Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión

La depresión es un trastorno caracterizado por la presencia de tristeza, pérdida de interés, sentimientos de culpa; se puede clasificar como leve, moderada o grave. El presente trabajo se centra en la influencia de los inhibidores selectivos de la recaptación de serotonina (ISRS) en la microbiota in...

Full description

Autores:
Ortegón Orduña, Juanita
Zuluaga Echeverri, Luz Yerly
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2022
Institución:
Colegio Mayor de Cundinamarca
Repositorio:
Repositorio Colegio Mayor de Cundinamarca
Idioma:
spa
OAI Identifier:
oai:repositorio.unicolmayor.edu.co:unicolmayor/6912
Acceso en línea:
https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6912
Palabra clave:
Depresión
Microbiota intestinal
Inhibidores Selectivos de la Recaptación de Serotonina (ISRS)
Disbiosis intestinal
Tratamiento
Rights
closedAccess
License
Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024
id UCOLMAYOR2_e4e7933368f0f5f38c6551a746fc96c9
oai_identifier_str oai:repositorio.unicolmayor.edu.co:unicolmayor/6912
network_acronym_str UCOLMAYOR2
network_name_str Repositorio Colegio Mayor de Cundinamarca
repository_id_str
dc.title.spa.fl_str_mv Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
title Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
spellingShingle Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
Depresión
Microbiota intestinal
Inhibidores Selectivos de la Recaptación de Serotonina (ISRS)
Disbiosis intestinal
Tratamiento
title_short Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
title_full Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
title_fullStr Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
title_full_unstemmed Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
title_sort Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión
dc.creator.fl_str_mv Ortegón Orduña, Juanita
Zuluaga Echeverri, Luz Yerly
dc.contributor.advisor.none.fl_str_mv Camacho Kurmen, Judith Elena
dc.contributor.author.none.fl_str_mv Ortegón Orduña, Juanita
Zuluaga Echeverri, Luz Yerly
dc.contributor.corporatename.spa.fl_str_mv Universidad Colegio Mayor de Cundinamarca
dc.subject.proposal.spa.fl_str_mv Depresión
Microbiota intestinal
Inhibidores Selectivos de la Recaptación de Serotonina (ISRS)
Disbiosis intestinal
Tratamiento
topic Depresión
Microbiota intestinal
Inhibidores Selectivos de la Recaptación de Serotonina (ISRS)
Disbiosis intestinal
Tratamiento
description La depresión es un trastorno caracterizado por la presencia de tristeza, pérdida de interés, sentimientos de culpa; se puede clasificar como leve, moderada o grave. El presente trabajo se centra en la influencia de los inhibidores selectivos de la recaptación de serotonina (ISRS) en la microbiota intestinal de las personas con depresión. Se basa en el eje intestino-cerebro que consiste en una red de comunicación que monitorea e integra las funciones intestinales y las vincula a los centros cognitivos y emocionales del cerebro. Esta investigación se lleva a cabo por una revisión bibliográfica y un análisis bibliométrico, donde se explica el eje, se analiza el impacto en la microbiota con el uso de antidepresivos, se describe el efecto de estos en pacientes con depresión y se indagan los tratamientos adicionales que pueden ser utilizados. Los ISRS son medicamentos de primera línea, estos inhiben los transportadores de serotonina aumentando los niveles de 5-hidroxitriptamina, la concentración prolongada de estos en la luz intestinal afectan la microbiota generando disbiosis, la cual se puede prevenir con el uso de probióticos, prebióticos, psicobióticos o dieta. Como conclusión los ISRS poseen acción antimicrobiana, el tratamiento más prometedor es el uso de probióticos por el gran beneficio que conlleva en el intestino. A nivel nacional pese al desarrollo de una Política Pública de Salud Mental no se cuenta con la cobertura adecuada se dificulta el acceso a los servicios y tratamientos incompletos; por lo que se sugiere seguir investigando sobre el tema y en planes de prevención.
publishDate 2022
dc.date.issued.none.fl_str_mv 2022-04
dc.date.accessioned.none.fl_str_mv 2024-05-23T17:29:55Z
dc.date.available.none.fl_str_mv 2024-05-23T17:29:55Z
dc.type.spa.fl_str_mv Trabajo de grado - Pregrado
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/TP
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_7a1f
status_str publishedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6912
url https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6912
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microb. [Internet] 2011 [cited 7 aug 2020];2(4):256-261. Available in: https://www.tandfonline.com/doi/abs/10.4161/gmic.2.4.16108
Lyte M. Microbial Endocrinology in the Microbiome-Gut-Brain Axis: How Bacterial Production and Utilization of Neurochemicals Influence Behavior. PLoS Pathog. [Internet] 2013 [cited 2 aug 2020];9(11):e1003726. Available in: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003726
Blier P, Mansari M. Serotonin and beyond: therapeutics for major depression. Philos Trans R Soc Lond B Biol Sci. [Internet] 2013 [cited 25 mar 2021];368 (1615):e20120536. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638389/
Ley 1616. Colombia. Congreso de Colombia; 21 Enero de 2013. Tomado de: https://www.asivamosensalud.org/politicas-publicas/normatividad-leyes/salud-publica/ley- 1616-de-2013-salud-menta
Krebber AMH,Buffart LM,Kleijn G, Riepma IC, Bree R,Leemans CR, et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psychooncology.[Internet] 2014 [cited 16 dec]; 23(2): 121–130. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282549/
Orel R, Trop TK. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease.World J Gastroenterol [Internet] 2014 [cited 12 jan 2022];20(33): 11505–11524.Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155344/
Dinan TG, Stilling RM, Stanton C, Cryan JF. Collective unconscious: How gut microbes shape human behavior. J Psychiatr Res. [Internet] 2015 [cited 17 aug 2020];63:1-9. Available in: https://www.sciencedirect.com/science/article/pii/ S0022395615000655?via%3Dihub
Jakubovski E , Varigonda A , Freemantle N , Taylor M, Bloch M.Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective-Serotonin Reuptake Inhibitors in Major Depressive Disorder.Am J Psychiatry.[Internet] 2016 [cited 14 dec 2020]; 1; 173(2): 174–183. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975858/
Fröhlich EE, Farzi A, Mayerhofer R, Reichmann F, Jačan A, Wagner B, et al. Cognitive Impairment by Antibiotic-Induced Gut Dysbiosis: Analysis of Gut Microbiota-Brain Communication. Brain Behav Immun. [Internet] 2016 [cited 28 aug 2020];56:140-155. Available in: https://www.sciencedirect.com/science/article/pii/S0889159 11630040X?via%3Dihub
Rogers GB, Keating DJ, Young RL, Wong ML, Licinio J, Wesselingh S. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry. [Internet] 2016 [cited 16 sep 2020];21(6):738–748. Available in: https://www.nature.com/articles/mp201650
Camacho DE, Oviedo HR, Ramos E, González TC. Bibliometric analysis of articles on nursing care published in colombian magazines. [Internet] 2016 [cited 6 aug 2021]; 44: 406-415. Available in: https://redib.org/Record/oai_articulo3209662-bibliometric-analysis-articles-nursing-care-p ublished-colombian-magazines
Liqing L, Chunmei W, Yong G, Xianguo Q, Zuxun L. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies.BMC Psychiatry.[Internet] 2016 [cited 17 dec 2021]; 16: 375.Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097837/
Cenit MC, Sanz Y, Codoñer P. Influence of gut microbiota on neuropsychiatric disorders.World J Gastroenterol. [Internet] 2017 [cited 2 sep 2020]; 23(30):5486–5498. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558112/
MacQueen G, Surette M, Moayyedi P. The gut microbiota and psychiatric illness. J Psychiatry Neurosci.[Internet] 2017 [cited 22 sep 2020];42(2):75-77. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373703/
Wan-Tzu L, Yen-Chun P, Chung-Hsin C, Hong-Zen L, Chi-Sen C. Relationship between use of selective serotonin reuptake inhibitors and irritable bowel syndrome: A population-based cohort study. World J Gastroenterol. [Internet] 2017 [Cited 22 mar 2021];23(19):3513-3521. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442087/
Jakobsen JC, Katakan KK, Schou A, Hellmuth SG, Elkjaer S, Leth-Moller K, et al. Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis. BMC Psychiatry. [Internet] 2017 [Cited 2 apr 2021];17(58). Available in: https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1173-2?utm_conte nt=buffer7e7cb&utm#Sec1
Koopman M, El Aidy S.Depressed gut? The microbiota-diet-inflammation trialogue in depression. Curr Opin Psychiatry. [Internet] 2017 [Cited 13 feb 2021];30(5): 369-377. Available in: https://www.ingentaconnect.com/content/wk/yco/2017/00000030/00000005/art00009
Bambling M, Edward S, Hall S, Vitetta L. A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested.Inflammopharmacology. [Internet] 2017 [Cited 19 feb 2021];25:271-274. Available in: https://link.springer.com/article/10.1007%2Fs10787-017-0311-x
Boletín de Salud Mental. Depresión. Subdirección de enfermedades no transmisibles. [Internet]. Ministerio de Salud. Bogota D.C: 2017 [citado 18 ago 2020] p 1-16. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/boletin-d epresion-marzo-2017.pdf
Vanegas J, Krause M, Bauer S, Moessner M, Espinosa D, Carrasco A, et al. Uso de e-mental health para el seguimiento post terapia de pacientes con depresión en Colombia. Revista Virtual Universidad Católica del Norte [Internet] 2017 [Citado 16 Diciembre de 2021] 52, 41-56. Tomado de: https://revistavirtual.ucn.edu.co/index.php/RevistaUCN/article/view/943/1390
Gómez M, Morales M. Comunicación bidireccional de la microbiota intestinal en el desarrollo del sistema nervioso central y en la enfermedad de Parkinson. Arch Neurocien [Internet] 2017 [citado 5 dic 2021]; 53(22). Disponible en: https://www.medigraphic.com/pdfs/arcneu/ane-2017/ane172f.pdf
Pérez R. Pharmacological treatment of depression: current and future directions.Rev. Fac. Med.[Internet] 2017 [cited 15 dec 2021];60(5). Available in: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0026-17422017000500007
Scriven M, Dinan TG, Cryan JF, Wall M. Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Diseases. [Internet] 2018 [cited 9 aug 2020];6 (3):78-91. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163507/
Skonieczna-Żydecka K, Marlicz W, Misera A, Koulaouzidis A, Łoniewski I. Microbiome—The Missing Link in the Gut-Brain Axis: Focus on Its Role in Gastrointestinal and Mental Health. J Clin Med.[Internet] 2018 [cited 12 aug 2020]; 7(12):521. Available in: https://www.mdpi.com/2077-0383/7/12/521
Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). [Internet] 2018 [cited 8 sep 2020];17(4):28–32. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469458/
Huang E, Kang S, Park H, Park S, Ji Y, Holzapfel WH. Differences in Anxiety Levels of Various Murine Models in Relation to the Gut Microbiota Composition. Biomedicines. [Internet] 2018 [cited 25 aug 2020]; 6(4):113. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315404/
Kim HN, Yun Y, Ryu S, Chang Y, Kwon MJ, Cho J, et al. Correlation between gut microbiota and personality in adults: A cross-sectional study.Brain Behav Immun. [Internet] 2018 [cited 10 sep 2020];69:374-385. Available in: https://pubmed.ncbi.nlm.nih.gov/29278751/
Getachew B , Aubee J , Schottenfeld R, Csoka A, Thompson Mark , Tizabi Y. Ketamine interactions with gut-microbiota in rats: relevance to its antidepressant and anti-inflammatory properties. BMC Microbiol. [Internet] 2018 [cited 22 feb 2021];18:222. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303954/
Ramsteijn A, Jašarević E, Houwing DJ, Bale TL, Olivier J.Antidepressant treatment modulates the gut microbiome and metabolome during pregnancy and lactation in rats with a depressive-like phenotype. Microbiome digest. [Internet] 2018 [cited 28 mar 2021];101101. Available in: https://www.biorxiv.org/content/10.1101/501742v1.full
Martin-Hernandez D, Caso J, Meana J, Callado L, Madrigal J, Garcia-Bueno B, et al. Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants.J Neuroinflammation. [Internet] 2018 [cited 8 apr 2021];15:251. Available in: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1294-2#autho r-information
Ministerio de Salud. Boletín de Salud Mental Análisis de Indicadores en Salud Mental por territorio. Subdirección de enfermedades no transmisibles. [Internet]. Ministerio de Salud. Bogota D.C:2018. [citado 19 ago 2020] p 1-16. Disponible en:https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/boleti n-onsm-abril-2018.pdf
Sánchez MA, Cabra ZL, Silva JB. Análisis de la salud mental en Colombia y la implementación de política pública nacional de 2018 [Tesis de pregrado]. Medellín, Antioquia; Universidad CES; 2018. Disponible en: https://repository.ces.edu.co/bitstream/10946/5192/1/1053829632_46678630_2021.pdf
Política Nacional de Salud Mental. Ministerio de Salud y Protección Social. 15 de Noviembre de 2018. Tomado de: m https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/politica-nacion al-salud-mental.pdf
Ministerio de Salud. Boletín de salud mental Oferta y Acceso a Servicios en Salud Mental en Colombia. [Internet]. Ministerio de Salud. 2019 [citado 19 ago 2020]; 6;1-18. Disponible en:https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/Boleti n-6-salud-mental-2018.pdf
Quintana I, Velazco Y. Reacciones adversas de los antidepresivos: consideraciones actuales.Rev.Med.Electrón.[Internet] 2018 [citado 16 dic 2020]; 40(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242018000200017
Aswall N, Kumar S, Kamarapu P.Study on Antidepressant Drug to Cure Depression. J Formul Sci Bioavailab [Internet]. 2018 [cited 19 sep 2021]; 2: 121. Available in:https://www.researchgate.net/publication/328403845_Study_on_Antidepressant_Drug_t o_Cure_Depression
Bastiaanssen TFS, Cowan CSM, Claesson MJ, Dinan TG, Cryan JF. Making Sense of … the Microbiome in Psychiatry.Int J Neuropsychopharmacol. [Internet] 2019 [cited 1 oct 2020]; 22(11):747–760. Available in: https://pubmed.ncbi.nlm.nih.gov/30099552/
Peirce JM, Alviña K. The role of inflammation and the gut microbiome in depression and anxiety. J Neurosci Res. [Internet] 2019 [cited 30 aug 2020]; 97:1223-1241. Available in: https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.24476
Ma ZF, Yusof N, Hamid N, Lawenko RM, Mohammad WMZ, Liong MT, et al. Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster. Benef Microbes. [Internet] 2019 [cited 11 aug 2020];10(2):111-120. Available in: https://www.wageningenacademic.com/doi/epdf/10.3920/BM2018.0008
Huang TT, Lai JB, Du YL, Xu Y, Ruan LM, Hu SH. Current Understanding of Gut Microbiota in Mood Disorders: An Update of Human Studies. Front Genet. [Internet] 2019 [cited 7 sep 2020];10:98. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389720/
Butler MI, Mörkl S, Sandhu KV, Cryan JF, Dinan TG. The Gut Microbiome and Mental Health: What Should We Tell Our Patients?: Le microbiote Intestinal et la Santé Mentale : que Devrions-Nous dire à nos Patients?. Can J Psychiatry. [Internet] 2019 [cited 16 aug 2020];64(11):747–760. Available in: https://journals.sagepub.com/doi/10.1177/0706743719874168
Ma Q , Xing C ,Long W, Wang HY , Liu Q, Wang RF. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.J Neuroinflammation. [Internet]. 2019. [cited 9 aug 2020];19:53. Available in: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1434-3
Audet MC. Stress-induced disturbances along the gut microbiota-immune-brain axis and implications for mental health: Does sex matter?.Front Neuroendocrinol. [Internet]. 2019. [cited 16 apr 2021];54:100772. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0091302218301262?via%3Dihub#
LuKic E, Dmitriy G, Ziv O, Oron O, Reuveni E, Koren O, et al. Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive - like behavior.Transl Psychiatry [Internet]. 2019. [cited 7 abr 2021];9:133. Available in: https://www.nature.com/articles/s41398-019-0466-x?fbclid=IwAR2bJkP8fkmV0x3oUMB K6scHgzhlH3_cE51O468P47sDARTKi6QRkLlp9IY#citeas
McGoven A, Hamlin A, Winter G. A review of the antimicrobial side of antidepressant and its putative implications in gut microbiome.Aust N Z J Psychiatry. [Internet]. 2019. [cited 7 abr 2021];53(12):1151-1166. Available in: https://journals.sagepub.com/doi/full/10.1177/0004867419877954
Danborg PB , Valdersdorf M, Gøtzsche PC. Long-term harms from previous use of selective serotonin reuptake inhibitors: A systematic review.Int J Risk Saf Med. [Internet]. 2019. [cited 25 feb 2021];30(2):59–71. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839490/
Wu B, Cai Q, Sheehan JJ, Benson C, Connolly N, Alphs L. An episode level evaluation of the treatment journey of patients with major depressive disorder and treatment-resistant depression. PLoS One. [Internet]. 2019. [cited 26 mar 2021]; 14(8);e0220763. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687173/
Lyte M, Daniels KM, Schmitz-Esser S. Fluoxetine-induced alteration of murine gut microbial community structure: evidence for a microbial endocrinology-based mechanism of action responsible for fluoxetine-induced side effects. PeerJ. [Internet]. 2019. [cited 10 apr 2021];7: e6199. Available in: https://ezproxy.unicolmayor.edu.co:2136/docview/2165584758/5029FAE718AE43F2PQ/1 8?accountid=50438
Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M, Salanti G.Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. Lancet Psychiatry. [Internet]. 2019. [cited 11 apr 2021];6(7):601–609. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586944/
McVey KA, Bienenstock J, Bharwani A, Champagne-Jorgensen K, Mao Y, West C, et al. Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling. Sci Rep. [Internet]. 2019. [cited 19 apr 2021]; 9:14290. Available in: https://www.nature.com/articles/s41598-019-50807-8
Fung TC, Vuong HE, Luna CDG, Pronovost GN, Aleksandrova AA, Riley NG, et al. Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. Nat Microbiol. [Internet]. 2019. [cited 20 apr 2021];4(12):2064-2073. Available in:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879823/
Bhagat V, Symbak NB, Husain R, Mat KC. The role of selective serotonin reuptake inhibitors and cognitive behavioral therapy in preventing relapse of Major Depressive Disorder. Reser J Pharm Tech [Internet]. 2019. [cited 24 mar 2021];12(8):3818-3824. Available in: https://ezproxy.unicolmayor.edu.co:2136/docview/2309321498/F89CCE8CE7D84025PQ/ 39?accountid=50438
Karaküçük Y, Beyoglu A, Çömez A, Fatma Özlem Orhan, Demir M. Early effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depression. Psych Clin Psychopharm. [Internet]. 2019. [cited 24 mar 2021];29(4):387-393. Available in: https://www.tandfonline.com/doi/full/10.1080/24750573.2019.1673944
LeMoult J, Gotlib I. Depression: A cognitive perspective. [Internet]. 2019. [Cited 04 aug 2021];69; 51-66.Available in: https://www.sciencedirect.com/science/article/abs/pii/S0272735817303914#!
Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B, et al. Neuroinflammation and depression: A review.[Internet]. 2019. [cited 04 aug 2021]; 53: 151-171.Available in: https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.14720
Rinninella E, Raoul P , Cintoni M , Franceschi F , Miggiano D , Gasbarrini A. et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. [Internet] 2019 . [cited 4 dec 2021]; 7(1): 14. Available in:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351938/
Cheng LH, Liu YW, ChenWua C, Wang S, Tsai YC. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders Author links open overlay panel.Journal of Food and Drug Analysis.[Internet] 2019. [cited 14 dec 2021];27(3):632-648. Available in: https://www.sciencedirect.com/science/article/pii/S1021949819300158?via%3Dihub#!
Londoño C, Velasco M, Pardo C, Escobar M, Quintero Y, Reyes L. Condiciones psicométricas de la escala de eventos vitales estresantes usada en la población Colombiana. Actualidades en psicología [Internet] 2019 [Cited 12 Diciembre 2021]; 33 -126. Tomado en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S2215-35352019000100083
Du Y, Gao XR, Peng L, Ge JF. Crosstalk between the microbiota-gut-brain axis and depression. Heliyon. [Internet]. 2020. [cited 26 apr 2021];6(6):e04097. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276434/
Wu W, Kong Q, Tian P, Zhai Q, Wang G, Liu Z, et al. Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders. Engineering. [Internet]. 2020. [cited 28 apr 2021]; 6(4):415-423. Available in: http://www.engineering.org.cn/en/10.1016/j.eng.2019.07.026
Liu RT, Rowan AD, Sheehan AE, Walsh RFL, Sanzari CM, Korry BJ, et al. Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults. Brain Behav Immun [Internet]. 2020. [cited 30 apr 2021]; 88; 308-324. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0889159119315314
Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, et al. Gut microbiome-derived lactate promotes anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway. Psychoneuroendocrinology. [Internet]. 2020. [cited 1 may 2021];117:e104699. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0306453020301189
Siopi E, Chevalier G, Katsimpardi L, Saha S, Bigot M, Moigneu C, et al. Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine. Cell Rep. [Internet]. 2020. [cited 1 may 2021];30(11):3682-3690.Available in: https://www.sciencedirect.com/science/article/pii/S2211124720302734
Järbrink-Sehgal EJ, Andreasson A. The gut microbiota and mental health in adults. [Internet]. 2020. [Cited 2 aug 2021];62;102-114.Available in: https://www.sciencedirect.com/science/article/pii/S0959438820300362
Moral-Muñoz J, Herrera-Viedma E, Santisteban-Espejo A, Cobo M.Software tools for conducting bibliometric analysis in science: An up-to-date review. [Internet]. 2020. [cited 9 aug 2021]; 29(1); e290103.Available in: https://revista.profesionaldelainformacion.com/index.php/EPI/article/view/epi.2020.ene.03 /47883
Ait Chait Y, Mottawea W, Tompkins TA, Hammami R. Unravelling the antimicrobial action of antidepressants on gut commensal microbes.[Internet]. 2020. [cited 28 jul 2021];10, 17878. Available in: https://www.nature.com/articles/s41598-020-74934-9#citeas
Fontana A, Manchia M, Panebianco C, Paribello P, Arzedi C, Cossu E, et al. Exploring the Role of Gut Microbiota in Major Depressive Disorder and in Treatment Resistance to Antidepressants.[Internet]. 2020. [cited 31 jul 2021];8 (9),311. Available in: https://www.mdpi.com/2227-9059/8/9/311/htm
Sousa V, Chaves A, Carneiro R, Marinho P, Ramo M, Noronha P, et al. Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression. [Internet]. 2020. [cited 05 aug 2021];268; 188-200. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0165032719326539
Bharwani A, Bala A, Surette M, Bienenstock J, Vigod S, Taylor V. Gut Microbiome Patterns Associated With Treatment Response in Patients With Major Depressive Disorder: Changements du microbiote intestinal associés à la réponse au traitement chez des patients souffrant de trouble dépressif majeur. [Internet]. 2020. [cited 05 aug 2021];65(4); 278-280. Available in: https://journals.sagepub.com/doi/full/10.1177/0706743719900464
Nanthakumaran S, Sridharan S, Somagutta M, Arnold A, May V, Pagad S, et al. The Gut-Brain Axis and Its Role in Depression. [Internet]. 2020. [cited 08 aug 2021]; 12(9); 10280. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538207/
ERDOĞAN Ç, REZAKİ HÖ, KOÇAK OM, Şadiye VB. Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects. [Internet]. 2020. [cited 08 aug 2021]; 31(2):90-98. Available in: https://ezproxy.unicolmayor.edu.co:2136/docview/2430155076/93B26F4FB97F490CPQ/4 1?accountid=50438
Departamento Administrativo Nacional de Estadística(DANE). Salud mental en Colombia: una aproximación desde las estadísticas oficiales en el contexto de la pandemia. [Internet]. Presentado en webinar, 2020. Bogotá D.C. [citado 25 ago 2021]. Disponible en: https://www.dane.gov.co/files/webinar/presentacion-webinar-salud-mental-en-colombia-2 1-10-2020.pdf
Cifuentes-Avellanada A, Rivera-Montero D, Vera Gil C, Murad-Rivera R, Sanchez S, Castaño L, et al. Informe 3: Ansiedad, depresión y miedo: Impulsores de la mala salud mental durante el distanciamiento físico en Colombia. [Internet]; Profamilia, 2020. [citado 26 ago 2021]. Disponible en: https://profamilia.org.co/wp-content/uploads/2020/05/Informe-3-Ansiedad-depresion-y-mi edo-impulsores-mala-salud-mental-durante-pandemia-Estudio-Solidaridad-Profamilia.pdf
Ministerio de Salud y Protección Social.RECOMENDACIONES PARA LA PROMOCIÓN DE LA CONVIVENCIA Y LA SALUD MENTAL PARA JÓVENES DURANTE EL BROTE DE COVID-19. [Internet];Consejo Nacional de Salud Mental. 2020.[citado 22 ago 2021]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/boletin-conviv encia-salud-mental-jovenes.pdf
Ministerio de Salud y Protección Social. Información de seguridad sobre los inhibidores selectivos de la recaptación de serotonina y noradrenalina asociado al riesgo de disfunción sexual persistente posterior al retiro. [Internet]; INVIMA; 2020: 3000-2991-20. [citado 26 ago 2020]. Disponible en: https://www.invima.gov.co/documents/20143/3834837/Inhibidores-selectivos-de-la-recapt acion-de-serotonina.pdf
Mazza MG,De Lorenzo R, Conte C, Poletti S,Vai B, Bollettini I et al.Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav Immun.[Internet ]2020 [cited 12 dec 2021]; 89: 594–600.Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390748/
Del Toro M, Hurtado A, Garcia LE, García T. Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products. Nutrients.[Internet] 2020 [cited dec 19 2021];12(12): 3896. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767237/
Benavides V, Villota N, Villalobos F. Conducta suicida en Colombia: Una revisión sistemática. Revista de psicopatología y psicología clínica [Internet]. 2020 [Citado el 03 Enero de 2022] 24 (3); 181-195. Tomado de: http://revistas.uned.es/index.php/RPPC/article/view/24251
Zhang W, Qu W, Wang H, Yan H. Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress. [Internet]. 2021. [cited 10 aug 2021]; 11 (1): 131. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892574/
Arias HR, Targowska-Duda KM, García-Colunga J, Ortells MO. Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors?. [Internet]. 2021. [cited 15 aug 2021]; 26(8):2149. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068400/
Departamento Nacional de Planeación (DNP). ¿Cómo se relaciona la pandemia del COVID-19 con la salud mental de los colombianos? Resumen de políticas según la iniciativa Respuestas Efectivas contra el COVID-19. [Internet] DNP. 2021[citado 24 ago 2021]. Disponible en: https://colaboracion.dnp.gov.co/CDT/Sinergia/Documentos/Notas_politica_publica_SAL UD%20MENTAL_22_04_21_V7.pdf
Chudzik A,Orzyłowska A, Rola R,Stanisz GJ. Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis.Biomolecules. [Internet] 2021 [cited 13 jan 2022]; 11(7):1000. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301955/
Becerra-Moreno L, Laiton A, Lopez-Moyano J, Oyola-Cifuentes L. Diseño de un curso corto para prevenir la depresión. [Tesis de Pregrado]. Bogotá, Colombia. Universidad Catolica de Colombia; 2021. Disponible en: https://repository.ucatolica.edu.co/handle/10983/26070
Sistema Integrado de Información de la Protección Social (SISPRO). Reportes por Indicadores de Salud Mental. [Internet] SISPRO- Portal Web.[citado 25 ago 2021]. Disponible en: http://rssvr2.sispro.gov.co/ObsSaludMental/
dc.rights.spa.fl_str_mv Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.creativecommons.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_14cb
rights_invalid_str_mv Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024
https://creativecommons.org/licenses/by-nc/4.0/
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
dc.format.extent.spa.fl_str_mv 105p.
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Colegio Mayor de Cundinamarca
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias de la Salud
dc.publisher.place.spa.fl_str_mv Bogotá D.C.
dc.publisher.program.spa.fl_str_mv Bacteriología y Laboratorio Clínico
institution Colegio Mayor de Cundinamarca
bitstream.url.fl_str_mv https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/1/Documento%20Final%20Monografia.pdf
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/2/Monografia%20Orteg%c3%b3n%20-%20Zuluaga.pdf
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/3/CARTA%20DERECHOS%20DE%20AUTOR%20Ortegon.pdf
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/4/FORMATO%20IDENTIFICACI%c3%93N%20TRABAJOS%20DE%20GRADO%20Zuluaga%20Luz%20-%20Ortegon%20Juanita.pdf
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/5/license.txt
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/6/Documento%20Final%20Monografia.pdf.txt
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/8/Monografia%20Orteg%c3%b3n%20-%20Zuluaga.pdf.txt
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/10/CARTA%20DERECHOS%20DE%20AUTOR%20Ortegon.pdf.txt
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/12/FORMATO%20IDENTIFICACI%c3%93N%20TRABAJOS%20DE%20GRADO%20Zuluaga%20Luz%20-%20Ortegon%20Juanita.pdf.txt
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/7/Documento%20Final%20Monografia.pdf.jpg
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/9/Monografia%20Orteg%c3%b3n%20-%20Zuluaga.pdf.jpg
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/11/CARTA%20DERECHOS%20DE%20AUTOR%20Ortegon.pdf.jpg
https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/13/FORMATO%20IDENTIFICACI%c3%93N%20TRABAJOS%20DE%20GRADO%20Zuluaga%20Luz%20-%20Ortegon%20Juanita.pdf.jpg
bitstream.checksum.fl_str_mv befa16863a5995512ec2f89bc5791d23
313a6098fde4d9f618574356e5feecaf
176225e33244958b7693f0c2f84b8847
572e361c8d8851a91ec7ffc2758afd01
2f9959eaf5b71fae44bbf9ec84150c7a
bedaeb76e64f07cec9b30d962d090260
c9f43491f0cb74dfef29ac6afc859b55
6c714b08f1f37c1746b664999afa1417
707373b4192c2ae83b94f522e9e41154
69a2632ac70b55328ba4c30358e1b6ac
8b268527c4d5df959064a273f56c52c2
0081f36dbfb0a8041accd4fcc1b6a7e6
5f67d786d214ea625f27b3abe8370f81
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Biblioteca Digital Unicolmayor
repository.mail.fl_str_mv repositorio@unicolmayor.edu.co
_version_ 1807009141284143104
spelling Camacho Kurmen, Judith Elena88ec3d87924bea44fb175e7780652267600Ortegón Orduña, Juanita4779734b101130f202b74326990f8fb7Zuluaga Echeverri, Luz Yerly306864651c7a0d35f07790a20a9165c3Universidad Colegio Mayor de Cundinamarca2024-05-23T17:29:55Z2024-05-23T17:29:55Z2022-04https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6912La depresión es un trastorno caracterizado por la presencia de tristeza, pérdida de interés, sentimientos de culpa; se puede clasificar como leve, moderada o grave. El presente trabajo se centra en la influencia de los inhibidores selectivos de la recaptación de serotonina (ISRS) en la microbiota intestinal de las personas con depresión. Se basa en el eje intestino-cerebro que consiste en una red de comunicación que monitorea e integra las funciones intestinales y las vincula a los centros cognitivos y emocionales del cerebro. Esta investigación se lleva a cabo por una revisión bibliográfica y un análisis bibliométrico, donde se explica el eje, se analiza el impacto en la microbiota con el uso de antidepresivos, se describe el efecto de estos en pacientes con depresión y se indagan los tratamientos adicionales que pueden ser utilizados. Los ISRS son medicamentos de primera línea, estos inhiben los transportadores de serotonina aumentando los niveles de 5-hidroxitriptamina, la concentración prolongada de estos en la luz intestinal afectan la microbiota generando disbiosis, la cual se puede prevenir con el uso de probióticos, prebióticos, psicobióticos o dieta. Como conclusión los ISRS poseen acción antimicrobiana, el tratamiento más prometedor es el uso de probióticos por el gran beneficio que conlleva en el intestino. A nivel nacional pese al desarrollo de una Política Pública de Salud Mental no se cuenta con la cobertura adecuada se dificulta el acceso a los servicios y tratamientos incompletos; por lo que se sugiere seguir investigando sobre el tema y en planes de prevención.TABLA DE CONTENIDO RESUMEN 6 INTRODUCCIÓN 8 1. ANTECEDENTES 10 2. MARCO REFERENCIAL 16 3. DISEÑO METODOLÓGICO 27 3.1. Universo, población y muestra 27 3.2. Hipótesis, variables, indicadores 27 3.3. Técnicas, procedimientos 28 4. RESULTADOS Y DISCUSIÓN 29 5. CONCLUSIONES 36 6. REFERENCIAS BIBLIOGRÁFICAS 37 7. ANEXOS 51PregradoBacteriólogo(a) y Laboratorista Clínico105p.application/pdfspaUniversidad Colegio Mayor de CundinamarcaFacultad de Ciencias de la SaludBogotá D.C.Bacteriología y Laboratorio ClínicoDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/closedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_14cbInfluencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresiónTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/bachelorThesishttps://purl.org/redcol/resource_type/TPinfo:eu-repo/semantics/publishedVersionMessaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microb. [Internet] 2011 [cited 7 aug 2020];2(4):256-261. Available in: https://www.tandfonline.com/doi/abs/10.4161/gmic.2.4.16108Lyte M. Microbial Endocrinology in the Microbiome-Gut-Brain Axis: How Bacterial Production and Utilization of Neurochemicals Influence Behavior. PLoS Pathog. [Internet] 2013 [cited 2 aug 2020];9(11):e1003726. Available in: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003726Blier P, Mansari M. Serotonin and beyond: therapeutics for major depression. Philos Trans R Soc Lond B Biol Sci. [Internet] 2013 [cited 25 mar 2021];368 (1615):e20120536. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638389/Ley 1616. Colombia. Congreso de Colombia; 21 Enero de 2013. Tomado de: https://www.asivamosensalud.org/politicas-publicas/normatividad-leyes/salud-publica/ley- 1616-de-2013-salud-mentaKrebber AMH,Buffart LM,Kleijn G, Riepma IC, Bree R,Leemans CR, et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psychooncology.[Internet] 2014 [cited 16 dec]; 23(2): 121–130. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282549/Orel R, Trop TK. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease.World J Gastroenterol [Internet] 2014 [cited 12 jan 2022];20(33): 11505–11524.Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155344/Dinan TG, Stilling RM, Stanton C, Cryan JF. Collective unconscious: How gut microbes shape human behavior. J Psychiatr Res. [Internet] 2015 [cited 17 aug 2020];63:1-9. Available in: https://www.sciencedirect.com/science/article/pii/ S0022395615000655?via%3DihubJakubovski E , Varigonda A , Freemantle N , Taylor M, Bloch M.Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective-Serotonin Reuptake Inhibitors in Major Depressive Disorder.Am J Psychiatry.[Internet] 2016 [cited 14 dec 2020]; 1; 173(2): 174–183. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975858/Fröhlich EE, Farzi A, Mayerhofer R, Reichmann F, Jačan A, Wagner B, et al. Cognitive Impairment by Antibiotic-Induced Gut Dysbiosis: Analysis of Gut Microbiota-Brain Communication. Brain Behav Immun. [Internet] 2016 [cited 28 aug 2020];56:140-155. Available in: https://www.sciencedirect.com/science/article/pii/S0889159 11630040X?via%3DihubRogers GB, Keating DJ, Young RL, Wong ML, Licinio J, Wesselingh S. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry. [Internet] 2016 [cited 16 sep 2020];21(6):738–748. Available in: https://www.nature.com/articles/mp201650Camacho DE, Oviedo HR, Ramos E, González TC. Bibliometric analysis of articles on nursing care published in colombian magazines. [Internet] 2016 [cited 6 aug 2021]; 44: 406-415. Available in: https://redib.org/Record/oai_articulo3209662-bibliometric-analysis-articles-nursing-care-p ublished-colombian-magazinesLiqing L, Chunmei W, Yong G, Xianguo Q, Zuxun L. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies.BMC Psychiatry.[Internet] 2016 [cited 17 dec 2021]; 16: 375.Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097837/Cenit MC, Sanz Y, Codoñer P. Influence of gut microbiota on neuropsychiatric disorders.World J Gastroenterol. [Internet] 2017 [cited 2 sep 2020]; 23(30):5486–5498. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558112/MacQueen G, Surette M, Moayyedi P. The gut microbiota and psychiatric illness. J Psychiatry Neurosci.[Internet] 2017 [cited 22 sep 2020];42(2):75-77. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373703/Wan-Tzu L, Yen-Chun P, Chung-Hsin C, Hong-Zen L, Chi-Sen C. Relationship between use of selective serotonin reuptake inhibitors and irritable bowel syndrome: A population-based cohort study. World J Gastroenterol. [Internet] 2017 [Cited 22 mar 2021];23(19):3513-3521. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442087/Jakobsen JC, Katakan KK, Schou A, Hellmuth SG, Elkjaer S, Leth-Moller K, et al. Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis. BMC Psychiatry. [Internet] 2017 [Cited 2 apr 2021];17(58). Available in: https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1173-2?utm_conte nt=buffer7e7cb&utm#Sec1Koopman M, El Aidy S.Depressed gut? The microbiota-diet-inflammation trialogue in depression. Curr Opin Psychiatry. [Internet] 2017 [Cited 13 feb 2021];30(5): 369-377. Available in: https://www.ingentaconnect.com/content/wk/yco/2017/00000030/00000005/art00009Bambling M, Edward S, Hall S, Vitetta L. A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested.Inflammopharmacology. [Internet] 2017 [Cited 19 feb 2021];25:271-274. Available in: https://link.springer.com/article/10.1007%2Fs10787-017-0311-xBoletín de Salud Mental. Depresión. Subdirección de enfermedades no transmisibles. [Internet]. Ministerio de Salud. Bogota D.C: 2017 [citado 18 ago 2020] p 1-16. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/boletin-d epresion-marzo-2017.pdfVanegas J, Krause M, Bauer S, Moessner M, Espinosa D, Carrasco A, et al. Uso de e-mental health para el seguimiento post terapia de pacientes con depresión en Colombia. Revista Virtual Universidad Católica del Norte [Internet] 2017 [Citado 16 Diciembre de 2021] 52, 41-56. Tomado de: https://revistavirtual.ucn.edu.co/index.php/RevistaUCN/article/view/943/1390Gómez M, Morales M. Comunicación bidireccional de la microbiota intestinal en el desarrollo del sistema nervioso central y en la enfermedad de Parkinson. Arch Neurocien [Internet] 2017 [citado 5 dic 2021]; 53(22). Disponible en: https://www.medigraphic.com/pdfs/arcneu/ane-2017/ane172f.pdfPérez R. Pharmacological treatment of depression: current and future directions.Rev. Fac. Med.[Internet] 2017 [cited 15 dec 2021];60(5). Available in: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0026-17422017000500007Scriven M, Dinan TG, Cryan JF, Wall M. Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signalling. Diseases. [Internet] 2018 [cited 9 aug 2020];6 (3):78-91. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163507/Skonieczna-Żydecka K, Marlicz W, Misera A, Koulaouzidis A, Łoniewski I. Microbiome—The Missing Link in the Gut-Brain Axis: Focus on Its Role in Gastrointestinal and Mental Health. J Clin Med.[Internet] 2018 [cited 12 aug 2020]; 7(12):521. Available in: https://www.mdpi.com/2077-0383/7/12/521Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). [Internet] 2018 [cited 8 sep 2020];17(4):28–32. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469458/Huang E, Kang S, Park H, Park S, Ji Y, Holzapfel WH. Differences in Anxiety Levels of Various Murine Models in Relation to the Gut Microbiota Composition. Biomedicines. [Internet] 2018 [cited 25 aug 2020]; 6(4):113. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315404/Kim HN, Yun Y, Ryu S, Chang Y, Kwon MJ, Cho J, et al. Correlation between gut microbiota and personality in adults: A cross-sectional study.Brain Behav Immun. [Internet] 2018 [cited 10 sep 2020];69:374-385. Available in: https://pubmed.ncbi.nlm.nih.gov/29278751/Getachew B , Aubee J , Schottenfeld R, Csoka A, Thompson Mark , Tizabi Y. Ketamine interactions with gut-microbiota in rats: relevance to its antidepressant and anti-inflammatory properties. BMC Microbiol. [Internet] 2018 [cited 22 feb 2021];18:222. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303954/Ramsteijn A, Jašarević E, Houwing DJ, Bale TL, Olivier J.Antidepressant treatment modulates the gut microbiome and metabolome during pregnancy and lactation in rats with a depressive-like phenotype. Microbiome digest. [Internet] 2018 [cited 28 mar 2021];101101. Available in: https://www.biorxiv.org/content/10.1101/501742v1.fullMartin-Hernandez D, Caso J, Meana J, Callado L, Madrigal J, Garcia-Bueno B, et al. Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants.J Neuroinflammation. [Internet] 2018 [cited 8 apr 2021];15:251. Available in: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1294-2#autho r-informationMinisterio de Salud. Boletín de Salud Mental Análisis de Indicadores en Salud Mental por territorio. Subdirección de enfermedades no transmisibles. [Internet]. Ministerio de Salud. Bogota D.C:2018. [citado 19 ago 2020] p 1-16. Disponible en:https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/boleti n-onsm-abril-2018.pdfSánchez MA, Cabra ZL, Silva JB. Análisis de la salud mental en Colombia y la implementación de política pública nacional de 2018 [Tesis de pregrado]. Medellín, Antioquia; Universidad CES; 2018. Disponible en: https://repository.ces.edu.co/bitstream/10946/5192/1/1053829632_46678630_2021.pdfPolítica Nacional de Salud Mental. Ministerio de Salud y Protección Social. 15 de Noviembre de 2018. Tomado de: m https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/politica-nacion al-salud-mental.pdfMinisterio de Salud. Boletín de salud mental Oferta y Acceso a Servicios en Salud Mental en Colombia. [Internet]. Ministerio de Salud. 2019 [citado 19 ago 2020]; 6;1-18. Disponible en:https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENT/Boleti n-6-salud-mental-2018.pdfQuintana I, Velazco Y. Reacciones adversas de los antidepresivos: consideraciones actuales.Rev.Med.Electrón.[Internet] 2018 [citado 16 dic 2020]; 40(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242018000200017Aswall N, Kumar S, Kamarapu P.Study on Antidepressant Drug to Cure Depression. J Formul Sci Bioavailab [Internet]. 2018 [cited 19 sep 2021]; 2: 121. Available in:https://www.researchgate.net/publication/328403845_Study_on_Antidepressant_Drug_t o_Cure_DepressionBastiaanssen TFS, Cowan CSM, Claesson MJ, Dinan TG, Cryan JF. Making Sense of … the Microbiome in Psychiatry.Int J Neuropsychopharmacol. [Internet] 2019 [cited 1 oct 2020]; 22(11):747–760. Available in: https://pubmed.ncbi.nlm.nih.gov/30099552/Peirce JM, Alviña K. The role of inflammation and the gut microbiome in depression and anxiety. J Neurosci Res. [Internet] 2019 [cited 30 aug 2020]; 97:1223-1241. Available in: https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.24476Ma ZF, Yusof N, Hamid N, Lawenko RM, Mohammad WMZ, Liong MT, et al. Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster. Benef Microbes. [Internet] 2019 [cited 11 aug 2020];10(2):111-120. Available in: https://www.wageningenacademic.com/doi/epdf/10.3920/BM2018.0008Huang TT, Lai JB, Du YL, Xu Y, Ruan LM, Hu SH. Current Understanding of Gut Microbiota in Mood Disorders: An Update of Human Studies. Front Genet. [Internet] 2019 [cited 7 sep 2020];10:98. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389720/Butler MI, Mörkl S, Sandhu KV, Cryan JF, Dinan TG. The Gut Microbiome and Mental Health: What Should We Tell Our Patients?: Le microbiote Intestinal et la Santé Mentale : que Devrions-Nous dire à nos Patients?. Can J Psychiatry. [Internet] 2019 [cited 16 aug 2020];64(11):747–760. Available in: https://journals.sagepub.com/doi/10.1177/0706743719874168Ma Q , Xing C ,Long W, Wang HY , Liu Q, Wang RF. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis.J Neuroinflammation. [Internet]. 2019. [cited 9 aug 2020];19:53. Available in: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1434-3Audet MC. Stress-induced disturbances along the gut microbiota-immune-brain axis and implications for mental health: Does sex matter?.Front Neuroendocrinol. [Internet]. 2019. [cited 16 apr 2021];54:100772. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0091302218301262?via%3Dihub#LuKic E, Dmitriy G, Ziv O, Oron O, Reuveni E, Koren O, et al. Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive - like behavior.Transl Psychiatry [Internet]. 2019. [cited 7 abr 2021];9:133. Available in: https://www.nature.com/articles/s41398-019-0466-x?fbclid=IwAR2bJkP8fkmV0x3oUMB K6scHgzhlH3_cE51O468P47sDARTKi6QRkLlp9IY#citeasMcGoven A, Hamlin A, Winter G. A review of the antimicrobial side of antidepressant and its putative implications in gut microbiome.Aust N Z J Psychiatry. [Internet]. 2019. [cited 7 abr 2021];53(12):1151-1166. Available in: https://journals.sagepub.com/doi/full/10.1177/0004867419877954Danborg PB , Valdersdorf M, Gøtzsche PC. Long-term harms from previous use of selective serotonin reuptake inhibitors: A systematic review.Int J Risk Saf Med. [Internet]. 2019. [cited 25 feb 2021];30(2):59–71. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839490/Wu B, Cai Q, Sheehan JJ, Benson C, Connolly N, Alphs L. An episode level evaluation of the treatment journey of patients with major depressive disorder and treatment-resistant depression. PLoS One. [Internet]. 2019. [cited 26 mar 2021]; 14(8);e0220763. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687173/Lyte M, Daniels KM, Schmitz-Esser S. Fluoxetine-induced alteration of murine gut microbial community structure: evidence for a microbial endocrinology-based mechanism of action responsible for fluoxetine-induced side effects. PeerJ. [Internet]. 2019. [cited 10 apr 2021];7: e6199. Available in: https://ezproxy.unicolmayor.edu.co:2136/docview/2165584758/5029FAE718AE43F2PQ/1 8?accountid=50438Furukawa TA, Cipriani A, Cowen PJ, Leucht S, Egger M, Salanti G.Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. Lancet Psychiatry. [Internet]. 2019. [cited 11 apr 2021];6(7):601–609. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586944/McVey KA, Bienenstock J, Bharwani A, Champagne-Jorgensen K, Mao Y, West C, et al. Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling. Sci Rep. [Internet]. 2019. [cited 19 apr 2021]; 9:14290. Available in: https://www.nature.com/articles/s41598-019-50807-8Fung TC, Vuong HE, Luna CDG, Pronovost GN, Aleksandrova AA, Riley NG, et al. Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. Nat Microbiol. [Internet]. 2019. [cited 20 apr 2021];4(12):2064-2073. Available in:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879823/Bhagat V, Symbak NB, Husain R, Mat KC. The role of selective serotonin reuptake inhibitors and cognitive behavioral therapy in preventing relapse of Major Depressive Disorder. Reser J Pharm Tech [Internet]. 2019. [cited 24 mar 2021];12(8):3818-3824. Available in: https://ezproxy.unicolmayor.edu.co:2136/docview/2309321498/F89CCE8CE7D84025PQ/ 39?accountid=50438Karaküçük Y, Beyoglu A, Çömez A, Fatma Özlem Orhan, Demir M. Early effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depression. Psych Clin Psychopharm. [Internet]. 2019. [cited 24 mar 2021];29(4):387-393. Available in: https://www.tandfonline.com/doi/full/10.1080/24750573.2019.1673944LeMoult J, Gotlib I. Depression: A cognitive perspective. [Internet]. 2019. [Cited 04 aug 2021];69; 51-66.Available in: https://www.sciencedirect.com/science/article/abs/pii/S0272735817303914#!Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B, et al. Neuroinflammation and depression: A review.[Internet]. 2019. [cited 04 aug 2021]; 53: 151-171.Available in: https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.14720Rinninella E, Raoul P , Cintoni M , Franceschi F , Miggiano D , Gasbarrini A. et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. [Internet] 2019 . [cited 4 dec 2021]; 7(1): 14. Available in:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351938/Cheng LH, Liu YW, ChenWua C, Wang S, Tsai YC. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders Author links open overlay panel.Journal of Food and Drug Analysis.[Internet] 2019. [cited 14 dec 2021];27(3):632-648. Available in: https://www.sciencedirect.com/science/article/pii/S1021949819300158?via%3Dihub#!Londoño C, Velasco M, Pardo C, Escobar M, Quintero Y, Reyes L. Condiciones psicométricas de la escala de eventos vitales estresantes usada en la población Colombiana. Actualidades en psicología [Internet] 2019 [Cited 12 Diciembre 2021]; 33 -126. Tomado en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S2215-35352019000100083Du Y, Gao XR, Peng L, Ge JF. Crosstalk between the microbiota-gut-brain axis and depression. Heliyon. [Internet]. 2020. [cited 26 apr 2021];6(6):e04097. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276434/Wu W, Kong Q, Tian P, Zhai Q, Wang G, Liu Z, et al. Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders. Engineering. [Internet]. 2020. [cited 28 apr 2021]; 6(4):415-423. Available in: http://www.engineering.org.cn/en/10.1016/j.eng.2019.07.026Liu RT, Rowan AD, Sheehan AE, Walsh RFL, Sanzari CM, Korry BJ, et al. Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults. Brain Behav Immun [Internet]. 2020. [cited 30 apr 2021]; 88; 308-324. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0889159119315314Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, et al. Gut microbiome-derived lactate promotes anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway. Psychoneuroendocrinology. [Internet]. 2020. [cited 1 may 2021];117:e104699. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0306453020301189Siopi E, Chevalier G, Katsimpardi L, Saha S, Bigot M, Moigneu C, et al. Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine. Cell Rep. [Internet]. 2020. [cited 1 may 2021];30(11):3682-3690.Available in: https://www.sciencedirect.com/science/article/pii/S2211124720302734Järbrink-Sehgal EJ, Andreasson A. The gut microbiota and mental health in adults. [Internet]. 2020. [Cited 2 aug 2021];62;102-114.Available in: https://www.sciencedirect.com/science/article/pii/S0959438820300362Moral-Muñoz J, Herrera-Viedma E, Santisteban-Espejo A, Cobo M.Software tools for conducting bibliometric analysis in science: An up-to-date review. [Internet]. 2020. [cited 9 aug 2021]; 29(1); e290103.Available in: https://revista.profesionaldelainformacion.com/index.php/EPI/article/view/epi.2020.ene.03 /47883Ait Chait Y, Mottawea W, Tompkins TA, Hammami R. Unravelling the antimicrobial action of antidepressants on gut commensal microbes.[Internet]. 2020. [cited 28 jul 2021];10, 17878. Available in: https://www.nature.com/articles/s41598-020-74934-9#citeasFontana A, Manchia M, Panebianco C, Paribello P, Arzedi C, Cossu E, et al. Exploring the Role of Gut Microbiota in Major Depressive Disorder and in Treatment Resistance to Antidepressants.[Internet]. 2020. [cited 31 jul 2021];8 (9),311. Available in: https://www.mdpi.com/2227-9059/8/9/311/htmSousa V, Chaves A, Carneiro R, Marinho P, Ramo M, Noronha P, et al. Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression. [Internet]. 2020. [cited 05 aug 2021];268; 188-200. Available in: https://www.sciencedirect.com/science/article/abs/pii/S0165032719326539Bharwani A, Bala A, Surette M, Bienenstock J, Vigod S, Taylor V. Gut Microbiome Patterns Associated With Treatment Response in Patients With Major Depressive Disorder: Changements du microbiote intestinal associés à la réponse au traitement chez des patients souffrant de trouble dépressif majeur. [Internet]. 2020. [cited 05 aug 2021];65(4); 278-280. Available in: https://journals.sagepub.com/doi/full/10.1177/0706743719900464Nanthakumaran S, Sridharan S, Somagutta M, Arnold A, May V, Pagad S, et al. The Gut-Brain Axis and Its Role in Depression. [Internet]. 2020. [cited 08 aug 2021]; 12(9); 10280. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538207/ERDOĞAN Ç, REZAKİ HÖ, KOÇAK OM, Şadiye VB. Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects. [Internet]. 2020. [cited 08 aug 2021]; 31(2):90-98. Available in: https://ezproxy.unicolmayor.edu.co:2136/docview/2430155076/93B26F4FB97F490CPQ/4 1?accountid=50438Departamento Administrativo Nacional de Estadística(DANE). Salud mental en Colombia: una aproximación desde las estadísticas oficiales en el contexto de la pandemia. [Internet]. Presentado en webinar, 2020. Bogotá D.C. [citado 25 ago 2021]. Disponible en: https://www.dane.gov.co/files/webinar/presentacion-webinar-salud-mental-en-colombia-2 1-10-2020.pdfCifuentes-Avellanada A, Rivera-Montero D, Vera Gil C, Murad-Rivera R, Sanchez S, Castaño L, et al. Informe 3: Ansiedad, depresión y miedo: Impulsores de la mala salud mental durante el distanciamiento físico en Colombia. [Internet]; Profamilia, 2020. [citado 26 ago 2021]. Disponible en: https://profamilia.org.co/wp-content/uploads/2020/05/Informe-3-Ansiedad-depresion-y-mi edo-impulsores-mala-salud-mental-durante-pandemia-Estudio-Solidaridad-Profamilia.pdfMinisterio de Salud y Protección Social.RECOMENDACIONES PARA LA PROMOCIÓN DE LA CONVIVENCIA Y LA SALUD MENTAL PARA JÓVENES DURANTE EL BROTE DE COVID-19. [Internet];Consejo Nacional de Salud Mental. 2020.[citado 22 ago 2021]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/boletin-conviv encia-salud-mental-jovenes.pdfMinisterio de Salud y Protección Social. Información de seguridad sobre los inhibidores selectivos de la recaptación de serotonina y noradrenalina asociado al riesgo de disfunción sexual persistente posterior al retiro. [Internet]; INVIMA; 2020: 3000-2991-20. [citado 26 ago 2020]. Disponible en: https://www.invima.gov.co/documents/20143/3834837/Inhibidores-selectivos-de-la-recapt acion-de-serotonina.pdfMazza MG,De Lorenzo R, Conte C, Poletti S,Vai B, Bollettini I et al.Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav Immun.[Internet ]2020 [cited 12 dec 2021]; 89: 594–600.Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390748/Del Toro M, Hurtado A, Garcia LE, García T. Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products. Nutrients.[Internet] 2020 [cited dec 19 2021];12(12): 3896. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767237/Benavides V, Villota N, Villalobos F. Conducta suicida en Colombia: Una revisión sistemática. Revista de psicopatología y psicología clínica [Internet]. 2020 [Citado el 03 Enero de 2022] 24 (3); 181-195. Tomado de: http://revistas.uned.es/index.php/RPPC/article/view/24251Zhang W, Qu W, Wang H, Yan H. Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress. [Internet]. 2021. [cited 10 aug 2021]; 11 (1): 131. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892574/Arias HR, Targowska-Duda KM, García-Colunga J, Ortells MO. Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors?. [Internet]. 2021. [cited 15 aug 2021]; 26(8):2149. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068400/Departamento Nacional de Planeación (DNP). ¿Cómo se relaciona la pandemia del COVID-19 con la salud mental de los colombianos? Resumen de políticas según la iniciativa Respuestas Efectivas contra el COVID-19. [Internet] DNP. 2021[citado 24 ago 2021]. Disponible en: https://colaboracion.dnp.gov.co/CDT/Sinergia/Documentos/Notas_politica_publica_SAL UD%20MENTAL_22_04_21_V7.pdfChudzik A,Orzyłowska A, Rola R,Stanisz GJ. Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain–Gut–Microbiome Axis.Biomolecules. [Internet] 2021 [cited 13 jan 2022]; 11(7):1000. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301955/Becerra-Moreno L, Laiton A, Lopez-Moyano J, Oyola-Cifuentes L. Diseño de un curso corto para prevenir la depresión. [Tesis de Pregrado]. Bogotá, Colombia. Universidad Catolica de Colombia; 2021. Disponible en: https://repository.ucatolica.edu.co/handle/10983/26070Sistema Integrado de Información de la Protección Social (SISPRO). Reportes por Indicadores de Salud Mental. [Internet] SISPRO- Portal Web.[citado 25 ago 2021]. Disponible en: http://rssvr2.sispro.gov.co/ObsSaludMental/DepresiónMicrobiota intestinalInhibidores Selectivos de la Recaptación de Serotonina (ISRS)Disbiosis intestinalTratamientoORIGINALDocumento Final Monografia.pdfDocumento Final Monografia.pdfapplication/pdf3914190https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/1/Documento%20Final%20Monografia.pdfbefa16863a5995512ec2f89bc5791d23MD51open accessMonografia Ortegón - Zuluaga.pdfMonografia Ortegón - Zuluaga.pdfapplication/pdf2395317https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/2/Monografia%20Orteg%c3%b3n%20-%20Zuluaga.pdf313a6098fde4d9f618574356e5feecafMD52open accessCARTA DERECHOS DE AUTOR Ortegon.pdfCARTA DERECHOS DE AUTOR Ortegon.pdfapplication/pdf154067https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/3/CARTA%20DERECHOS%20DE%20AUTOR%20Ortegon.pdf176225e33244958b7693f0c2f84b8847MD53metadata only accessFORMATO IDENTIFICACIÓN TRABAJOS DE GRADO Zuluaga Luz - Ortegon Juanita.pdfFORMATO IDENTIFICACIÓN TRABAJOS DE GRADO Zuluaga Luz - Ortegon Juanita.pdfapplication/pdf1723151https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/4/FORMATO%20IDENTIFICACI%c3%93N%20TRABAJOS%20DE%20GRADO%20Zuluaga%20Luz%20-%20Ortegon%20Juanita.pdf572e361c8d8851a91ec7ffc2758afd01MD54metadata only accessLICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/5/license.txt2f9959eaf5b71fae44bbf9ec84150c7aMD55open accessTEXTDocumento Final Monografia.pdf.txtDocumento Final Monografia.pdf.txtExtracted texttext/plain180958https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/6/Documento%20Final%20Monografia.pdf.txtbedaeb76e64f07cec9b30d962d090260MD56open accessMonografia Ortegón - Zuluaga.pdf.txtMonografia Ortegón - Zuluaga.pdf.txtExtracted texttext/plain22532https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/8/Monografia%20Orteg%c3%b3n%20-%20Zuluaga.pdf.txtc9f43491f0cb74dfef29ac6afc859b55MD58open accessCARTA DERECHOS DE AUTOR Ortegon.pdf.txtCARTA DERECHOS DE AUTOR Ortegon.pdf.txtExtracted texttext/plain1145https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/10/CARTA%20DERECHOS%20DE%20AUTOR%20Ortegon.pdf.txt6c714b08f1f37c1746b664999afa1417MD510metadata only accessFORMATO IDENTIFICACIÓN TRABAJOS DE GRADO Zuluaga Luz - Ortegon Juanita.pdf.txtFORMATO IDENTIFICACIÓN TRABAJOS DE GRADO Zuluaga Luz - Ortegon Juanita.pdf.txtExtracted texttext/plain2539https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/12/FORMATO%20IDENTIFICACI%c3%93N%20TRABAJOS%20DE%20GRADO%20Zuluaga%20Luz%20-%20Ortegon%20Juanita.pdf.txt707373b4192c2ae83b94f522e9e41154MD512metadata only accessTHUMBNAILDocumento Final Monografia.pdf.jpgDocumento Final Monografia.pdf.jpgGenerated Thumbnailimage/jpeg6060https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/7/Documento%20Final%20Monografia.pdf.jpg69a2632ac70b55328ba4c30358e1b6acMD57open accessMonografia Ortegón - Zuluaga.pdf.jpgMonografia Ortegón - Zuluaga.pdf.jpgGenerated Thumbnailimage/jpeg10652https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/9/Monografia%20Orteg%c3%b3n%20-%20Zuluaga.pdf.jpg8b268527c4d5df959064a273f56c52c2MD59open accessCARTA DERECHOS DE AUTOR Ortegon.pdf.jpgCARTA DERECHOS DE AUTOR Ortegon.pdf.jpgGenerated Thumbnailimage/jpeg9407https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/11/CARTA%20DERECHOS%20DE%20AUTOR%20Ortegon.pdf.jpg0081f36dbfb0a8041accd4fcc1b6a7e6MD511metadata only accessFORMATO IDENTIFICACIÓN TRABAJOS DE GRADO Zuluaga Luz - Ortegon Juanita.pdf.jpgFORMATO IDENTIFICACIÓN TRABAJOS DE GRADO Zuluaga Luz - Ortegon Juanita.pdf.jpgGenerated Thumbnailimage/jpeg12046https://repositorio.unicolmayor.edu.co/bitstream/unicolmayor/6912/13/FORMATO%20IDENTIFICACI%c3%93N%20TRABAJOS%20DE%20GRADO%20Zuluaga%20Luz%20-%20Ortegon%20Juanita.pdf.jpg5f67d786d214ea625f27b3abe8370f81MD513metadata only accessunicolmayor/6912oai:repositorio.unicolmayor.edu.co:unicolmayor/69122024-05-24 03:01:33.701An error occurred on the license name.|||https://creativecommons.org/licenses/by-nc/4.0/open accessBiblioteca Digital Unicolmayorrepositorio@unicolmayor.edu.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