Genetic regulation of the antibody response to the parasite Ascris spp
Thesis (Doctor of Biomedical Sciences) - University of Cartagena. Institute of Immunology, 2017
- Autores:
-
Bornacelly Mendoza, Adriana
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Cartagena
- Repositorio:
- Repositorio Universidad de Cartagena
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unicartagena.edu.co:11227/8061
- Acceso en línea:
- https://hdl.handle.net/11227/8061
http://dx.doi.org/10.57799/11227/82
- Palabra clave:
- Enfermedades por nematodos
Áscaris lumbricoides - Aspectos inmunológicos
Áscaris - Aspectos inmunológicos
Inmunoglobulinas - Investigaciones
Ascaris - Aspects immunological
Nematode diseases
Ascaris lumbricoides - Aspects immunological
- Rights
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0
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| dc.title.es.fl_str_mv |
Genetic regulation of the antibody response to the parasite Ascris spp |
| title |
Genetic regulation of the antibody response to the parasite Ascris spp |
| spellingShingle |
Genetic regulation of the antibody response to the parasite Ascris spp Enfermedades por nematodos Áscaris lumbricoides - Aspectos inmunológicos Áscaris - Aspectos inmunológicos Inmunoglobulinas - Investigaciones Ascaris - Aspects immunological Nematode diseases Ascaris lumbricoides - Aspects immunological |
| title_short |
Genetic regulation of the antibody response to the parasite Ascris spp |
| title_full |
Genetic regulation of the antibody response to the parasite Ascris spp |
| title_fullStr |
Genetic regulation of the antibody response to the parasite Ascris spp |
| title_full_unstemmed |
Genetic regulation of the antibody response to the parasite Ascris spp |
| title_sort |
Genetic regulation of the antibody response to the parasite Ascris spp |
| dc.creator.fl_str_mv |
Bornacelly Mendoza, Adriana |
| dc.contributor.advisor.none.fl_str_mv |
Acevedo, Nathalie Caraballo, Luis |
| dc.contributor.author.none.fl_str_mv |
Bornacelly Mendoza, Adriana |
| dc.subject.es.fl_str_mv |
Enfermedades por nematodos Áscaris lumbricoides - Aspectos inmunológicos Áscaris - Aspectos inmunológicos Inmunoglobulinas - Investigaciones Ascaris - Aspects immunological Nematode diseases Ascaris lumbricoides - Aspects immunological |
| topic |
Enfermedades por nematodos Áscaris lumbricoides - Aspectos inmunológicos Áscaris - Aspectos inmunológicos Inmunoglobulinas - Investigaciones Ascaris - Aspects immunological Nematode diseases Ascaris lumbricoides - Aspects immunological |
| description |
Thesis (Doctor of Biomedical Sciences) - University of Cartagena. Institute of Immunology, 2017 |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2019-05-08T19:40:57Z |
| dc.date.available.none.fl_str_mv |
2019-05-08T19:40:57Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Doctorado |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
| dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
| dc.identifier.citation.es.fl_str_mv |
TD616.0799 / B645 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11227/8061 http://dx.doi.org/10.57799/11227/82 |
| identifier_str_mv |
TD616.0799 / B645 |
| url |
https://hdl.handle.net/11227/8061 http://dx.doi.org/10.57799/11227/82 |
| dc.language.iso.es.fl_str_mv |
eng |
| language |
eng |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-nd/4.0 |
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https://creativecommons.org/licenses/by-nc-nd/4.0 http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
| dc.publisher.es.fl_str_mv |
University Cartagena |
| institution |
Universidad de Cartagena |
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| spelling |
Acevedo, NathalieCaraballo, LuisBornacelly Mendoza, Adriana2019-05-08T19:40:57Z2019-05-08T19:40:57Z2017TD616.0799 / B645https://hdl.handle.net/11227/8061http://dx.doi.org/10.57799/11227/82Thesis (Doctor of Biomedical Sciences) - University of Cartagena. Institute of Immunology, 2017The nematode Ascaris spp. causes ascariasis in humans and pigs. Ascariasis in humans causes anemia, growth retardation and cognitive deficit, being one of the most prevalent helminthiases around the world. The infection in pigs is an ideal model to study immunological aspects of ascariasis in humans. In both hosts, worm loads are aggregated, with few individuals harboring the highest worm burden which may be attributed to genetic factors. The locus 13q33 has been linked as a QTL for Ascaris susceptibility and total IgE in humans being TNFSF13B (encoding for the cytokine B cell activating factor-BAFF) the major positional candidate gene. A tagSNP in TNFSF13B was associated with the levels of IgG to Ascaris and IgE to ABA-1 in a Colombian population but causal variants remained to be explored. This thesis aimed to analyze the genetic regulation of the antibody response to Ascaris including this genomic region (13q33) and other candidate regions related to type-2 (Th2) immunity, as well as to analyze the relationship between BAFF and the strength of the antibody response to Ascaris, in order to get a better understanding of the role of TNFSF13B/BAFF in the mechanisms of Ascaris susceptibility/resistance using human and pig data under different purposes.application/pdfengUniversity Cartagenahttps://creativecommons.org/licenses/by-nc-nd/4.0http://purl.org/coar/access_right/c_abf2Enfermedades por nematodosÁscaris lumbricoides - Aspectos inmunológicosÁscaris - Aspectos inmunológicosInmunoglobulinas - InvestigacionesAscaris - Aspects immunologicalNematode diseasesAscaris lumbricoides - Aspects immunologicalGenetic regulation of the antibody response to the parasite Ascris sppTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06PublicationTEXTGenetic regulation of the antibody response to Ascaris spp..pdf.txtGenetic regulation of the antibody response to Ascaris spp..pdf.txtExtracted texttext/plain361526https://dspace7-unicartagena.metabuscador.org/bitstreams/392957a5-979d-4c38-980d-13e0836cfef4/downloadb6d2da8cc30b4458c2a7b0a27de7cdf1MD53THUMBNAILGenetic regulation of the antibody response to Ascaris spp..pdf.jpgGenetic regulation of the antibody response to Ascaris spp..pdf.jpgIM Thumbnailimage/jpeg10652https://dspace7-unicartagena.metabuscador.org/bitstreams/6cb1f9ad-0e87-48fd-9c45-7625bc08aa4b/download01d07111246614732a2b956f42791800MD54ORIGINALGenetic regulation of the antibody response to Ascaris spp..pdfGenetic regulation of the antibody response to Ascaris spp..pdfapplication/pdf8771809https://dspace7-unicartagena.metabuscador.org/bitstreams/daf4584b-b22f-44cd-9c27-5b9f05bdfad1/downloada597cf8c42ed37ea80e7187fe6872000MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81739https://dspace7-unicartagena.metabuscador.org/bitstreams/5afc56c3-f2b5-42d2-a2da-7304f6ba352f/download80f4fab81256c9c749645bab750e44eaMD5211227/8061oai:dspace7-unicartagena.metabuscador.org:11227/80612024-08-28 16:58:54.805https://creativecommons.org/licenses/by-nc-nd/4.0open.accesshttps://dspace7-unicartagena.metabuscador.orgBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.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 |