Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex

The prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of th...

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Autores:
García-Saldívar, Norma Laura
Reyes-González-López, María
Monroy, Juana
Domínguez, Roberto
Cruz-Morales, Sara Eugenia
Tipo de recurso:
Article of journal
Fecha de publicación:
2014
Institución:
Universidad Católica de Colombia
Repositorio:
RIUCaC - Repositorio U. Católica
Idioma:
eng
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oai:repository.ucatolica.edu.co:10983/2277
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http://hdl.handle.net/10983/2277
Palabra clave:
STRESSORS
NORADRENALINE
SEROTONIN
PREFRONTAL CORTEX
CORTICOSTERON6A
ESTRESORES
NORADRENALINA
SEROTONINA
CORTEZA PREFRONTAL
CORTICOSTERONA
ESTRESSORES
CÓRTEX PRÉ-FRONTAL
ESTRÉS (FISIOLOGÍA)
NEUROTRANSMISORES-INVESTIGACIONES
CORTEZA CEREBRAL
HORMONAS ADRENOCORTICALES-INVESTIGACIONES
PSICOLOGÍA EXPERIMENTAL
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Derechos Reservados - Universidad Católica de Colombia, 2014
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network_acronym_str UCATOLICA2
network_name_str RIUCaC - Repositorio U. Católica
repository_id_str
dc.title.spa.fl_str_mv Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
dc.title.translated.eng.fl_str_mv Efectos agudos de la restricción, choque y entrenamiento en el laberinto elevado en T en los sistemas de noradrenalina y serotonina en la corteza prefrontal
Efeitos agudos da restrição, choque e treinamento no labirinto elevado em T nos sistemas de noradrenalina e serotonina no córtex pré-frontal
title Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
spellingShingle Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
STRESSORS
NORADRENALINE
SEROTONIN
PREFRONTAL CORTEX
CORTICOSTERON6A
ESTRESORES
NORADRENALINA
SEROTONINA
CORTEZA PREFRONTAL
CORTICOSTERONA
ESTRESSORES
CÓRTEX PRÉ-FRONTAL
ESTRÉS (FISIOLOGÍA)
NEUROTRANSMISORES-INVESTIGACIONES
CORTEZA CEREBRAL
HORMONAS ADRENOCORTICALES-INVESTIGACIONES
PSICOLOGÍA EXPERIMENTAL
title_short Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
title_full Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
title_fullStr Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
title_full_unstemmed Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
title_sort Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex
dc.creator.fl_str_mv García-Saldívar, Norma Laura
Reyes-González-López, María
Monroy, Juana
Domínguez, Roberto
Cruz-Morales, Sara Eugenia
dc.contributor.author.spa.fl_str_mv García-Saldívar, Norma Laura
Reyes-González-López, María
Monroy, Juana
Domínguez, Roberto
Cruz-Morales, Sara Eugenia
dc.subject.spa.fl_str_mv STRESSORS
NORADRENALINE
SEROTONIN
PREFRONTAL CORTEX
CORTICOSTERON6A
ESTRESORES
NORADRENALINA
SEROTONINA
CORTEZA PREFRONTAL
CORTICOSTERONA
ESTRESSORES
CÓRTEX PRÉ-FRONTAL
topic STRESSORS
NORADRENALINE
SEROTONIN
PREFRONTAL CORTEX
CORTICOSTERON6A
ESTRESORES
NORADRENALINA
SEROTONINA
CORTEZA PREFRONTAL
CORTICOSTERONA
ESTRESSORES
CÓRTEX PRÉ-FRONTAL
ESTRÉS (FISIOLOGÍA)
NEUROTRANSMISORES-INVESTIGACIONES
CORTEZA CEREBRAL
HORMONAS ADRENOCORTICALES-INVESTIGACIONES
PSICOLOGÍA EXPERIMENTAL
dc.subject.lemb.spa.fl_str_mv ESTRÉS (FISIOLOGÍA)
NEUROTRANSMISORES-INVESTIGACIONES
CORTEZA CEREBRAL
HORMONAS ADRENOCORTICALES-INVESTIGACIONES
PSICOLOGÍA EXPERIMENTAL
description The prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of the stressor and the assessment. The aims of the present study were to assess the acute effect of different stressors on NA and 5-HT activities in the PFC and its relation with corticosterone levels. Independent groups of male Wistar rats (250-280 g) were submitted to restraint, footshock or training in the elevated T-maze (ETMT). The animals were sacrificed immediately (T0) or one hour (T1) after stress exposure. An untreated group sacrificed concurrently with treated animals was included as control. Samples of the PFC were dissected and the concentration of NA, 5-HT and their metabolites were measured by HPLC. Corticosterone levels were measured in serum. None of the treatments modified NA levels in the PFC. Animals exposed to footshock or ETMT showed significantly higher concentrations of 5-HT at T0. Restraint and footshock treatments were associated with higher corticosterone levels at T0 and T1 after the respective treatment. Taken together the results show that in the PFC, the noradrenergic and serotonergic systems, and the corticosterone levels respond in different ways to different stressors.
publishDate 2014
dc.date.issued.spa.fl_str_mv 2014-07
dc.date.accessioned.spa.fl_str_mv 2015-05-26T20:39:38Z
dc.date.available.spa.fl_str_mv 2015-05-26T20:39:38Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.spa.fl_str_mv García-Saldívar, N., Reyes-González-López, M., Monroy, J., Domínguez, R., & Cruz-Morales, S. (2014). Acute effects of restraint, shock and training in the elevated t-maze on noradrenaline and serotonin systems of the prefrontal cortex. Acta Colombiana de Psicología, 17(2), 23-31. Recuperado de http://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/161
dc.identifier.issn.spa.fl_str_mv 0123-9155
dc.identifier.uri.spa.fl_str_mv http://hdl.handle.net/10983/2277
identifier_str_mv García-Saldívar, N., Reyes-González-López, M., Monroy, J., Domínguez, R., & Cruz-Morales, S. (2014). Acute effects of restraint, shock and training in the elevated t-maze on noradrenaline and serotonin systems of the prefrontal cortex. Acta Colombiana de Psicología, 17(2), 23-31. Recuperado de http://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/161
0123-9155
url http://hdl.handle.net/10983/2277
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartof.spa.fl_str_mv Acta Colombiana de Psicología, Vol. 17, no. 2 (jul.-dic. 2014); p. 23-31
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spelling García-Saldívar, Norma Laura495f84e5-6f0d-4acf-85b9-cb58d56d1144-1Reyes-González-López, María367faa01-51c9-445d-9e38-662de67da367-1Monroy, Juana6335e29d-2eba-4852-aae2-9fdd4421ce1a-1Domínguez, Roberto38a5b590-2ac3-41de-b83d-01f7457042aa-1Cruz-Morales, Sara Eugeniac910031b-2d12-414e-8282-ac1322ffd16e-12015-05-26T20:39:38Z2015-05-26T20:39:38Z2014-07The prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of the stressor and the assessment. The aims of the present study were to assess the acute effect of different stressors on NA and 5-HT activities in the PFC and its relation with corticosterone levels. Independent groups of male Wistar rats (250-280 g) were submitted to restraint, footshock or training in the elevated T-maze (ETMT). The animals were sacrificed immediately (T0) or one hour (T1) after stress exposure. An untreated group sacrificed concurrently with treated animals was included as control. Samples of the PFC were dissected and the concentration of NA, 5-HT and their metabolites were measured by HPLC. Corticosterone levels were measured in serum. None of the treatments modified NA levels in the PFC. Animals exposed to footshock or ETMT showed significantly higher concentrations of 5-HT at T0. Restraint and footshock treatments were associated with higher corticosterone levels at T0 and T1 after the respective treatment. Taken together the results show that in the PFC, the noradrenergic and serotonergic systems, and the corticosterone levels respond in different ways to different stressors.La corteza prefrontal (CPF) participa en las funciones cognitivas y la regulación del estrés. Las concentraciones de noradrenalina (NA) y serotonina (5-HT) en algunas regiones en el sistema nervioso central son modificadas por el estrés agudo. El efecto depende del estresor y del tiempo que transcurra entre el estresor y la evaluación. El objetivo del presente estudio fue evaluar el efecto agudo de diferentes estresores en la actividad de la NA y 5-HT en la CPF y su relación con los niveles de corticosterona. Grupos independientes de ratas (250-270 g) fueron sometidos a restricción, choque o entrenamiento en el laberinto elevado en T (ELET). Los animales fueron sacrificados inmediatamente (T0) o una hora (T1) después de la exposición al estrés. Un grupo no tratado, sacrificado al mismo tiempo que los animales tratados, se incluyó como control. Las muestras de la CPF fueron disecadas y la concentración de NA, 5-HT y sus metabolitos fue detectada por la técnica de HPLC. Las concentraciones de corticosterona fueron medidas en el suero. Ninguno de los tratamientos modificó las concentraciones de NA en la CPF. Al T0 los animales expuestos a choque o al ELET mostraron concentraciones de 5-HT significativamente mayores que el control. Los tratamientos de restricción y choque estuvieron asociados con altas concentraciones de corticosterona al T0 y a T1 después del tratamiento respectivo. En conjunto, los resultados mostraron que en la CPF los sistemas noradrenérgico y serotonérgico y la concentración de corticosterona responden en forma diferente a los distintos estresores.O córtex pré-frontal (CPF) participa nas funções cognitivas e na regulação do estresse. As concentrações de noradrenalina (NA) e serotonina (5-HT) em algumas regiões do sistema nervoso central são modificadas pelo estresse agudo. O efeito depende do estressor e do tempo que transcorra entre o estressor e a avaliação. O objetivo do presente estudo foi avaliar o efeito agudo de diferentes estressores na atividade da NA e 5-HT no PFC e sua relação com os níveis de corticosterona. Grupos independentes de ratos (250-270 g) foram submetidos a restrição, choque ou treinamento no labirinto elevado em T (ELET). Os animais foram sacrificados imediatamente (T0) ou uma hora (T1) depois da exposição ao estresse. Um grupo não tratado, sacrificado ao mesmo tempo que os animais tratados, incluiu-se como controle. As mostras do PFC foram dissecadas e a concentração de NA, 5-HT e seus metabolitos foi detectada pela técnica de HPLC. As concentrações de corticosterona foram medidas no soro. Nenhum dos tratamentos modificou as concentrações de NA no PFC. Em T0 os animais expostos a choque o ao ELET mostraram concentrações de 5-HT significativamente maiores que o controle. Os tratamentos de restrição e choque estiveram associados com altas concentrações de corticosterona em T0 e em T1 depois do tratamento respectivo. 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Brain Research, 459, 54-59.Derechos Reservados - Universidad Católica de Colombia, 2014info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2STRESSORSNORADRENALINESEROTONINPREFRONTAL CORTEXCORTICOSTERON6AESTRESORESNORADRENALINASEROTONINACORTEZA PREFRONTALCORTICOSTERONAESTRESSORESCÓRTEX PRÉ-FRONTALESTRÉS (FISIOLOGÍA)NEUROTRANSMISORES-INVESTIGACIONESCORTEZA CEREBRALHORMONAS ADRENOCORTICALES-INVESTIGACIONESPSICOLOGÍA EXPERIMENTALAcute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortexEfectos agudos de la restricción, choque y entrenamiento en el laberinto elevado en T en los sistemas de noradrenalina y serotonina en la corteza prefrontalEfeitos agudos da restrição, choque e treinamento no labirinto elevado em T nos sistemas de noradrenalina e serotonina no córtex pré-frontalArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationORIGINALv17n2a03.pdfv17n2a03.pdfapplication/pdf324065https://repository.ucatolica.edu.co/bitstreams/b7e2eb66-31a9-418a-b12d-f39c95eb0c8d/download0e01022a7277fd665cb1171a2cd7d5efMD51TEXTv17n2a03.pdf.txtv17n2a03.pdf.txtExtracted texttext/plain41547https://repository.ucatolica.edu.co/bitstreams/4670ecf9-8bd4-4839-8549-39a626dd2b7d/download15cf809e4b67a258281b896ef8e3c6b0MD52THUMBNAILv17n2a03.pdf.jpgv17n2a03.pdf.jpgRIUCACimage/jpeg4631https://repository.ucatolica.edu.co/bitstreams/f4fb40d8-bf4c-47ad-a88f-b9bc80417025/download43e504eeda09b0deb473b8e3f7c328d5MD5310983/2277oai:repository.ucatolica.edu.co:10983/22772023-03-24 14:46:14.904https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad Católica de Colombia, 2014https://repository.ucatolica.edu.coRepositorio Institucional Universidad Católica de Colombia - RIUCaCbdigital@metabiblioteca.com

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