Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.

La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan u...

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Autores:
Cortés-Salazar, Felipe
Suárez-Ortiz, Josué Omar
Cendejas-Trejo, Nancy Mónica
Mancilla-Díaz, Juan Manuel
López-Alonso, Verónica Elsa
Escartín-Pérez, Rodrigo Erick
Tipo de recurso:
Article of investigation
Fecha de publicación:
2014
Institución:
Universidad Católica de Colombia
Repositorio:
RIUCaC - Repositorio U. Católica
Idioma:
eng
OAI Identifier:
oai:repository.ucatolica.edu.co:10983/27985
Acceso en línea:
https://hdl.handle.net/10983/27985
https://doi.org/10.14718/ACP.2014.17.2.7
Palabra clave:
Cannabinoids
Food
Nucleus accumbens shell
Behavioral satiety sequence
Canabinoides
Alimentación
Núcleo accumbens shell
Secuencia de saciedad conductual
Rights
openAccess
License
Acta Colombiana de Psicología - 2014
id UCATOLICA2_5010927488aa22a2741ea1ccad9f5180
oai_identifier_str oai:repository.ucatolica.edu.co:10983/27985
network_acronym_str UCATOLICA2
network_name_str RIUCaC - Repositorio U. Católica
repository_id_str
dc.title.spa.fl_str_mv Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
dc.title.translated.eng.fl_str_mv Effects of CB1 cannabinoid receptor activation in the nucleos accumbens shell on feeding behavior.
title Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
spellingShingle Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
Cannabinoids
Food
Nucleus accumbens shell
Behavioral satiety sequence
Canabinoides
Alimentación
Núcleo accumbens shell
Secuencia de saciedad conductual
title_short Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
title_full Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
title_fullStr Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
title_full_unstemmed Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
title_sort Efectos de la activación del receptor cannabinoide CB1 en el núcleo accumbens shell sobre la conducta alimentaria.
dc.creator.fl_str_mv Cortés-Salazar, Felipe
Suárez-Ortiz, Josué Omar
Cendejas-Trejo, Nancy Mónica
Mancilla-Díaz, Juan Manuel
López-Alonso, Verónica Elsa
Escartín-Pérez, Rodrigo Erick
dc.contributor.author.spa.fl_str_mv Cortés-Salazar, Felipe
Suárez-Ortiz, Josué Omar
Cendejas-Trejo, Nancy Mónica
Mancilla-Díaz, Juan Manuel
López-Alonso, Verónica Elsa
Escartín-Pérez, Rodrigo Erick
dc.subject.eng.fl_str_mv Cannabinoids
Food
Nucleus accumbens shell
Behavioral satiety sequence
topic Cannabinoids
Food
Nucleus accumbens shell
Behavioral satiety sequence
Canabinoides
Alimentación
Núcleo accumbens shell
Secuencia de saciedad conductual
dc.subject.spa.fl_str_mv Canabinoides
Alimentación
Núcleo accumbens shell
Secuencia de saciedad conductual
description La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan un papel clave en la génesis y desarrollo de la obesidad. Se ha propuesto que los receptores a canabinoides CB1 (RCB1) expresados en el núcleo accumbensshell (NAcS) están involucrados en el incremento de las propiedades hedónicas del alimento. Para probar esta hipótesis, este estudio tuvo como objetivo evaluar los efectos de la activación de los RCB1 en el NAcS sobre la ingesta de alimento estándar durante la fase de luz del ciclo luz-oscuridad. Se evaluaron los efectos de la activación de los RCB1 con WIN 55-212-2 y CP 55,940 (0.125, 0.25, y 0.5 nmol) en el NAcS sobre la conducta alimentaria y la secuencia de saciedad conductual en ratas. Se encontró que ambos agonistas aumentaron la ingesta de alimento y demoraron la expresión de la saciedad durante la fase de luz. Lo anterior sugiere que los agonistas canabinoides estimulan el consumo de alimento cuando la motivación por el mismo es baja y la palatabilidad es normal.
publishDate 2014
dc.date.accessioned.none.fl_str_mv 2014-07-01 00:00:00
2023-01-23T15:36:00Z
dc.date.available.none.fl_str_mv 2014-07-01 00:00:00
2023-01-23T15:36:00Z
dc.date.issued.none.fl_str_mv 2014-07-01
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 0123-9155
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dc.relation.citationedition.spa.fl_str_mv Núm. 2 , Año 2014
dc.relation.citationendpage.none.fl_str_mv 68
dc.relation.citationissue.spa.fl_str_mv 2
dc.relation.citationstartpage.none.fl_str_mv 61
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dc.relation.ispartofjournal.spa.fl_str_mv Acta Colombiana de Psicología
dc.relation.references.eng.fl_str_mv Bassareo, V. & Di Chiara, G. (1999). Modulation of feedinginduced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. European Journal of Neuroscience, 11(12), 4389-4397.
Berner, L. A., Avena, N. M. & Hoebel, B. G. (2008). Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity (Silver Spring) 16,1998-2002. Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C., Pasquali, R., Lutz, B., Stalla, G. K. & Pagotto, U. (2003). The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation, 112, 423-431.
Di Patrizio, N. V. & Simansky, K. J. (2008). Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats.Journal of Neuroscience, 28(39),9702-9709.
Dimitriou, S. G., Rice, H. B. & Corwin, R. L. (2000). Effects of limited access to a fat option on food intake and body composition in female rats. International Journal of Eating Disorders, 28,436-445.
Drews, E., Schneider, M. & Koch, M. (2005). Effects of the cannabinoid receptor agonist win 55,212-2 on operant behavior and locomotor activity in rats. Pharmacology Biochemistry and Behavior, 80(1),145-150.
Escartín-Pérez, R. E., Cendejas-Trejo, N. M., Cruz-Martínez, A. M., González-Hernández B., Mancilla-Díaz, J. M. & Florán-Garduño, B. (2009). Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. Physiology and Behavior, 96, 646-650.
Gardner, E. L. (2005). Endocannabinoid signaling system and brain reward: Emphasis on dopamine. Pharmacology, Biochemistry and Behavior, 81(2), 263-284.
Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A. & Uhla, G. R. (2006). Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Research, 1071,10-23.
González, B., Paz, F., Florán, L., Aceves, J., Erlij, D. & Floran, B. (2009). Cannabinoid agonists stimulate [3H]-GABA release in the globus pallidus of the rat when Gi proteinreceptor coupling is restricted. Journal of Pharmacology and Experimental Therapeutics, 328, 822-828.
Guegan, T., Cutando, L., Ayuso, E., Santini, E., Fisone, G., Bosch, F., Martinez, A., Valjent, E., Maldonado, R. & Martina, M. (2013). Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit. European Neuropsychopharmacology, 23(2), 146-159. Jamshidy, N. & Taylor, D.A. (2001). Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.British Journal of Pharmacology, 134, 1151-1154.
Kirkham, T. C., Williams, C. M., Fezza, F., & Di Marzo, V. (2002). Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. British Journal of Pharmacology, 136(4), 550-557.
Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S. & Avigliano, L. (2010). The endocannabinoid system and its relevance for nutrition. Annual Reviews of Nutrition, 30, 423-440.
Matias, I., Cristino, L. & Di Marzo, V. (2008). Endocannabinoids: Some like it fat (and sweet too). Journal of Neuroendocrinology, 20(1), 100-109.
Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A. & Melis, M. R. (2007). The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neuroscience Letters, 419 (3), 231-235.
Nederkoorn, C., Braet, B., Van Eijs, Y., Tanghe, A. & Jansen, A. (2006). Why obese children cannot resist food: The role of impulsivity. Eating Behaviors, 7, 315-322.
Pandolfo, P., Pamplona, F. A., Prediger, R. D. & Takahashi, R. N. (2007). Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2. European Journal of Pharmacology, 563(1–3), 141-148.
Paxinos, G. & Watson, C. (1998). The brain in stereotaxic coordinates. New York: Academic Press.
Perello, M., Chuang, J., Scott, M. M. & Lutter, M. (2010). Translational Neuroscience approaches to hyperphagia. The Journal of Neuroscience, 30(35), 11549-11554.
Quarta C., Bellocchio L., Manzini G., Mazza R., Cervino C., Braulke L., Fekete C., Latorre R., Nanni C., Bucci M., Clemens L., Heldmaier G., Watanabe M., Leste-Lassere T., Maitre M., Tedesco L., FanelliF., Reuss S., KlausS., Srivastava R., Monory K., Valerio A., Grandis A., de Giorgio R., Pasquali R., Nisoli E., Cota D., Lutz B., Marsicano G. & Pagotto U. (2010). CB1 signaling in forebrain and sympathetic neurons is a key Determinant of endocannabinoid actions on energy balance. Cell Metabolism, 11, 273-285.
Ravinet-Trillou, C., Delgorge, C., Menet, C., Arnone, M. & Soubrié, P. (2004). CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity, 28, 640-648.
Sanudo-Pena, M.C., Patrick, S. L., Patrick, R.L. & Walker, J.M. (1996). Effects of intranigral cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system. Neuroscience Letters, 206, 21-24.
Soria-Gómez, E., Matías, I., Rueda-Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L. Di Marzo, V. & Próspero-García, O. (2007). Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. British Journal of Pharmacology, 151, 1109-1116.
Verty, A.N., McGregor, I.S. & Mallet, P.E. (2005). Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)tetrahydrocannabinol. Neuropharmacology, 49 (8), 1101-1109.
dc.rights.eng.fl_str_mv Acta Colombiana de Psicología - 2014
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spelling Cortés-Salazar, Feliped5025318-aed0-4002-a9c2-fdf0c6aa4f10Suárez-Ortiz, Josué Omar6cdfa870-0066-4b40-9adf-1f58480c3202Cendejas-Trejo, Nancy Mónica036b2ea6-c4bf-4476-88f0-4bda3bf44e8bMancilla-Díaz, Juan Manuel5407e59b-8ba6-4e0d-92bd-27ee1ec523a1López-Alonso, Verónica Elsad150f476-58ea-4f76-aceb-17a5f3fec7e0Escartín-Pérez, Rodrigo Erickc3643e47-4b7e-446a-9183-71a0c95ef29b2014-07-01 00:00:002023-01-23T15:36:00Z2014-07-01 00:00:002023-01-23T15:36:00Z2014-07-01La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan un papel clave en la génesis y desarrollo de la obesidad. Se ha propuesto que los receptores a canabinoides CB1 (RCB1) expresados en el núcleo accumbensshell (NAcS) están involucrados en el incremento de las propiedades hedónicas del alimento. Para probar esta hipótesis, este estudio tuvo como objetivo evaluar los efectos de la activación de los RCB1 en el NAcS sobre la ingesta de alimento estándar durante la fase de luz del ciclo luz-oscuridad. Se evaluaron los efectos de la activación de los RCB1 con WIN 55-212-2 y CP 55,940 (0.125, 0.25, y 0.5 nmol) en el NAcS sobre la conducta alimentaria y la secuencia de saciedad conductual en ratas. Se encontró que ambos agonistas aumentaron la ingesta de alimento y demoraron la expresión de la saciedad durante la fase de luz. Lo anterior sugiere que los agonistas canabinoides estimulan el consumo de alimento cuando la motivación por el mismo es baja y la palatabilidad es normal.Obesity and its related pathologies are well- known health hazards. Although obesity and overweight have multifactorial causes, overeating is common in both of these conditions. According to animal models, endocannabinoids and their receptors in the brain play a key role in the genesis and development of obesity. It has been proposed that the cannabinoid receptors CB1 (RCB1) expressed in the nucleus accumbens shell (NAC) are involved in the increase of the hedonic properties of food. To test this hypothesis, thisstudy aimed to assess the effects of activating the NACs RCB1 on standard food intake during the light phase of the light-dark cycle. The effects of activating the RCB1 with CP 55,940 and WIN 55-212-2 (0.125, 0.25 and 0.5 nmol) in the NACS on feeding behavior and the behavioral satiety sequence of rats were assessed. It wasfound that both agonists increased food intake and delayed expression of satiety during the light phase. These results suggest that cannabinoid agonists encourage food intake when motivation is low and palatability is normal.application/pdf10.14718/ACP.2014.17.2.71909-97110123-9155https://hdl.handle.net/10983/27985https://doi.org/10.14718/ACP.2014.17.2.7engUniversidad Católica de Colombiahttps://actacolombianapsicologia.ucatolica.edu.co/article/download/165/205Núm. 2 , Año 20146826117Acta Colombiana de PsicologíaBassareo, V. & Di Chiara, G. (1999). Modulation of feedinginduced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. European Journal of Neuroscience, 11(12), 4389-4397.Berner, L. A., Avena, N. M. & Hoebel, B. G. (2008). Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity (Silver Spring) 16,1998-2002. Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C., Pasquali, R., Lutz, B., Stalla, G. K. & Pagotto, U. (2003). The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation, 112, 423-431.Di Patrizio, N. V. & Simansky, K. J. (2008). Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats.Journal of Neuroscience, 28(39),9702-9709.Dimitriou, S. G., Rice, H. B. & Corwin, R. L. (2000). Effects of limited access to a fat option on food intake and body composition in female rats. International Journal of Eating Disorders, 28,436-445.Drews, E., Schneider, M. & Koch, M. (2005). Effects of the cannabinoid receptor agonist win 55,212-2 on operant behavior and locomotor activity in rats. Pharmacology Biochemistry and Behavior, 80(1),145-150.Escartín-Pérez, R. E., Cendejas-Trejo, N. M., Cruz-Martínez, A. M., González-Hernández B., Mancilla-Díaz, J. M. & Florán-Garduño, B. (2009). Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. Physiology and Behavior, 96, 646-650.Gardner, E. L. (2005). Endocannabinoid signaling system and brain reward: Emphasis on dopamine. Pharmacology, Biochemistry and Behavior, 81(2), 263-284.Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A. & Uhla, G. R. (2006). Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Research, 1071,10-23.González, B., Paz, F., Florán, L., Aceves, J., Erlij, D. & Floran, B. (2009). Cannabinoid agonists stimulate [3H]-GABA release in the globus pallidus of the rat when Gi proteinreceptor coupling is restricted. Journal of Pharmacology and Experimental Therapeutics, 328, 822-828.Guegan, T., Cutando, L., Ayuso, E., Santini, E., Fisone, G., Bosch, F., Martinez, A., Valjent, E., Maldonado, R. & Martina, M. (2013). Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit. European Neuropsychopharmacology, 23(2), 146-159. Jamshidy, N. & Taylor, D.A. (2001). Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.British Journal of Pharmacology, 134, 1151-1154.Kirkham, T. C., Williams, C. M., Fezza, F., & Di Marzo, V. (2002). Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. British Journal of Pharmacology, 136(4), 550-557.Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S. & Avigliano, L. (2010). The endocannabinoid system and its relevance for nutrition. Annual Reviews of Nutrition, 30, 423-440.Matias, I., Cristino, L. & Di Marzo, V. (2008). Endocannabinoids: Some like it fat (and sweet too). Journal of Neuroendocrinology, 20(1), 100-109.Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A. & Melis, M. R. (2007). The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neuroscience Letters, 419 (3), 231-235.Nederkoorn, C., Braet, B., Van Eijs, Y., Tanghe, A. & Jansen, A. (2006). Why obese children cannot resist food: The role of impulsivity. Eating Behaviors, 7, 315-322.Pandolfo, P., Pamplona, F. A., Prediger, R. D. & Takahashi, R. N. (2007). Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2. European Journal of Pharmacology, 563(1–3), 141-148.Paxinos, G. & Watson, C. (1998). The brain in stereotaxic coordinates. New York: Academic Press.Perello, M., Chuang, J., Scott, M. M. & Lutter, M. (2010). Translational Neuroscience approaches to hyperphagia. The Journal of Neuroscience, 30(35), 11549-11554.Quarta C., Bellocchio L., Manzini G., Mazza R., Cervino C., Braulke L., Fekete C., Latorre R., Nanni C., Bucci M., Clemens L., Heldmaier G., Watanabe M., Leste-Lassere T., Maitre M., Tedesco L., FanelliF., Reuss S., KlausS., Srivastava R., Monory K., Valerio A., Grandis A., de Giorgio R., Pasquali R., Nisoli E., Cota D., Lutz B., Marsicano G. & Pagotto U. (2010). CB1 signaling in forebrain and sympathetic neurons is a key Determinant of endocannabinoid actions on energy balance. Cell Metabolism, 11, 273-285.Ravinet-Trillou, C., Delgorge, C., Menet, C., Arnone, M. & Soubrié, P. (2004). CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity, 28, 640-648.Sanudo-Pena, M.C., Patrick, S. L., Patrick, R.L. & Walker, J.M. (1996). Effects of intranigral cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system. Neuroscience Letters, 206, 21-24.Soria-Gómez, E., Matías, I., Rueda-Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L. Di Marzo, V. & Próspero-García, O. (2007). Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. British Journal of Pharmacology, 151, 1109-1116.Verty, A.N., McGregor, I.S. & Mallet, P.E. (2005). Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)tetrahydrocannabinol. 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