Cocaína durante la gestación y conducta materna postparto en ratones

El abuso materno de cocaína durante la gestación se relaciona con negligencia, maltrato y perturbación del vínculo madre-hijo, lo que incide directamente en el desarrollo de los infantes; por esto, las diversas problemáticas neuroconductuales de los hijos de padres drogodependientes podrían atribuir...

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Autores:: Santacruz-Ortega, María del Pilar
Marrero-Quevedo, Rosario J.
Bethencourth-Pérez, Juan Manuel
Castellano, Miguel Ángel
Peñate-Castro, Wenceslao

Tipo de recurso:: Article of journal

Fecha de publicación:: 2017

Institución:: Universidad Católica de Colombia

Repositorio:: RIUCaC - Repositorio U. Católica

Idioma:: eng
spa
por

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dc.title.spa.fl_str_mv	Cocaína durante la gestación y conducta materna postparto en ratones
dc.title.translated.eng.fl_str_mv	Cocaine exposure during pregnancy and postpartum maternal behavior in mice Cocaína durante a gestação e comportamento materno pós-parto em ratos
title	Cocaína durante la gestación y conducta materna postparto en ratones
spellingShingle	Cocaína durante la gestación y conducta materna postparto en ratones CONDUCTA MATERNA POSTPARTO COCAÍNA ÍNDICES PROXIMALES MOTORES Y AUTOMANTENIMIENTO POSPARTUM MATERNAL BEHAVIOR COCAINE PROXIMAL INDEXES MOTOR ACTIVITY AND SELF-MAINTENANCE COMPORTAMENTO MATERNO PÓS-PARTO ÍNDICES PROXIMAIS MOTORES E AUTOMANUTENÇÃO
title_short	Cocaína durante la gestación y conducta materna postparto en ratones
title_full	Cocaína durante la gestación y conducta materna postparto en ratones
title_fullStr	Cocaína durante la gestación y conducta materna postparto en ratones
title_full_unstemmed	Cocaína durante la gestación y conducta materna postparto en ratones
title_sort	Cocaína durante la gestación y conducta materna postparto en ratones
dc.creator.fl_str_mv	Santacruz-Ortega, María del Pilar Marrero-Quevedo, Rosario J. Bethencourth-Pérez, Juan Manuel Castellano, Miguel Ángel Peñate-Castro, Wenceslao
dc.contributor.author.spa.fl_str_mv	Santacruz-Ortega, María del Pilar Marrero-Quevedo, Rosario J. Bethencourth-Pérez, Juan Manuel Castellano, Miguel Ángel Peñate-Castro, Wenceslao
dc.subject.proposal.spa.fl_str_mv	CONDUCTA MATERNA POSTPARTO COCAÍNA ÍNDICES PROXIMALES MOTORES Y AUTOMANTENIMIENTO POSPARTUM MATERNAL BEHAVIOR COCAINE PROXIMAL INDEXES MOTOR ACTIVITY AND SELF-MAINTENANCE COMPORTAMENTO MATERNO PÓS-PARTO ÍNDICES PROXIMAIS MOTORES E AUTOMANUTENÇÃO
topic	CONDUCTA MATERNA POSTPARTO COCAÍNA ÍNDICES PROXIMALES MOTORES Y AUTOMANTENIMIENTO POSPARTUM MATERNAL BEHAVIOR COCAINE PROXIMAL INDEXES MOTOR ACTIVITY AND SELF-MAINTENANCE COMPORTAMENTO MATERNO PÓS-PARTO ÍNDICES PROXIMAIS MOTORES E AUTOMANUTENÇÃO
description	El abuso materno de cocaína durante la gestación se relaciona con negligencia, maltrato y perturbación del vínculo madre-hijo, lo que incide directamente en el desarrollo de los infantes; por esto, las diversas problemáticas neuroconductuales de los hijos de padres drogodependientes podrían atribuirse a la inadecuada conducta materna o a la exposición prenatal a la droga. El objetivo de esta investigación fue analizar los efectos de la administración crónica de cocaína durante la gestación en la conducta materna postparto de ratones. Para esto se asignaron aleatoriamente 21 ratones CD1 hembras gestantes para la administración de solución salina y cocaína (25 mg/kg/día y 50 mg/kg/día), desde el octavo hasta el día veintiuno de gestación. Después del parto, durante 20 días (15 minutos diarios), se registró individualmente la frecuencia de presentación de 16 índices de conducta materna mediante un etograma. Se encontró que la cocaína afectó levemente la frecuencia de la conducta materna, aunque posiblemente afecte otros parámetros como la latencia, duración y secuencia de esta conducta.
publishDate	2017
dc.date.issued.spa.fl_str_mv	2017-01
dc.date.accessioned.spa.fl_str_mv	2018-02-10T17:46:05Z
dc.date.available.spa.fl_str_mv	2018-02-10T17:46:05Z
dc.type.spa.fl_str_mv	Artículo de revista
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dc.type.content.spa.fl_str_mv	Text
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dc.identifier.citation.spa.fl_str_mv	Santacruz-Ortega, M., Marrero-Quevedo, R., Bethencourth-Perez, J., Castellano, M., & Peñate-Castro, W. (2017). Cocaína durante la gestación y conducta materna postparto en ratones- Cocaine exposure during pregnancy and postpartum maternal behavior in mice- Cocaína durante a gestação e comportamento materno pós-parto em ratos. Acta Colombiana de Psicología, 20(1). Recuperado de http://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/1301
dc.identifier.issn.spa.fl_str_mv	0123-9155
dc.identifier.uri.spa.fl_str_mv	http://hdl.handle.net/10983/15506
identifier_str_mv	Santacruz-Ortega, M., Marrero-Quevedo, R., Bethencourth-Perez, J., Castellano, M., & Peñate-Castro, W. (2017). Cocaína durante la gestación y conducta materna postparto en ratones- Cocaine exposure during pregnancy and postpartum maternal behavior in mice- Cocaína durante a gestação e comportamento materno pós-parto em ratos. Acta Colombiana de Psicología, 20(1). Recuperado de http://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/1301 0123-9155
url	http://hdl.handle.net/10983/15506
dc.language.iso.spa.fl_str_mv	eng spa por
language	eng spa por
dc.relation.ispartof.spa.fl_str_mv	Acta Colombiana de Psicología, Vol. 20, no. 1 (ene.-jun. 2017); p. 154-165
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Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behavioral Neuroscien ce, 121, 1353-1363. doi: 10.1037/0735-7044.121.6.1353 Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003). Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiology & Behavior, 79, 359-371. doi: 10.1016/S0031-9384(03)00149-5 Chaplin, T. M, Visconti, K. J., Molfese, P. J., Susman, E. J., Klein, L. C., Sinha, R., & Mayes, L. C. (2014). Prenatal cocaine exposure differentially affects stress responses in girls and boys: Associations with future substance use. Development and Psychopathology, 18, 1-8. doi: 10.1017/S0954579414000716. Colado, M. I., & Alguacil, F. (2008). Drogas de abuso (Capitulo 20). En: P. Lorenzo, A., Moreno, I., Lizasoain, J. C., Leza, M. H., Moro, M. H., Portolés, A. (Eds.), Velázquez, & Farmacología Básica y Clínica (pp 335-354). Buenos Aires: Edit. 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Genetic, Social and General Psychology Monographs, 132, 5-94. doi: 10.3200/MONO.132.1.5-94. Hess, C. W., Hahn, M. E., Benno, R. H., & Schanz, N. (2002). Prenatal cocaine exposure alters maternal retrieval behavior in mice. Behavioral Genetics, 32, 259-266. doi: 10.1023/A:1019776729821. Jaworski, J., Francis, D., Brommer, C., Morgan, E., & Kuhar, M. (2005). Effects of early maternal separation on ethanol intake, GABA receptors and metabolizing enzymes in adult rats. Psychopharmacology , 181, 8-15. doi: 10.1007/s00213-005-2232-4. Johns, J. M., Elliott, D. L., Hofler, V. E., Joyner, P. W., McMurray, M. S., Jarrett, T. M., Haslup, A. M., Middleton, C. L., Elliott, J. C., & Walker, C. H. (2005). Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats. Behavioral Neuroscience , 119, 1605-1618. doi: 10.1037/0735-7044.119.6.1605. Johns, J. M., Noonan, L. R., Li, L., & Pedersen, C.A. (1994). Effects of chronic and acute cocaine treatment on the onset of maternal behavior and aggression in Sprague-Dawley rats. Behavioral Neuroscience , 108, 107-112. doi: 10.1037/0735-7044.108.1.107. Johns, J. M., Noonan, L. R., Zimmerman, L. I., Li, L., & Pedersen, C. A. (1997). Effects of short- and long-term withdrawal from gestational cocaine treatment on maternal be havior and aggression in sprague-dawley rats. Development Neurosciences, 19, 368-374. doi: 10.1159/000111234. Kinsley, C. H., Turco, D., Bauer, A., Beverly, M., Wellman, J., & Graham, A. L. (1994). Cocaine alters the onset and maintenance of maternal behavior in lactating rats. Phar macology Biochemistry and Behavior, 47, 857-864. doi: 10.1016/0091-3057(94)90288-7. Kippin, T. E., Campbell, J. C., Ploense, K., Knight, C. P., & Bagley, J. (2015). Prenatal Stress and Adult Drug-Seeking Behavior: Interactions with Genes and Relation to Nondrug-Related Behavior. In Perinatal Programming of Neurodevelopment (pp. 75-100). New York: Springer. doi: 10.1007/978-1-4939-1372-5_5. Kristal, M. B. (2009). The biopsychology of maternal behavior in nonhuman mammals. ILAAR Journal, 50, 51-63. doi: 10.1093/ilar.50.1.51. Lambert, B. L., & Bauer, C. R. (2012). Developmental and behavioral consequences of prenatal cocaine exposure: a re view. Journal of Perinatology, 32, 819-828. doi: 10.1038/jp.2012.90. Lester, B. M., Lin, H., Degarmo, D. S., Fisher, P. A., Lagasse, L. L., Levine, T. P., Shankaran, S., Bada, H. S., Bauer, C. R., Hammond, J. A., Whitaker, T. M., & Higgins, R. D. (2012). Neurobehavioral disinhibition predicts initiation of substance use in children with prenatal cocaine exposure. Drug Alcohol Dependence, 126, 80-86. doi: 10.1016/j.drugalcdep.2012.04.014. Lester, B. M., & Padbury, J. F. (2009). Third pathophysiology of prenatal cocaine exposure. Developmental Neuroscience , 31, 23-35. doi: 10.1159/000207491. Lippard, E. C., Jarrett, T. M., McMurray, M. S., Zeskind, P. S., Garber, K. A., Zoghby, C. R., Glaze, K., Tate, W., & Johns, J. M. (2015). Early postpartum pup preference is altered by gestational cocaine treatment: Associations with infant cues and oxytocin expression in the MPOA. Behavioural Brain Research, 278, 176-185. doi: 10.1016/j.bbr.2014.09.045. Lucantonio, F., Stalnaker, T. A., Shaham, Y., Niv, Y., & Schoen-baum, G. (2012). The impact of orbitofrontal dysfunction on cocaine addiction. Nature Neuroscience , 15, 358-66. doi: 10.1038/nn.3014. Martínez-Raga, J., Knecht, C., Ramírez, N., & Szerman, N. (2009) Sistemas de neurotransmisión glutamatérgica y adicción a la cocaína. Progresos en el tratamiento farma cológico. Revista de Psiquiatría del Uruguay, 73, 63-72. Recuperado de http://www.spu.org.uy/revista/ago2009/02_TO_05.pdf. McMurray, M. S. (2011). A rodent model of cocaine's effect on the mother infant dyad. (Order No. 3465053, The University of North Carolina at Chapel Hill). ProQuest Dissertations and Theses. 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Results from the 2006 Na tional Survey on Drug Use and Health: National findings (DHHS Publication No. SMA 07-4293, NSDUH Series H-32). Olive, M. F., Koenig, H. N., Nannini, M. A., & Hodge, C.W (2001). Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine. The Journal of Neuroscience , 21, 1-5. doi=10.1.1.336.2239. Pereira, M., & Ferreira, A. (2015). Affective, Cognitive and Motivational Processes of Maternal Care. En Perinatal Programming of Neurodevelopment (pp. 199-217). New York: Springer . Quiñones Jenab, V., Batel, P., Schlussman, S. D., Ho, A., & Kreek, M. J. (1997). Cocaine impairs maternal nest building in pregnant rats. Pharmacology Biochemist Behavior, 58, 1009-1013. doi: 10.1016/S0091-3057(97)00311-0. Richardson, G. A., Goldschmidt, L., Larkby, C., & Day, N. L. (2013) Effects of prenatal cocaine exposure on child behavior and growth at 10 years of age. 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Psychoneuroendocrinology, 52, 212-228. doi: 10.1016/j.psyneuen.2014.11.016. Strathearn, L., & Mayes, L. C. (2010). Cocaine addiction in mothers: potential effects on maternal care and infant development. Annals of the New York Academic Sciences. 1187. 172-83. doi: 10.1111/j.1749-6632.2009.05142.x. Szyf, M. (2014). Nongenetic inheritance and transgenerational epigenetics. Trends in Molecular Medicine, 21,134-144. doi: 10.1016/j.molmed.2014.12.004. Téllez-Mosquera, J., & Cote-Menéndez, M. (2005). Efectos toxicológicos y neuropsiquiátricos producidos por consumo de cocaína. Revista Facultad de Medicina Universidad Nacional de Colombia, 53, 10-26. Toth, M. (2015). Mechanisms of non-genetic inheritance and psychiatric disorders. Neuropsychopharmacology , 40, 129-140. doi: 10.1038/npp.2014.127. Wang, Z., & Storm, D.R. (2011). Maternal behavior is impaired in female mice lacking type 3-adenylylcyclase. Neuropsy-chopharmacology, 36, 772-781. doi: 10.1038/npp.2010.211. Wickham, M. 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spelling	Santacruz-Ortega, María del Pilar9bb13de8-ee55-4ffe-84de-ab0be874f031Marrero-Quevedo, Rosario J.21eda894-44ee-42d4-a884-3b6df280a3d1-1Bethencourth-Pérez, Juan Manuelfb6c77a8-e78f-4613-bd42-a1f393226a74Castellano, Miguel Ángel35273951-f6fc-4056-9753-a1623832db9a-1Peñate-Castro, Wenceslao32bd41f6-6009-4744-8b57-6d5c3b82f4ff-12018-02-10T17:46:05Z2018-02-10T17:46:05Z2017-01El abuso materno de cocaína durante la gestación se relaciona con negligencia, maltrato y perturbación del vínculo madre-hijo, lo que incide directamente en el desarrollo de los infantes; por esto, las diversas problemáticas neuroconductuales de los hijos de padres drogodependientes podrían atribuirse a la inadecuada conducta materna o a la exposición prenatal a la droga. El objetivo de esta investigación fue analizar los efectos de la administración crónica de cocaína durante la gestación en la conducta materna postparto de ratones. Para esto se asignaron aleatoriamente 21 ratones CD1 hembras gestantes para la administración de solución salina y cocaína (25 mg/kg/día y 50 mg/kg/día), desde el octavo hasta el día veintiuno de gestación. Después del parto, durante 20 días (15 minutos diarios), se registró individualmente la frecuencia de presentación de 16 índices de conducta materna mediante un etograma. Se encontró que la cocaína afectó levemente la frecuencia de la conducta materna, aunque posiblemente afecte otros parámetros como la latencia, duración y secuencia de esta conducta.Maternal cocaine abuse during pregnancy is associated to neglect, abuse, and mother-child bond disruption, which directly affects infant development; therefore, various neurobehavioral problems of children of drug-dependent parents could be attributed to inadequate maternal behavior or prenatal exposure to drugs. Thus, the aim of this research was to analyze the effects of chronic cocaine administration during pregnancy on postpartum maternal behavior. To do this, 21 CD1 pregnant female mice were randomly assigned for administration of saline solution and cocaine (25 mg/kg/day and 50 mg/kg/day), from day 8 to 21 of gestation. After delivery, for 15 minutes a day, during 20 days, the frequency of occurrence of 16 behavioral patterns of maternal behavior was individually recorded, using an ethogram. Cocaine slightly affected maternal behavior frequency, although it may have affected other parameters, such as latency, duration, and sequence of this behavior.O abuso materno de cocaína durante a gestação está relacionado com negligência, maltrato, perturbação do vínculo mãe-filho, o que incide diretamente no desenvolvimento das crianças. Por isso, as diversas problemáticas neurocomportamentais dos filhos de pais drogodependentes poderiam ser atribuídas ao inadequado comportamento materno ou à exposição prénatal à droga. O objetivo desta pesquisa foi analisar os efeitos da administração crônica de cocaína durante a gestação no comportamento materno pós-parto de ratos. Para isso, designaram-se aleatoriamente 21 ratos CD1 fêmeas gestantes para a administração de solução salina e cocaína (25 mg/kg/dia e 50 mg/kg/dia), desde o oitavo até o 21° dia de gestação. Após o parto, durante 20 dias (15 minutos diários), registrou-se individualmente a frequência de apresentação de 16 índices de comportamento materno mediante um etograma. Constatou-se que a cocaína afetou levemente a frequência do comportamento materno, embora possivelmente afete outros parâmetros como latência, duração e sequência desse comportamento.application/pdfSantacruz-Ortega, M., Marrero-Quevedo, R., Bethencourth-Perez, J., Castellano, M., & Peñate-Castro, W. 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K., & Johns, J. M. (2014). Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction. Pharmacology, Biochemistry and Behavior , 119, 10-21. doi: http://dx.doi.org/10.1016/j.pbb.2013.07.004.Williams, S. K., Lauder, J. M., & Johns, J. M. (2011).Prenatal cocaine disrupts serotonin signaling-dependent behaviors: Implications for sex differences, early stress and prenatal SSRI exposure. Current Neuropharmacology, 9, 478-511. doi: 10.2174/157015911796557957.Derechos Reservados - Universidad Católica de Colombia, 2017info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)https://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2CONDUCTA MATERNA POSTPARTOCOCAÍNAÍNDICES PROXIMALESMOTORES Y AUTOMANTENIMIENTOPOSPARTUM MATERNAL BEHAVIORCOCAINEPROXIMAL INDEXESMOTOR ACTIVITY AND SELF-MAINTENANCECOMPORTAMENTO MATERNO PÓS-PARTOÍNDICES PROXIMAISMOTORES E AUTOMANUTENÇÃOCocaína durante la gestación y conducta materna postparto en ratonesCocaine exposure during pregnancy and postpartum maternal behavior in miceCocaína durante a gestação e comportamento materno pós-parto em ratosArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationORIGINALCocaína durante la gestación.pdfCocaína durante la gestación.pdfArtículo en españolapplication/pdf700945https://repository.ucatolica.edu.co/bitstreams/19cbf333-cf55-4aa3-82f2-53c2c26f1370/downloade38556a827cfdae5154b5f571244dae9MD51Cocaine exposure during pregnancy.pdfCocaine exposure during pregnancy.pdfArtículo en inglesapplication/pdf705215https://repository.ucatolica.edu.co/bitstreams/b1d52e1b-fcf9-4a54-a4a3-b2bf56eaa9fc/download4d44f2b4f67402435a413601b656c853MD52TEXTCocaína durante la gestación.pdf.txtCocaína durante la gestación.pdf.txtExtracted texttext/plain53501https://repository.ucatolica.edu.co/bitstreams/09f08610-796e-4a8c-aa65-3159aa0768e0/downloade85aa1846b86c196d988197af9e15c20MD53Cocaine exposure during pregnancy.pdf.txtCocaine exposure during pregnancy.pdf.txtExtracted texttext/plain50349https://repository.ucatolica.edu.co/bitstreams/5c99369a-b713-43ee-a5d2-5f3b7f583f2f/download197a9cc1edc7f3aaef80e4e4982a3a63MD55THUMBNAILCocaína durante la gestación.pdf.jpgCocaína durante la gestación.pdf.jpgRIUCACimage/jpeg4822https://repository.ucatolica.edu.co/bitstreams/b9a12a5e-71b1-42cf-94c9-240e379c66a4/downloade9ada2fb51c2a902fef2654634f782f5MD54Cocaine exposure during pregnancy.pdf.jpgCocaine exposure during pregnancy.pdf.jpgRIUCACimage/jpeg4842https://repository.ucatolica.edu.co/bitstreams/c4bd4f97-8156-4e09-9b48-d424df4bbad3/downloaddd7fe80a000d81e9cf63b4673155e4dbMD5610983/15506oai:repository.ucatolica.edu.co:10983/155062023-07-28 12:44:30.115https://creativecommons.org/licenses/by-nc-nd/4.0/Derechos Reservados - Universidad Católica de Colombia, 2017https://repository.ucatolica.edu.coRepositorio Institucional Universidad Católica de Colombia - RIUCaCbdigital@metabiblioteca.com

Cocaína durante la gestación y conducta materna postparto en ratones

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