Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas

Autores:: Avcıoğlu, Merve
Akar, Ferda

Tipo de recurso:: Article of journal

Fecha de publicación:: 2022

Institución:: Universidad de Córdoba

Repositorio:: Repositorio Institucional Unicórdoba

Idioma:: spa

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dc.title.spa.fl_str_mv	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
dc.title.translated.eng.fl_str_mv	Gastroprotective effect of Hypericum perforatum extract on indomethacin induced gastric ulcer in rats
title	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
spellingShingle	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas antioxidant gastric ulcer Hypericum perforatum indomethacin oxidant antioxidante úlcera gástrica Hypericum perforatum indometacina oxidante
title_short	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
title_full	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
title_fullStr	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
title_full_unstemmed	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
title_sort	Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas
dc.creator.fl_str_mv	Avcıoğlu, Merve Akar, Ferda
dc.contributor.author.spa.fl_str_mv	Avcıoğlu, Merve Akar, Ferda
dc.subject.eng.fl_str_mv	antioxidant gastric ulcer Hypericum perforatum indomethacin oxidant
topic	antioxidant gastric ulcer Hypericum perforatum indomethacin oxidant antioxidante úlcera gástrica Hypericum perforatum indometacina oxidante
dc.subject.spa.fl_str_mv	antioxidante úlcera gástrica Hypericum perforatum indometacina oxidante
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2022-07-31 22:38:42 2022-08-01T09:36:26Z
dc.date.available.none.fl_str_mv	2022-07-31 22:38:42 2022-08-01T09:36:26Z
dc.date.issued.none.fl_str_mv	2022-07-31
dc.type.spa.fl_str_mv	Artículo de revista
dc.type.eng.fl_str_mv	Journal article
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dc.identifier.doi.none.fl_str_mv	10.21897/rmvz.2355
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dc.language.iso.spa.fl_str_mv	spa
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dc.relation.references.spa.fl_str_mv	Guyton AC. Texbook of Medical Physiology. Physiology of Gastrointestinal Disorders. 11thed. Philadelphia: Saunders Company; 2006; 819-822. https://www.moscmm.org/pdf/Guyton%20physiology.pdf Kaya S. Veteriner Farmakoloji 5. Baskı Cilt 2, Kaya S, Pirinçci İ, Ünsal A, Traş B, Bilgili A, Akar F (eds) Medisan Yayınevi: Ankara; 2009. Kurumbail R, Kiefer JR, Marnett LJ. Cyclooxygenase enzymes: Catalysis and inhibition. Curr Opin Struct Biol. 2001; 11(6):752-760. https://doi.org/10.1016/s0959-440x(01)00277-9 Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep. 2007; 59:247-258. https://pubmed.ncbi.nlm.nih.gov/17652824/ Baskose I, Savran A. A new species from southern Anatolia (Dedegöl Mountain Series — Çürük Mountain) in Turkey: Hypericum bilgehan-bilgilii (Hypericaceae). Phytotaxa. 2018; 374(2):110-118. https://doi.org/10.11646/phytotaxa.374.2.2 Ersoy E, Özkan EE, Mat A. Pharmacological Actiivities of Hypericum Species in Light of New Studies. JARHS. 2019; 2(2):71-79. https://doi.org/10.26650/JARHS2019-616370 Greeson J, Sanford B, Monti DA. St. John’s worth (Hypericum perforatum): a review of the current pharmacological, toxicological and clinical literature. Psychopharmacology 2001; 153:402-414. https://doi.org/10.1007/s002130000625 Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John’s Wort (L.) on chicken embryonic fibroblasts. J Ethnopharmacol. 2007; 111:33-39. https://doi.org/10.1016/j.jep.2006.10.029 Prisacaru AI, Andritoiu C, Andriescu C. Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury. Rom J Morphol Embryol. 2013; 54(4):1053-1059. https://pubmed.ncbi.nlm.nih.gov/24399001/ Kıyan S, Uyanıkgil Y, Altuncı YA, Çavuşoğlu T, Uyanikgil EOC, Karabey F. Investigation of acute effects of Hypericum perforatum (St. John’s Wort-Kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment, Ulus Travma Acil Cerrahi Derg. 2015; 21: 323-336. https://dx.doi.org/10.5505/tjtes.2015.63822 Arsić I, Žugić A, Antić DR, Zdunić G, Dekanski D, Marković G, Tadić V. Hypericum Perforatum L. Hypericaceae/Guttiferae Sunflower, Olive and Palm Oil Еxtracts Attenuate Cold Restraint Stress –Induced Gastric Lesions. Molecules 2010; 15:6688-6698. https://doi.org/10.3390/molecules15106688 Karaboğa İ, Dökmeci AH, Ovalı MA, Yılmaz A. Etanol Uyarımlı Sıçan Akut Mide Mukoza Hasar Modelinde Hypericum perforatum’un Koruyucu Etkilerinin İncelenmesi. NKMJ 2017; 5(3):99-108. https://dergipark.org.tr/tr/download/issue-full-file/33411 Abdel-Salam OME. Anti-Inflammatory, Antinociceptive and Gastric Effects of Hypericum perforatum in Rats. ScientificWorldJournal. 2005; 5:585–596. https://doi.org/10.1100/tsw.2005.78 Odabaşoğlu F, Halici Z, Cakir A, Halici M, Aygun H. Beneficial effects of vegetable oils (corn, olive and sunflower oils) and α-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin rats. Eur. J. Pharmaco. 2008; 591:300-306. https://doi.org/10.1016/j.ejphar.2008.06.075 Guidobono F, Pagani F, Ticozzi C, Sibilia V, Pecile A, Netti C. Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats. Br J Clin Pharmacol 1997; 120(4): 581-6. https://doi.org/10.1038/sj.bjp.0700941 Sun Y, Oberley LW, Li Y. A simple for clinical assay of superoxide dismutase. Clin Chem. 1988; 34:497-500. https://pubmed.ncbi.nlm.nih.gov/3349599/ Aebi H. Catalase in vitro assay methods. Methods in Enzymology. 1984; 105:121-126. https://doi.org/10.1016/s0076-6879(84)05016-3 Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969; 27(3):502-522. https://doi.org/10.1016/0003-2697(69)90064-5 Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95:351-358. https://doi.org/10.1016/0003-2697(79)90738-3 Nguelefack TB, Feumebo CB, Ateufack G, Watcho P, Tatsimo S, Atsamo D, Tane P, Kaman-yi A. Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats. J Ethnopharmacol 2005; 119(1): 135-40. https://doi.org/10.1016/j.jep.2008.06.008 Schubert ML. Gastric secretion. Curr Opin Gastroenterol. 2014; 30: 578-582. https://doi.org/10.1097/MOG.0000000000000125 Kılıçarslan H, Kalyon S, Yenice N. Etiopathogenesis of Peptic Ulser, Okmeydanı Tıp Dergisi. 2011; 27(2):65-69. http://doi.org/10.5222/otd.2011.065 Eminler AT, Uslan Mİ, Köksal AŞ, Parlak E. Non-Steroid Anti-İnflamatuvar İlaçların Üst Gastrointestinal Sistem Yan Etkileri ve Önlenmesi. Güncel Gastroenteroloji. 2014; 18(3):333-338. http://guncel.tgv.org.tr/journal/53/pdf/100245.pdf Dündar Y, Aslan R. Hekimlikte Oksidatif Stres, Afyon Kocatepe Üniversitesi Yayınları: Ankara; 2000. Zdunic G, Godevac D, Milenkovic M, Vucievic D, Savikin K, Menkovic N, et al. Evalution of Hypericum perforatum oil extract for an antiinflammatory and gastroprotective activity in rats. Phytotherapy Research. 2009; 23(11):1559-1564. https://doi.org/10.1002/ptr.2809 Kurt H, Özbayer, C, Değirmenci İ, Burukoğlu D, Saadat SM, Üstüner MC, et al. İndomethazine Bağlı Oluşan Gastrik Mukozal Hasar Üzerine Hypericum Perforatum Yağının Koruyucu Etkisi. Bozok Tıp Derg. 2016; 6(3):46-52. https://app.trdizin.gov.tr/makale/TWpVM05qQTFOUT09/indomethazine-bagli-olusan-gastrik-mukozal-hasar-uzerine-hypericum Cayci MK, Dayioglu H. Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats. Saudi Med J. 2009; 30(6):750-754. https://pubmed.ncbi.nlm.nih.gov/19526154/ Vieira SM, Silva RL, Lemos HP, Amorim RC, Silva EC, Reinach PS, Cunha FQ, Pohlit AM, Cunha TM. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia. 2014; 95:8-15. https://doi.org/10.1016/j.fitote.2014.02.008 Diniz PB, Ribeiro AR, Estevam CS, Bani CC, Thomazzi SM. Possible mechanisms of action of Caesalpinia pyramidalis against ethanol-induced gastric damage. J Ethnopharmacol. 2015; 20(168):79-86. https://doi.org/10.1016/j.jep.2015.03.054 Yoshiwaka T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, et al. Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut. 1993; 34(6):732-737. https://doi.org/10.1136/gut.34.6.732 Dengiz GÖ, Gürsan N. Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer models in rats. Turk J Gastroenterol. 2005; 16(2):85-88. https://pubmed.ncbi.nlm.nih.gov/16252198/ Kim JH, Kim BW, Kwon HJ, Nam SW. Curative Effect of Selenium Against Indomethacin- Induced Gastric Ulcers in Rats. Microbial Biotechnology. 2011; 21(4):400-404. https://pubmed.ncbi.nlm.nih.gov/21532324/ El-Masry TA, Elahwel AM, Emara AM. Study on treating ethanol-induced gastric lesions with omeprazole, Nigella sativa oil or both. Toxicological and Enviromental Chemistry. 2010; 92:1765-1782. https://doi.org/10.1080/02772241003730589 Boyacioglu M, Kum C, Sekkin S, Yalinkilinc HS, Avci H, Epikmen ET, Karademir U. The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. Clin Nutr. 2016; 35:428-435. https://doi.org/10.1016/j.clnu.2015.03.006 Chattopadhyay I, Bandyopadhyay U, Biswas K, Maity P, Banerjee RK. Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radic Biol Med. 2006; 40:1397-1408. https://doi.org/10.1016/j.freeradbiomed.2005.12.016
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dc.relation.citationedition.spa.fl_str_mv	Núm. 2 , Año 2022 : Revista MVZ Córdoba Volumen 27(2) Mayo-Agosto 2022
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dc.rights.spa.fl_str_mv	Merve Avcıoğlu, Ferda Akar - 2022
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spelling	Avcıoğlu, Mervebe766ce4-0e5e-49eb-bb71-0860abf63d8a-1Akar, Ferda998c8dee-0b45-4c43-bd24-33642fb5978c-12022-07-31 22:38:422022-08-01T09:36:26Z2022-07-31 22:38:422022-08-01T09:36:26Z2022-07-310122-0268https://repositorio.unicordoba.edu.co/handle/ucordoba/620510.21897/rmvz.2355https://doi.org/10.21897/rmvz.23551909-0544application/pdfapplication/pdfaudio/mpegaudio/mpegspaUniversidad de CórdobaMerve Avcıoğlu, Ferda Akar - 2022https://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.http://purl.org/coar/access_right/c_abf2https://revistamvz.unicordoba.edu.co/article/view/2355antioxidantgastric ulcerHypericum perforatumindomethacinoxidantantioxidanteúlcera gástricaHypericum perforatumindometacinaoxidanteEfecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratasGastroprotective effect of Hypericum perforatum extract on indomethacin induced gastric ulcer in ratsArtículo de revistaJournal articleinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREFhttp://purl.org/coar/version/c_970fb48d4fbd8a85Guyton AC. Texbook of Medical Physiology. Physiology of Gastrointestinal Disorders. 11thed. Philadelphia: Saunders Company; 2006; 819-822. https://www.moscmm.org/pdf/Guyton%20physiology.pdfKaya S. Veteriner Farmakoloji 5. Baskı Cilt 2, Kaya S, Pirinçci İ, Ünsal A, Traş B, Bilgili A, Akar F (eds) Medisan Yayınevi: Ankara; 2009.Kurumbail R, Kiefer JR, Marnett LJ. Cyclooxygenase enzymes: Catalysis and inhibition. Curr Opin Struct Biol. 2001; 11(6):752-760. https://doi.org/10.1016/s0959-440x(01)00277-9Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep. 2007; 59:247-258. https://pubmed.ncbi.nlm.nih.gov/17652824/Baskose I, Savran A. A new species from southern Anatolia (Dedegöl Mountain Series — Çürük Mountain) in Turkey: Hypericum bilgehan-bilgilii (Hypericaceae). Phytotaxa. 2018; 374(2):110-118. https://doi.org/10.11646/phytotaxa.374.2.2Ersoy E, Özkan EE, Mat A. Pharmacological Actiivities of Hypericum Species in Light of New Studies. JARHS. 2019; 2(2):71-79. https://doi.org/10.26650/JARHS2019-616370Greeson J, Sanford B, Monti DA. St. John’s worth (Hypericum perforatum): a review of the current pharmacological, toxicological and clinical literature. Psychopharmacology 2001; 153:402-414. https://doi.org/10.1007/s002130000625Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John’s Wort (L.) on chicken embryonic fibroblasts. J Ethnopharmacol. 2007; 111:33-39. https://doi.org/10.1016/j.jep.2006.10.029Prisacaru AI, Andritoiu C, Andriescu C. Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury. Rom J Morphol Embryol. 2013; 54(4):1053-1059. https://pubmed.ncbi.nlm.nih.gov/24399001/Kıyan S, Uyanıkgil Y, Altuncı YA, Çavuşoğlu T, Uyanikgil EOC, Karabey F. Investigation of acute effects of Hypericum perforatum (St. John’s Wort-Kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment, Ulus Travma Acil Cerrahi Derg. 2015; 21: 323-336. https://dx.doi.org/10.5505/tjtes.2015.63822Arsić I, Žugić A, Antić DR, Zdunić G, Dekanski D, Marković G, Tadić V. Hypericum Perforatum L. Hypericaceae/Guttiferae Sunflower, Olive and Palm Oil Еxtracts Attenuate Cold Restraint Stress –Induced Gastric Lesions. Molecules 2010; 15:6688-6698. https://doi.org/10.3390/molecules15106688Karaboğa İ, Dökmeci AH, Ovalı MA, Yılmaz A. Etanol Uyarımlı Sıçan Akut Mide Mukoza Hasar Modelinde Hypericum perforatum’un Koruyucu Etkilerinin İncelenmesi. NKMJ 2017; 5(3):99-108. https://dergipark.org.tr/tr/download/issue-full-file/33411Abdel-Salam OME. Anti-Inflammatory, Antinociceptive and Gastric Effects of Hypericum perforatum in Rats. ScientificWorldJournal. 2005; 5:585–596. https://doi.org/10.1100/tsw.2005.78Odabaşoğlu F, Halici Z, Cakir A, Halici M, Aygun H. Beneficial effects of vegetable oils (corn, olive and sunflower oils) and α-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin rats. Eur. J. Pharmaco. 2008; 591:300-306. https://doi.org/10.1016/j.ejphar.2008.06.075Guidobono F, Pagani F, Ticozzi C, Sibilia V, Pecile A, Netti C. Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats. Br J Clin Pharmacol 1997; 120(4): 581-6. https://doi.org/10.1038/sj.bjp.0700941Sun Y, Oberley LW, Li Y. A simple for clinical assay of superoxide dismutase. Clin Chem. 1988; 34:497-500. https://pubmed.ncbi.nlm.nih.gov/3349599/Aebi H. Catalase in vitro assay methods. Methods in Enzymology. 1984; 105:121-126. https://doi.org/10.1016/s0076-6879(84)05016-3Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969; 27(3):502-522. https://doi.org/10.1016/0003-2697(69)90064-5Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95:351-358. https://doi.org/10.1016/0003-2697(79)90738-3Nguelefack TB, Feumebo CB, Ateufack G, Watcho P, Tatsimo S, Atsamo D, Tane P, Kaman-yi A. Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats. J Ethnopharmacol 2005; 119(1): 135-40. https://doi.org/10.1016/j.jep.2008.06.008Schubert ML. Gastric secretion. Curr Opin Gastroenterol. 2014; 30: 578-582. https://doi.org/10.1097/MOG.0000000000000125Kılıçarslan H, Kalyon S, Yenice N. Etiopathogenesis of Peptic Ulser, Okmeydanı Tıp Dergisi. 2011; 27(2):65-69. http://doi.org/10.5222/otd.2011.065Eminler AT, Uslan Mİ, Köksal AŞ, Parlak E. Non-Steroid Anti-İnflamatuvar İlaçların Üst Gastrointestinal Sistem Yan Etkileri ve Önlenmesi. Güncel Gastroenteroloji. 2014; 18(3):333-338. http://guncel.tgv.org.tr/journal/53/pdf/100245.pdfDündar Y, Aslan R. Hekimlikte Oksidatif Stres, Afyon Kocatepe Üniversitesi Yayınları: Ankara; 2000.Zdunic G, Godevac D, Milenkovic M, Vucievic D, Savikin K, Menkovic N, et al. Evalution of Hypericum perforatum oil extract for an antiinflammatory and gastroprotective activity in rats. Phytotherapy Research. 2009; 23(11):1559-1564. https://doi.org/10.1002/ptr.2809Kurt H, Özbayer, C, Değirmenci İ, Burukoğlu D, Saadat SM, Üstüner MC, et al. İndomethazine Bağlı Oluşan Gastrik Mukozal Hasar Üzerine Hypericum Perforatum Yağının Koruyucu Etkisi. Bozok Tıp Derg. 2016; 6(3):46-52. https://app.trdizin.gov.tr/makale/TWpVM05qQTFOUT09/indomethazine-bagli-olusan-gastrik-mukozal-hasar-uzerine-hypericumCayci MK, Dayioglu H. Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats. Saudi Med J. 2009; 30(6):750-754. https://pubmed.ncbi.nlm.nih.gov/19526154/Vieira SM, Silva RL, Lemos HP, Amorim RC, Silva EC, Reinach PS, Cunha FQ, Pohlit AM, Cunha TM. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia. 2014; 95:8-15. https://doi.org/10.1016/j.fitote.2014.02.008Diniz PB, Ribeiro AR, Estevam CS, Bani CC, Thomazzi SM. Possible mechanisms of action of Caesalpinia pyramidalis against ethanol-induced gastric damage. J Ethnopharmacol. 2015; 20(168):79-86. https://doi.org/10.1016/j.jep.2015.03.054Yoshiwaka T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, et al. Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut. 1993; 34(6):732-737. https://doi.org/10.1136/gut.34.6.732Dengiz GÖ, Gürsan N. Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer models in rats. Turk J Gastroenterol. 2005; 16(2):85-88. https://pubmed.ncbi.nlm.nih.gov/16252198/Kim JH, Kim BW, Kwon HJ, Nam SW. Curative Effect of Selenium Against Indomethacin- Induced Gastric Ulcers in Rats. Microbial Biotechnology. 2011; 21(4):400-404. https://pubmed.ncbi.nlm.nih.gov/21532324/El-Masry TA, Elahwel AM, Emara AM. Study on treating ethanol-induced gastric lesions with omeprazole, Nigella sativa oil or both. Toxicological and Enviromental Chemistry. 2010; 92:1765-1782. https://doi.org/10.1080/02772241003730589Boyacioglu M, Kum C, Sekkin S, Yalinkilinc HS, Avci H, Epikmen ET, Karademir U. 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Free Radic Biol Med. 2006; 40:1397-1408. https://doi.org/10.1016/j.freeradbiomed.2005.12.016https://revistamvz.unicordoba.edu.co/article/download/2355/3884https://revistamvz.unicordoba.edu.co/article/download/2355/3885https://revistamvz.unicordoba.edu.co/article/download/2355/3905https://revistamvz.unicordoba.edu.co/article/download/2355/3906https://revistamvz.unicordoba.edu.co/article/download/2355/3907Núm. 2 , Año 2022 : Revista MVZ Córdoba Volumen 27(2) Mayo-Agosto 2022e23552e235527Revista MVZ CórdobaPublicationOREORE.xmltext/xml3191https://repositorio.unicordoba.edu.co/bitstreams/6d14028b-7d56-4807-8ce2-50b766ca3f21/downloadbc405886a29afc5691d8fd53c8639809MD51ucordoba/6205oai:repositorio.unicordoba.edu.co:ucordoba/62052023-10-06 00:46:13.225https://creativecommons.org/licenses/by-nc-sa/4.0Merve Avcıoğlu, Ferda Akar - 2022metadata.onlyhttps://repositorio.unicordoba.edu.coRepositorio Universidad de Córdobabdigital@metabiblioteca.com

Efecto gastroprotector del extracto de Hypericum perforatum sobre la úlcera gástrica inducida por indometacina en ratas

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