News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological

Revista Ciencias Biomédicas Vol.10, Núm.2 (2021) Pag. 109-119

Autores:
Llamas Nieves, Andrés Elías
Lozada-Martínez, Iván David
Torres Llinás, Daniela Marcela
Manzur Jattin, Fernando
Cardales Periñán, Miguel
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Universidad de Cartagena
Repositorio:
Repositorio Universidad de Cartagena
Idioma:
eng
OAI Identifier:
oai:repositorio.unicartagena.edu.co:11227/11878
Acceso en línea:
https://hdl.handle.net/11227/11878
https://doi.org/10.32997/rcb-2021-3371
Palabra clave:
Atrial Fibrillation
Renin-Angiotensin System;
Angiotensin II
Cardiovascular Diseases
Cardiac Arrhythmias
Rights
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.title.es.fl_str_mv News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
title News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
spellingShingle News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
Atrial Fibrillation
Renin-Angiotensin System;
Angiotensin II
Cardiovascular Diseases
Cardiac Arrhythmias
title_short News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
title_full News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
title_fullStr News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
title_full_unstemmed News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
title_sort News on angiotensin II and atrial fibrillation: from the molecular to the pathophysiological
dc.creator.fl_str_mv Llamas Nieves, Andrés Elías
Lozada-Martínez, Iván David
Torres Llinás, Daniela Marcela
Manzur Jattin, Fernando
Cardales Periñán, Miguel
dc.contributor.author.none.fl_str_mv Llamas Nieves, Andrés Elías
Lozada-Martínez, Iván David
Torres Llinás, Daniela Marcela
Manzur Jattin, Fernando
Cardales Periñán, Miguel
dc.subject.es.fl_str_mv Atrial Fibrillation
Renin-Angiotensin System;
Angiotensin II
Cardiovascular Diseases
Cardiac Arrhythmias
topic Atrial Fibrillation
Renin-Angiotensin System;
Angiotensin II
Cardiovascular Diseases
Cardiac Arrhythmias
description Revista Ciencias Biomédicas Vol.10, Núm.2 (2021) Pag. 109-119
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-05-22T00:26:59Z
dc.date.available.none.fl_str_mv 2021-05-22T00:26:59Z
dc.date.issued.none.fl_str_mv 2021
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11227/11878
dc.identifier.doi.spa.fl_str_mv 10.32997/rcb-2021-3371
dc.identifier.eissn.spa.fl_str_mv 2389-7252
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url https://hdl.handle.net/11227/11878
https://doi.org/10.32997/rcb-2021-3371
dc.language.iso.es.fl_str_mv eng
language eng
dc.relation.ispartofjournal.spa.fl_str_mv Revista Ciencias Biomédicas
dc.relation.citationedition.spa.fl_str_mv (2021)
dc.relation.citationendpage.none.fl_str_mv 119
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dc.relation.citationstartpage.none.fl_str_mv 109
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dc.publisher.es.fl_str_mv Universidad de Cartagena
institution Universidad de Cartagena
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spelling Llamas Nieves, Andrés ElíasLozada-Martínez, Iván DavidTorres Llinás, Daniela MarcelaManzur Jattin, FernandoCardales Periñán, Miguel2021-05-22T00:26:59Z2021-05-22T00:26:59Z20212215-7840https://hdl.handle.net/11227/1187810.32997/rcb-2021-33712389-7252https://doi.org/10.32997/rcb-2021-3371Revista Ciencias Biomédicas Vol.10, Núm.2 (2021) Pag. 109-119Introduction: atrial fibrillation is the most prevalent arrhythmia in the world, having high morbidity and mortality rates. Numerous studies have shown the involvement of the angiotensin renin system in the pathogenesis of atrial fibrillation, and in several of these, the underlying mechanism involving a process of atrial tissue remodeling is speculated. Objective: present literature related to the pathophysiological mechanisms of Atrial Fibrillation, its impact on cardiovascular risk, and related aspects between angiotensin II and atrial fibrillation. Methods: a non-systematic review of the available literature was conducted using key terms such as "Atrial Fibrillation" and "Angiotensin II", in addition to synonyms, which were combined with the "AND" and "OR" connectors, both in English and Spanish, in the PubMed, ScienceDirect, Embase, EBSCO, and MEDLINE databases. Results: atrial fibrosis is a structural alteration that facilitates the maintenance of atrial fibrillation, Angiotensin II contributes to this process extensively by stimulating inflammatory processes, decreasing the activity of collagenase, increased expression of MAPK, and changes in cardiac electrophysiological properties through binding to the AT1 receptor. Conclusions: getting to know the pathophysiology of atrial fibrillation at the molecular level, allows to further elucidate the context and possible complications of affected patients, facilitating the generation of hypotheses that contribute to the timely, accurate and effective diagnosis, the development of new therapeutic targets, as well as a better approach in the clinical area.application/pdfengUniversidad de CartagenaRevista Ciencias Biomédicas(2021)119210910https://creativecommons.org/licenses/by-nc-nd/4.0/openAccesshttp://purl.org/coar/access_right/c_abf32http://purl.org/coar/access_right/c_abf2Atrial FibrillationRenin-Angiotensin System;Angiotensin IICardiovascular DiseasesCardiac ArrhythmiasNews on angiotensin II and atrial fibrillation: from the molecular to the pathophysiologicalArtículo de revistahttp://purl.org/coar/version/c_970fb48d4fbd8a115http://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlePublicationORIGINALArticulo 3.pdfArticulo 3.pdfapplication/pdf388227https://dspace7-unicartagena.metabuscador.org/bitstreams/3e5979d1-854d-4110-833d-d74e51d9a4c2/downloadc12ec89a234e9e586f22175162b22221MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81756https://dspace7-unicartagena.metabuscador.org/bitstreams/7789550d-0dc5-402f-a4b6-148b556dbeba/download7b38fcee9ba3bc8639fa56f350c81be3MD52TEXTArticulo 3.pdf.txtArticulo 3.pdf.txtExtracted texttext/plain42224https://dspace7-unicartagena.metabuscador.org/bitstreams/7c08bc9a-f7f9-45d0-8764-da3d16cf16ba/downloadf4cd0f1ee4d6076312c848953331eb3bMD53THUMBNAILArticulo 3.pdf.jpgArticulo 3.pdf.jpgGenerated Thumbnailimage/jpeg15422https://dspace7-unicartagena.metabuscador.org/bitstreams/9d0ddf36-4f52-46c0-8657-72e9430b618f/download777fcea134d4ad720a753c0ac4e345d1MD5411227/11878oai:dspace7-unicartagena.metabuscador.org:11227/118782024-08-28 17:38:34.423https://creativecommons.org/licenses/by-nc-nd/4.0/open.accesshttps://dspace7-unicartagena.metabuscador.orgBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.comCkFsIGZpcm1hciB5IHByZXNlbnRhciBlc3RhIGxpY2VuY2lhLCB1c3RlZCAoQVVUT1IgTyBBVVRPUkVTKSAgbyBsb3MgZGVyZWNob3MgZGUgYXV0b3IgZGVsIHByb3BpZXRhcmlvKFMpIGdhcmFudGl6YSBhICBsYSBVTklWRVJTSURBRCBERSBDQVJUQUdFTkEgZWwgZGVyZWNobyBleGNsdXNpdm8gZGUgcmVwcm9kdWNpciwgdHJhZHVjaXIgKGNvbW8gc2UgZGVmaW5lIG3DoXMgYWRlbGFudGUpIHkvbyBkaXN0cmlidWlyIHN1IGRvY3VtZW50byAoaW5jbHV5ZW5kbyBlbCByZXN1bWVuKSBlbiB0b2RvIGVsIG11bmRvICBlbiBmb3JtYSBpbXByZXNhIHkgZW4gZm9ybWF0byBlbGVjdHLDs25pY28geSBlbiBjdWFscXVpZXIgbWVkaW8sIGluY2x1eWVuZG8gYXVkaW8gbyB2aWRlby4KClVzdGVkIGFjZXB0YSBxdWUgbGEgVU5JVkVSU0lEQUQgREUgQ0FSVEFHRU5BICBwdWVkZSwgc2luIGNhbWJpYXIgZWwgY29udGVuaWRvIGNvbnZlcnRpcmxvLCBwcmVzZW50YXJsbyAgYSBjdWFscXVpZXIgbWVkaW8gbyBmb3JtYXRvIHBhcmEgbG9zIGZpbmVzIGRlIGNvbnNlcnZhY2nDs24uCgpVc3RlZCB0YW1iacOpbiBhY2VwdGEgcXVlIGxhIFVOSVZFUlNJREFEIERFIENBUlRBR0VOQSAgIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBkZSBlc3RlIGRvY3VtZW50byBwYXJhIGZpbmVzIGRlIHNlZ3VyaWRhZCB5IHByZXNlcnZhY2nDs24uCgpVc3RlZCBkZWNsYXJhIHF1ZSBlbCBkb2N1bWVudG8gZXMgdW4gdHJhYmFqbyBvcmlnaW5hbCB5ICBxdWUgdGllbmUgZWwgZGVyZWNobyBkZSBvdG9yZ2FyIGxvcyBkZXJlY2hvcyBjb250ZW5pZG9zIGVuIGVzdGEgbGljZW5jaWEuICBUYW1iacOpbiByZXByZXNlbnRhbiAgbG8gbWVqb3IgZGUgc3UgY29ub2NpbWllbnRvIHkgbm8gaW5mcmluZ2VuICBsb3MgZGVyZWNob3MgZGUgYXV0b3IgZGUgbmFkaWUuCgpTaSBlbCBkb2N1bWVudG8gY29udGllbmUgbWF0ZXJpYWxlcyBkZSBsb3MgcXVlIG5vIHRpZW5lIGxvcyAgZGVyZWNob3MgZGUgYXV0b3IsIHVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGVsIHBlcm1pc28gc2luIHJlc3RyaWNjacOzbiBkZWwgcHJvcGlldGFyaW8gZGUgbG9zIGRlcmVjaG9zLCBkYSBhIGNvbmNlZGVyICBsb3MgZGVyZWNob3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBsaWNlbmNpYSwgeSBxdWUgY29tbyBtYXRlcmlhbCBwcm9waWVkYWQgIGRlIHRlcmNlcm9zICBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyB5IHJlY29ub2NpZG8gZGVudHJvIGRlbCB0ZXh0byBvIGVsIGNvbnRlbmlkbyBkZSBsYSBwcmVzZW50YWNpw7NuLgoKU2kgbGEgcHJlc2VudGFjacOzbiBzZSBiYXNhIGVuICB0cmFiYWpvcyBRVUUgU0UgSEEgcGF0cm9jaW5hZG8gbyBhcG95YWRvIFBPUiBVTkEgQUdFTkNJQSBVIE9SR0FOSVpBQ0nDk04gUVVFIE5PIFNFQSBMQSBVTklWRVJTSURBRCBERSBDQVJUQUdFTkEsIE1BTklGSUVTVEEgUVVFIFRJRU5FIFFVRSBDVU1QTElSIGRlcmVjaG9zIGEgcmV2aXNpw7NuIHUgb3RyYXMgb2JsaWdhY2lvbmVzIHF1ZSBleGlnZW4gZXN0ZSBDb250cmF0byBvIGFjdWVyZG8uCgpEaWNlIHF1ZSBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgc3Ugbm9tYnJlIChzKSBjb21vIGVsIGF1dG9yIChzKSBvIHByb3BpZXRhcmlvIChhKSBkZSBsb3MgZG9jdW1lbnRvIHkgbm8gaGFyw6EgbmluZ3VuYSBhbHRlcmFjacOzbiwgZXhlbnRvIGxhcyBwZXJtaXRpZGFzIGVuIGVzdGEgbGljZW5jaWEgcGFyYSBzdSBwcmVzZW50YWNpw7NuLgoKCg==

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