Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex

The prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of th...

Full description

Autores:
García-Saldívar, Norma Laura
Reyes-González-López, María
Monroy, Juana
Domínguez, Roberto
Cruz-Morales, Sara Eugenia
Tipo de recurso:
Article of journal
Fecha de publicación:
2014
Institución:
Universidad Católica de Colombia
Repositorio:
RIUCaC - Repositorio U. Católica
Idioma:
eng
OAI Identifier:
oai:repository.ucatolica.edu.co:10983/2277
Acceso en línea:
http://hdl.handle.net/10983/2277
Palabra clave:
STRESSORS
NORADRENALINE
SEROTONIN
PREFRONTAL CORTEX
CORTICOSTERON6A
ESTRESORES
NORADRENALINA
SEROTONINA
CORTEZA PREFRONTAL
CORTICOSTERONA
ESTRESSORES
CÓRTEX PRÉ-FRONTAL
ESTRÉS (FISIOLOGÍA)
NEUROTRANSMISORES-INVESTIGACIONES
CORTEZA CEREBRAL
HORMONAS ADRENOCORTICALES-INVESTIGACIONES
PSICOLOGÍA EXPERIMENTAL
Rights
openAccess
License
Derechos Reservados - Universidad Católica de Colombia, 2014
Description
Summary:The prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of the stressor and the assessment. The aims of the present study were to assess the acute effect of different stressors on NA and 5-HT activities in the PFC and its relation with corticosterone levels. Independent groups of male Wistar rats (250-280 g) were submitted to restraint, footshock or training in the elevated T-maze (ETMT). The animals were sacrificed immediately (T0) or one hour (T1) after stress exposure. An untreated group sacrificed concurrently with treated animals was included as control. Samples of the PFC were dissected and the concentration of NA, 5-HT and their metabolites were measured by HPLC. Corticosterone levels were measured in serum. None of the treatments modified NA levels in the PFC. Animals exposed to footshock or ETMT showed significantly higher concentrations of 5-HT at T0. Restraint and footshock treatments were associated with higher corticosterone levels at T0 and T1 after the respective treatment. Taken together the results show that in the PFC, the noradrenergic and serotonergic systems, and the corticosterone levels respond in different ways to different stressors.