G. J., & Celis, J. C. (2023). DETECCIÓN DE HEMOTRÓPICOS EN MURCIÉLAGOS (Mammalia:Chiroptera) EN EL DEPARTAMENTO DE CÓRDOBA, COLOMBIA.Genchi, C. K. (2020). La prevalencia de Dirofilaria immitis y D. repens en el Viejo Mundo. Parasitología Veterinaria. Volumen 280.Genchi, C., Rinaldi, L., Mortarino, M., Genchi, M., & Cringol, G. (2009). Climate and Dirofilaria infection in Europe. Veterinary Parasitology,(19398159), 286-292. https://doi.org/10.1016/j.vetpar.2009.03.026Giangaspero, A., Marangi, M., Latrofa, M. S., Martinelli, D., Traversa, D., Otranto, D., & Genchi, C. (2013). Evidences of increasing risk of dirofilarioses in southern Italy. Parasitol Res(23224639), 1357–1361. https://doi.org/10.1007/s00436-012-3206-1Gibson, K., Rikihisa, Y., Zhang, C., & Martin, C. (2005). Neorickettsia risticii is vertically transmitted in the trematode Acanthatrium oregonense and horizontally transmitted to bats. Environmental Microbiology, 7(15658987), 203-212. https://doi.org/10.1111/j.1462-2920.2004.00683.xGleim, E. R., Garrison, L. E., Vello, M., Salvaje, M. Y., López, G., Berghaus, R., & Yabsley, M. (2016). Factors associated with tick bites and pathogen prevalence in ticks parasitizing humans in Georgia, USA. Parasit Vectors(PMC4776404). https://doi.org/10.1186/s13071-016-1408-6Guo, W. P., Tian, J.-H., Lin, X.-D., Ni, X. B., Chen, X. P., Liao, Y., Yang, S.-Y., Dumler, S., Holmes, E., & Zhang, Y.-Z. (2016). Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species. Sci Rep(27934910). https://doi.org/10.1038/srep38770Hayman, D. 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