Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar
A pesar del amplio uso de la estimulación cerebral profunda para controlar patologías neurológicas y neuropsiquiátricas, su mecanismo de acción aún no es claramente conocido, y existen pocos estudios sistemáticos que relacionen la variación de parámetros de estimulación eléctrica (frecuencia, intens...
- Autores:
-
Herrera, María Laura
Guisselle-Rubio, Natalia
Quintanilla, Juan Pablo
Huerta, Víctor Manuel
Osorio-Forero, Alejandro
Cárdenas-Molano, Melissa André
Corredor-Páez, Karen
Valderrama, Mario
Cárdenas, Fernando
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad Católica de Colombia
- Repositorio:
- RIUCaC - Repositorio U. Católica
- Idioma:
- spa
- OAI Identifier:
- oai:repository.ucatolica.edu.co:10983/22342
- Acceso en línea:
- https://hdl.handle.net/10983/22342
- Palabra clave:
- COMPORTAMIENTO EMOCIONAL
ESTIMULACIÓN ELÉCTRICA CEREBRAL PROFUNDA
HABÉNULA
RATAS
DEEP BRAIN STIMULATION
EMOTIONAL BEHAVIOR
HABENULA
RATS
COMPORTAMENTO EMOCIONAL
ESTIMULAÇÃO ELÉTRICA CEREBRAL PROFUNDA
HABÊNULA
RATOS
- Rights
- openAccess
- License
- Derechos Reservados - Universidad Católica de Colombia, 2018
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| dc.title.spa.fl_str_mv |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| dc.title.translated.eng.fl_str_mv |
Effects of electrical stimulation of the habenula on the modulation of emotional responses in Wistar rats Efeitos da estimulação elétrica habenular na modulação de respostas emocionais em ratos Wistar |
| title |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| spellingShingle |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar COMPORTAMIENTO EMOCIONAL ESTIMULACIÓN ELÉCTRICA CEREBRAL PROFUNDA HABÉNULA RATAS DEEP BRAIN STIMULATION EMOTIONAL BEHAVIOR HABENULA RATS COMPORTAMENTO EMOCIONAL ESTIMULAÇÃO ELÉTRICA CEREBRAL PROFUNDA HABÊNULA RATOS |
| title_short |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| title_full |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| title_fullStr |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| title_full_unstemmed |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| title_sort |
Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar |
| dc.creator.fl_str_mv |
Herrera, María Laura Guisselle-Rubio, Natalia Quintanilla, Juan Pablo Huerta, Víctor Manuel Osorio-Forero, Alejandro Cárdenas-Molano, Melissa André Corredor-Páez, Karen Valderrama, Mario Cárdenas, Fernando |
| dc.contributor.author.spa.fl_str_mv |
Herrera, María Laura Guisselle-Rubio, Natalia Quintanilla, Juan Pablo Huerta, Víctor Manuel Osorio-Forero, Alejandro Cárdenas-Molano, Melissa André Corredor-Páez, Karen Valderrama, Mario Cárdenas, Fernando |
| dc.subject.proposal.spa.fl_str_mv |
COMPORTAMIENTO EMOCIONAL ESTIMULACIÓN ELÉCTRICA CEREBRAL PROFUNDA HABÉNULA RATAS DEEP BRAIN STIMULATION EMOTIONAL BEHAVIOR HABENULA RATS COMPORTAMENTO EMOCIONAL ESTIMULAÇÃO ELÉTRICA CEREBRAL PROFUNDA HABÊNULA RATOS |
| topic |
COMPORTAMIENTO EMOCIONAL ESTIMULACIÓN ELÉCTRICA CEREBRAL PROFUNDA HABÉNULA RATAS DEEP BRAIN STIMULATION EMOTIONAL BEHAVIOR HABENULA RATS COMPORTAMENTO EMOCIONAL ESTIMULAÇÃO ELÉTRICA CEREBRAL PROFUNDA HABÊNULA RATOS |
| description |
A pesar del amplio uso de la estimulación cerebral profunda para controlar patologías neurológicas y neuropsiquiátricas, su mecanismo de acción aún no es claramente conocido, y existen pocos estudios sistemáticos que relacionen la variación de parámetros de estimulación eléctrica (frecuencia, intensidad, duración del pulso) y la ejecución comportamental. La habénula es una estructura reguladora de respuestas emocionales diana en tratamientos para dolor crónico y depresión, pero la relación entre su estimulación crónica y el desempeño animal en pruebas conductuales no se ha establecido con claridad. Con el objetivo de evaluar el efecto emocional de la estimulación habenular crónica, en este estudio se utilizaron ratas Wistar que recibieron estimulación habenular a intensidad baja (10-80 pA) o alta (120-260 pA) y frecuencia baja (80-150 Hz) o alta (240380 Hz): BIBF-AIBF-BIAF-AIAF, durante 15 minutos a lo largo de tres días consecutivos. Al cuarto día, se hizo la evaluación en un laberinto elevado en cruz y en campo abierto. Los resultados indican un efecto de tipo ansiolítico en el tratamiento BIAF, en comparación con BIBF y AIBF (aumento del número de entradas, porcentaje de tiempo en brazos abiertos y de la distancia recorrida en ellos), efecto que no se explica por cambios en la locomotricidad (distancia recorrida en los brazos cerrados y la exploración en el campo abierto). Se concluye que el parámetro frecuencia posee mayor impacto sobre el efecto comportamental que la intensidad -lo que puede explicar algunos hallazgos paradójicos previos-, que los parámetros utilizados no poseen efecto ansiogénico, y que los efectos potencialmente ansiogénicos de la estimulación a baja frecuencia y el papel de los sistemas dopaminérgicos y serotoninérgicos encontrados deben ser estudiados en futuras investigaciones. |
| publishDate |
2018 |
| dc.date.accessioned.spa.fl_str_mv |
2018-11-19T15:43:58Z |
| dc.date.available.spa.fl_str_mv |
2018-11-19T15:43:58Z |
| dc.date.issued.spa.fl_str_mv |
2018-07 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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info:eu-repo/semantics/article |
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http://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Herrera, M., Rubio, N., Quintanilla, J., Huerta, V., Osorio-Forero, A., Cárdenas-Molano, M., Corredor-Páez, K., Valderrama, M., & Cárdenas, F. (2018). Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar. Acta Colombiana de Psicología, 21(2), 212-235. Recuperado de https://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/1455 |
| dc.identifier.issn.spa.fl_str_mv |
0123-9155 |
| dc.identifier.uri.spa.fl_str_mv |
https://hdl.handle.net/10983/22342 |
| identifier_str_mv |
Herrera, M., Rubio, N., Quintanilla, J., Huerta, V., Osorio-Forero, A., Cárdenas-Molano, M., Corredor-Páez, K., Valderrama, M., & Cárdenas, F. (2018). Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar. Acta Colombiana de Psicología, 21(2), 212-235. Recuperado de https://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/1455 0123-9155 |
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https://hdl.handle.net/10983/22342 |
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spa |
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spa |
| dc.relation.ispartof.spa.fl_str_mv |
Acta Colombiana de Psicología, Vol. 21 no. 2 (jul.-dic. 2018); p. 212-235 |
| dc.relation.references.spa.fl_str_mv |
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Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze. Behavioral Brain Research, 194, 181-186. Doi: https://doi:10.1016/j.bbr.2008.07.005 Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017). Involvement of Infralimbic Prefrontal Cortex but not Lateral Habenula in Dopamine Attenuation After Chronic Mild Stress. Neuropsychopharmacology, 42, 904-913. Doi: https://doi:10.1038/npp.2016.249 Motta, V., Maisonnette, S., Morato, S., Castrechini, P., & Brandao, M. L. (1992). Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze. Psychopharmacology (Berl), 107, 135-139. Mulders, A. E. P., Plantinga, B. R., Schruers, K., Duits, A., Janssen, M. L. F., Ackermans, L., ... Temel, Y. (2016). Deep brain stimulation of the subthalamic nucleus in obsessive-compulsive disorder: Neuroanatomical and pathophysiological considerations. European Neuropsychopharmacology, 26, 1909-1919. Doi: https://doi:10.1016/j.euro-neuro.2016.10.011 Murphy, C. A., DiCamillo, A. M., Haun, F., & Murray, M. (1996). Lesion of the habenular efferent pathway produces anxiety and locomotor hyperactivity in rats: a comparison of the effects of neonatal and adult lesions. Behavioral Brain Research, 81, 43-52. Doi: https://doi.org/10.1016/S0166-4328(96)00041-1 Murrow, R. W. (2014). Penfield's Prediction: A Mechanism for Deep Brain Stimulation. Frontiers in Neurology, 5, 213. Doi: https://doi:10.3389/fneur.2014.00213 Nicolaidis, S. (2017). Neurosurgery of the future: Deep brain stimulations and manipulations. Metabolism, 69S, S16-S20. Doi: https://doi:10.1016/j.metabol.2017.01.013 Ootsuka, Y., & Mohammed, M. (2015). Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress. PhysiologicalReports, 3. Doi:https://doi:10.14814/phy2.12297 Ostrem, J. L., San, L. M., Dodenhoff, K. A., Ziman, N., Markun, L. C., Racine, C. A., ... Starr, P. A. (2017). Subthalamic nucleus deep brain stimulation in isolated dystonia: A 3-year follow-up study. Neurology, 88, 25-35. Doi: https://doi:10.1212/WNL.0000000000003451 Paxinos, G., & Watson, C. (2006). The Rat Brain in Stereotaxic Coordinates: Hard Cover Edition. Elsevier Science. Plotkin, R. (1982). Results in 60 cases of deep brain stimulation for chronic intractable pain. Applied Neurophysiology, 45, 173-178. Pobbe, R. L., & Zangrossi, H., Jr. (2010). The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter. Neuroscience Letters, 479, 87-91. Doi: https://doi:10.1016/j.neulet.2010.05.021 Ray, C. D., & Burton, C. V. (1980). Deep brain stimulation for severe, chronic pain. Acta Neurochirurgica Supplement (Wien.), 30, 289-293. Rolls, E. T. (2017). The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons. Neuroscience & Biobehavioral Reviews, 75, 331-334. Doi: https://doi:10.1016/j.neubiorev.2017.02.013 Rosenow, J. M., Mogilnert, A. Y., Ahmed, A., & Rezai, A. R. (2004). Deep brain stimulation for movement disorders. Neurological Research, 26, 9-20. Doi: https://doi:10.1179/016164104773026480 Roth, R. M., Flashman, L. A., Saykin, A. J., & Roberts, D. W. (2001). Deep brain stimulation in neuropsychiatric disorders. Current Psychiatry Reports, 3, 366-372. Salgado-Lopez, L., Pomarol-Clotet, E., Roldan, A., Rodriguez, R., Molet, J., ... Sarro, S. (2016). Letter to the Editor: Deep brain stimulation for schizophrenia. Journal of Neurosurgery, 125, 229-230. Doi: https://doi:10.3171/2015.12.JNS152874 Schwalb, J. M., & Hamani, C. (2008). The history and future of deep brain stimulation. Neurotherapeutics, 5, 3-13. Doi:https://doi:10.1016/j.nurt.2007.11.003 Setem, J., Pinheiro, A. P., Motta, V. A., Morato, S., & Cruz, A. P. (1999). Ethopharmacological analysis of 5-HT ligands on the rat elevated plus-maze. Pharmacology, Biochemistry and Behavior, 62, 515-521. doi.org/10.1016/S0091-3057(98)00193-2 Shelton, L., Becerra, L., & Borsook, D. (2012). Unmasking the mysteries of the habenula in pain and analgesia. Progress in Neurobiology, 96, 208-219. Doi: https://doi:10.1016/j.pneurobio.2012.01.004 Song, M., Jo, Y. S., Lee, Y. K., & Choi, J. S. (2017). Lesions of the lateral habenula facilitate active avoidance learning and threat extinction. Behavioral Brain Research, 318, 12-17. Doi: https://doi:10.1016/j.bbr.2016.10.013 Sourani, D., Eitan, R., Gordon, N., & Goelman, G. (2012). The habenula couples the dopaminergic and the serotonergic systems: application to depression in Parkinson's disease. 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Herrera, María Laura8f7dfdf2-8f53-4832-879f-8ab4ace91f58-1Guisselle-Rubio, Nataliad1a15f48-a48a-4ba2-bf56-caaa7c980098-1Quintanilla, Juan Pablo2faa22c5-1943-4d73-abcc-88433525942f-1Huerta, Víctor Manuel2199de64-8b4a-4efc-b08a-b96bebf79e58-1Osorio-Forero, Alejandro57ef82e7-8b71-4e3e-9318-d3d43713432e-1Cárdenas-Molano, Melissa Andrébb4ecbec-67ab-4802-aa32-56fc99e28555Corredor-Páez, Karencfb07a1f-a016-4ec0-b664-f506b3935f83-1Valderrama, Mariobbf4fcd2-9626-4948-8c4f-2a93cfa51e7d-1Cárdenas, Fernandod803bba3-57ee-4175-aa7c-b7eab3d2f109-12018-11-19T15:43:58Z2018-11-19T15:43:58Z2018-07A pesar del amplio uso de la estimulación cerebral profunda para controlar patologías neurológicas y neuropsiquiátricas, su mecanismo de acción aún no es claramente conocido, y existen pocos estudios sistemáticos que relacionen la variación de parámetros de estimulación eléctrica (frecuencia, intensidad, duración del pulso) y la ejecución comportamental. La habénula es una estructura reguladora de respuestas emocionales diana en tratamientos para dolor crónico y depresión, pero la relación entre su estimulación crónica y el desempeño animal en pruebas conductuales no se ha establecido con claridad. Con el objetivo de evaluar el efecto emocional de la estimulación habenular crónica, en este estudio se utilizaron ratas Wistar que recibieron estimulación habenular a intensidad baja (10-80 pA) o alta (120-260 pA) y frecuencia baja (80-150 Hz) o alta (240380 Hz): BIBF-AIBF-BIAF-AIAF, durante 15 minutos a lo largo de tres días consecutivos. Al cuarto día, se hizo la evaluación en un laberinto elevado en cruz y en campo abierto. Los resultados indican un efecto de tipo ansiolítico en el tratamiento BIAF, en comparación con BIBF y AIBF (aumento del número de entradas, porcentaje de tiempo en brazos abiertos y de la distancia recorrida en ellos), efecto que no se explica por cambios en la locomotricidad (distancia recorrida en los brazos cerrados y la exploración en el campo abierto). Se concluye que el parámetro frecuencia posee mayor impacto sobre el efecto comportamental que la intensidad -lo que puede explicar algunos hallazgos paradójicos previos-, que los parámetros utilizados no poseen efecto ansiogénico, y que los efectos potencialmente ansiogénicos de la estimulación a baja frecuencia y el papel de los sistemas dopaminérgicos y serotoninérgicos encontrados deben ser estudiados en futuras investigaciones.Apesar do amplo uso da estimulação cerebral profunda para controlar patologias neurológicas e neuropsiquiátricas, seu mecanismo de ação ainda não é claramente conhecido e existem poucos estudos sistemáticos que relacionem a variação de parâmetros de estimulação elétrica (frequência, intensidade, duração do pulso) e a execução comportamental. A habênula é uma estrutura reguladora de respostas emocionais específicas em tratamentos para dor crònica e depressão, mas a relação entre sua estimulação crònica e o desempenho animal em testes comportamentais não foi claramente estabelecida. Com o objetivo de avaliar o efeito emocional da estimulação habenular crònica, neste estudo foram utilizados ratos Wistar que receberam estimulação habenular de intensidade baixa (10-80 pA) ou alta (120-260 pA) e frequência baixa (80-150 Hz) ou alta (240-380 Hz): BIBF-AIBF-BIAF-AIAF, durante 15 minutos ao longo de três dias consecutivos. No quarto dia, foi feita a avaliação em um labirinto em cruz elevado e em campo aberto. Os resultados indicam um efeito de tipo ansiolítico no tratamento BIAF, em comparação com BIBF e AIBF (aumento do número de entradas, porcentagem de tempo em braços abertos e da distância percorrida neles), efeito que não se explica por mudanças na locomotividade (distância percorrida nos braços fechados e a exploração no campo aberto). Conclui-se que o parâmetro "frequência" tem mais impacto sobre o efeito comportamental do que a "intensidade" - o que pode explicar algumas descobertas paradoxais prévias -, que os parâmetros utilizados não tenham efeito ansiogênico, e que os efeitos potencialmente ansiogênicos da estimulação de baixa frequência e o papel dos sistemas dopaminérgicos e serotoninérgicos encontrados devem ser estudados em pesquisas futuras.Deep brain stimulation is a widely-used approach to the treatment of neurologic and neuropsychiatric diseases. However, its mechanisms remain unclear. There are few systematic studies relating variations on electrical stimulation parameters (frequency, intensity, pulse duration) and behavioral outcome. The habenula relates to emotional behavior and is a main target for chronic pain and depression stimulation treatment. The relation between habenular electrical stimulation and performance in behavioral tests has not been clearly defined. In order to assess the emotional effects of chronic habenular electrical stimulation, Wistar male rats were unilaterally implanted with electrodes aimed to the lateral habenula and assigned to low (10-80 pA) or high (120-260 pA) intensity and low (80-150 Hz) or high (240-380 Hz) frequency conditions: BIBF-AIBF-BIAF-AIAF. They received electrical stimulation 15 minutes/day for three consecutive days and on the fourth day were tested in the elevated plus maze and the open field. The results of these study show that BIAF stimulation has a possible anxiolytic-like effect when compared to BIBF and AIBF (increase in the percentage of open-arms time, entries into the open-arms and total-distance-run in the open-arms). This is not due to any changes in locomotion (total-distance-run and open field exploration). It is concluded that frequency is more important than intensity for behavioral modification. This could explain some previous inconsistent results. The data also suggest that these parameters of stimulation have no anxiogenic effects. The role for dopaminergic and serotonergic systems must be subsequently evaluated as well as potential anxiogenic-like effects of low frequency stimulation.application/pdfHerrera, M., Rubio, N., Quintanilla, J., Huerta, V., Osorio-Forero, A., Cárdenas-Molano, M., Corredor-Páez, K., Valderrama, M., & Cárdenas, F. (2018). Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar. Acta Colombiana de Psicología, 21(2), 212-235. Recuperado de https://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/14550123-9155https://hdl.handle.net/10983/22342spaUniversidad Católica de Colombia. Facultad de PsicologíaActa Colombiana de Psicología, Vol. 21 no. 2 (jul.-dic. 2018); p. 212-235Accolla, E. A., Aust, S., Merkl, A., Schneider, G. H., Kuhn, A. A., Draganski, B. (2016). Deep brain stimulation of the posterior gyrus rectus region for treatment resistant depression. Journal of Affective Disorders, 194, 33-37. Doi: https://doi:10.1016/j.jad.2016.01.022Agarwal, P., Sarris, C. E., Herschman, Y., Agarwal, N., & Mammis, A. (2016). Schizophrenia and neurosurgery: A dark past with hope of a brighter future. Journal of Clinical Neuroscience, 34, 53-58. Doi: https://doi:10.1016/j.jocn.2016.08.009Almeida, L., Martinez-Ramirez, D., Ahmed, B., Deeb, W., Jesus, S., & Okun, M. S. (2017). A pilot trial of square biphasic pulse deep brain stimulation for dystonia: The BIP dystonia study. Movement Disorders Journal, 32, 615-618. Doi: https://doi:10.1002/mds.26906Amat, J., Sparks, P. D., Matus-Amat, P., Griggs, J., Watkins, L. R., & Maier, S. F. (2001). The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Research Bulletin, 917, 118-126. Doi: https://doi.org/10.1016/S0006-8993(01)02934-1Andersen, S. L., & Teicher, M. H. (1999). Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats. Neuroreport Journal, 10, 3497-3500.Arocho-Quinones, E. V., Hammer, M. J., Bock, J. M., & Pahapill, P. A. (2017). Effects of deep brain stimulation on vocal fold immobility in Parkinson's disease. Surgical Neurology International, 8, 22. Doi: https://doi:10.4103/2152-7806.200580.eBakay, R. A. (2009). Deep brain stimulation for schizophrenia. Stereotactic and functional neurosurgery, 87, 266. Doi: https://doi.org/10.1159/000225980Baker, P. M., Jhou, T., Li, B., Matsumoto, M., Mizumori, S. J., ... Vicentic, A. (2016). The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. Journal of Neuroscience, 36, 11482-11488. Doi: https://doi.org/10.1523/JNEUROSCI.2350-16.2016Baker, P. M., Oh, S. E., Kidder, K. S., & Mizumori, S. J. (2015). Ongoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats. Frontiers in Behavioral Neuroscience, 9, 295. Doi: https://doi:10.3389/fnbeh.2015.00295Baker, P. M., Raynor, S. A., Francis, N. T., & Mizumori, S. J. (2017). Lateral habenula integration of proactive and retroactive information mediates behavioral flexibility. Neuroscience, 345, 89-98. Doi: https://doi:10.1016/j.neuroscien-ce.2016.02.010Baldwin, P. R., Alanis, R., & Salas, R. (2011). The Role of the Habenula in Nicotine Addiction. 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Doi:https://doi:10.1016/j.brs.2017.01.581Birchall, E. L., Walker, H. C., Cutter, G., Guthrie, S., Joop, A., ... Amara, A. W (2017). The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's disease. Brain Stimulation, 10, 651-656. Doi: https://doi:10.1016/j.brs.2016.12.014Boadas-Vaello, P., Homs, J., Reina, F., Carrera, A., & Verdu, E. (2017). Neuroplasticity of Supraspinal Structures Associated with Pathological Pain. Anatomical Record, (Hoboken). Doi: https://doi:10.1002/ar.23587Boccard, S. G., Pereira, E. A., & Aziz, T. Z. (2015). Deep brain stimulation for chronic pain. Journal of Clinical Neuroscience, 22, 1537-1543. Doi: https://doi:10.1016/j.jocn.2015.04.005Borgonovo, J., Allende-Castro, C., Laliena, A., Guerrero, N., Silva, H., & Concha, M. L. (2017). Changes in neural circuitry associated with depression at pre-clinical, premotor and early motor phases of Parkinson's disease. Parkinsonism and Related Disorders, 35, 17-24. 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