Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos
El cadmio (Cd) se considera un metal pesado y tóxico para los ecosistemas y el ser humano. Se puede bioacumular en el suelo, los lodos, las plantas y fuentes hídricas. Ingresa a la cadena alimenticia del ser humano al ingerir alimentos o animales contaminados con Cd. Este trabajo es una revisión doc...
- Autores:
-
Ramírez Almanza, Carlos Andrés
Ramírez Moreno, Dayra Liliana
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2021
- Institución:
- Colegio Mayor de Cundinamarca
- Repositorio:
- Repositorio Colegio Mayor de Cundinamarca
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicolmayor.edu.co:unicolmayor/6892
- Acceso en línea:
- https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6892
- Palabra clave:
- Metal pesado
Efectos tóxicos en la salud
Biorremediación
Suelo
Microorganismos
Plantas
- Rights
- closedAccess
- License
- Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024
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Repositorio Colegio Mayor de Cundinamarca |
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dc.title.spa.fl_str_mv |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
title |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
spellingShingle |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos Metal pesado Efectos tóxicos en la salud Biorremediación Suelo Microorganismos Plantas |
title_short |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
title_full |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
title_fullStr |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
title_full_unstemmed |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
title_sort |
Toxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectos |
dc.creator.fl_str_mv |
Ramírez Almanza, Carlos Andrés Ramírez Moreno, Dayra Liliana |
dc.contributor.advisor.none.fl_str_mv |
Camacho Kurmen, Judith Elena Jaime Rodríguez, Carolina |
dc.contributor.author.none.fl_str_mv |
Ramírez Almanza, Carlos Andrés Ramírez Moreno, Dayra Liliana |
dc.contributor.corporatename.spa.fl_str_mv |
Universidad Colegio Mayor de Cundinamarca |
dc.subject.proposal.spa.fl_str_mv |
Metal pesado Efectos tóxicos en la salud Biorremediación Suelo Microorganismos Plantas |
topic |
Metal pesado Efectos tóxicos en la salud Biorremediación Suelo Microorganismos Plantas |
description |
El cadmio (Cd) se considera un metal pesado y tóxico para los ecosistemas y el ser humano. Se puede bioacumular en el suelo, los lodos, las plantas y fuentes hídricas. Ingresa a la cadena alimenticia del ser humano al ingerir alimentos o animales contaminados con Cd. Este trabajo es una revisión documental sobre las consecuencias del cadmio en la salud del ser humano y el uso del proceso de biorremediación del suelo contaminado con este metal pesado, para disminuir sus efectos. Se realizó una revisión bibliográfica, identificando las principales fuentes de exposición de este metal pesado (antropogénica, industrial, agrícola, entre otras), los daños que puede causar en la salud humana (apoptosis, carcinoma, etc.) y los microorganismos o plantas que se pueden emplear en los diferentes procesos de biorremediación. Las enfermedades asociadas al Cd en el ser humano, incluyen alteraciones a nivel placentario, fetal y abortos con 28%, seguido de alteración renal, ósea, reproductiva y hormonal con 20%. El 24 % reporta apoptosis, citotoxicidad y como agente carcinógeno con 8%. Los factores determinantes para la biorremediación en suelos del Cd son: el pH, la mayoría de técnicas, independientemente del método y el microorganismo o planta utilizados, empleando de 5.0 a 6.0 (45%), la temperatura empleada fue de 24°C – Mayor de 30°C, origen y la concentración de Cd, la biomasa (microorganismos) o plantas utilizados para biorremediar el metal y el contenido de materia orgánica. Siendo el mejor proceso para biorremediar, la bioacumulación, el cual se puede desarrollar con plantas, hongos o bacterias. |
publishDate |
2021 |
dc.date.issued.none.fl_str_mv |
2021 |
dc.date.accessioned.none.fl_str_mv |
2024-05-21T17:43:29Z |
dc.date.available.none.fl_str_mv |
2024-05-21T17:43:29Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/TP |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_7a1f |
status_str |
publishedVersion |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6892 |
url |
https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6892 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
Camacho VB, Díaz RG. Evaluation of contamination by heavy metals in soils of the Cayapas Mataje Mangrove Reserve (REMACAM)-Ecuado. Entramado. 2018 Oct 11;14(1):104–10. LUIS FERNANDO LONDOÑO-FRANCO 1 PTL-M 2. LOS RIESGOS DE LOS METALES PESADOS EN LA SALUD HUMANA Y ANIMAL. 2016 [cited 2021 Oct 15];14(2). Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1692-3561201600 0200017 Abbas G, Murtaza B, Bibi I, Shahid M, Niazi NK, Khan MI, et al. Arsenic uptake, toxicity, detoxification, and speciation in plants: Physiological, biochemical, and molecular aspects. International Journal of Environmental Research and Public Health [Internet]. 2018 Jan 2 [cited 2021 Apr 27];15(1). Available from: /pmc/articles/PMC5800158/ Širić I, Kasap A, Bedeković D, Falandysz J. Lead, cadmium and mercury contents and bioaccumulation potential of wild edible saprophytic and ectomycorrhizal mushrooms, Croatia. http://dx.doi.org.ez.unisabana.edu.co/101080/0360123420171261538 [Internet]. 2017 Mar 4 [cited 2021 Jul 27];52(3):156–65. Available from: https://www-tandfonline-com.ez.unisabana.edu.co/doi/abs/10.1080/03601234. 2017.1261538 Del Cacao D. PROGRAMA NACIONAL DE VIGILANCIA Y CONTROL DE CADMIO EN PRODUCTOS [Internet]. 2016 [cited 2021 Apr 27]. Available from: https://www.invima.gov.co/documents/20143/441038/Documento-tecnico-Cad mio-en-cacao.pdf/36200805-c21d-c444-ee08-47a0f6c8c230 2014 09-12 oportunidades de mercado para exportar cacao colombiano [Internet]. [cited 2021 Apr 27]. Available from: https://es.slideshare.net/pasante/2014-0912-oportunidades-de-mercado-paraexportar- cacao-colombiano Bolan N, Kunhikrishnan A, Thangarajan R, Kumpiene J, Park J, Makino T, et al. Remediation of heavy metal(loid)s contaminated soils - To mobilize or to immobilize? J Hazard Mater [Internet]. 2014 Feb 15 [cited 2021 Apr 27];266:141–66. Available from: https://pubmed.ncbi.nlm.nih.gov/24394669/ Benavides MP, Gallego SM, Tomaro ML. Cadmium toxicity in plants. Brazilian J Plant Physiol [Internet]. 2005 [cited 2021 Apr 27];17(1):21–34. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-0420200500010 0003&lng=en&nrm=iso&tlng=en Brian J. Alloway. Heavy Metals in Soils [Internet]. Alloway BJ, editor. Dordrecht: Springer Netherlands; 2013 [cited 2021 Apr 27]. (Environmental Pollution; vol. 22). Available from: http://link.springer.com/10.1007/978-94-007-4470-7 Charania NA, Tsuji LJS, Martin ID, Liberda EN, Coté S, Ayotte P, et al. An examination of traditional foods and cigarette smoking as cadmium sources among the nine First Nations of Eeyou Istchee, northern Quebec, Canada. Environ Sci Process Impacts [Internet]. 2014 [cited 2021 Apr 27];16(6):1422–33. Available from: https://pubmed.ncbi.nlm.nih.gov/24781002/ Dunia M, Heredia R. ARTÍCULO DE REVISIÓN Intoxicación ocupacional por metales pesados Occupational poisoning due to heavy metals. MEDISAN. 2017;21(12):3372. E A, N H, IH S, Z J, MH S, LX J. Role of jasmonic acid in improving tolerance of rapeseed (Brassica napus L.) to Cd toxicity. J Zhejiang Univ Sci B [Internet]. 2018 Feb 1 [cited 2021 Oct 15];19(2):130–46. Available from: https://pubmed.ncbi.nlm.nih.gov/29405041/ Perales-Aguilar L, Esquivel-Rivera JA, Silos-Espino H, Carrillo-Rodríguez JC, Perales-Segovia C, Perales-Aguilar L, et al. Tolerancia de plantas de zonas áridas a metales pesados. Terra Latinoam [Internet]. 2021 Jan 1 [cited 2021 Oct 15];39. Available from: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0187-577920210 00100108&lng=es&nrm=iso&tlng=es Cristaldi A, Oliveri Conti G, Cosentino SL, Mauromicale G, Copat C, Grasso A, et al. Phytoremediation potential of Arundo donax (Giant Reed) in contaminated soil by heavy metals. Environ Res [Internet]. 2020 Jun 1 [cited 2021 Jul 27];185:109427. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S00139 35120303200?via%3Dihub Charrupi Riascos N, Carolina Martínez Novoa D. Estudio ambiental del cadmio y su relación con suelos destinados al cultivo de cacao en los departamentos de Arauca y Nariño. 2017 [cited 2021 Oct 15]; Available from: https://ciencia.lasalle.edu.co/ing_ambiental_sanitaria/718 Esmeralda P, García P, Isabel M, Cruz A. Rev Esp Méd Quir Volumen 17, Núm. 3, julio-septiembre. Rev Esp Méd Quir [Internet]. 2012 [cited 2021 Oct 15];17(3):199–205. Available from: www.nietoeditores.com.mx Marini M, Angouria-Tsorochidou E, Caro D, Thomsen M. Daily intake of heavy metals and minerals in food – A case study of four Danish dietary profiles. J Clean Prod [Internet]. 2021 Jan 20 [cited 2021 Oct 15];280:124279. Available from: https://www.sciencedirect.com/science/article/pii/S0959652620343249 Producto Límite (ppm). 2015 [cited 2021 Oct 15];21. Available from: https://alimentacion-animal.elika.eus/wp-content/uploads/sites/6/2017/12/CAD MIO-2015maquetado.pdf Alengebawy A, Abdelkhalek ST, Qureshi SR, Wang MQ. Heavy metals and pesticides toxicity in agricultural soil and plants: Ecological risks and human health implications. Toxics. 2021;9(3):1–34. Zhang F, Xiao X, Wu X. Physiological and molecular mechanism of cadmium (Cd) tolerance at initial growth stage in rapeseed (Brassica napus L.). Ecotoxicol Environ Saf [Internet]. 2020 Jul 1 [cited 2021 Oct 15];197:110613. Available from: https://www.sciencedirect.com/science/article/pii/S0147651320304528 Parlamento Europeo El Consejo De EY. DIRECTIVA 2000/36/CE DEL PARLAMENTO EUROPEO Y DEL CONSEJO de 23 de junio de 2000 relativa a los productos de cacao y de chocolate destinados a la alimentación humana [Internet]. 2000 Jun [cited 2021 Apr 28]. Available from: https://eur-lex.europa.eu/legal-content/Es/TXT/PDF/?uri=CELEX:02000L0036- 20131118&rid=1 Del Cacao D. PROGRAMA NACIONAL DE VIGILANCIA Y CONTROL DE CADMIO EN PRODUCTOS. [cited 2021 Aug 20]; Available from: https://www.invima.gov.co/documents/20143/441038/Documento-tecnico-Cad mio-en-cacao.pdf/36200805-c21d-c444-ee08-47a0f6c8c230 Manuel Santos Calderón J, Gabriel Uribe J, Soto Carreño Supervisora de consultoría Marcela Bonilla Madriñán A. República de Colombia Ministerio de Ambiente y Desarrollo Sostenible [Internet]. 2012 [cited 2021 Apr 28]. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/INEC/IGUB/ Diagnostico de salud Ambiental compilado.pdf Soto-Benavente M, Rodriguez-Achata L, Olivera M, Sanchez VA, Nano CC, Quispe JG. Health risks due to the presence of heavy metals in agricultural products cultivated in areas abandoned by gold mining in the Peruvian Amazon. Sci Agropecu [Internet]. 2020 Mar 1 [cited 2021 Apr 28];11(1):49–59. Available from: https://www.researchgate.net/publication/340384081_Health_risks_due_to_the _presence_of_heavy_metals_in_agricultural_products_cultivated_in_areas_ab andoned_by_gold_mining_in_the_Peruvian_Amazon Cayotopa-Torres J, Arévalo-López L, Pichis-García R, Olivera-Cayotopa D, Rimachi-Valle M, Márquez-Dávila K, et al. Nuevos agentes de biorremediación de cadmio: Especies de Trichoderma nativas de la rizósfera de árboles de cacao. Sci Agropecu [Internet]. 2021 Apr 1 [cited 2021 Oct 15];12(2):155–60. Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2077-9917202100 0200155&lng=es&nrm=iso&tlng=en Yadav SK. Heavy metals toxicity in plants: An overview on the role of glutathione and phytochelatins in heavy metal stress tolerance of plants. South African J Bot [Internet]. 2010;76(2):167–79. Available from: http://dx.doi.org/10.1016/j.sajb.2009.10.007 Mendez JP, Mendez JP, RamÃrez CAG, Gutiérrez ADR, Garcia FP. PLANT CONTAMINATION AND PHYTOTOXICITY DUE TO HEAVY METALS FROM SOIL AND WATER. Trop Subtrop Agroecosystems [Internet]. 2008 Dec 16 [cited 2021 Apr 28];10(1):19–44. Available from: https://www.revista.ccba.uady.mx/ojs/index.php/TSA/article/view/25 Gerhard I, Waibel S, Daniel V, Runnebaum B. Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages. Hum Reprod Update [Internet]. 1998 May [cited 2021 Apr 28];4(3):301–9. Available from: https://pubmed.ncbi.nlm.nih.gov/9741713/ Garbisu C, Alkorta I. Basic concepts on heavy metal soil bioremediation. The European Journal of Mineral Processing and Environmental Protection [Internet]. 2003 [cited 2021 Apr 28];3(1):58–66. Available from: https://www.911metallurgist.com/blog/wp-content/uploads/2015/12/Basic-conc epts-on-heavy-metal-soil-bioremediation.pdf para optar al Título Profesional de Médico Veterinario M. CLAUDIA ISABEL SANTANDER FUENZALIDA PROFESOR GUÍA: LORETO DEL CARMEN MUÑOZ ARENAS. 2007 [cited 2021 Oct 15]; Available from: https://repositorio.uchile.cl/bitstream/handle/2250/131233/Detección-de-cadmi o%2C-mercurio-y-plomo-en-gatos.pdf?sequence=1&isAllowed=y OMS | Cadmio Programa Internacional de Seguridad de las Sustancias Químicas [Internet]. [cited 2021 Apr 28]. Available from: https://www.who.int/ipcs/assessment/public_health/cadmium/es/ Sabath E, Robles-Osorio ML. Medio ambiente y riñón: nefrotoxicidad por metales pesados. 2012 [cited 2021 Apr 28];32(3):279–86. Available from: http://www.revistanefrologia.com Bustos Viteri KT, Cacuango Gualacata JJ. Identificación molecular de bacterias resistentes a cadmio y cromo aisladas de aguas contaminadas de la zona de Papallacta cantón Quijos de la provincia de Napo. 2017 Jan [cited 2021 Apr 28]; Available from: http://dspace.ups.edu.ec/handle/123456789/13535 Kumar A, Subrahmanyam G, Mondal R, Cabral-Pinto MMS, Shabnam AA, Jigyasu DK, et al. Bio-remediation approaches for alleviation of cadmium contamination in natural resources. Chemosphere [Internet]. 2021 Apr 1 [cited 2021 Jul 28];268:128855. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0045653520330538?via %3Dihub Georgescu B, Georgescu C, Dărăban S, Bouaru A, Paşcalău S. Heavy Metals Acting as Endocrine Disrupters [Internet]. Scientific Papers: Animal Science and Biotechnologies. 2011 [cited 2021 Apr 28]. Available from: https://www.usab-tm.ro/utilizatori/ZOOTEHNIE/file/REVISTA 2011/vol 44/2/BIOCHIM/Georgescu.pdf Steliga T, Kluk D. Application of Festuca arundinacea in phytoremediation of soils contaminated with Pb, Ni, Cd and petroleum hydrocarbons. Ecotoxicol Environ Saf [Internet]. 2020 May 1 [cited 2021 Jul 27];194:110409. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S01476 51320302487?via%3Dihub Beltrán-Pineda ME, Gómez-Rodríguez AM. Biorremediación de metales pesados cadmio (Cd), cromo (Cr) y mercurio (Hg), mecanismos bioquímicos e ingeniería genética: una revisión. Rev Fac Ciencias Básicas [Internet]. 2016;12(2):172–97. Available from: file:///C:/Users/LENOVO/Downloads/2027-Texto del artículo-6473-1-10-20160901.pdf Nwidi I, Agunwamba J. Selection of Biosorbents for Biosorption of Three Heavy Metals in a Flow-Batch Reactor Using Removal Efficiency as Parameter. Niger J Technol [Internet]. 2015 Mar 31 [cited 2021 Apr 28];34(2):406. Available from: https://www.researchgate.net/publication/220039321_Bacterial_Biosorption_of _heavy_metals Xu S, Xing Y, Liu S, Hao X, Chen W, Huang Q. Characterization of Cd2+ biosorption by Pseudomonas sp. strain 375, a novel biosorbent isolated from soil polluted with heavy metals in Southern China. Chemosphere [Internet]. 2020 Feb 1 [cited 2021 Apr 28];240. Available from: https://pubmed.ncbi.nlm.nih.gov/31550585/ Ayubb T N, Cerra G A, Chamorro A L, Pérez C A. Resistencia a cadmio (Cd) de bacterias endófitas y bacterias rizosféricas aisladas a partir de Oriza sativa en Colombia. Rev Colomb Cienc Anim - RECIA [Internet]. 2017 Dec 1 [cited 2021 Apr 28];9(2):281. Available from: http://www.recia.edu.co Profesional Agronomía C DE. EFECTO DE TRES SISTEMAS DE MANEJO SOBRE EL CONTENIDO DE CADMIO (Cd) EN LA HOJARASCA Y EN LA CÁSCARA DE CACAO (Theobroma cacao L.) EN SAN ALEJANDRO UCAYALI, PERÚ. [Internet]. 2019 [cited 2021 Apr 28]. Available from: http://repositorio.unu.edu.pe/bitstream/handle/UNU/4229/UNU_AGRONOMIA_ 2019_T_KERVIN-TUESTA.pdf?sequence=1&isAllowed=y Pro E. Effects of heavy metals on soil microbial biomass carbon. 2019 [cited 2021 Apr 28]; Available from: http://medcraveonline.com Jan M, Shah G, Masood S, Iqbal Shinwari K, Hameed R, Rha ES, et al. Bacillus Cereus Enhanced Phytoremediation Ability of Rice Seedlings under Cadmium Toxicity. Biomed Res Int [Internet]. 2019 [cited 2021 Apr 28];2019. Available from: https://www.hindawi.com/journals/bmri/2019/8134651/ Manguilimotan LC, Bitacura JG. Biosorption of Cadmium by Filamentous Fungi Isolated from Coastal Water and Sediments. J Toxicol [Internet]. 2018 [cited 2021 Apr 28];2018. Available from: https://www.hindawi.com/journals/jt/2018/7170510/ Ameen FA, Hamdan AM, El-Naggar MY. Assessment of the heavy metal bioremediation efficiency of the novel marine lactic acid bacterium, Lactobacillus plantarum MF042018. Sci Rep [Internet]. 2020 Dec 1 [cited 2021 Apr 28];10(1):1–11. Available from: www.nature.com/scientificreports Sánchez Barrón G, Sánchez Barrón G. Ecotoxicología del cadmio riesgo para la salud de la utilización de suelos ricos en cadmio. 2016 [cited 2021 Apr 28]; Available from: https://eprints.ucm.es/id/eprint/50902/ Mauricio R, Beltran S, De G, De Biorremediación M, La P, De R. GUÍA DE MÉTODOS DE BIORREMEDIACIÓN PARA LA RECUPERACIÓN DE SUELOS CONTAMINADOS POR HIDROCARBUROS [Internet]. 2013 [cited 2021 Apr 28]. Available from: https://repository.unilibre.edu.co/bitstream/handle/10901/10607/TRABAJO FINAL cd.pdf?sequence=1 Marrero-Coto J, Díaz-Valdivia A, Coto-Pérez O. Mecanismos moleculares de resistencia a metales pesados en las bacterias y sus aplicaciones en la biorremediación [Internet]. Vol. 41, Revista CENIC Ciencias Biológicas. 2016 [cited 2021 Apr 28]. Available from: https://revista.cnic.edu.cu/index.php/RevBiol/article/view/609 Apaza-Aquino H, Valencia MREV. EFICIENCIA DE LA BIOMASA DE RHIZOPUS SP EN LA REMOCIÓN DE CADMIO (II). Rev Investig la Esc Posgrado la UNA PUNO [Internet]. 2020 Oct 31 [cited 2021 Jul 27];9(4):1805–16. Available from: http://revistas.unap.edu.pe/epg/index.php/investigaciones/article/view/2288 Cuba C, Rubio OE, Zamora M, Hernández Baranda AM;, Cabrera Rodríguez Y;, Guridi JA;, et al. EFECTOS DE LA APLICACIÓN DE UNA MEZCLA DE OLIGOGALACTURÓNIDOS SOBRE UN SUELO CONTAMINADO CULTIVADO CON PLÁNTULAS DE TOMATE. Cultiv Trop [Internet]. 2016 [cited 2021 Apr 28];37:160–7. Available from: http://dx.doi.org/10.13140/RG.2.2.20663.52642 Álvarez Calvo ML. Tratamiento de suelos contaminados por metales mediante combinación de técnicas de fitorremediación con adición de biochar [Internet]. Universidad Politécnica de Madrid; 2019 [cited 2021 Apr 27]. Available from: http://oa.upm.es/55865/ Xu C, He S, Liu Y, Zhang W, Lu D. Bioadsorption and biostabilization of cadmium by Enterobacter cloacae TU. Chemosphere [Internet]. 2017 Apr 1 [cited 2021 Jul 27];173:622–9. Available from: https://www.sciencedirect.com/science/article/abs/pii/S004565351730005X?ca sa_token=QhUhq_NtpRIAAAAA:cgmhnTBapnTo4Ww46kPh7-s9jrAMSoq_RxS iZz2uU2O2ATizpskBE2bvFMqFjfiWoxv3kYOu6B0 Moreno-Sánchez R, Rodríguez-Enríquez S, Jasso-Chávez R, Saavedra E, García-García JD. Biochemistry and Physiology of Heavy Metal Resistance and Accumulation in Euglena. Adv Exp Med Biol [Internet]. 2017 [cited 2021 Jul 27];979:91–121. Available from: https://link-springer-com.ez.unisabana.edu.co/chapter/10.1007/978-3-319-549 10-1_6 Motamayor JC, Risterucci AM, Lopez PA, Ortiz CF, Moreno A, Lanaud C. Cacao domestication I: The origin of the cacao cultivated by the Mayas. Heredity (Edinb) [Internet]. 2002 Nov 28 [cited 2021 Apr 27];89(5):380–6. Available from: www.nature.com/hdy Yang Z, Shi W, Yang W, Liang L, Yao W, Chai L, et al. Combination of bioleaching by gross bacterial biosurfactants and flocculation: A potential remediation for the heavy metal contaminated soils. Chemosphere [Internet]. 2018 Sep 1 [cited 2021 Jul 27];206:83–91. Available from: https://www.sciencedirect.com/science/article/abs/pii/S004565351830821X?ca sa_token=3m1qBRwwDGwAAAAA:xJh9Td_ncRcO69fljJsEer-vjtLI41vYHxqdG f8Fa7DbUN4PfrZ3At-4jQa9lKR_OJ-f8nG1QGw Maldaner J, Steffen GPK, Missio EL, Saldanha CW, Morais RM de, Nicoloso FT. Tolerance of Trichoderma isolates to increasing concentrations of heavy metals. https://doi-org.ez.unisabana.edu.co/101080/0020723320201778290 [Internet]. 2020 [cited 2021 Jul 27];78(2):1–13. Available from: https://www-tandfonline-com.ez.unisabana.edu.co/doi/abs/10.1080/00207233. 2020.1778290 Pons ML, Collin B, Doelsch E, Chaurand P, Fehlauer T, Levard C, et al. X-ray absorption spectroscopy evidence of sulfur-bound cadmium in the Cd-hyperaccumulator Solanum nigrum and the non-accumulator Solanum melongena. Environ Pollut [Internet]. 2021 Jun 15 [cited 2021 Jul 27];279:116897. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S02697 49121004796?via%3Dihub#sec1 Albert Q, Leleyter L, Lemoine M, Heutte N, Rioult JP, Sage L, et al. Comparison of tolerance and biosorption of three trace metals (Cd, Cu, Pb) by the soil fungus Absidia cylindrospora. Chemosphere [Internet]. 2018 Apr 1 [cited 2021 Jul 27];196:386–92. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S00456 53517321343?via%3Dihub Kortenkamp A. 12. Are Cadmium and Other Heavy Metal Compounds Acting as Endocrine Disrupters? In: Metal ions in life sciences [Internet]. Met Ions Life Sci; 2010 [cited 2021 Apr 28]. p. 305–17. Available from: http://ebook.rsc.org/?DOI=10.1039/9781849732116-00305 Lizandra Pérez Bou ISB. Biosorción microbiana de metales pesados: características del proceso / Biosorption of heavy metals: characteristics of the process | Pérez Bou | Revista Cubana de Ciencias Biológicas [Internet]. Vol. 6, Núm. 1. 2018 [cited 2021 Aug 20]. Available from: http://www.rccb.uh.cu/index.php/RCCB/article/view/216 Galman JL, Slabu I, Weise NJ, Iglesias C, Parmeggiani F, Lloyd RC, et al. Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Green Chem [Internet]. 2017 Jan 23 [cited 2021 Oct 18];19(2):361–6. Available from: https://pubs.rsc.org/en/content/articlehtml/2017/gc/c6gc02102f Li X, Li D and bioaccumulation characteristics of cadmium by plant growth-promoting rhizobacteria, Yan Z, Ao Y. Biosorption and bioaccumulation characteristics of cadmium by plant growth-promoting rhizobacteria. RSC Adv [Internet]. 2018 Aug 30 [cited 2021 Jul 27];8(54):30902–11. Available from: https://pubs.rsc.org/en/content/articlehtml/2018/ra/c8ra06270f Bahobil A, Bayoumi RA, Atta HM, El-Sehrawey MM. Fungal Biosorption for Cadmium and Mercury Heavy Metal Ions Isolated from Some Polluted Localities in KSA. IntJCurrMicrobiolAppSci [Internet]. 2017 [cited 2021 Oct 18];6(6):2138–54. Available from: https://doi.org/10.20546/ijcmas.2017.606.253 Costa F, Tavares T. Biosorption of nickel and cadmium in the presence of diethylketone by a Streptococcus equisimilis biofilm supported on vermiculite. Int Biodeterior Biodegrad [Internet]. 2016 Nov 1 [cited 2021 Oct 18];115:119–32. Available from: https://www.semanticscholar.org/paper/Biosorption-of-nickel-and-cadmium-in-t he-presence-a-Costa-Tavares/ce875673996b4232da58f543e83786da6109157 c Bras. Carla Mendieta Webster y Katerine Taisigüe Lóp. Acumulación y traslocación de metales, metaloides y no metales en plantas nativas de la zona minera de Chontales: Implicaciones para el potencial de fito-remediación [Internet]. 2014 [cited 2021 Oct 15]. Available from: https://biorem.univie.ac.at/fileadmin/user_upload/p_biorem/education/research /methods/Accumulation-and-Translocation-metals-in-native-plants_Extended-a bstract.pdf Olaniran AO, Balgobind A, Pillay B. Bioavailability of heavy metals in soil: Impact on microbial biodegradation of organic compounds and possible improvement strategies. Int J Mol Sci [Internet]. 2013 [cited 2021 Apr 27];14(5):10197–228. Available from: /pmc/articles/PMC3676836/ Yang Z, Zhang Z, Chai L, Wang Y, Liu Y, Xiao R. Bioleaching remediation of heavy metal-contaminated soils using Burkholderia sp. Z-90. J Hazard Mater [Internet]. 2016 Jan 15 [cited 2021 Jul 27];301:145–52. Available from: https://www.sciencedirect.com/science/article/abs/pii/S030438941530039X Haider FU, Liqun C, Coulter JA, Cheema SA, Wu J, Zhang R, et al. Cadmium toxicity in plants: Impacts and remediation strategies. Ecotoxicol Environ Saf. 2021 Mar 15;211:111887. Muñoz-Silva L, Olivera-Gonzales P, Santillán Torres M, Tamariz-Angeles C. Microorganismos tolerantes a metales pesados del pasivo minero Santa Rosa, Jangas (Perú). Rev Peru Biol [Internet]. 2019 [cited 2021 Oct 15];26(1):109–18. Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1727-9933201900 0100013&lng=es&nrm=iso&tlng=es Arambawatta-Lekamge SH, Pathiratne A, Rathnayake IVN. Sensitivity of freshwater organisms to cadmium and copper at tropical temperature exposures: Derivation of tropical freshwater ecotoxicity thresholds using species sensitivity distribution analysis. Ecotoxicol Environ Saf. 2021 Mar 15;211. Garzón JM, Pablo Rodríguez-Miranda J, Org O. Aporte de la biorremediación para solucionar problemas de contaminación y su relación con el desarrollo sostenible Contribution of bioremediation to solve pollution problems and its relationship with sustainable development. [cited 2021 Apr 27]; Available from: http://dx.doi.org/10.22267/rus.171902.93 Ashrafzadeh S, Leung DWM. Development of Cadmium-Safe Crop Cultivars: A Mini Review. J Crop Improv. 2016 Mar 3;30(2):107–17. Correa García C, Correa García C. Ecotoxicología del cadmio, riesgo para la salud por la utilización de suelos ricos en cadmio. 2016 [cited 2021 Apr 28]; Available from: https://eprints.ucm.es/id/eprint/49137/ Rizwan M, Ali S, Zia ur Rehman M, Rinklebe J, Tsang DCW, Bashir A, et al. Cadmium phytoremediation potential of Brassica crop species: A review. Sci Total Environ [Internet]. 2018 Aug 1 [cited 2021 Apr 28];631–632:1175–91. Available from: https://pubmed.ncbi.nlm.nih.gov/29727943/ P.S C, Sanyal D, Dasgupta S, Banik A. Cadmium biosorption and biomass production by two freshwater microalgae Scenedesmus acutus and Chlorella pyrenoidosa: An integrated approach. Chemosphere [Internet]. 2021 Apr 1 [cited 2021 Apr 28];269:128755. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0045653520329532?via %3Dihub Ricardo Israel Ramírez Gottfried1, Mario García Carrillo1§, Vicente de Paul Álvarez Reyna1, Guillermo González Cervantes2, Vicente Hernández Hernández1. Potencial fitorremediador de la chicura (Ambrosia ambrosioides) en suelos contaminados por metales pesados - Dialnet. 2019 [cited 2021 Jul 27];10(7):1529–40. Available from: https://dialnet.unirioja.es/servlet/articulo?codigo=7152652 Manousaki E, Kalogerakis N. Phytoextraction of Pb and Cd by the Mediterranean saltbush (AtripLex halimus L.): Metal uptake in relation to salinity. Environ Sci Pollut Res [Internet]. 2009 Nov [cited 2021 Oct 15];16(7):844–54. Available from: https://pubmed.ncbi.nlm.nih.gov/29727943/ UVM P. METODOLOGIA DE LA INVESTIGACION DISENO Y EJECUCION [Internet]. 2011 [cited 2021 Apr 28]. Available from: https://www.academia.edu/35258714/METODOLOGIA_DE_LA_INVESTIGACI ON_DISENO_Y_EJECUCION Investigación cuantitativa y cualitativa. 2002 [cited 2021 Apr 28]; Available from: http://www.fisterra.com/mbe/investiga/cuanti_cuali/cuanti_cuali.asp Roberto Hernández, Carlos Fernández Collado, Pilar Baptista Lucio. Metodología de la Investigación [Internet]. 2014 [cited 2021 Apr 28]. Available from: https://academia.utp.edu.co/grupobasicoclinicayaplicadas/files/2013/06/Metod ología-de-la-Investigación.pdf María L, Dulzaides Iglesias1 E, María LA, Gómez1 M. Análisis documental y de información: dos componentes de un mismo proceso. 2004 [cited 2021 Apr 28]; Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1024-94352004000200 011 El análisis de contenido como herramienta de utilidad para la realización de una investigación descriptiva. Un ejemplo de aplicación práctica utilizado para conocer las investigaciones realizadas sobre la imagen de marca de España y el efecto país de origen [Internet]. 2013 [cited 2021 Apr 28]. Available from: https://www.redalyc.org/pdf/555/55530465007.pdf Colectiva S, Aires B. Los lenguajes de indización en e-Salud: su aplicación a los documentos sobre trastornos de la conducta alimentaria Indexing languages in e-Health: applications for documents about eating disorders [Internet]. Vol. 7, Octubre. 2011 [cited 2021 Apr 28]. Available from: https://www.scielosp.org/article/scol/2011.v7suppl1/S61-S69/es/ Zeng T, Liang Y, Chen J, Cao G, Yang Z, Zhao X, et al. Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure. Environ Int [Internet]. 2021 Sep 1 [cited 2021 Aug 20];154:106646. Available from: https://www.sciencedirect.com/science/article/pii/S0160412021002713 Bolan N, Kunhikrishnan A, Thangarajan R, Kumpiene J, Park J, Makino T, et al. Remediation of heavy metal(loid)s contaminated soils – To mobilize or to immobilize? J Hazard Mater. 2014 Feb 15;266:141–66. Munive Cerrón R, Loli Figueroa O, Azabache Leyton A, Gamarra Sánchez G. Fitorremediación con Maíz (Zea mays L.) y compost de Stevia en suelos degradados por contaminación con metales pesados. Sci Agropecu [Internet]. 2018 Dec 31 [cited 2021 Jul 27];9(4):551–60. Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2077-9917201800 0400011&lng=es&nrm=iso&tlng=es Kumar R, Sharma P, Umar A, Kumar R, Singh N, Joshi PK, et al. In Vitro Bioadsorption of Cd 2+ Ions: Adsorption Isotherms, Mechanism, and an Insight to Mycoremediation. 1085 [cited 2021 Oct 18];8. Available from: www.mdpi.com/journal/processes Li K, Cao C, Ma Y, Su D, Li J. Identification of cadmium bioaccumulation in rice (Oryza sativa L.) by the soil-plant transfer model and species sensitivity distribution. Sci Total Environ [Internet]. 2019 Nov 20 [cited 2021 Jul 27];692:1022–8. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S00489 69719332048?via%3Dihub#s0005 Choińska-Pulit A, Sobolczyk-Bednarek J, Łaba W. Optimization of copper, lead and cadmium biosorption onto newly isolated bacterium using a Box-Behnken design. Ecotoxicol Environ Saf [Internet]. 2018 Mar 1 [cited 2021 Jul 27];149:275–83. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S01476 51317308369?via%3Dihub J R-Z, S G, C M-B, R N, CA N, A P, et al. Response of the biomining Acidithiobacillus ferrooxidans to high cadmium concentrations. J Proteomics [Internet]. 2019 Apr 30 [cited 2021 Jul 27];198:132–44. Available from: https://pubmed.ncbi.nlm.nih.gov/30553947/ Brito JP, Ramada MH, de Magalhães MT, Silva LP, Ulhoa CJ. Peptaibols from Trichoderma asperellum TR356 strain isolated from Brazilian soil. SpringerPlus 2014 31 [Internet]. 2014 Oct 13 [cited 2021 Oct 18];3(1):1–10. Available from: https://springerplus.springeropen.com/articles/10.1186/2193-1801-3-600 Kumar A, Subrahmanyam G, Mondal R, Cabral-Pinto MMS, Shabnam AA, Jigyasu DK, et al. Bio-remediation approaches for alleviation of cadmium contamination in natural resources. Chemosphere [Internet]. 2021;268(November). Available from: https://www.researchgate.net/publication/345087752_Bio-remediation_approa ches_for_alleviation_of_cadmium_contamination_in_natural_resources Cely Torres LA. Oferta productiva del cacao colombiano en el posconflicto. Estrategias para el aprovechamiento de oportunidades comerciales en el marco del acuerdo comercial Colombia-Unión Europea. Equidad y Desarro [Internet]. 2017 Jul 5 [cited 2021 Apr 27];1(28):167–95. Available from: https://ciencia.lasalle.edu.co/eq/vol1/iss28/7 |
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Camacho Kurmen, Judith Elena88ec3d87924bea44fb175e7780652267Jaime Rodríguez, Carolina78f2aa662a283d0f3d182b27d8566b4bRamírez Almanza, Carlos Andrés17b864d393b8eeef89e4e693e6e507f3Ramírez Moreno, Dayra Liliana25445d5302a5a2cd83c0bed0248a587bUniversidad Colegio Mayor de Cundinamarca2024-05-21T17:43:29Z2024-05-21T17:43:29Z2021https://repositorio.unicolmayor.edu.co/handle/unicolmayor/6892El cadmio (Cd) se considera un metal pesado y tóxico para los ecosistemas y el ser humano. Se puede bioacumular en el suelo, los lodos, las plantas y fuentes hídricas. Ingresa a la cadena alimenticia del ser humano al ingerir alimentos o animales contaminados con Cd. Este trabajo es una revisión documental sobre las consecuencias del cadmio en la salud del ser humano y el uso del proceso de biorremediación del suelo contaminado con este metal pesado, para disminuir sus efectos. Se realizó una revisión bibliográfica, identificando las principales fuentes de exposición de este metal pesado (antropogénica, industrial, agrícola, entre otras), los daños que puede causar en la salud humana (apoptosis, carcinoma, etc.) y los microorganismos o plantas que se pueden emplear en los diferentes procesos de biorremediación. Las enfermedades asociadas al Cd en el ser humano, incluyen alteraciones a nivel placentario, fetal y abortos con 28%, seguido de alteración renal, ósea, reproductiva y hormonal con 20%. El 24 % reporta apoptosis, citotoxicidad y como agente carcinógeno con 8%. Los factores determinantes para la biorremediación en suelos del Cd son: el pH, la mayoría de técnicas, independientemente del método y el microorganismo o planta utilizados, empleando de 5.0 a 6.0 (45%), la temperatura empleada fue de 24°C – Mayor de 30°C, origen y la concentración de Cd, la biomasa (microorganismos) o plantas utilizados para biorremediar el metal y el contenido de materia orgánica. Siendo el mejor proceso para biorremediar, la bioacumulación, el cual se puede desarrollar con plantas, hongos o bacterias.Contenido 1. INTRODUCCIÓN 9 2. OBJETIVOS 10 2.1 Objetivo general 10 2.2 Objetivos específicos 10 3. ANTECEDENTES 10 4. MARCO TEÓRICO 12 4.1 Cadmio 12 4.1.1 Normativa de niveles de cadmio en alimentos 13 4.1.2 Ecotoxicidad 13 4.1.3 Toxicidad de cadmio en el ser humano 13 4.2 Biorremediación de cadmio 13 4.2.1 Bioadsorción o biosorción 16 4.2.2 Bioacumulación 18 4.2.3 Fitorremediación 18 4.2.4 Biolixiviación 18 4.2.5 Biotransformación 18 5. DISEÑO METODOLÓGICO 18 5.1 METODOLOGÍA PROPUESTA 18 5.2 UNIVERSO, POBLACIÓN, MUESTRA 18 5.2.1 UNIVERSO 18 5.2.2 POBLACIÓN 18 5.2.3 MUESTRA 18 5.3 CRITERIOS DE SELECCIÓN DE LOS OBJETOS DE ESTUDIO 18 5.4 CRITERIOS DE INCLUSIÓN O EXCLUSIÓN. 18 5.5 TÉCNICAS Y PROCEDIMIENTOS 19 5.6 ANÁLISIS DE LA INFORMACIÓN 19 6. RESULTADOS Y DISCUSIÓN 19 6.1 Recopilación, clasificación y análisis de la información. 19 6.2 Consecuencias de la exposición de Cd en la salud humana. 22 6.3 Fuentes de contaminación por Cd en el ser humano. 23 6.4 Procesos de biorremediación 25 6.5 Microorganismos utilizados en los procesos de biorremediación. 31 7. CONCLUSIONES 36 8. RECOMENDACIONES 36 9. BIBLIOGRAFIA 37 10. ANEXOS. 45PregradoBacteriólogo(a) y Laboratorista Clínico61p.application/pdfspaUniversidad Colegio Mayor de CundinamarcaFacultad de Ciencias de la SaludBogotá D.CBacteriología y Laboratorio ClínicoDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/closedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_14cbToxicidad del Cadmio y la estrategia de biorremediación de suelos contaminados para disminuir sus efectosTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/bachelorThesishttps://purl.org/redcol/resource_type/TPinfo:eu-repo/semantics/publishedVersionCamacho VB, Díaz RG. Evaluation of contamination by heavy metals in soils of the Cayapas Mataje Mangrove Reserve (REMACAM)-Ecuado. Entramado. 2018 Oct 11;14(1):104–10.LUIS FERNANDO LONDOÑO-FRANCO 1 PTL-M 2. LOS RIESGOS DE LOS METALES PESADOS EN LA SALUD HUMANA Y ANIMAL. 2016 [cited 2021 Oct 15];14(2). Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1692-3561201600 0200017Abbas G, Murtaza B, Bibi I, Shahid M, Niazi NK, Khan MI, et al. Arsenic uptake, toxicity, detoxification, and speciation in plants: Physiological, biochemical, and molecular aspects. International Journal of Environmental Research and Public Health [Internet]. 2018 Jan 2 [cited 2021 Apr 27];15(1). Available from: /pmc/articles/PMC5800158/Širić I, Kasap A, Bedeković D, Falandysz J. Lead, cadmium and mercury contents and bioaccumulation potential of wild edible saprophytic and ectomycorrhizal mushrooms, Croatia. http://dx.doi.org.ez.unisabana.edu.co/101080/0360123420171261538 [Internet]. 2017 Mar 4 [cited 2021 Jul 27];52(3):156–65. Available from: https://www-tandfonline-com.ez.unisabana.edu.co/doi/abs/10.1080/03601234. 2017.1261538Del Cacao D. PROGRAMA NACIONAL DE VIGILANCIA Y CONTROL DE CADMIO EN PRODUCTOS [Internet]. 2016 [cited 2021 Apr 27]. Available from: https://www.invima.gov.co/documents/20143/441038/Documento-tecnico-Cad mio-en-cacao.pdf/36200805-c21d-c444-ee08-47a0f6c8c2302014 09-12 oportunidades de mercado para exportar cacao colombiano [Internet]. [cited 2021 Apr 27]. Available from: https://es.slideshare.net/pasante/2014-0912-oportunidades-de-mercado-paraexportar- cacao-colombianoBolan N, Kunhikrishnan A, Thangarajan R, Kumpiene J, Park J, Makino T, et al. Remediation of heavy metal(loid)s contaminated soils - To mobilize or to immobilize? J Hazard Mater [Internet]. 2014 Feb 15 [cited 2021 Apr 27];266:141–66. Available from: https://pubmed.ncbi.nlm.nih.gov/24394669/Benavides MP, Gallego SM, Tomaro ML. Cadmium toxicity in plants. Brazilian J Plant Physiol [Internet]. 2005 [cited 2021 Apr 27];17(1):21–34. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-0420200500010 0003&lng=en&nrm=iso&tlng=enBrian J. Alloway. Heavy Metals in Soils [Internet]. Alloway BJ, editor. Dordrecht: Springer Netherlands; 2013 [cited 2021 Apr 27]. (Environmental Pollution; vol. 22). Available from: http://link.springer.com/10.1007/978-94-007-4470-7Charania NA, Tsuji LJS, Martin ID, Liberda EN, Coté S, Ayotte P, et al. An examination of traditional foods and cigarette smoking as cadmium sources among the nine First Nations of Eeyou Istchee, northern Quebec, Canada. Environ Sci Process Impacts [Internet]. 2014 [cited 2021 Apr 27];16(6):1422–33. Available from: https://pubmed.ncbi.nlm.nih.gov/24781002/Dunia M, Heredia R. ARTÍCULO DE REVISIÓN Intoxicación ocupacional por metales pesados Occupational poisoning due to heavy metals. MEDISAN. 2017;21(12):3372.E A, N H, IH S, Z J, MH S, LX J. Role of jasmonic acid in improving tolerance of rapeseed (Brassica napus L.) to Cd toxicity. J Zhejiang Univ Sci B [Internet]. 2018 Feb 1 [cited 2021 Oct 15];19(2):130–46. Available from: https://pubmed.ncbi.nlm.nih.gov/29405041/Perales-Aguilar L, Esquivel-Rivera JA, Silos-Espino H, Carrillo-Rodríguez JC, Perales-Segovia C, Perales-Aguilar L, et al. Tolerancia de plantas de zonas áridas a metales pesados. Terra Latinoam [Internet]. 2021 Jan 1 [cited 2021 Oct 15];39. Available from: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0187-577920210 00100108&lng=es&nrm=iso&tlng=esCristaldi A, Oliveri Conti G, Cosentino SL, Mauromicale G, Copat C, Grasso A, et al. Phytoremediation potential of Arundo donax (Giant Reed) in contaminated soil by heavy metals. Environ Res [Internet]. 2020 Jun 1 [cited 2021 Jul 27];185:109427. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S00139 35120303200?via%3DihubCharrupi Riascos N, Carolina Martínez Novoa D. Estudio ambiental del cadmio y su relación con suelos destinados al cultivo de cacao en los departamentos de Arauca y Nariño. 2017 [cited 2021 Oct 15]; Available from: https://ciencia.lasalle.edu.co/ing_ambiental_sanitaria/718Esmeralda P, García P, Isabel M, Cruz A. Rev Esp Méd Quir Volumen 17, Núm. 3, julio-septiembre. Rev Esp Méd Quir [Internet]. 2012 [cited 2021 Oct 15];17(3):199–205. Available from: www.nietoeditores.com.mxMarini M, Angouria-Tsorochidou E, Caro D, Thomsen M. Daily intake of heavy metals and minerals in food – A case study of four Danish dietary profiles. J Clean Prod [Internet]. 2021 Jan 20 [cited 2021 Oct 15];280:124279. Available from: https://www.sciencedirect.com/science/article/pii/S0959652620343249Producto Límite (ppm). 2015 [cited 2021 Oct 15];21. Available from: https://alimentacion-animal.elika.eus/wp-content/uploads/sites/6/2017/12/CAD MIO-2015maquetado.pdfAlengebawy A, Abdelkhalek ST, Qureshi SR, Wang MQ. Heavy metals and pesticides toxicity in agricultural soil and plants: Ecological risks and human health implications. Toxics. 2021;9(3):1–34.Zhang F, Xiao X, Wu X. Physiological and molecular mechanism of cadmium (Cd) tolerance at initial growth stage in rapeseed (Brassica napus L.). Ecotoxicol Environ Saf [Internet]. 2020 Jul 1 [cited 2021 Oct 15];197:110613. Available from: https://www.sciencedirect.com/science/article/pii/S0147651320304528Parlamento Europeo El Consejo De EY. DIRECTIVA 2000/36/CE DEL PARLAMENTO EUROPEO Y DEL CONSEJO de 23 de junio de 2000 relativa a los productos de cacao y de chocolate destinados a la alimentación humana [Internet]. 2000 Jun [cited 2021 Apr 28]. Available from: https://eur-lex.europa.eu/legal-content/Es/TXT/PDF/?uri=CELEX:02000L0036- 20131118&rid=1Del Cacao D. PROGRAMA NACIONAL DE VIGILANCIA Y CONTROL DE CADMIO EN PRODUCTOS. [cited 2021 Aug 20]; Available from: https://www.invima.gov.co/documents/20143/441038/Documento-tecnico-Cad mio-en-cacao.pdf/36200805-c21d-c444-ee08-47a0f6c8c230Manuel Santos Calderón J, Gabriel Uribe J, Soto Carreño Supervisora de consultoría Marcela Bonilla Madriñán A. República de Colombia Ministerio de Ambiente y Desarrollo Sostenible [Internet]. 2012 [cited 2021 Apr 28]. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/INEC/IGUB/ Diagnostico de salud Ambiental compilado.pdfSoto-Benavente M, Rodriguez-Achata L, Olivera M, Sanchez VA, Nano CC, Quispe JG. Health risks due to the presence of heavy metals in agricultural products cultivated in areas abandoned by gold mining in the Peruvian Amazon. Sci Agropecu [Internet]. 2020 Mar 1 [cited 2021 Apr 28];11(1):49–59. Available from: https://www.researchgate.net/publication/340384081_Health_risks_due_to_the _presence_of_heavy_metals_in_agricultural_products_cultivated_in_areas_ab andoned_by_gold_mining_in_the_Peruvian_AmazonCayotopa-Torres J, Arévalo-López L, Pichis-García R, Olivera-Cayotopa D, Rimachi-Valle M, Márquez-Dávila K, et al. Nuevos agentes de biorremediación de cadmio: Especies de Trichoderma nativas de la rizósfera de árboles de cacao. Sci Agropecu [Internet]. 2021 Apr 1 [cited 2021 Oct 15];12(2):155–60. Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2077-9917202100 0200155&lng=es&nrm=iso&tlng=enYadav SK. Heavy metals toxicity in plants: An overview on the role of glutathione and phytochelatins in heavy metal stress tolerance of plants. South African J Bot [Internet]. 2010;76(2):167–79. Available from: http://dx.doi.org/10.1016/j.sajb.2009.10.007Mendez JP, Mendez JP, RamÃrez CAG, Gutiérrez ADR, Garcia FP. PLANT CONTAMINATION AND PHYTOTOXICITY DUE TO HEAVY METALS FROM SOIL AND WATER. Trop Subtrop Agroecosystems [Internet]. 2008 Dec 16 [cited 2021 Apr 28];10(1):19–44. Available from: https://www.revista.ccba.uady.mx/ojs/index.php/TSA/article/view/25Gerhard I, Waibel S, Daniel V, Runnebaum B. Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages. Hum Reprod Update [Internet]. 1998 May [cited 2021 Apr 28];4(3):301–9. Available from: https://pubmed.ncbi.nlm.nih.gov/9741713/Garbisu C, Alkorta I. Basic concepts on heavy metal soil bioremediation. The European Journal of Mineral Processing and Environmental Protection [Internet]. 2003 [cited 2021 Apr 28];3(1):58–66. Available from: https://www.911metallurgist.com/blog/wp-content/uploads/2015/12/Basic-conc epts-on-heavy-metal-soil-bioremediation.pdfpara optar al Título Profesional de Médico Veterinario M. CLAUDIA ISABEL SANTANDER FUENZALIDA PROFESOR GUÍA: LORETO DEL CARMEN MUÑOZ ARENAS. 2007 [cited 2021 Oct 15]; Available from: https://repositorio.uchile.cl/bitstream/handle/2250/131233/Detección-de-cadmi o%2C-mercurio-y-plomo-en-gatos.pdf?sequence=1&isAllowed=yOMS | Cadmio Programa Internacional de Seguridad de las Sustancias Químicas [Internet]. [cited 2021 Apr 28]. Available from: https://www.who.int/ipcs/assessment/public_health/cadmium/es/Sabath E, Robles-Osorio ML. Medio ambiente y riñón: nefrotoxicidad por metales pesados. 2012 [cited 2021 Apr 28];32(3):279–86. Available from: http://www.revistanefrologia.comBustos Viteri KT, Cacuango Gualacata JJ. Identificación molecular de bacterias resistentes a cadmio y cromo aisladas de aguas contaminadas de la zona de Papallacta cantón Quijos de la provincia de Napo. 2017 Jan [cited 2021 Apr 28]; Available from: http://dspace.ups.edu.ec/handle/123456789/13535Kumar A, Subrahmanyam G, Mondal R, Cabral-Pinto MMS, Shabnam AA, Jigyasu DK, et al. Bio-remediation approaches for alleviation of cadmium contamination in natural resources. Chemosphere [Internet]. 2021 Apr 1 [cited 2021 Jul 28];268:128855. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0045653520330538?via %3DihubGeorgescu B, Georgescu C, Dărăban S, Bouaru A, Paşcalău S. Heavy Metals Acting as Endocrine Disrupters [Internet]. Scientific Papers: Animal Science and Biotechnologies. 2011 [cited 2021 Apr 28]. Available from: https://www.usab-tm.ro/utilizatori/ZOOTEHNIE/file/REVISTA 2011/vol 44/2/BIOCHIM/Georgescu.pdfSteliga T, Kluk D. Application of Festuca arundinacea in phytoremediation of soils contaminated with Pb, Ni, Cd and petroleum hydrocarbons. Ecotoxicol Environ Saf [Internet]. 2020 May 1 [cited 2021 Jul 27];194:110409. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S01476 51320302487?via%3DihubBeltrán-Pineda ME, Gómez-Rodríguez AM. Biorremediación de metales pesados cadmio (Cd), cromo (Cr) y mercurio (Hg), mecanismos bioquímicos e ingeniería genética: una revisión. Rev Fac Ciencias Básicas [Internet]. 2016;12(2):172–97. Available from: file:///C:/Users/LENOVO/Downloads/2027-Texto del artículo-6473-1-10-20160901.pdfNwidi I, Agunwamba J. Selection of Biosorbents for Biosorption of Three Heavy Metals in a Flow-Batch Reactor Using Removal Efficiency as Parameter. Niger J Technol [Internet]. 2015 Mar 31 [cited 2021 Apr 28];34(2):406. Available from: https://www.researchgate.net/publication/220039321_Bacterial_Biosorption_of _heavy_metalsXu S, Xing Y, Liu S, Hao X, Chen W, Huang Q. Characterization of Cd2+ biosorption by Pseudomonas sp. strain 375, a novel biosorbent isolated from soil polluted with heavy metals in Southern China. Chemosphere [Internet]. 2020 Feb 1 [cited 2021 Apr 28];240. Available from: https://pubmed.ncbi.nlm.nih.gov/31550585/Ayubb T N, Cerra G A, Chamorro A L, Pérez C A. Resistencia a cadmio (Cd) de bacterias endófitas y bacterias rizosféricas aisladas a partir de Oriza sativa en Colombia. Rev Colomb Cienc Anim - RECIA [Internet]. 2017 Dec 1 [cited 2021 Apr 28];9(2):281. Available from: http://www.recia.edu.coProfesional Agronomía C DE. EFECTO DE TRES SISTEMAS DE MANEJO SOBRE EL CONTENIDO DE CADMIO (Cd) EN LA HOJARASCA Y EN LA CÁSCARA DE CACAO (Theobroma cacao L.) EN SAN ALEJANDRO UCAYALI, PERÚ. [Internet]. 2019 [cited 2021 Apr 28]. Available from: http://repositorio.unu.edu.pe/bitstream/handle/UNU/4229/UNU_AGRONOMIA_ 2019_T_KERVIN-TUESTA.pdf?sequence=1&isAllowed=yPro E. Effects of heavy metals on soil microbial biomass carbon. 2019 [cited 2021 Apr 28]; Available from: http://medcraveonline.comJan M, Shah G, Masood S, Iqbal Shinwari K, Hameed R, Rha ES, et al. Bacillus Cereus Enhanced Phytoremediation Ability of Rice Seedlings under Cadmium Toxicity. Biomed Res Int [Internet]. 2019 [cited 2021 Apr 28];2019. Available from: https://www.hindawi.com/journals/bmri/2019/8134651/Manguilimotan LC, Bitacura JG. Biosorption of Cadmium by Filamentous Fungi Isolated from Coastal Water and Sediments. J Toxicol [Internet]. 2018 [cited 2021 Apr 28];2018. Available from: https://www.hindawi.com/journals/jt/2018/7170510/Ameen FA, Hamdan AM, El-Naggar MY. Assessment of the heavy metal bioremediation efficiency of the novel marine lactic acid bacterium, Lactobacillus plantarum MF042018. Sci Rep [Internet]. 2020 Dec 1 [cited 2021 Apr 28];10(1):1–11. Available from: www.nature.com/scientificreportsSánchez Barrón G, Sánchez Barrón G. Ecotoxicología del cadmio riesgo para la salud de la utilización de suelos ricos en cadmio. 2016 [cited 2021 Apr 28]; Available from: https://eprints.ucm.es/id/eprint/50902/Mauricio R, Beltran S, De G, De Biorremediación M, La P, De R. GUÍA DE MÉTODOS DE BIORREMEDIACIÓN PARA LA RECUPERACIÓN DE SUELOS CONTAMINADOS POR HIDROCARBUROS [Internet]. 2013 [cited 2021 Apr 28]. Available from: https://repository.unilibre.edu.co/bitstream/handle/10901/10607/TRABAJO FINAL cd.pdf?sequence=1Marrero-Coto J, Díaz-Valdivia A, Coto-Pérez O. Mecanismos moleculares de resistencia a metales pesados en las bacterias y sus aplicaciones en la biorremediación [Internet]. Vol. 41, Revista CENIC Ciencias Biológicas. 2016 [cited 2021 Apr 28]. Available from: https://revista.cnic.edu.cu/index.php/RevBiol/article/view/609Apaza-Aquino H, Valencia MREV. EFICIENCIA DE LA BIOMASA DE RHIZOPUS SP EN LA REMOCIÓN DE CADMIO (II). Rev Investig la Esc Posgrado la UNA PUNO [Internet]. 2020 Oct 31 [cited 2021 Jul 27];9(4):1805–16. Available from: http://revistas.unap.edu.pe/epg/index.php/investigaciones/article/view/2288Cuba C, Rubio OE, Zamora M, Hernández Baranda AM;, Cabrera Rodríguez Y;, Guridi JA;, et al. EFECTOS DE LA APLICACIÓN DE UNA MEZCLA DE OLIGOGALACTURÓNIDOS SOBRE UN SUELO CONTAMINADO CULTIVADO CON PLÁNTULAS DE TOMATE. Cultiv Trop [Internet]. 2016 [cited 2021 Apr 28];37:160–7. Available from: http://dx.doi.org/10.13140/RG.2.2.20663.52642Álvarez Calvo ML. Tratamiento de suelos contaminados por metales mediante combinación de técnicas de fitorremediación con adición de biochar [Internet]. Universidad Politécnica de Madrid; 2019 [cited 2021 Apr 27]. Available from: http://oa.upm.es/55865/Xu C, He S, Liu Y, Zhang W, Lu D. Bioadsorption and biostabilization of cadmium by Enterobacter cloacae TU. Chemosphere [Internet]. 2017 Apr 1 [cited 2021 Jul 27];173:622–9. Available from: https://www.sciencedirect.com/science/article/abs/pii/S004565351730005X?ca sa_token=QhUhq_NtpRIAAAAA:cgmhnTBapnTo4Ww46kPh7-s9jrAMSoq_RxS iZz2uU2O2ATizpskBE2bvFMqFjfiWoxv3kYOu6B0Moreno-Sánchez R, Rodríguez-Enríquez S, Jasso-Chávez R, Saavedra E, García-García JD. Biochemistry and Physiology of Heavy Metal Resistance and Accumulation in Euglena. Adv Exp Med Biol [Internet]. 2017 [cited 2021 Jul 27];979:91–121. Available from: https://link-springer-com.ez.unisabana.edu.co/chapter/10.1007/978-3-319-549 10-1_6Motamayor JC, Risterucci AM, Lopez PA, Ortiz CF, Moreno A, Lanaud C. Cacao domestication I: The origin of the cacao cultivated by the Mayas. Heredity (Edinb) [Internet]. 2002 Nov 28 [cited 2021 Apr 27];89(5):380–6. Available from: www.nature.com/hdyYang Z, Shi W, Yang W, Liang L, Yao W, Chai L, et al. Combination of bioleaching by gross bacterial biosurfactants and flocculation: A potential remediation for the heavy metal contaminated soils. Chemosphere [Internet]. 2018 Sep 1 [cited 2021 Jul 27];206:83–91. Available from: https://www.sciencedirect.com/science/article/abs/pii/S004565351830821X?ca sa_token=3m1qBRwwDGwAAAAA:xJh9Td_ncRcO69fljJsEer-vjtLI41vYHxqdG f8Fa7DbUN4PfrZ3At-4jQa9lKR_OJ-f8nG1QGwMaldaner J, Steffen GPK, Missio EL, Saldanha CW, Morais RM de, Nicoloso FT. Tolerance of Trichoderma isolates to increasing concentrations of heavy metals. https://doi-org.ez.unisabana.edu.co/101080/0020723320201778290 [Internet]. 2020 [cited 2021 Jul 27];78(2):1–13. Available from: https://www-tandfonline-com.ez.unisabana.edu.co/doi/abs/10.1080/00207233. 2020.1778290Pons ML, Collin B, Doelsch E, Chaurand P, Fehlauer T, Levard C, et al. X-ray absorption spectroscopy evidence of sulfur-bound cadmium in the Cd-hyperaccumulator Solanum nigrum and the non-accumulator Solanum melongena. Environ Pollut [Internet]. 2021 Jun 15 [cited 2021 Jul 27];279:116897. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S02697 49121004796?via%3Dihub#sec1Albert Q, Leleyter L, Lemoine M, Heutte N, Rioult JP, Sage L, et al. Comparison of tolerance and biosorption of three trace metals (Cd, Cu, Pb) by the soil fungus Absidia cylindrospora. Chemosphere [Internet]. 2018 Apr 1 [cited 2021 Jul 27];196:386–92. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S00456 53517321343?via%3DihubKortenkamp A. 12. Are Cadmium and Other Heavy Metal Compounds Acting as Endocrine Disrupters? In: Metal ions in life sciences [Internet]. Met Ions Life Sci; 2010 [cited 2021 Apr 28]. p. 305–17. Available from: http://ebook.rsc.org/?DOI=10.1039/9781849732116-00305Lizandra Pérez Bou ISB. Biosorción microbiana de metales pesados: características del proceso / Biosorption of heavy metals: characteristics of the process | Pérez Bou | Revista Cubana de Ciencias Biológicas [Internet]. Vol. 6, Núm. 1. 2018 [cited 2021 Aug 20]. Available from: http://www.rccb.uh.cu/index.php/RCCB/article/view/216Galman JL, Slabu I, Weise NJ, Iglesias C, Parmeggiani F, Lloyd RC, et al. Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases. Green Chem [Internet]. 2017 Jan 23 [cited 2021 Oct 18];19(2):361–6. Available from: https://pubs.rsc.org/en/content/articlehtml/2017/gc/c6gc02102fLi X, Li D and bioaccumulation characteristics of cadmium by plant growth-promoting rhizobacteria, Yan Z, Ao Y. Biosorption and bioaccumulation characteristics of cadmium by plant growth-promoting rhizobacteria. RSC Adv [Internet]. 2018 Aug 30 [cited 2021 Jul 27];8(54):30902–11. Available from: https://pubs.rsc.org/en/content/articlehtml/2018/ra/c8ra06270fBahobil A, Bayoumi RA, Atta HM, El-Sehrawey MM. Fungal Biosorption for Cadmium and Mercury Heavy Metal Ions Isolated from Some Polluted Localities in KSA. IntJCurrMicrobiolAppSci [Internet]. 2017 [cited 2021 Oct 18];6(6):2138–54. Available from: https://doi.org/10.20546/ijcmas.2017.606.253Costa F, Tavares T. Biosorption of nickel and cadmium in the presence of diethylketone by a Streptococcus equisimilis biofilm supported on vermiculite. Int Biodeterior Biodegrad [Internet]. 2016 Nov 1 [cited 2021 Oct 18];115:119–32. Available from: https://www.semanticscholar.org/paper/Biosorption-of-nickel-and-cadmium-in-t he-presence-a-Costa-Tavares/ce875673996b4232da58f543e83786da6109157 cBras. Carla Mendieta Webster y Katerine Taisigüe Lóp. Acumulación y traslocación de metales, metaloides y no metales en plantas nativas de la zona minera de Chontales: Implicaciones para el potencial de fito-remediación [Internet]. 2014 [cited 2021 Oct 15]. Available from: https://biorem.univie.ac.at/fileadmin/user_upload/p_biorem/education/research /methods/Accumulation-and-Translocation-metals-in-native-plants_Extended-a bstract.pdfOlaniran AO, Balgobind A, Pillay B. Bioavailability of heavy metals in soil: Impact on microbial biodegradation of organic compounds and possible improvement strategies. Int J Mol Sci [Internet]. 2013 [cited 2021 Apr 27];14(5):10197–228. Available from: /pmc/articles/PMC3676836/Yang Z, Zhang Z, Chai L, Wang Y, Liu Y, Xiao R. Bioleaching remediation of heavy metal-contaminated soils using Burkholderia sp. Z-90. J Hazard Mater [Internet]. 2016 Jan 15 [cited 2021 Jul 27];301:145–52. Available from: https://www.sciencedirect.com/science/article/abs/pii/S030438941530039XHaider FU, Liqun C, Coulter JA, Cheema SA, Wu J, Zhang R, et al. Cadmium toxicity in plants: Impacts and remediation strategies. Ecotoxicol Environ Saf. 2021 Mar 15;211:111887.Muñoz-Silva L, Olivera-Gonzales P, Santillán Torres M, Tamariz-Angeles C. Microorganismos tolerantes a metales pesados del pasivo minero Santa Rosa, Jangas (Perú). Rev Peru Biol [Internet]. 2019 [cited 2021 Oct 15];26(1):109–18. Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1727-9933201900 0100013&lng=es&nrm=iso&tlng=esArambawatta-Lekamge SH, Pathiratne A, Rathnayake IVN. Sensitivity of freshwater organisms to cadmium and copper at tropical temperature exposures: Derivation of tropical freshwater ecotoxicity thresholds using species sensitivity distribution analysis. Ecotoxicol Environ Saf. 2021 Mar 15;211.Garzón JM, Pablo Rodríguez-Miranda J, Org O. Aporte de la biorremediación para solucionar problemas de contaminación y su relación con el desarrollo sostenible Contribution of bioremediation to solve pollution problems and its relationship with sustainable development. [cited 2021 Apr 27]; Available from: http://dx.doi.org/10.22267/rus.171902.93Ashrafzadeh S, Leung DWM. Development of Cadmium-Safe Crop Cultivars: A Mini Review. J Crop Improv. 2016 Mar 3;30(2):107–17.Correa García C, Correa García C. Ecotoxicología del cadmio, riesgo para la salud por la utilización de suelos ricos en cadmio. 2016 [cited 2021 Apr 28]; Available from: https://eprints.ucm.es/id/eprint/49137/Rizwan M, Ali S, Zia ur Rehman M, Rinklebe J, Tsang DCW, Bashir A, et al. Cadmium phytoremediation potential of Brassica crop species: A review. Sci Total Environ [Internet]. 2018 Aug 1 [cited 2021 Apr 28];631–632:1175–91. Available from: https://pubmed.ncbi.nlm.nih.gov/29727943/P.S C, Sanyal D, Dasgupta S, Banik A. Cadmium biosorption and biomass production by two freshwater microalgae Scenedesmus acutus and Chlorella pyrenoidosa: An integrated approach. Chemosphere [Internet]. 2021 Apr 1 [cited 2021 Apr 28];269:128755. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0045653520329532?via %3DihubRicardo Israel Ramírez Gottfried1, Mario García Carrillo1§, Vicente de Paul Álvarez Reyna1, Guillermo González Cervantes2, Vicente Hernández Hernández1. Potencial fitorremediador de la chicura (Ambrosia ambrosioides) en suelos contaminados por metales pesados - Dialnet. 2019 [cited 2021 Jul 27];10(7):1529–40. Available from: https://dialnet.unirioja.es/servlet/articulo?codigo=7152652Manousaki E, Kalogerakis N. Phytoextraction of Pb and Cd by the Mediterranean saltbush (AtripLex halimus L.): Metal uptake in relation to salinity. Environ Sci Pollut Res [Internet]. 2009 Nov [cited 2021 Oct 15];16(7):844–54. Available from: https://pubmed.ncbi.nlm.nih.gov/29727943/UVM P. METODOLOGIA DE LA INVESTIGACION DISENO Y EJECUCION [Internet]. 2011 [cited 2021 Apr 28]. Available from: https://www.academia.edu/35258714/METODOLOGIA_DE_LA_INVESTIGACI ON_DISENO_Y_EJECUCIONInvestigación cuantitativa y cualitativa. 2002 [cited 2021 Apr 28]; Available from: http://www.fisterra.com/mbe/investiga/cuanti_cuali/cuanti_cuali.aspRoberto Hernández, Carlos Fernández Collado, Pilar Baptista Lucio. Metodología de la Investigación [Internet]. 2014 [cited 2021 Apr 28]. Available from: https://academia.utp.edu.co/grupobasicoclinicayaplicadas/files/2013/06/Metod ología-de-la-Investigación.pdfMaría L, Dulzaides Iglesias1 E, María LA, Gómez1 M. Análisis documental y de información: dos componentes de un mismo proceso. 2004 [cited 2021 Apr 28]; Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1024-94352004000200 011El análisis de contenido como herramienta de utilidad para la realización de una investigación descriptiva. Un ejemplo de aplicación práctica utilizado para conocer las investigaciones realizadas sobre la imagen de marca de España y el efecto país de origen [Internet]. 2013 [cited 2021 Apr 28]. Available from: https://www.redalyc.org/pdf/555/55530465007.pdfColectiva S, Aires B. Los lenguajes de indización en e-Salud: su aplicación a los documentos sobre trastornos de la conducta alimentaria Indexing languages in e-Health: applications for documents about eating disorders [Internet]. Vol. 7, Octubre. 2011 [cited 2021 Apr 28]. Available from: https://www.scielosp.org/article/scol/2011.v7suppl1/S61-S69/es/Zeng T, Liang Y, Chen J, Cao G, Yang Z, Zhao X, et al. Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure. Environ Int [Internet]. 2021 Sep 1 [cited 2021 Aug 20];154:106646. Available from: https://www.sciencedirect.com/science/article/pii/S0160412021002713Bolan N, Kunhikrishnan A, Thangarajan R, Kumpiene J, Park J, Makino T, et al. Remediation of heavy metal(loid)s contaminated soils – To mobilize or to immobilize? J Hazard Mater. 2014 Feb 15;266:141–66.Munive Cerrón R, Loli Figueroa O, Azabache Leyton A, Gamarra Sánchez G. Fitorremediación con Maíz (Zea mays L.) y compost de Stevia en suelos degradados por contaminación con metales pesados. Sci Agropecu [Internet]. 2018 Dec 31 [cited 2021 Jul 27];9(4):551–60. Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2077-9917201800 0400011&lng=es&nrm=iso&tlng=esKumar R, Sharma P, Umar A, Kumar R, Singh N, Joshi PK, et al. In Vitro Bioadsorption of Cd 2+ Ions: Adsorption Isotherms, Mechanism, and an Insight to Mycoremediation. 1085 [cited 2021 Oct 18];8. Available from: www.mdpi.com/journal/processesLi K, Cao C, Ma Y, Su D, Li J. Identification of cadmium bioaccumulation in rice (Oryza sativa L.) by the soil-plant transfer model and species sensitivity distribution. Sci Total Environ [Internet]. 2019 Nov 20 [cited 2021 Jul 27];692:1022–8. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S00489 69719332048?via%3Dihub#s0005Choińska-Pulit A, Sobolczyk-Bednarek J, Łaba W. Optimization of copper, lead and cadmium biosorption onto newly isolated bacterium using a Box-Behnken design. Ecotoxicol Environ Saf [Internet]. 2018 Mar 1 [cited 2021 Jul 27];149:275–83. Available from: https://www-sciencedirect-com.ez.unisabana.edu.co/science/article/pii/S01476 51317308369?via%3DihubJ R-Z, S G, C M-B, R N, CA N, A P, et al. Response of the biomining Acidithiobacillus ferrooxidans to high cadmium concentrations. J Proteomics [Internet]. 2019 Apr 30 [cited 2021 Jul 27];198:132–44. Available from: https://pubmed.ncbi.nlm.nih.gov/30553947/Brito JP, Ramada MH, de Magalhães MT, Silva LP, Ulhoa CJ. Peptaibols from Trichoderma asperellum TR356 strain isolated from Brazilian soil. SpringerPlus 2014 31 [Internet]. 2014 Oct 13 [cited 2021 Oct 18];3(1):1–10. Available from: https://springerplus.springeropen.com/articles/10.1186/2193-1801-3-600Kumar A, Subrahmanyam G, Mondal R, Cabral-Pinto MMS, Shabnam AA, Jigyasu DK, et al. Bio-remediation approaches for alleviation of cadmium contamination in natural resources. Chemosphere [Internet]. 2021;268(November). Available from: https://www.researchgate.net/publication/345087752_Bio-remediation_approa ches_for_alleviation_of_cadmium_contamination_in_natural_resourcesCely Torres LA. Oferta productiva del cacao colombiano en el posconflicto. Estrategias para el aprovechamiento de oportunidades comerciales en el marco del acuerdo comercial Colombia-Unión Europea. Equidad y Desarro [Internet]. 2017 Jul 5 [cited 2021 Apr 27];1(28):167–95. 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Unicolmayorrepositorio@unicolmayor.edu.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