Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba

Los arbovirus, en particular los transmitidos por los mosquitos Aedes aegypti, son una amenaza importante para la salud de las poblaciones caribeñas. Estos virus, entre ellos el dengue, el Zika y el Chikungunya, se transmiten horizontalmente por ingestión de sangre virémica. Aedes aegypti y Aedes al...

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Autores:
Clímaco Montesino, Daniela
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2024
Institución:
Universidad de Córdoba
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Repositorio Institucional Unicórdoba
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spa
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https://repositorio.unicordoba.edu.co/handle/ucordoba/8449
https://repositorio.unicordoba.edu.co/home
Palabra clave:
Aedes
Infección natural
Arbovirus
Aedes
Infection
Arbovirus
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Copyright Universidad de Córdoba, 2024
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dc.title.spa.fl_str_mv Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
title Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
spellingShingle Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
Aedes
Infección natural
Arbovirus
Aedes
Infection
Arbovirus
title_short Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
title_full Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
title_fullStr Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
title_full_unstemmed Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
title_sort Infección natural de mosquitos Aedes aegypti por arbovirus en el departamento Córdoba
dc.creator.fl_str_mv Clímaco Montesino, Daniela
dc.contributor.advisor.none.fl_str_mv Tique Salleg, Vaneza Paulin
dc.contributor.author.none.fl_str_mv Clímaco Montesino, Daniela
dc.contributor.jury.none.fl_str_mv Calderón Rangel, Alfonso
Reza García, Lázaro Antonio
dc.subject.proposal.none.fl_str_mv Aedes
Infección natural
Arbovirus
topic Aedes
Infección natural
Arbovirus
Aedes
Infection
Arbovirus
dc.subject.keywords.none.fl_str_mv Aedes
Infection
Arbovirus
description Los arbovirus, en particular los transmitidos por los mosquitos Aedes aegypti, son una amenaza importante para la salud de las poblaciones caribeñas. Estos virus, entre ellos el dengue, el Zika y el Chikungunya, se transmiten horizontalmente por ingestión de sangre virémica. Aedes aegypti y Aedes albopictus (Aedes) son los principales vectores de estos virus, causando una morbilidad y mortalidad significativas en las zonas urbanas. La capacidad vectorial de Aedes aegypti es compleja debido a la interacción entre factores biológicos y abióticos. En Colombia, la presencia de mosquitos infectados por Aedes aegypti sugiere que la transmisión vertical es un evento más frecuente y de mayor relevancia epidemiológica. En América Latina se ha detectado CHIKV en Aedes aegypti y se ha reportado la primera detección de Zika en transmisión natural vertical en Aedes aegypti. Colombia es un país hiperendémico para el dengue, con más de 26 millones de personas expuestas al virus. Sin embargo, la falta de conocimientos precisos y oportunos sobre la epidemiología molecular de los arbovirus está dificultando la predicción del riesgo real de nuevos casos y su propagación en poblaciones humanas.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-28T20:21:32Z
dc.date.available.none.fl_str_mv 2024-07-28T20:21:32Z
2025-07-25
dc.date.issued.none.fl_str_mv 2025-07-25
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.instname.none.fl_str_mv Universidad de Córdoba
dc.identifier.reponame.none.fl_str_mv Repositorio universidad de Córdoba
dc.identifier.repourl.none.fl_str_mv https://repositorio.unicordoba.edu.co/home
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identifier_str_mv Universidad de Córdoba
Repositorio universidad de Córdoba
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dc.relation.references.none.fl_str_mv 1. Mantilla-Granados JS, Sarmiento-Senior D, Manzano J, Calderón-Peláez M, Velandia-Romero ML, Buitrago LS, et al. Multidisciplinary approach for surveillance and risk identification of yellow fever and other arboviruses in Colombia. One Health 2022 -12;15:100438.
2. Oliveira M, Silva J, Lima Viana J, Tadei W, Pinheiro VC. Efficiency of oviposition traps with biolarvicides for monitoring Aedes aegypti and Aedes albopictus (Diptera, Culicidae), northeast Brazil. Acta Scientiarum Biological Sciences 2022 -03-16;44:e59231.
3. Ahebwa A, Hii J, Neoh K-B, Chareonviriyaphap T. Aedes aegypti and Aedes albopictus (Diptera: Culicidae) ecology, biology, behaviour, and implications on arbovirus transmission in Thailand: Review. One Health [Internet]. 2023;16(100555):100555.
4. Giraldo-Jaramillo T, Rua-Uribe G, Triana-Chávez O, Pérez-Pérez J. Vertical transmission of Dengue virus in Aedes aegypti and Aedes albopictus in Medellin, Colombia; 2019.
5. de Curcio JS, Salem-Izacc SM, Pereira Neto LM, Nunes EB, Anunciação CE, Silveira-Lacerda EdP. Detection of Mayaro virus in Aedes aegypti mosquitoes circulating in Goiânia-Goiás-Brazil. Microbes Infect 2022 -06;24(4):104948.
6. Izquierdo-Suzán M, Zárate S, Torres-Flores J, Correa-Morales F, González-Acosta C, Sevilla-Reyes EE, et al. Natural Vertical Transmission of Zika Virus in Larval Aedes aegypti Populations, Morelos, Mexico. Emerg Infect Dis 2019 -08;25(8):1477-1484.
7. Cantillo-Barraza O, Medina M, Granada Y, Muñoz C, Valverde C, Cely F, et al. Susceptibility to Insecticides and Natural Infection in Aedes aegypti: An Initiative to Improve the Mosquito Control Actions in Boyacá, Colombia. Ann Glob Health 2020 -08-06;86(1):94
8. Gómez M, Martinez D, Hernández D, Luna Niño N, Patino L, Melo R, et al. Arbovirus infection in Aedes aegypti from different departments of Colombia. Frontiers in Ecology and Evolution 2022 September 1,;10:999169.
9. Avilés-Vergara PA, Trujillo-Correa A, Gómez-Suárez LA, Ricardo-Caldera D, Soto-De León SC, Brango H, et al. DENV and ZIKV detection in patients with acute febrile syndrome in Córdoba, Colombia. Int J Infect Dis 2020 -10
10. Córdoba: Departamento de Córdoba Colombia. Available.
11. Santiago GA, Vergne E, Quiles Y, Cosme J, Vazquez J, Medina JF, et al. Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus. 2013;7(7):e2311.
12. Pfeffer M, Proebster B, Kinney RM, Kaaden O-R. Genus-specific detection of alphaviruses by a semi-nested reverse transcription-polymerase chain reaction. Am J Trop Med Hyg. 1997;57(6):709–18.
13. Baleotti FG, Moreli ML, Figueiredo LTM. Brazilian Flavivirus phylogeny based on NS5. Mem Inst Oswaldo Cruz . 2003;98(3):379–82.
14. de alarma Grave, S. S. de A. C. S. (s/f). Dengue Periodo epidemiológico 01. Gov.co. Recuperado el 18 de marzo de 2024, de https://www.ins.gov.co/buscador-eventos/Informesdeevento/DENGUE%20PE%20I%202024.pdf#search=informe%20epidemiologico%20dengue%202024
15. Pérez-Pérez J, Rojo-Ospina R, Henao-Correa E, García-Huertas P, Triana-Chavez O, Rúa-Uribe GL. Natural infection of Aedes aegypti, Ae. albopictus and Culex spp. with Zika virus in Medellin, Colombia. CES MEDICINA 2019 27-09-;33(3):175-181.
16. Ruiz-López F, González-Mazo A, Vélez-Mira A, Gómez GF, Zuleta L, Uribe S, et al. Presence of Aedes (Stegomyia) aegypti (Linnaeus, 1762) and its natural infection with dengue virus at
17. Martínez NE, Dzul-Manzanilla F, Gutiérrez-Castro C, Ibarra-López J, Bibiano-Marín W, López-Damián L, et al. Natural vertical transmission of dengue-1 virus in Aedes aegypti populations in Acapulco, Mexico. J Am Mosq Control Assoc 2014 -06;30(2):143-146.
18. Danis-Lozano R, Díaz-González EE, Malo-García IR, Rodríguez MH, Ramos-Castañeda J, Juárez-Palma L, et al. Vertical transmission of dengue virus in Aedes aegypti and its role in the epidemiological persistence of dengue in Central and Southern Mexico. Trop Med Int Health 2019 -11;24(11):1311-1319.
19. Edillo FE, Sarcos JR, Sayson SL. Natural vertical transmission of dengue viruses in Aedes aegypti in selected sites in Cebu City, Philippines. J Vector Ecol. 2015 Dec;40(2):282-91. doi: 10.1111/jvec.12166. PMID: 26611963.
20. Zhu C, Jiang Y, Zhang Q, Gao J, Gu Z, Lan C, et al. Vertical Transmission of Zika Virus by Jiegao and Mengding Aedes aegypti (Diptera: Culicidae) Strains in Yunnan Province in China
21. Le Goff G, Revollo J, Guerra M, Cruz M, Barja Simon Z, Roca Y, et al. Natural vertical transmission of dengue viruses by Aedes aegypti in Bolivia. Parasite 2011 -08;18(3):277-28.
22. Ferreira-de-Lima VH, Lima-Camara TN. Natural vertical transmission of dengue virus in Aedes aegypti and Aedes albopictus: a systematic review. Parasit Vectors. 2018 Feb 1;11(1):77.
23. Agarwal A, Dash PK, Singh AK, Sharma S, Gopalan N, Rao PVL, et al. Evidence of experimental vertical transmission of emerging novel ECSA genotype of Chikungunya Virus in Aedes aegypti. PLoS Negl Trop Dis 2014;8(7):e2990.
24. Krokovsky L, Lins CRB, Guedes DRD, Wallau GdL, Ayres CFJ, Paiva MHS. Dynamic of Mayaro Virus Transmission in Aedes aegypti, Culex quinquefasciatus Mosquitoes, and a Mice Model. Viruses 2023 March 21,;15(3):799.
25. Long KC, Ziegler SA, Thangamani S, Hausser NL, Kochel TJ, Higgs S, et al. Experimental Transmission of Mayaro Virus by Aedes aegypti. Am J Trop Med Hyg 2011 October 1,;85(4):750-757.
26. da Costa CF, da Silva AV, do Nascimento VA, de Souza VC, Monteiro DCdS, Terrazas WCM, et al. Evidence of vertical transmission of Zika virus in field-collected eggs of Aedes aegypti in the Brazilian Amazon. PLoS Negl Trop Dis 2018 -07;12(7):e0006594.
27. Thongrungkiat S, Wasinpiyamongkol L, Maneekan P, Prummongkol S, Samung Y. Natural transovarial dengue virus infection rate in both sexes of dark and pale forms of Aedes aegypti from an urban area of Bangkok, Thailand. Southeast Asian J Trop Med Public Health 2012 -09;43(5):1146-1152.
28. Heath CJ, Grossi-Soyster EN, Ndenga BA, Mutuku FM, Sahoo MK, Ngugi HN, et al. Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya. PLOS Neglected Tropical Diseases 2020 19 jun.;14(6):e0008362.
29. Cruz LC, Serra OP, Leal-Santos FA, Ribeiro AL, Slhessarenko RD, Santos MA. Natural transovarial transmission of dengue virus 4 in Aedes aegypti from Cuiabá, State of Mato Grosso, Brazil. Rev Soc Bras Med Trop. 2015 Jan-Feb;48(1):18-25.
30. Velandia-Romero ML, Olano VA, Coronel-Ruiz C, Cabezas L, Calderón-Peláez MA, Castellanos JE, et al. Dengue virus detection in Aedes aegypti larvae and pupae collected in rural areas of Anapoima, Cundinamarca, Colombia. Biomedica [Internet]. 2017 [cited 2024 Apr 16];37(Sup. 2):193.
31. Hoyos-López R, Suaza-Vasco J, Rúa-Uribe G, Uribe S, Gallego-Gómez JC. Molecular detection of flaviviruses and alphaviruses in mosquitoes (Diptera: Culicidae) from coastal ecosystems in the Colombian Caribbean. Mem Inst Oswaldo Cruz 2016 October 3,;111:625-634.
32. Pereira-Silva JW, do Nascimento VA, Belchior HCM, Almeida JF, Pessoa FAC, Naveca FG, et al. First evidence of Zika virus venereal transmission in Aedes aegypti mosquitoes. Mem Inst Oswaldo Cruz 2018 January 1,;113(1):56-61.
33. Delrieu M, Martinet J, O’Connor O, Viennet E, Menkes C, Burtet-Sarramegna V, et al. Temperature and transmission of chikungunya, dengue, and Zika viruses: A systematic review of experimental studies on Aedes aegypti and Aedes albopictus. Curr Res Parasitol Vector Borne Dis 2023 August 24,;4:100139.
34. De Figueiredo ML, de C Gomes, A, Amarilla AA, de S Leandro A, de S Orrico A, de Araujo et al. Mosquitoes infected with dengue viruses in Brazil. Virol J. 2010; 7:152. doi.ORG/10.1186/1743-422X-7-152.
35. Lwande OW, Obanda V, Lindström A, Ahlm C, Evander M, Näslund J, et al. Globe-Trotting Aedes aegypti and Aedes albopictus: Risk Factors for Arbovirus Pandemics. 2020;20(2):71–81.
36. Wilson-Bahun TA, Kamgang B, Lenga A, Wondji CS. Larval ecology and infestation indices of two major arbovirus vectors, Aedes aegypti and Aedes albopictus (Diptera: Culicidae), in Brazzaville, the capital city of the Republic of the Congo. 2020;13(1).
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spelling Tique Salleg, Vaneza Paulina53d3295-81c9-4112-81f8-1d740ddbb059600Clímaco Montesino, Daniela6a61c5e4-384a-4b12-a7ee-8d81b2d20adf-1Calderón Rangel, Alfonsode728744-ff95-4637-b2ec-975af9ce3e3b600Reza García, Lázaro Antonio10c2b4a1-eb38-462a-98fe-3186a1730a60-12024-07-28T20:21:32Z2025-07-252024-07-28T20:21:32Z2025-07-25https://repositorio.unicordoba.edu.co/handle/ucordoba/8449Universidad de CórdobaRepositorio universidad de Córdobahttps://repositorio.unicordoba.edu.co/homeLos arbovirus, en particular los transmitidos por los mosquitos Aedes aegypti, son una amenaza importante para la salud de las poblaciones caribeñas. Estos virus, entre ellos el dengue, el Zika y el Chikungunya, se transmiten horizontalmente por ingestión de sangre virémica. Aedes aegypti y Aedes albopictus (Aedes) son los principales vectores de estos virus, causando una morbilidad y mortalidad significativas en las zonas urbanas. La capacidad vectorial de Aedes aegypti es compleja debido a la interacción entre factores biológicos y abióticos. En Colombia, la presencia de mosquitos infectados por Aedes aegypti sugiere que la transmisión vertical es un evento más frecuente y de mayor relevancia epidemiológica. En América Latina se ha detectado CHIKV en Aedes aegypti y se ha reportado la primera detección de Zika en transmisión natural vertical en Aedes aegypti. Colombia es un país hiperendémico para el dengue, con más de 26 millones de personas expuestas al virus. Sin embargo, la falta de conocimientos precisos y oportunos sobre la epidemiología molecular de los arbovirus está dificultando la predicción del riesgo real de nuevos casos y su propagación en poblaciones humanas.1. AGRADECIMIENTOS..................................................... 32. INTRODUCCION................................................... 43. OBJETIVOS...................................................................... 73.1 General ............................................................................... 73.2 Específicos ................................................................. 74. METODOLOGIA.............................................. 8Tabla 1. Descripciones y secuencias de los oligonucleotidos y sondas................... 94.6 Detección de serotipos de dengue (DENV-1, DENV-2, DENV-3, DENV-4) mediante reacción en cadena de la polimerasa con transcripción inversa en tiempo real (qRT- PCR).................. 10Tabla 2. Descripciones y secuencias de los oligonucleotidos y sondas................. 104.7 Detección de arbovirus mediante reacción en cadena de la polimerasa con transcripción inversa (RT- PCR) y semi RT -Nested PCR para Alfavirus y Flavivirus 115. RESULTADOS.................................... 125.1 Descripción de los arbovirus detectados.................... 12Tabla 4. Infección natural por arbovirus en mosquitos Aedes aegypti en el departamento de Córdoba, Colombia ........ 125.2 Áreas de infección natural por arbovirus en mosquitos del género Aedes aegyti .......................... 136. DISCUSIÓN ..................................... 14Tabla 4. Infección natural por arbovirus en mosquitos F1 Aedes aegypti en el mundo. ................................. 157. CONCLUSIÓN........................... 218. REFERENCIAS...................................... 22PregradoMédico(a) Veterinario(a) y ZootecniaMonografíasapplication/pdfspaUniversidad de CórdobaFacultad de Medicina Veterinaria y ZootecniaBerástegui, Córdoba, ColombiaMedicina Veterinaria y ZootecniaCopyright Universidad de Córdoba, 2024https://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfInfección natural de mosquitos Aedes aegypti por arbovirus en el departamento CórdobaTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/acceptedVersionText1. Mantilla-Granados JS, Sarmiento-Senior D, Manzano J, Calderón-Peláez M, Velandia-Romero ML, Buitrago LS, et al. Multidisciplinary approach for surveillance and risk identification of yellow fever and other arboviruses in Colombia. One Health 2022 -12;15:100438.2. Oliveira M, Silva J, Lima Viana J, Tadei W, Pinheiro VC. Efficiency of oviposition traps with biolarvicides for monitoring Aedes aegypti and Aedes albopictus (Diptera, Culicidae), northeast Brazil. Acta Scientiarum Biological Sciences 2022 -03-16;44:e59231.3. Ahebwa A, Hii J, Neoh K-B, Chareonviriyaphap T. Aedes aegypti and Aedes albopictus (Diptera: Culicidae) ecology, biology, behaviour, and implications on arbovirus transmission in Thailand: Review. One Health [Internet]. 2023;16(100555):100555.4. Giraldo-Jaramillo T, Rua-Uribe G, Triana-Chávez O, Pérez-Pérez J. Vertical transmission of Dengue virus in Aedes aegypti and Aedes albopictus in Medellin, Colombia; 2019.5. de Curcio JS, Salem-Izacc SM, Pereira Neto LM, Nunes EB, Anunciação CE, Silveira-Lacerda EdP. Detection of Mayaro virus in Aedes aegypti mosquitoes circulating in Goiânia-Goiás-Brazil. Microbes Infect 2022 -06;24(4):104948.6. Izquierdo-Suzán M, Zárate S, Torres-Flores J, Correa-Morales F, González-Acosta C, Sevilla-Reyes EE, et al. Natural Vertical Transmission of Zika Virus in Larval Aedes aegypti Populations, Morelos, Mexico. Emerg Infect Dis 2019 -08;25(8):1477-1484.7. Cantillo-Barraza O, Medina M, Granada Y, Muñoz C, Valverde C, Cely F, et al. Susceptibility to Insecticides and Natural Infection in Aedes aegypti: An Initiative to Improve the Mosquito Control Actions in Boyacá, Colombia. Ann Glob Health 2020 -08-06;86(1):948. Gómez M, Martinez D, Hernández D, Luna Niño N, Patino L, Melo R, et al. Arbovirus infection in Aedes aegypti from different departments of Colombia. Frontiers in Ecology and Evolution 2022 September 1,;10:999169.9. Avilés-Vergara PA, Trujillo-Correa A, Gómez-Suárez LA, Ricardo-Caldera D, Soto-De León SC, Brango H, et al. DENV and ZIKV detection in patients with acute febrile syndrome in Córdoba, Colombia. Int J Infect Dis 2020 -1010. Córdoba: Departamento de Córdoba Colombia. Available.11. Santiago GA, Vergne E, Quiles Y, Cosme J, Vazquez J, Medina JF, et al. Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus. 2013;7(7):e2311.12. Pfeffer M, Proebster B, Kinney RM, Kaaden O-R. Genus-specific detection of alphaviruses by a semi-nested reverse transcription-polymerase chain reaction. Am J Trop Med Hyg. 1997;57(6):709–18.13. Baleotti FG, Moreli ML, Figueiredo LTM. Brazilian Flavivirus phylogeny based on NS5. Mem Inst Oswaldo Cruz . 2003;98(3):379–82.14. de alarma Grave, S. S. de A. C. S. (s/f). Dengue Periodo epidemiológico 01. Gov.co. Recuperado el 18 de marzo de 2024, de https://www.ins.gov.co/buscador-eventos/Informesdeevento/DENGUE%20PE%20I%202024.pdf#search=informe%20epidemiologico%20dengue%20202415. Pérez-Pérez J, Rojo-Ospina R, Henao-Correa E, García-Huertas P, Triana-Chavez O, Rúa-Uribe GL. Natural infection of Aedes aegypti, Ae. albopictus and Culex spp. with Zika virus in Medellin, Colombia. 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PLOS Neglected Tropical Diseases 2020 19 jun.;14(6):e0008362.29. Cruz LC, Serra OP, Leal-Santos FA, Ribeiro AL, Slhessarenko RD, Santos MA. Natural transovarial transmission of dengue virus 4 in Aedes aegypti from Cuiabá, State of Mato Grosso, Brazil. Rev Soc Bras Med Trop. 2015 Jan-Feb;48(1):18-25.30. Velandia-Romero ML, Olano VA, Coronel-Ruiz C, Cabezas L, Calderón-Peláez MA, Castellanos JE, et al. Dengue virus detection in Aedes aegypti larvae and pupae collected in rural areas of Anapoima, Cundinamarca, Colombia. Biomedica [Internet]. 2017 [cited 2024 Apr 16];37(Sup. 2):193.31. Hoyos-López R, Suaza-Vasco J, Rúa-Uribe G, Uribe S, Gallego-Gómez JC. Molecular detection of flaviviruses and alphaviruses in mosquitoes (Diptera: Culicidae) from coastal ecosystems in the Colombian Caribbean. Mem Inst Oswaldo Cruz 2016 October 3,;111:625-634.32. Pereira-Silva JW, do Nascimento VA, Belchior HCM, Almeida JF, Pessoa FAC, Naveca FG, et al. 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2024embargohttps://repositorio.unicordoba.edu.coRepositorio Universidad de 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