Cocaína durante la gestación y conducta materna postparto en ratones.

El abuso materno de cocaína durante la gestación se relaciona con negligencia, maltrato y perturbación del vínculo madre- hijo, lo que incide directamente en el desarrollo de los infantes; por esto, las diversas problemáticas neuroconductuales de los hijos de padres drogodependientes podrían atribui...

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Autores:: Santacruz-Ortega, María del Pilar
Marrero-Quevedo, Rosario J.
Bethencourth-Pérez, Juan Manuel
Castellano, Miguel Ángel
Peñate-Castro, Wenceslao

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2016

Institución:: Universidad Católica de Colombia

Repositorio:: RIUCaC - Repositorio U. Católica

Idioma:: spa

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dc.title.spa.fl_str_mv	Cocaína durante la gestación y conducta materna postparto en ratones.
dc.title.translated.eng.fl_str_mv	Cocaine exposure during pregnancy and pospartum maternal behavior in mice.
title	Cocaína durante la gestación y conducta materna postparto en ratones.
spellingShingle	Cocaína durante la gestación y conducta materna postparto en ratones. Pospartum maternal behavior Cocaine Proximal indexes Motor activity and self-maintenance Conducta materna postparto Cocaína Índices proximales Actividad motora y automantenimiento Cocaína Comportamento materno pós-parto Índices proximais Motores e automanutenção
title_short	Cocaína durante la gestación y conducta materna postparto en ratones.
title_full	Cocaína durante la gestación y conducta materna postparto en ratones.
title_fullStr	Cocaína durante la gestación y conducta materna postparto en ratones.
title_full_unstemmed	Cocaína durante la gestación y conducta materna postparto en ratones.
title_sort	Cocaína durante la gestación y conducta materna postparto en ratones.
dc.creator.fl_str_mv	Santacruz-Ortega, María del Pilar Marrero-Quevedo, Rosario J. Bethencourth-Pérez, Juan Manuel Castellano, Miguel Ángel Peñate-Castro, Wenceslao
dc.contributor.author.spa.fl_str_mv	Santacruz-Ortega, María del Pilar Marrero-Quevedo, Rosario J. Bethencourth-Pérez, Juan Manuel Castellano, Miguel Ángel Peñate-Castro, Wenceslao
dc.subject.eng.fl_str_mv	Pospartum maternal behavior Cocaine Proximal indexes Motor activity and self-maintenance
topic	Pospartum maternal behavior Cocaine Proximal indexes Motor activity and self-maintenance Conducta materna postparto Cocaína Índices proximales Actividad motora y automantenimiento Cocaína Comportamento materno pós-parto Índices proximais Motores e automanutenção
dc.subject.spa.fl_str_mv	Conducta materna postparto Cocaína Índices proximales Actividad motora y automantenimiento Cocaína Comportamento materno pós-parto Índices proximais Motores e automanutenção
description	El abuso materno de cocaína durante la gestación se relaciona con negligencia, maltrato y perturbación del vínculo madre- hijo, lo que incide directamente en el desarrollo de los infantes; por esto, las diversas problemáticas neuroconductuales de los hijos de padres drogodependientes podrían atribuirse a la inadecuada conducta materna o a la exposición prenatal a la droga. El objetivo de esta investigación fue analizar los efectos de la administración crónica de cocaína durante la gestación en la conducta materna postparto de ratones. Para esto se asignaron aleatoriamente 21 ratones CD1 hembras gestantes para la administración de solución salina y cocaína (25 mg/kg/día y 50 mg/kg/día), desde el octavo hasta el día veintiuno de gestación. Después del parto, durante 20 días (15 minutos diarios), se registró individualmente la frecuencia de presentación de 16 índices de conducta materna mediante un etograma. Se encontró que la cocaína afectó levemente la frecuencia de la conducta materna, aunque posiblemente afecte otros parámetros como la latencia, duración y secuencia de esta conducta.
publishDate	2016
dc.date.issued.none.fl_str_mv	2016-01-01
dc.date.accessioned.none.fl_str_mv	2017-01-01 00:00:00 2023-01-23T15:42:10Z
dc.date.available.none.fl_str_mv	2017-01-01 00:00:00 2023-01-23T15:42:10Z
dc.type.spa.fl_str_mv	Artículo de revista
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dc.type.local.eng.fl_str_mv	Journal article
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dc.identifier.doi.none.fl_str_mv	10.14718/ACP.2017.20.8
dc.identifier.eissn.none.fl_str_mv	1909-9711
dc.identifier.issn.none.fl_str_mv	0123-9155
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/10983/28395
dc.identifier.url.none.fl_str_mv	https://doi.org/10.14718/ACP.2017.20.8
identifier_str_mv	10.14718/ACP.2017.20.8 1909-9711 0123-9155
url	https://hdl.handle.net/10983/28395 https://doi.org/10.14718/ACP.2017.20.8
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language	spa
dc.relation.bitstream.none.fl_str_mv	https://actacolombianapsicologia.ucatolica.edu.co/article/download/1301/1228 https://actacolombianapsicologia.ucatolica.edu.co/article/download/1301/1229
dc.relation.citationedition.spa.fl_str_mv	Núm. 1 , Año 2017 : Acta Colombiana de Psicología
dc.relation.citationendpage.none.fl_str_mv	165
dc.relation.citationissue.spa.fl_str_mv	1
dc.relation.citationstartpage.none.fl_str_mv	154
dc.relation.citationvolume.spa.fl_str_mv	20
dc.relation.ispartofjournal.spa.fl_str_mv	Acta Colombiana de Psicología
dc.relation.references.spa.fl_str_mv	Ackerman, J. P., Riggins, T., & Black, M. M. (2010). A review of the effects of prenatal cocaine exposure among schoolaged children. Pediatrics, 125, 554-565. doi: 10.1542/ peds.2009-0637 Adinoff, B., Devous, M. D., Williams, M. J., Best, S. E., Harris, T. S., Minhajuddin, A. Z., & Cullum, M. (2010). Altered neural cholinergic receptor systems in cocaine-addicted subjects. Neuropsychopharmacology, 35, 1485-1499. doi: 10.1038/npp.2010.18 Alsina Llanes, M., Brun, V. D., & Olazábal, D. E. (2015). Development and expression of maternal behavior in naive female C57BL/6 mice. Developmental Psychobiology, 57, 189-200. doi: 10.1002/dev.21276 Angoa-Perez, M., & Kuhn, D. M. (2015). Neuronal serotonin in the regulation of maternal behavior in rodents. Neurotransmitter, 2,1-6. doi: 10.14800/nt.615 Bennett, D., Bendersky, M., & Lewis, M. (2007). Preadolescent health risk behavior as a function of prenatal cocaine exposure and gender. 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Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behavioral Neuroscience, 121, 1353-1363. doi: 10.1037/0735-7044.121.6.1353 Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003). Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiology & Behavior, 79, 359-371. doi: 10.1016/S00319384(03)00149-5 Chaplin, T. M, Visconti K. J., Molfese, P. J., Susman, E. J., Klein, L. C., Sinha, R., & Mayes, L. C. (2014). Prenatal cocaine exposure differentially affects stress responses in girls and boys: Associations with future substance use. Development and Psychopathology, 18, 1-8. doi: 10.1017/S0954579414000716 Colado, M. I., & Alguacil, F. (2008). Drogas de abuso (Capitulo 20). En: P. Lorenzo, A., Moreno, I. Lizasoain, J. C. Leza, M. H. Moro, M. H., Portolés, A. (Eds.), Velázquez, & Farmacología Básica y Clínica (pp 335-354). Buenos Aires: Edit. Médica Panamericana. Coleman, L. G., Liu, W., Oguz, I., Styner, M., & Crews, F. T. (2014). Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility. Pharmacology, Biochemistry and Behavior, 116, 142-151. doi: 10.1016/j.pbb.2013.11.021 Dow-Edwards, D., Iijima, M., Stephenson, S., Jackson, A., & Weedon, J. (2014). The effects of prenatal cocaine, postweaning housing and sex on conditioned place preference in adolescent rats. Psychopharmacology, 231, 1543-1555. doi: 10.1007/s00213-013-3418-9 Eiden, R. D., Schuetze, P., & Coles, C. D. (2011). Maternal cocaine use and mother-infant interactions: direct and moderated associations. Neurotoxicology and Teratology, 33, 120-128. doi: http://dx.doi.org/10.1016/j.ntt.2010.08.005 Eyler, F. D., Warner, T. D., Behnke, M., Hou, W., Wobie, K., & Garvan, C. W. (2009). Executive functioning at ages 5 and 7 years in children with prenatal cocaine exposure. 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New York: Springer. doi:10.1007/978-1-4939-1372-5_5 Kristal, M. B. (2009). The biopsychology of maternal behavior in nonhuman mammals. ILAR Journal, 50, 51-63. doi: 10.1093/ilar.50.1.51 Lambert, B. L., & Bauer, C. R. (2012). Developmental and behavioral consequences of prenatal cocaine exposure: a review. Journal of Perinatology, 32, 819-828. doi: 10.1038/ jp.2012.90 Lester, B. M., Lin, H., Degarmo, D. S., Fisher, P. A., Lagasse, L. L., Levine, T. P., Shankaran, S., Bada, H. S., Bauer, C. R., Hammond, J. A., Whitaker, T. M., & Higgins, R. D. (2012). Neurobehavioral disinhibition predicts initiation of substance use in children with prenatal cocaine exposure. Drug Alcohol Dependence, 126, 80-86. doi: 10.1016/j.drugalcdep.2012.04.014 Lester, B. M., & Padbury, J. F. (2009). Third pathophysiology of prenatal cocaine exposure. Developmental Neuroscience, 31, 23-35. doi: 10.1159/000207491 Lippard, E. C., Jarrett, T. M., McMurray, M. S., Zeskind, P. S., Garber, K. A., Zoghby, C. 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Neurotoxicology and Teratology, 40, 1-8. doi:10.1016/j.ntt.2013.08.001 Rodríguez-Borrero, E., Rivera-Escalera, F., Candelas, F., Montalvo, J., Muñoz-Miranda, W. J., Walker, J. R., & Maldonado-Vlaar, C. S. (2010). Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats. Neuropharmacology, 58(1):88-101. Silverman, M. (1978) Animal Behavior, in the laboratory. New York: Lancet. Sinha, R. (2008). Chronic stress, drug use and vulnerability to addiction. Annals of the New York Academy of Sciences, 1141, 105-130. doi: 10.1196/annals.1441.030 Stamatakis, A., Kalpachidou, T., Raftogianni, A., Zografou, E., Tzanou, A., Pondiki, S., & Stylianopoulou, F. (2015). Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERa, ERß), oxytocin and serotonin (5-HT1A) in their brain. Psychoneuroendocrinology, 52, 212-228. doi: 10.1016/j. psyneuen.2014.11.016. Strathearn, L., & Mayes, L. C. (2010). Cocaine addiction in mothers: potential effects on maternal care and infant development. Annals of the New York Academic Sciences. 1187. 172-83. doi: 10.1111/j.1749-6632.2009.05142.x Szyf, M. (2014). Nongenetic inheritance and transgenerational epigenetics. Trends in Molecular Medicine, 21,134-144. doi: 10.1016/j.molmed.2014.12.004 Téllez-Mosquera, J., & Cote-Menéndez, M. (2005). Efectos toxicológicos y neuropsiquiátricos producidos por consumo de cocaína. Revista Facultad de Medicina Universidad Nacional de Colombia, 53, 10-26. Toth, M. (2015). Mechanisms of non-genetic inheritance and psychiatric disorders. Neuropsychopharmacology, 40, 129140. doi: 10.1038/npp.2014.127. Wang, Z., & Storm, D.R. (2011). Maternal behavior is impaired in female mice lacking type 3-adenylylcyclase. Neuropsychopharmacology, 36, 772-781. doi: 10.1038/npp.2010.211. Wickham, M. E., Senthilselvan, A., Wild, T. C., Hoglund, W. L., & Colman, I. (2015). Maternal depressive symptoms during childhood and risky adolescent health behaviors. Pediatrics, 135, 59-67. doi: 10.1542/peds.2014-0628 Williams, S. K., & Johns, J. M. (2014). Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction. Pharmacology, Biochemistry and Behavior, 119, 10-21. doi: http://dx.doi.org/10.1016/j.pbb.2013.07.004 Williams, S. K., Lauder, J. M., & Johns, J. M. (2011).Prenatal cocaine disrupts serotonin signaling-dependent behaviors: Implications for sex differences, early stress and prenatal SSRI exposure. Current Neuropharmacology, 9, 478-511. doi: 10.2174/157015911796557957
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spelling	Santacruz-Ortega, María del Pilar9bb13de8-ee55-4ffe-84de-ab0be874f031Marrero-Quevedo, Rosario J.21eda894-44ee-42d4-a884-3b6df280a3d1Bethencourth-Pérez, Juan Manuelfb6c77a8-e78f-4613-bd42-a1f393226a74Castellano, Miguel Ángel35273951-f6fc-4056-9753-a1623832db9a300Peñate-Castro, Wenceslao32bd41f6-6009-4744-8b57-6d5c3b82f4ff2017-01-01 00:00:002023-01-23T15:42:10Z2017-01-01 00:00:002023-01-23T15:42:10Z2016-01-01El abuso materno de cocaína durante la gestación se relaciona con negligencia, maltrato y perturbación del vínculo madre- hijo, lo que incide directamente en el desarrollo de los infantes; por esto, las diversas problemáticas neuroconductuales de los hijos de padres drogodependientes podrían atribuirse a la inadecuada conducta materna o a la exposición prenatal a la droga. El objetivo de esta investigación fue analizar los efectos de la administración crónica de cocaína durante la gestación en la conducta materna postparto de ratones. Para esto se asignaron aleatoriamente 21 ratones CD1 hembras gestantes para la administración de solución salina y cocaína (25 mg/kg/día y 50 mg/kg/día), desde el octavo hasta el día veintiuno de gestación. Después del parto, durante 20 días (15 minutos diarios), se registró individualmente la frecuencia de presentación de 16 índices de conducta materna mediante un etograma. Se encontró que la cocaína afectó levemente la frecuencia de la conducta materna, aunque posiblemente afecte otros parámetros como la latencia, duración y secuencia de esta conducta. Maternal cocaine abuse during pregnancy is associated to neglect, abuse, and mother-child bond disruption, which directly affects infant development; therefore, various neurobehavioral problems of children of drug-dependent parents could be attributed to inadequate maternal behavior or prenatal exposure to drugs. Thus, the aim of this research was to analyze the effects of chronic cocaine administration during pregnancy on postpartum maternal behavior. To do this, 21 CD1 pregnant female mice were randomly assigned for administration of saline solution and cocaine (25 mg/kg/day and 50 mg/kg/day), from day 8 to 21 of gestation. After delivery, for 15 minutes a day, during 20 days, the frequency of occurrence of 16 behavioral patterns of maternal behavior was individually recorded, using an ethogram. Cocaine slightly affected maternal behavior frequency, although it may have affected other parameters, such as latency, duration, and sequence of this behavior. application/pdfapplication/pdf10.14718/ACP.2017.20.81909-97110123-9155https://hdl.handle.net/10983/28395https://doi.org/10.14718/ACP.2017.20.8spaUniversidad Católica de Colombiahttps://actacolombianapsicologia.ucatolica.edu.co/article/download/1301/1228https://actacolombianapsicologia.ucatolica.edu.co/article/download/1301/1229Núm. 1 , Año 2017 : Acta Colombiana de Psicología165115420Acta Colombiana de PsicologíaAckerman, J. P., Riggins, T., & Black, M. M. (2010). A review of the effects of prenatal cocaine exposure among schoolaged children. Pediatrics, 125, 554-565. doi: 10.1542/ peds.2009-0637Adinoff, B., Devous, M. D., Williams, M. J., Best, S. E., Harris, T. S., Minhajuddin, A. Z., & Cullum, M. (2010). Altered neural cholinergic receptor systems in cocaine-addicted subjects. 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Current Neuropharmacology, 9, 478-511. doi: 10.2174/157015911796557957María del Pilar Santacruz Ortega - 2017info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/https://actacolombianapsicologia.ucatolica.edu.co/article/view/1301Pospartum maternal behaviorCocaineProximal indexesMotor activity and self-maintenanceConducta materna postpartoCocaínaÍndices proximalesActividad motora y automantenimientoCocaínaComportamento materno pós-partoÍndices proximaisMotores e automanutençãoCocaína durante la gestación y conducta materna postparto en ratones.Cocaine exposure during pregnancy and pospartum maternal behavior in mice.Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionPublicationOREORE.xmltext/xml3349https://repository.ucatolica.edu.co/bitstreams/ff05964f-850f-4183-b628-85ae741d1f1c/download0f8d7fa71ad5b42e9617ff6b8b6c2f74MD5110983/28395oai:repository.ucatolica.edu.co:10983/283952023-03-24 14:56:08.743https://creativecommons.org/licenses/by-nc-sa/4.0/María del Pilar Santacruz Ortega - 2017https://repository.ucatolica.edu.coRepositorio Institucional Universidad Católica de Colombia - RIUCaCbdigital@metabiblioteca.com

Cocaína durante la gestación y conducta materna postparto en ratones.

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