Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura
Los aceites esenciales (AE), son compuestos complejos los cuales están formados por metabolitos secundarios que se producen por reacciones químicas de compuestos derivados del metabolismo primario de las plantas, estos aceites esenciales han sido ampliamente usados en diferentes industrias, como en...
- Autores:
-
Gil Hoyos, Laura Carolina
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2018
- Institución:
- Colegio Mayor de Cundinamarca
- Repositorio:
- Repositorio Colegio Mayor de Cundinamarca
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicolmayor.edu.co:unicolmayor/3651
- Acceso en línea:
- https://repositorio.unicolmayor.edu.co/handle/unicolmayor/3651
- Palabra clave:
- Metabolitos
Reacciones químicas
Metabolismo
Bacterias
Aceites esenciales
Resistencia bacteriana
Antimicrobiano
- Rights
- closedAccess
- License
- Universidad Colegio Mayor de Cundinamarca, 2018
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dc.title.spa.fl_str_mv |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
title |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
spellingShingle |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura Metabolitos Reacciones químicas Metabolismo Bacterias Aceites esenciales Resistencia bacteriana Antimicrobiano |
title_short |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
title_full |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
title_fullStr |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
title_full_unstemmed |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
title_sort |
Uso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literatura |
dc.creator.fl_str_mv |
Gil Hoyos, Laura Carolina |
dc.contributor.advisor.none.fl_str_mv |
Acero Godoy, Jovanna Acero |
dc.contributor.author.none.fl_str_mv |
Gil Hoyos, Laura Carolina |
dc.contributor.corporatename.spa.fl_str_mv |
Universidad Colegio Mayor de Cundinamarca |
dc.subject.lem.none.fl_str_mv |
Metabolitos |
topic |
Metabolitos Reacciones químicas Metabolismo Bacterias Aceites esenciales Resistencia bacteriana Antimicrobiano |
dc.subject.lemb.none.fl_str_mv |
Reacciones químicas Metabolismo Bacterias |
dc.subject.proposal.spa.fl_str_mv |
Aceites esenciales Resistencia bacteriana Antimicrobiano |
description |
Los aceites esenciales (AE), son compuestos complejos los cuales están formados por metabolitos secundarios que se producen por reacciones químicas de compuestos derivados del metabolismo primario de las plantas, estos aceites esenciales han sido ampliamente usados en diferentes industrias, como en la alimentaria, donde su mayor uso ha sido como preservante de los mismos. Otra de las utilidades que se les ha dado tiene que ver con sus propiedades medicinales ya que desde hace muchos años las plantas se han usado en comunidades donde el acceso a la medicina convencional es limitado y debido a la creciente problemática mundial del desarrollo y diseminación de resistencias a los antibióticos por parte de las bacterias ha sido necesario recurrir a nuevas alternativas para controlar su actividad. Es por ello por lo que se han realizado muchos estudios en diferentes partes del mundo donde se ha evidenciado la amplia actividad antibacteriana que tienen los aceites esenciales contra bacterias patógenas para los humanos y causantes de frecuentes enfermedades como la E. coli, P. mirabilis, S. typhi, P. aeruginosa, S, aureus y L. monocytogenes entre otras. Estos compuestos con actividad antimicrobiana se pueden extraer de diferentes partes de la planta y por medio de diferentes métodos por ejemplo uno de los mas usados es la destilación con vapor la cual es ampliamente utilizada en producciones comerciales a escala. |
publishDate |
2018 |
dc.date.issued.none.fl_str_mv |
2018-11 |
dc.date.accessioned.none.fl_str_mv |
2021-11-12T21:04:02Z |
dc.date.available.none.fl_str_mv |
2021-11-12T21:04:02Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/TP |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_7a1f |
status_str |
publishedVersion |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unicolmayor.edu.co/handle/unicolmayor/3651 |
dc.identifier.barcode.none.fl_str_mv |
58648 |
url |
https://repositorio.unicolmayor.edu.co/handle/unicolmayor/3651 |
identifier_str_mv |
58648 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
Rolain JM, Abat C, Jimeno MT, Fournier PE and Raoult D. Do we need new antibiotics? Clinical Microbiology and Infection. 2016 May; Vol. 22 N° 5 Organización Mundial de la Salud. Resistencia a los antibióticos. Informe mensual. Febrero 2018. Disponible en: www.who.int/es/news-room/factsheets/detail/resistencia-a-los-antibióticos Organización Panamericana de la Salud/ Organización Mundial de la Salud. Alerta epidemiológica: Enterobacterias con resitencia transferible a colistina, implicaciones para la salud pública en las Américas, 10 de junio de 2016, Washington, D.C. OPS/OMS 2016 Fair RJ and Tor Y. Antibiotics and Bacterial Resistance in the 21st Century. Perspectives in Medicinal Chemistry. 2014:6 25–64 doi: 10.4137/PMC.S14459 Djilani A and Dicko A. The therapeutic benefits of essential oils. Nutrition. 2012 155-178 Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils – a review. Food Chem. Toxicol. 2008;46 446–475 Sokovic M, Marin P, Brkic D, van Griensven L. Chemical composition and antibacterial activity of essential oils of ten aromatic plants against human pathogenic bacteria. Global Science. 2008 Zhang Z, Vriesekoop F, Yuan Q and Liang H. Effects of nisin on the antimicrobial activity of D-limonene and its nanoemulsion. Food chemistry. 2014;150 307-312 Ghalem B and Mohamed B. Antibacterial activity of leaf essential oils of Eucalyptus globuslus and Eucalyptus camaldulensis. African journal of pharmacy and pharmacology. 2008;2 211-215 Oke F, Aslim B, Ozturk S and Altundag A. Essential oil composition, antimicrobial and antioxidant activities of Satureja cuneifolia Ten. Food Chem. 2009;112 874-87 Cao L, Si JY, Liu Y, Sun H, Jin W, Li Z, Zhao XH, Pan RL. Essential oil composition, antimicrobial and antioxidant properties of Mosla chinensis Maxim. Food Chemistry. 2009;115, 801–805 Naz S, Jabeen S, Ilyas S, Manzoor F, Aslam F and Ali A. Antibacterial activity of Curcuma longa varieties against different strains of bacteria. Pakistan Journal Botanic. 2010;42 455-462 Galvao LC, Furletti VF, Bersan SM, Da Cunha MG, Ruiz AL, Carvalho JE, Sartoratto A, Rehder VL, Figueira GM, Teixeira Duarte MC, Ikegaki M, DeAlencar SM, Rosalen PL. Antimicrobial activity of essential oils against Streptococcus mutans and their antiproliferative effects. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 751435 doi:10.1155/2012/751435 Abdelhady MI and Aly HAH. Antioxidant antimicrobial activities of Callistemon comboynensis essential oil. Free Radic Antioxidants. 2012;2 37–41 .Teixeira B, Marques A, Ramos C, Neng N, Nogueira J, Saraiva JA and Nunes ML. Chemical composition and antibacterial and antioxidant properties of comercial essential oils. Industrial crops and products. 2013;43 587-595 Portilho S, Araujo M, Ferreira P, Bertolaccini B, Alkmim A, Masako L, Francescato D. Antibacterial activity of Melaleuca sp.oil against clinical isolates of antibiotics resistant Staphylococcus aureus. Acta cirurgica brasileira. 2015;30 .Kacem N, Roumy V, Duhal N, Merouane F, Neut C, Christen P, Hostettmann K, Rhouati S. Chemical composition of the essential oil from Agerian Genista quadriflora Munby and determination of its antibacterial and antifungal activities. Industrial crops and products. 2016;90 87-93 Carneiro N, Alves C, Alves J, Egea M, Martins C, Silva T, Bretanha L, Balleste M, Micke G, Silveira E, Miranda M. Chemical composition, antioxidant and antibacterial activities of essential oils from leaves and flowers of Eugenia klotzschiana Berg (Myrtaceae). Anais da academia brasileira de ciencias. 2017;89 Al-Aamri M, Al-Abousi M, Al-Jabri S, Alam T and Khan S. Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman. Journal of taibah university medical sciences. 2018;13 108-112 Pírez M and Mota M. Temas de bacteriología y virología médica. Morfología y estructura bacteriana. Pág. 23-42 Saga T and Yamaguchi K. History of antimicrobial agents and resistant bacteria. JMAJ. 2009;52 103-108 Kapoor G, Saigal,S, and Elongavan A. Action and resistance mechanisms of antibiotics: A guide for clinicians. Journal of Anaesthesiology Clin. Pharmacol. 2017 Jul-Sep; 33(3): 300–30 Etebu E and Arikekpar I. Antibiotics: Classification and mechanisms of action with emphasis on molecular perspectives. Interinational Journal of Applied Microbiology and Biotechnology Research. 2016;90-101 Rolain JM, Abat C, Jimeno MT, Fournier PE and Raoult D. Do we need new antibiotics? Clinical Microbiology and Infection. 2016 May; Vol. 22 N° 5 Park JT and Uehara T. How bacteria consume their own exoskeleton (turnover and recycling of cell wall-peptidoglycan). Microbiology Molecular Biology. 2008;72 211-227 .Falagas ME, Rafailidis PI and Matthaiou DK. Resistance to polymyxins: Mechanisms, frequency and treatment options. Drug Resistance Update. 2010;13 132-138 Kohanski MA, Dwyer DJ and Collins JJ. How antibiotics kill bacteria: from targets to networks. Nat. Rev. Microbiol. 2010;8 423-435 Hong W, Zeng J and Xie J. Antibiotic drugs targeting bacterial RNAs. Acta Pharm. Sin B. 2014;4 258-265 Kang HK and Park Y. Glycopeptide antibiotics: Structure and mechanism of action. Journal Bacteriol. Virology. 2015;45 67-78. Appelbaum PC, Potential for the start of a second pre-antibiotic era? Journal Antimicrobiotic Chemother. 2012;67(9):2062–8 Fair RJ and Tor Y. Antibiotics and Bacterial Resistance in the 21st Century. Perspectives in Medicinal Chemistry. 2014:6 25–64 doi: 10.4137/PMC.S14459 .Piddock LJ. Multidrug-resistance efflux pumps — not just for resistance. Nature Rev. Microbiol. 2008;4 629–636 van Veen HW. Structural biology: last of the multidrug transporters. Nature. 2010;467 926–927 Ramirez MS and Tolmasky ME. Aminoglycoside modifying enzymes. Drug Resistance Update. 2010;13 151–171 Wilson DN. Ribosome-targeting antibiotics and mechanisms of bacterial resistance. Nature. 2014;12 35-48 Giedraitiene A, Vitkauskiene A, Naginiene R and Pavilonis A. Antibiotic Resistance Mechanisms of Clinically Important Bacteria. Medicina (Kaunas). 2011;47(3);137-46 .Davies J, and Davies D. Origins and Evolution of Antibiotic Resistance. Microbiology and Molecular Biology Reviews. 2010;74(3) 417–433 Efferth T and Koch E. Complex interations between phytochemicals. The multi-target therapeutic concept of phytotherapy. Current drug targets. 2011;12 122-132 .Hounsome N, Hounsome B, Tomos D and Edwards-Jones G. Plant metabolites and nutritional quality of vegetables. Journal of food science. 2008;73 48-65.Hounsome N, Hounsome B, Tomos D and Edwards-Jones G. Plant metabolites and nutritional quality of vegetables. Journal of food science. 2008;73 48-65 .Ávalos A, Perez-Urrutia E. Metabolismo secundario de plantas. Reduca. 2009;3 119-145 Raut JS, Karuppayil SM. A status review on the medicinal properties of essential oils. Industrial Crops and Products. 2014;62 250-264 Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils – a review. Food Chem. Toxicol. 2008;46 446–475 Vigan, M. Essential oils: renewal of interest and toxicity. Eur. Journal Dermatological 2010;20, 685–692. Hammer KA, Carson CF, Riley TV and Nielsen JB. A review of the toxicity of Melaleuca alternifolia (tea tree) oil. Food Chemistry Toxicology. 2008;44,616–625. Cao L, Si JY, Liu Y, Sun H, Jin W, Li Z, Zhao XH, Pan RL. Essential oil composition, antimicrobial and antioxidant properties of Mosla chinensis Maxim. Food Chemistry. 2009;115, 801–805 Galvao LC, Furletti VF, Bersan SM, Da Cunha MG, Ruiz AL, Carvalho JE, Sartoratto A, Rehder VL, Figueira GM, Teixeira Duarte MC, Ikegaki M, DeAlencar SM, Rosalen PL. Antimicrobial activity of essential oils against Streptococcus mutans and their antiproliferative effects. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 751435 doi:10.1155/2012/751435 Lang G and Buchbauer G. A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals: a review. Flavour and Fragrance Journal. 2012;27 13–39 Abdelhady M and Aly H. Antioxidant anticrobial activities of Callistemon comboynensis essential oil. Free radicals and antioxidants. 2012;2 37-41 Aguirre A, Borneo R and León AE. Antimicrobial, mechanical and barrier properties of triticale protein films incorporated with oregano essential oil. Food Biosci. 2013;1 2–9 Simoes M, Bennett RN and Rosa EA. Understanding antimicrobial activities of phytochemicals against multidrug resistance bacteria and biofilms. Nature product reports. 2009;26 746-757 Ncube NS, Afolayan AJ and Okoh AI. Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends. African journal of biotechnology. 2008;7 1797 .Ramirez L and Marin D. Metodologias para evaluar in vitro la actividad antibacteriana de compuestos de origen vegetal. Scientia et technica. 2009;42 263-268 Tongnuanchan P and Benjakul S. Essential oils: Extraction, bioactivities, and treir uses for food preservation. Journal of Food Science. 2014;79 7 1231-1249 Okoh OO, Sadimenko AP, Afolayan AJ. Comparative evaluation of the antibacterial activities of the essential oils of Rosmarinus officinalis L. obtained by hydrodistillation and solvent free microwave extraction methods. Food Chemistry. 2010;120 308-312 Vian MA, Fernandez X, Visinoni F, Chemat F. Microwave hydrodiffusion and gravity, a new technique for extraction of essential oils. Journal of Chromatography A. 2008;1190 14–17 Li XM, Tian SL, Pang ZC, Shi JY, Feng ZS, Zhang YM. Extraction of Cuminumcyminum essential oil by combination technology of organic solvent with low boiling point and steam distillation. Food Chemistry. 2009;115 1114–1119 .Gironi F and Maschietti M. Continuous countercurrent deterpenation of lemon essential oil by means of supercritical carbon dioxide: experimental data and process modelling. Chemical Engineering Science. 2008;63 651– 661 Costagli G and Betti M. Avocado oil extraction processes: method for coldpressed high-quality edible oil production versus traditional production. Journal of agricultural engineering. 2015;46 115-122 .Al-Aamri M, Al-Abousi M, Al-Jabri S, Alam T and Khan S. Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman. Journal of taibah university medical sciences. 2018;13 108-112 .Gaviria M, Quijano C, Pino J, Madriñan S. Chemical composition and antibacterial activity of the essential oil of Drimys granadensis L.f. leaves from Colombia. Chemistry and biodiversity. 2011;8 532-539 Bueno-Sanchez J, Martinez-Morales J, Stashenko E. Actividad antimicobacteriana de terpenos. Bol Latinoam Caribe Plant Med Aromat. 2009;41 231-235 .Reina J, Reina N. Fagoterapia ¿una alternativa a la antibioticoterapia?. Rev esp quimioter. 2018;31 101-104 Gorski A, Miedzybrodzi R, Weber-Dabrowska B, Fortuna W, Letkiewicz S and Rogoz P. Phage therapy: combating infections with potential for evolving from merely a treatment for complications to targeting diseases. Front microbiology. 2016;7 1515 Kingwell K. Bacteriophage therapies re-enter clinical trials. Nat rev drug discov. 2015;14 515 Cooper RA, Bjarnsholt T and Alhede M. Biofilms in wounds: a review of present knowledge. Jornal wound care. 2014;23 570-580 Rather M, Dar B, Dar M, Wani B, Shah W, Bhat B, Ganai B, Bhat K, Anand R and Qurishi M. Chemical composition, antioxidant and antibacterial activities of the leaf essential oil of Junglans regia L. and its constituents. Phytomedice. 2012;19 1185-1190 Sharma P, Ravikumar G, Kalaiselvi M, Gomathi D and Uma C. In vitro antibacterial and free radical scavenging activity of green hull of Junglans regia. Journal of pharmaceutical Analysis, 2013;3 298-302 Settanni L, Palazzolo E, Guarrasi V, Aleo A, Mammina C, Moschetti G and Germana MA. Inhibition of foodborne pathogen bacteria by essential oils extracted from citrus fruits cultivated in Sicily. Food control. 2012;26 326- 330 Carramiñana JJ, Rota C, Burillo J and Herrera A. Antibacterial efficiency of Spanish Santureja montana essential oil against Listeria monocytogenes among natural flora in minced pork. Journal of food protection. 2008;71 502- 50 Zaouali Y, Bouzaine T and Boussaid M. Essential oils composition in two Rosmarinus officinalis L. varieties and incidence for antimicrobial an antioxidant activities. Food and chemical Toxicology. 2010;48 3144-3152 Cuellar A and Hussein R. Evaluation of the yield and the antimicrobial activity of the essential oils from: Eucalyptus globulus, Cymbopogon citratus and Rosmarinus officinalis in Mbarara district (Uganda). Revista colombiana cienc. Anim. 2009;1 Akin M, Aktumsek A and Nostro A. Antibacterial activity and composition of the essential oils of Eucalyptus camaldulensis Dehn. And Myrtus communis L. growing in Northern Cyprus. African journal of biotechnology. 2010;9 531- 53 Naik M, Fomda B, Jaykumar E, Bhat J. Antibacterial activity of lemongrass (Cymbopogon citratus) oil against some selected pathogenic bacterias. Asia pacific journal of tropical medice. 2010 535-538 Bassole IHN, Lamien-Meda A, Bayala B, Obame LC, Ilboudo AJ, Franz, Novak J, Nebie RC and Dicko MH. Chemical composition and antimicrobial activity of Cymbopogon citratus and Cymbopogon giganteus essential oils alone and in combination. Phytomedicine. 2011;18 1070-1074 Oliveira RA, Moreira IS and Oliveira FF. Linalol and methyl chavicol present basil (Ocimum sp) cultivated in Brazil. Rev. Bras. PI. Med. 2013;15 309-311 Sahib NG, Anwar F, Gilani A, Hamid A, Saari N and Alkharfy K. Coriander (Coriander sativum L.): A potential source of high-value components for funtional foods and nutraceuticals-a review. Phytotherapy research. 2012;27 1439-1456 7.Roldan L, Diaz G, Duringer J. Composition and antibacterial activity of essential oils obteined from plants of the Lamiaceae family against pathogenic and beneficial bacteria. Revista colombiana de ciencias pecuarias. 2010; 23 451-461 Oyedemi SO, Okoh AI, Mabinya LV, Pirochenva G, Afolayan AJ. The proposed mechanism of bactericidal action of eugenol, _-terpineol and _- terpinene against Listeria monocytogenes, Streptococcus pyogenes, Proteus vulgaris and Escherichia coli. Afric. Journal Biotechnol. 2009;8 1280–1286 Wang W, Li N, Luo M, Zu Y and Effeth T. Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to thet of its main components. Molecules. 2012;17 Nordmann P. Carbapenemase-producing enterobacteriaceae: overview of a major public health challege. Medecine et maladies infectieuses. 2014;44 51-56 Chanthaphon S, Chanthachum S and Honhpattarakere T. Antimicrobial activities of essential oils crude extracts from tropical Citrus spp. Against food-related microorganisms. Songklanakarin journal of science and technology. 2008;1 125-13 Imelouane B, Amhamdi H, Wathelet JP, Ankit M and Bachiri A. Chemical composition and antimicrobial activity of essential oil of thyme (Thymus vulgaris) from eastern Morocco. International journal of agricultura and biology. 2009;11 205-208 Moussaoui F, Alaoui T. Evaluation of antibacterial activity and synergistic affect between antibiotic and the essential oils of some medicinal plants. Asian pacific journal of tropical biomedicine. 2016;6 32-37 Ruiz-Navajas Y, Viuda-Martos M, Sendra E, Perez-Alvarez JA, FernandezLopez J. In vitro antibacterial and antioxidant properties of chitosan edible films incorporated with Thymus moroderi or Thymus piperella essential oils. Food control. 2013;30 386-392 Betancourt L, Phandanauvong V, Patiño R, Ariza-Nieto C, Afanador-Tellez G. Composition and bactericidal activity against beneficial and pathogenic bacteria of oregano essential oils from four chemotypes of Origanum and Lippia Genus. Revista de la facultad de medicina veterinaria y de zootecnia. 2012;59 Cuca L, Bernal F, Coy C, Coy E. Essential oil composition and anticrobial activity of fruits of Iryanthera ulei W. from Colombia. Journal of the chilean chemical society. 2009;54 363-365 Gil E, Cuca L, Delgado W. Chemical composition and anticrobial activity of the essential oil of the leaves of Ocotea caudata (Nees) Mez (Lauraceae) from Colombia. Blacpma. 2016;15 258-263 Pino Benítez N, Melendez E, Stashenko E. Composición química y actividad antibacteriana del aceite esencial de hojas de Piper lanceaefolium, planta usada tradicionalmente en Colombia. Bol Latinoam Caribe Plant Med Aromat. 2009;8 301–304 .Rodríguez Quintanilla R, Ruiz Nova C, Arias Moyano G, Castro Salazar H, Martínez J, Stashenko E. Estudio comparativo de la composición de los aceites esenciales de cuatro especies del género Cymbopogon (Poaceae) cultivadas en Colombia. Bol Latinoam Caribe Plant Med Aromat. 2012;11 77-85 .Bueno-Sanchez J, Martinez-Morales J, Stashenko E, Ribón W. Antitubercular activity of eleven aromatic and medicinal plants occurring in Colombia. Biomédica. 2009;29 51-60 .Rubilar J, Cruz R, Silva H, Vicebte A, Khemelinskii and Vieira M. Physicomechanical properties of chitosan films with carvacrol and grape seed extract. Journal of food engineering. 2013;115 466-474 Pino Benítez N, Stashenko E. Validación antibiótica de plantas medicinales del noroeste de Colombia contra Staphylococcus aureus. Bol Latinoam Caribe Plant Med Aromat. 2009;8 145-150 |
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Acero Godoy, Jovanna Acero4a0a0f85acd06f61b62c4ce04806cb2f600Gil Hoyos, Laura Carolinabfe2e6213477f753f32ccd7067a00692600Universidad Colegio Mayor de Cundinamarca2021-11-12T21:04:02Z2021-11-12T21:04:02Z2018-11https://repositorio.unicolmayor.edu.co/handle/unicolmayor/365158648Los aceites esenciales (AE), son compuestos complejos los cuales están formados por metabolitos secundarios que se producen por reacciones químicas de compuestos derivados del metabolismo primario de las plantas, estos aceites esenciales han sido ampliamente usados en diferentes industrias, como en la alimentaria, donde su mayor uso ha sido como preservante de los mismos. Otra de las utilidades que se les ha dado tiene que ver con sus propiedades medicinales ya que desde hace muchos años las plantas se han usado en comunidades donde el acceso a la medicina convencional es limitado y debido a la creciente problemática mundial del desarrollo y diseminación de resistencias a los antibióticos por parte de las bacterias ha sido necesario recurrir a nuevas alternativas para controlar su actividad. Es por ello por lo que se han realizado muchos estudios en diferentes partes del mundo donde se ha evidenciado la amplia actividad antibacteriana que tienen los aceites esenciales contra bacterias patógenas para los humanos y causantes de frecuentes enfermedades como la E. coli, P. mirabilis, S. typhi, P. aeruginosa, S, aureus y L. monocytogenes entre otras. Estos compuestos con actividad antimicrobiana se pueden extraer de diferentes partes de la planta y por medio de diferentes métodos por ejemplo uno de los mas usados es la destilación con vapor la cual es ampliamente utilizada en producciones comerciales a escala.Essential oils (AE), are complex compounds which are formed by secondary metabolites that are produced by chemical reactions of compounds derived from the primary metabolism of plants, these essential oils have been widely used in different industries, such as food, their greater use has been as a preservative of them. Another of the utilities that has been given to them has to do with their medicinal properties since for many years the plants have been used in communities where access to conventional medicine is limited and due to the growing global problem of the development and dissemination of Resistance to antibiotics by bacteria has been necessary to resort to new alternatives to control their activity. That is why so many studies have been carried out in different parts of the world where it has been demonstrated the broad antibacterial activity of essential oils against bacteria that are pathogenic for humans and cause frequent diseases such as E. coli, P. mirabilis, S. typhi, P. aeruginosa, S, aureus and L. monocytogenes among others. These compounds with antimicrobial activity can be extracted from different parts of the plant and by means of different methods for example one of the most used is steam distillation which is widely used in commercial scale production.INDICE DE TABLAS 9 INDICE DE FIGURAS 10 RESUMEN 11 INTRODUCCIÓN 14 OBJETIVOS 16 1. ANTECEDENTES 17 2. MARCO TEORICO 23 2.1 Bacterias 23 2.1.2 Morfología 23 2.2 Antibióticos 24 2.2.2 Clasificación 25 2.2.3 Mecanismos de Acción 25 2.3 Resistencia bacteriana 27 2.4 Fitoterápia 29 2.4.2 Metabolitos primarios y secundarios 29 2.4.3 Aceites Esenciales 32 2.4.4 Clasificación de los aceites esenciales 33 2.4.5 Actividad antibacteriana de los aceites esenciales 39 2.4.6 Mecanismo de acción de los aceites esenciales 37 2.4.7 Medición de la actividad antibacteriana 39 2.4.8 Extracción de aceites esenciales 44 2.5 Reportes en el mundo 47 2.5.2 En Colombia 48 2.6 Otra alternativa-Fagoterápia 54 3. DISEÑO METODOLÓGICO 55 3.1 Tipo de Investigación 55 3.2 Población de estudio 55 3.3 Métodos 55 4. RESULTADOS 57 5. DISCUSIÓN 77 6. CONCLUSIONES 80 REFERENCIAS BIBLIOGRAFICAS 82PregradoBacteriólogo(a) y Laboratorista Clínico91p.application/pdfspaUniversidad Colegio Mayor de CundinamarcaFacultad de Ciencias de la SaludBogotá D.CBacteriología y Laboratorio ClínicoUniversidad Colegio Mayor de Cundinamarca, 2018https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/closedAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_14cbUso de aceites esenciales como alternativa antimicrobiana contra infecciones de tipo bacteriano-revisión de literaturaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/bachelorThesishttps://purl.org/redcol/resource_type/TPinfo:eu-repo/semantics/publishedVersionRolain JM, Abat C, Jimeno MT, Fournier PE and Raoult D. Do we need new antibiotics? Clinical Microbiology and Infection. 2016 May; Vol. 22 N° 5Organización Mundial de la Salud. Resistencia a los antibióticos. Informe mensual. Febrero 2018. Disponible en: www.who.int/es/news-room/factsheets/detail/resistencia-a-los-antibióticosOrganización Panamericana de la Salud/ Organización Mundial de la Salud. Alerta epidemiológica: Enterobacterias con resitencia transferible a colistina, implicaciones para la salud pública en las Américas, 10 de junio de 2016, Washington, D.C. OPS/OMS 2016Fair RJ and Tor Y. Antibiotics and Bacterial Resistance in the 21st Century. Perspectives in Medicinal Chemistry. 2014:6 25–64 doi: 10.4137/PMC.S14459Djilani A and Dicko A. The therapeutic benefits of essential oils. Nutrition. 2012 155-178Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils – a review. Food Chem. Toxicol. 2008;46 446–475Sokovic M, Marin P, Brkic D, van Griensven L. Chemical composition and antibacterial activity of essential oils of ten aromatic plants against human pathogenic bacteria. Global Science. 2008Zhang Z, Vriesekoop F, Yuan Q and Liang H. Effects of nisin on the antimicrobial activity of D-limonene and its nanoemulsion. Food chemistry. 2014;150 307-312Ghalem B and Mohamed B. Antibacterial activity of leaf essential oils of Eucalyptus globuslus and Eucalyptus camaldulensis. African journal of pharmacy and pharmacology. 2008;2 211-215Oke F, Aslim B, Ozturk S and Altundag A. Essential oil composition, antimicrobial and antioxidant activities of Satureja cuneifolia Ten. Food Chem. 2009;112 874-87Cao L, Si JY, Liu Y, Sun H, Jin W, Li Z, Zhao XH, Pan RL. Essential oil composition, antimicrobial and antioxidant properties of Mosla chinensis Maxim. Food Chemistry. 2009;115, 801–805Naz S, Jabeen S, Ilyas S, Manzoor F, Aslam F and Ali A. Antibacterial activity of Curcuma longa varieties against different strains of bacteria. Pakistan Journal Botanic. 2010;42 455-462Galvao LC, Furletti VF, Bersan SM, Da Cunha MG, Ruiz AL, Carvalho JE, Sartoratto A, Rehder VL, Figueira GM, Teixeira Duarte MC, Ikegaki M, DeAlencar SM, Rosalen PL. Antimicrobial activity of essential oils against Streptococcus mutans and their antiproliferative effects. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 751435 doi:10.1155/2012/751435Abdelhady MI and Aly HAH. Antioxidant antimicrobial activities of Callistemon comboynensis essential oil. Free Radic Antioxidants. 2012;2 37–41.Teixeira B, Marques A, Ramos C, Neng N, Nogueira J, Saraiva JA and Nunes ML. Chemical composition and antibacterial and antioxidant properties of comercial essential oils. Industrial crops and products. 2013;43 587-595Portilho S, Araujo M, Ferreira P, Bertolaccini B, Alkmim A, Masako L, Francescato D. Antibacterial activity of Melaleuca sp.oil against clinical isolates of antibiotics resistant Staphylococcus aureus. Acta cirurgica brasileira. 2015;30.Kacem N, Roumy V, Duhal N, Merouane F, Neut C, Christen P, Hostettmann K, Rhouati S. Chemical composition of the essential oil from Agerian Genista quadriflora Munby and determination of its antibacterial and antifungal activities. Industrial crops and products. 2016;90 87-93Carneiro N, Alves C, Alves J, Egea M, Martins C, Silva T, Bretanha L, Balleste M, Micke G, Silveira E, Miranda M. Chemical composition, antioxidant and antibacterial activities of essential oils from leaves and flowers of Eugenia klotzschiana Berg (Myrtaceae). Anais da academia brasileira de ciencias. 2017;89Al-Aamri M, Al-Abousi M, Al-Jabri S, Alam T and Khan S. Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman. Journal of taibah university medical sciences. 2018;13 108-112Pírez M and Mota M. Temas de bacteriología y virología médica. Morfología y estructura bacteriana. Pág. 23-42Saga T and Yamaguchi K. History of antimicrobial agents and resistant bacteria. JMAJ. 2009;52 103-108Kapoor G, Saigal,S, and Elongavan A. Action and resistance mechanisms of antibiotics: A guide for clinicians. Journal of Anaesthesiology Clin. Pharmacol. 2017 Jul-Sep; 33(3): 300–30Etebu E and Arikekpar I. Antibiotics: Classification and mechanisms of action with emphasis on molecular perspectives. Interinational Journal of Applied Microbiology and Biotechnology Research. 2016;90-101Rolain JM, Abat C, Jimeno MT, Fournier PE and Raoult D. Do we need new antibiotics? Clinical Microbiology and Infection. 2016 May; Vol. 22 N° 5Park JT and Uehara T. How bacteria consume their own exoskeleton (turnover and recycling of cell wall-peptidoglycan). Microbiology Molecular Biology. 2008;72 211-227.Falagas ME, Rafailidis PI and Matthaiou DK. Resistance to polymyxins: Mechanisms, frequency and treatment options. Drug Resistance Update. 2010;13 132-138Kohanski MA, Dwyer DJ and Collins JJ. How antibiotics kill bacteria: from targets to networks. Nat. Rev. Microbiol. 2010;8 423-435Hong W, Zeng J and Xie J. Antibiotic drugs targeting bacterial RNAs. Acta Pharm. Sin B. 2014;4 258-265Kang HK and Park Y. Glycopeptide antibiotics: Structure and mechanism of action. Journal Bacteriol. Virology. 2015;45 67-78.Appelbaum PC, Potential for the start of a second pre-antibiotic era? Journal Antimicrobiotic Chemother. 2012;67(9):2062–8Fair RJ and Tor Y. Antibiotics and Bacterial Resistance in the 21st Century. Perspectives in Medicinal Chemistry. 2014:6 25–64 doi: 10.4137/PMC.S14459.Piddock LJ. Multidrug-resistance efflux pumps — not just for resistance. Nature Rev. Microbiol. 2008;4 629–636van Veen HW. Structural biology: last of the multidrug transporters. Nature. 2010;467 926–927Ramirez MS and Tolmasky ME. Aminoglycoside modifying enzymes. Drug Resistance Update. 2010;13 151–171Wilson DN. Ribosome-targeting antibiotics and mechanisms of bacterial resistance. Nature. 2014;12 35-48Giedraitiene A, Vitkauskiene A, Naginiene R and Pavilonis A. Antibiotic Resistance Mechanisms of Clinically Important Bacteria. Medicina (Kaunas). 2011;47(3);137-46.Davies J, and Davies D. Origins and Evolution of Antibiotic Resistance. Microbiology and Molecular Biology Reviews. 2010;74(3) 417–433Efferth T and Koch E. Complex interations between phytochemicals. The multi-target therapeutic concept of phytotherapy. Current drug targets. 2011;12 122-132.Hounsome N, Hounsome B, Tomos D and Edwards-Jones G. Plant metabolites and nutritional quality of vegetables. Journal of food science. 2008;73 48-65.Hounsome N, Hounsome B, Tomos D and Edwards-Jones G. Plant metabolites and nutritional quality of vegetables. Journal of food science. 2008;73 48-65.Ávalos A, Perez-Urrutia E. Metabolismo secundario de plantas. Reduca. 2009;3 119-145Raut JS, Karuppayil SM. A status review on the medicinal properties of essential oils. Industrial Crops and Products. 2014;62 250-264Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils – a review. Food Chem. Toxicol. 2008;46 446–475Vigan, M. Essential oils: renewal of interest and toxicity. Eur. Journal Dermatological 2010;20, 685–692.Hammer KA, Carson CF, Riley TV and Nielsen JB. A review of the toxicity of Melaleuca alternifolia (tea tree) oil. Food Chemistry Toxicology. 2008;44,616–625.Cao L, Si JY, Liu Y, Sun H, Jin W, Li Z, Zhao XH, Pan RL. Essential oil composition, antimicrobial and antioxidant properties of Mosla chinensis Maxim. Food Chemistry. 2009;115, 801–805Galvao LC, Furletti VF, Bersan SM, Da Cunha MG, Ruiz AL, Carvalho JE, Sartoratto A, Rehder VL, Figueira GM, Teixeira Duarte MC, Ikegaki M, DeAlencar SM, Rosalen PL. Antimicrobial activity of essential oils against Streptococcus mutans and their antiproliferative effects. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 751435 doi:10.1155/2012/751435Lang G and Buchbauer G. A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals: a review. Flavour and Fragrance Journal. 2012;27 13–39Abdelhady M and Aly H. Antioxidant anticrobial activities of Callistemon comboynensis essential oil. Free radicals and antioxidants. 2012;2 37-41Aguirre A, Borneo R and León AE. Antimicrobial, mechanical and barrier properties of triticale protein films incorporated with oregano essential oil. Food Biosci. 2013;1 2–9Simoes M, Bennett RN and Rosa EA. Understanding antimicrobial activities of phytochemicals against multidrug resistance bacteria and biofilms. Nature product reports. 2009;26 746-757Ncube NS, Afolayan AJ and Okoh AI. Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends. African journal of biotechnology. 2008;7 1797.Ramirez L and Marin D. Metodologias para evaluar in vitro la actividad antibacteriana de compuestos de origen vegetal. Scientia et technica. 2009;42 263-268Tongnuanchan P and Benjakul S. Essential oils: Extraction, bioactivities, and treir uses for food preservation. Journal of Food Science. 2014;79 7 1231-1249Okoh OO, Sadimenko AP, Afolayan AJ. Comparative evaluation of the antibacterial activities of the essential oils of Rosmarinus officinalis L. obtained by hydrodistillation and solvent free microwave extraction methods. Food Chemistry. 2010;120 308-312Vian MA, Fernandez X, Visinoni F, Chemat F. Microwave hydrodiffusion and gravity, a new technique for extraction of essential oils. Journal of Chromatography A. 2008;1190 14–17Li XM, Tian SL, Pang ZC, Shi JY, Feng ZS, Zhang YM. Extraction of Cuminumcyminum essential oil by combination technology of organic solvent with low boiling point and steam distillation. Food Chemistry. 2009;115 1114–1119.Gironi F and Maschietti M. Continuous countercurrent deterpenation of lemon essential oil by means of supercritical carbon dioxide: experimental data and process modelling. Chemical Engineering Science. 2008;63 651– 661Costagli G and Betti M. Avocado oil extraction processes: method for coldpressed high-quality edible oil production versus traditional production. Journal of agricultural engineering. 2015;46 115-122.Al-Aamri M, Al-Abousi M, Al-Jabri S, Alam T and Khan S. Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman. Journal of taibah university medical sciences. 2018;13 108-112.Gaviria M, Quijano C, Pino J, Madriñan S. Chemical composition and antibacterial activity of the essential oil of Drimys granadensis L.f. leaves from Colombia. Chemistry and biodiversity. 2011;8 532-539Bueno-Sanchez J, Martinez-Morales J, Stashenko E. Actividad antimicobacteriana de terpenos. Bol Latinoam Caribe Plant Med Aromat. 2009;41 231-235.Reina J, Reina N. Fagoterapia ¿una alternativa a la antibioticoterapia?. Rev esp quimioter. 2018;31 101-104Gorski A, Miedzybrodzi R, Weber-Dabrowska B, Fortuna W, Letkiewicz S and Rogoz P. Phage therapy: combating infections with potential for evolving from merely a treatment for complications to targeting diseases. Front microbiology. 2016;7 1515Kingwell K. Bacteriophage therapies re-enter clinical trials. Nat rev drug discov. 2015;14 515Cooper RA, Bjarnsholt T and Alhede M. Biofilms in wounds: a review of present knowledge. Jornal wound care. 2014;23 570-580Rather M, Dar B, Dar M, Wani B, Shah W, Bhat B, Ganai B, Bhat K, Anand R and Qurishi M. Chemical composition, antioxidant and antibacterial activities of the leaf essential oil of Junglans regia L. and its constituents. Phytomedice. 2012;19 1185-1190Sharma P, Ravikumar G, Kalaiselvi M, Gomathi D and Uma C. In vitro antibacterial and free radical scavenging activity of green hull of Junglans regia. Journal of pharmaceutical Analysis, 2013;3 298-302Settanni L, Palazzolo E, Guarrasi V, Aleo A, Mammina C, Moschetti G and Germana MA. Inhibition of foodborne pathogen bacteria by essential oils extracted from citrus fruits cultivated in Sicily. Food control. 2012;26 326- 330Carramiñana JJ, Rota C, Burillo J and Herrera A. Antibacterial efficiency of Spanish Santureja montana essential oil against Listeria monocytogenes among natural flora in minced pork. Journal of food protection. 2008;71 502- 50Zaouali Y, Bouzaine T and Boussaid M. Essential oils composition in two Rosmarinus officinalis L. varieties and incidence for antimicrobial an antioxidant activities. Food and chemical Toxicology. 2010;48 3144-3152Cuellar A and Hussein R. Evaluation of the yield and the antimicrobial activity of the essential oils from: Eucalyptus globulus, Cymbopogon citratus and Rosmarinus officinalis in Mbarara district (Uganda). Revista colombiana cienc. Anim. 2009;1Akin M, Aktumsek A and Nostro A. Antibacterial activity and composition of the essential oils of Eucalyptus camaldulensis Dehn. And Myrtus communis L. growing in Northern Cyprus. African journal of biotechnology. 2010;9 531- 53Naik M, Fomda B, Jaykumar E, Bhat J. Antibacterial activity of lemongrass (Cymbopogon citratus) oil against some selected pathogenic bacterias. Asia pacific journal of tropical medice. 2010 535-538Bassole IHN, Lamien-Meda A, Bayala B, Obame LC, Ilboudo AJ, Franz, Novak J, Nebie RC and Dicko MH. Chemical composition and antimicrobial activity of Cymbopogon citratus and Cymbopogon giganteus essential oils alone and in combination. Phytomedicine. 2011;18 1070-1074Oliveira RA, Moreira IS and Oliveira FF. Linalol and methyl chavicol present basil (Ocimum sp) cultivated in Brazil. Rev. Bras. PI. Med. 2013;15 309-311Sahib NG, Anwar F, Gilani A, Hamid A, Saari N and Alkharfy K. Coriander (Coriander sativum L.): A potential source of high-value components for funtional foods and nutraceuticals-a review. Phytotherapy research. 2012;27 1439-14567.Roldan L, Diaz G, Duringer J. Composition and antibacterial activity of essential oils obteined from plants of the Lamiaceae family against pathogenic and beneficial bacteria. Revista colombiana de ciencias pecuarias. 2010; 23 451-461Oyedemi SO, Okoh AI, Mabinya LV, Pirochenva G, Afolayan AJ. The proposed mechanism of bactericidal action of eugenol, _-terpineol and _- terpinene against Listeria monocytogenes, Streptococcus pyogenes, Proteus vulgaris and Escherichia coli. Afric. Journal Biotechnol. 2009;8 1280–1286Wang W, Li N, Luo M, Zu Y and Effeth T. Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to thet of its main components. Molecules. 2012;17Nordmann P. Carbapenemase-producing enterobacteriaceae: overview of a major public health challege. Medecine et maladies infectieuses. 2014;44 51-56Chanthaphon S, Chanthachum S and Honhpattarakere T. Antimicrobial activities of essential oils crude extracts from tropical Citrus spp. Against food-related microorganisms. Songklanakarin journal of science and technology. 2008;1 125-13Imelouane B, Amhamdi H, Wathelet JP, Ankit M and Bachiri A. Chemical composition and antimicrobial activity of essential oil of thyme (Thymus vulgaris) from eastern Morocco. International journal of agricultura and biology. 2009;11 205-208Moussaoui F, Alaoui T. Evaluation of antibacterial activity and synergistic affect between antibiotic and the essential oils of some medicinal plants. Asian pacific journal of tropical biomedicine. 2016;6 32-37Ruiz-Navajas Y, Viuda-Martos M, Sendra E, Perez-Alvarez JA, FernandezLopez J. In vitro antibacterial and antioxidant properties of chitosan edible films incorporated with Thymus moroderi or Thymus piperella essential oils. Food control. 2013;30 386-392Betancourt L, Phandanauvong V, Patiño R, Ariza-Nieto C, Afanador-Tellez G. Composition and bactericidal activity against beneficial and pathogenic bacteria of oregano essential oils from four chemotypes of Origanum and Lippia Genus. Revista de la facultad de medicina veterinaria y de zootecnia. 2012;59Cuca L, Bernal F, Coy C, Coy E. Essential oil composition and anticrobial activity of fruits of Iryanthera ulei W. from Colombia. Journal of the chilean chemical society. 2009;54 363-365Gil E, Cuca L, Delgado W. Chemical composition and anticrobial activity of the essential oil of the leaves of Ocotea caudata (Nees) Mez (Lauraceae) from Colombia. Blacpma. 2016;15 258-263Pino Benítez N, Melendez E, Stashenko E. Composición química y actividad antibacteriana del aceite esencial de hojas de Piper lanceaefolium, planta usada tradicionalmente en Colombia. Bol Latinoam Caribe Plant Med Aromat. 2009;8 301–304.Rodríguez Quintanilla R, Ruiz Nova C, Arias Moyano G, Castro Salazar H, Martínez J, Stashenko E. Estudio comparativo de la composición de los aceites esenciales de cuatro especies del género Cymbopogon (Poaceae) cultivadas en Colombia. Bol Latinoam Caribe Plant Med Aromat. 2012;11 77-85.Bueno-Sanchez J, Martinez-Morales J, Stashenko E, Ribón W. Antitubercular activity of eleven aromatic and medicinal plants occurring in Colombia. Biomédica. 2009;29 51-60.Rubilar J, Cruz R, Silva H, Vicebte A, Khemelinskii and Vieira M. Physicomechanical properties of chitosan films with carvacrol and grape seed extract. Journal of food engineering. 2013;115 466-474Pino Benítez N, Stashenko E. Validación antibiótica de plantas medicinales del noroeste de Colombia contra Staphylococcus aureus. 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Unicolmayorrepositorio@unicolmayor.edu.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