Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.

Autores:: Ricagni, Leandro
Rivero Fuentes, Milexys
Aguiar, Sergio
Sallabanda, Kita

Tipo de recurso:: Article of journal

Fecha de publicación:: 2021

Institución:: Universidad de Cartagena

Repositorio:: Repositorio Universidad de Cartagena

Idioma:: spa

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dc.title.spa.fl_str_mv	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
dc.title.translated.eng.fl_str_mv	Role of the radiosurgery in the treatment of cerebral arterio- venous malformations : review of the literature and analysis of results.
title	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
spellingShingle	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados. Malformaciones arteriovenosas Radiocirugía Cirugía Embolización terapéutica Hemorragia Arteriovenous malformations Radiosurgery Surgery Therapeutic embolization Hemorrhage
title_short	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
title_full	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
title_fullStr	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
title_full_unstemmed	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
title_sort	Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.
dc.creator.fl_str_mv	Ricagni, Leandro Rivero Fuentes, Milexys Aguiar, Sergio Sallabanda, Kita
dc.contributor.author.spa.fl_str_mv	Ricagni, Leandro Rivero Fuentes, Milexys Aguiar, Sergio Sallabanda, Kita
dc.subject.spa.fl_str_mv	Malformaciones arteriovenosas Radiocirugía Cirugía Embolización terapéutica Hemorragia
topic	Malformaciones arteriovenosas Radiocirugía Cirugía Embolización terapéutica Hemorragia Arteriovenous malformations Radiosurgery Surgery Therapeutic embolization Hemorrhage
dc.subject.eng.fl_str_mv	Arteriovenous malformations Radiosurgery Surgery Therapeutic embolization Hemorrhage
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-07-15 00:00:00
dc.date.available.none.fl_str_mv	2021-07-15 00:00:00
dc.date.issued.none.fl_str_mv	2021-07-15
dc.type.spa.fl_str_mv	Artículo de revista
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dc.identifier.doi.none.fl_str_mv	10.32997/rcb-2021-3214
dc.identifier.eissn.none.fl_str_mv	2389-7252
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dc.relation.bitstream.none.fl_str_mv	https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3214/2948
dc.relation.citationedition.spa.fl_str_mv	Núm. 3 , Año 2021
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dc.relation.references.spa.fl_str_mv	Vlaskou Badra E, Ermiş E, Mordasini P, Herrmann E. Radiosurgery and radiotherapy for arteriovenous malformations: outcome predictors and review of the literature. J neurosurgical sci. 2018; 62(4): 490-504. DOI: https://doi.org/10.23736/S0390-5616.18.04406-5 Brown, R. D., Jr, Wiebers, D. O., Forbes, G., O'Fallon, W. M., Piepgras, D. G., Marsh, W. R., & Maciunas, R. J. The natural history of unruptured intracranial arteriovenous malformations. J Neurosurg. 1988; 68(3): 352-357. https://doi.org/10.3171/jns.1988.68.3.0352 Van Beijnum J, Lovelock CE, Cordonnier C, Rothwell PM, Klijn CJ, Salman RA. Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies. Brain. 2009; 132(Pt 2): 537-543. https://doi.org/10.1093/brain/awn318 Laakso, A., Dashti, R., Seppänen, J., Juvela, S., Väärt, K., Niemelä, M., et.al. Long-term excess mortality in 623 patients with brain arteriovenous malformations. Neurosurgery. 2008; 63(2): 244-53. https://doi.org/10.1227/01.NEU.0000320439.27895.24 Hernesniemi JA, Dashti R, Juvela S, Vaart K, Niemela M, Laakso A. Natural history of brain arteriovenous malformations: a long-term follow-up study of risk of hemorrhage in 238 patients. Neurosurgery. 2008; 63(5): 823-831. https://doi.org/10.1227/01.NEU.0000330401.82582.5E Stapf, C., Mast, H., Sciacca, R. R., Choi, J. H., Khaw, A. V., Connolly, E. S., et.al.. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology. 2006; 66(9): 1350-5. https://doi.org/10.1212/01.wnl.0000210524.68507.87 Stapf C, Mohr JP, Pile-Spellman J, Sciacca RR, Hartmann A, Schumacher HC, et al. Concurrent arterial aneurysms in brain arteriovenous malformations with haemorrhagic presentation. J Neurol Neurosurg Psychiatry. 2002; 73(3), 294-298. https://doi.org/10.1136/jnnp.73.3.294 Pollock BE, Lunsford LD. A call to define stereotactic radiosurgery. Neurosurgery. 2004; 55: 1371-1373. https://doi.org/10.1227/01.NEU.0000143613.13759.D4 Sallabanda K, Ley Urzaiz L, Lorenzana Honrado L. Radiocirugía en las Malformaciones Arterio Venosas. En: Samblas J, Sallabanda K, Martínez R, Calvo F. Radiocirugía: fundamentos, avances tecnológicos, indicaciones y resultados. Madrid: Aran; 2012. p. 319-334. Guo, W. Y., Lee, S. M., Chang, Y. C., & Pan, H. C. The impact of arteriovenous malformation radiosurgery on the brain: From morphology and perfusion to neurocognition. Stereotactic and functional neurosurgery. 2006; 84(4), 162-169. https://doi.org/10.1159/000094955 Nataf F, Schlienger M, Bayram M, Ghossoub M, George B, Roux FX. Microsurgery or radiosurgery for cerebral arteriovenous malformations? A study of two paired series. Neurosurgery. 2007; 61(1): 39-50. https://doi.org/10.1227/01.neu.0000279722.60155.d3 Yen, C. P., Ding, D., Cheng, C. H., Starke, R. M., Shaffrey, M., & Sheehan, J. Gamma Knife surgery for incidental cerebral arteriovenous malformations. Journal of neurosurgery. 2014; 121(5), 1015-1021. https://doi.org/10.3171/2014.7.JNS131397 Kim, B. S., Yeon, J. Y., Kim, J. S., Hong, S. C., Shin, H. J., & Lee, J. I. Gamma Knife Radiosurgery for ARUBA-Eligible Patients with Unruptured Brain Arteriovenous Malformations. Journal of Korean medical science. 2019; 34(36), e232. https://doi.org/10.3346/jkms.2019.34.e232 Ding, D., Yen, C. P., Xu, Z., Starke, R. M., & Sheehan, J. P. Radiosurgery for patients with unruptured intracranial arteriovenous malformations. J Neurosurgery. 2013; 118(5): 958-966. https://doi.org/10.3171/2013.2.JNS121239 Ding, D., Starke, R. M., Kano, H., Mathieu, D., Huang, P., Kondziolka, et.al. Radiosurgery for Cerebral Arteriovenous Malformations in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)-Eligible Patients: A Multicenter Study. Stroke. 2016; 47(2), 342-349. https://doi.org/10.1161/STROKEAHA.115.011400 Han, J. H., Kim, D. G., Chung, H. T., Park, C. K., Paek, S. H., Kim, J. E., et. al. Clinical and neuroimaging outcome of cerebral arteriovenous malformations after Gamma Knife surgery: analysis of the radiation injury rate depending on the arteriovenous malformation volume. Journal of neurosurgery. 2008; 109(2), 191-198. https://doi.org/10.3171/JNS/2008/109/8/0191 Hanakita, S., Shin, M., Koga, T., Igaki, H., & Saito, N. Risk Reduction of Cerebral Stroke After Stereotactic Radiosurgery for Small Unruptured Brain Arteriovenous Malformations. Stroke. 2016; 47(5), 1247-1252. https://doi.org/10.1161/STROKEAHA.116.013132 Javalkar V, Pillai P, Vannemreddy P, Caldito G, Ampil F, Nanda A. Gamma knife radiosurgery for arteriovenous malformations located in eloquent regions of the brain. Neurol India. 2009; 57: 617-21. https://www.neurologyindia.com/text.asp?2009/57/5/617/57818 ; https://doi.org/10.4103/0028-3886.57818 Flickinger JC, Pollock BE, Kondziolka D, Lunsford LD. A dose-response analysis of arteriovenous malformation obliteration after radiosurgery. Int J Radiat Oncol Biol Phys. 1996; 36(4): 873-879. https://doi.org/10.1016/S0360-3016(96)00316-1 Donald A. Ross, Howard M. Sandler, James M. Balter, James A. Hayman, John Deveikis, Donna L. Auer. Stereotactic Radiosurgery of Cerebral Arteriovenous Malformations with a Multileaf Collimator and a Single Isocenter, Neurosurgery. 2000; 47(1): 123-130. https://doi.org/10.1097/00006123-200007000-00026 Yen, C. P., Sheehan, J. P., Schwyzer, L., & Schlesinger, D. Hemorrhage risk of cerebral arteriovenous malformations before and during the latency period after GAMMA knife radiosurgery. Stroke. 2011; 42(6), 1691-1696. https://doi.org/10.1161/STROKEAHA.110.602706 Maruyama, K., Kawahara, N., Shin, M., Tago, M., Kishimoto, J., Kurita, H., et.al. The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations. The New England journal of medicine. 2005; 352(2), 146-153. https://doi.org/10.1056/NEJMoa040907 Wang YC, Huang YC, Chen HC, Wei KC, Chang CN, Lee ST, et. al. Linear accelerator stereotactic radiosurgery in the management of intracranial arteriovenous malformations: long-term outcome. Cerebrovasc Dis. 2014; 37(5): 342-349. https://doi.org/10.1159/000360756 Steiner L, Lindquist C, Adler JR, Torner JC, Alves W, Steiner M. Clinical outcome of radiosurgery for cerebral arteriovenous malformations. J Neurosurg. 1992; 77:1-8. Disponible en: https://doi.org/10.3171/jns.1992.77.1.0001 Parkhutik, V., Lago, A., Aparici, F., Vazquez, J. F., Tembl, J. I., Guillen, L., et.al. Late clinical and radiological complications of stereotactical radiosurgery of arteriovenous malformations of the brain. Neuroradiology 2013; 55(4), 405-412. https://doi.org/10.1007/s00234-012-1115-8 Starke, Robert & Po Yen, Chun & Chen, Ching-Jen & Ding, Dale & Mohila, Carrie & Jensen, Mary & Kassell, Neal & P Sheehan, Jason. An Updated Assessment of the Risk of Radiation-InducedNeoplasia After Radiosurgery of Arteriovenous Malformations. World Neurosurgery. 2014; 395-401. https://doi.org/10.1016/j.wneu.2013.02.008 Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014; Lancet. 2014 Feb 15; 383(9917): 614-21. Epub 2013 Nov 20. Disponible en: https://doi.org/10.1016/S0140-6736(13)62302-8 Ding, D., Starke, R. M., Kano, H., Lee, J. Y., Mathieu, D., Pierce, J., et. al. Stereotactic radiosurgery for Spetzler-Martin Grade III arteriovenous malformations: an international multicenter study. Journal of neurosurgery. 2017; 126(3), 859-871: https://doi.org/10.3171/2016.1.JNS152564 Link, T. W., Winston, G., Schwarz, J. T., Lin, N., Patsalides, A., Gobin, P., et.al. Treatment of Unruptured Brain Arteriovenous Malformations: A Single-Center Experience of 86 Patients and a Critique of the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) Trial. World neurosurgery. 2018; 120, e1156-e1162. https://doi.org/10.1016/j.wneu.2018.09.025 Lang, M., Moore, N. Z., Rasmussen, P. A., & Bain, M. D. Treatment Outcomes of A Randomized Trial of Unruptured Brain Arteriovenous Malformation-Eligible Unruptured Brain Arteriovenous Malformation Patients. Neurosurgery. 2018; 83(3), 548-555. https://doi.org/10.1093/neuros/nyx506 Raboud, M., Tuleasca, C., Maeder, P., Schiappacasse, L., Marguet, M., Daniel, R. T., & Levivier, M. Gamma knife radiosurgery for arteriovenous malformations: general principles and preliminary results in a Swiss cohort. Swiss medical weekly. 2018; 148, w14602. https://doi.org/10.4414/smw.2018.14602 Veznedaroglu E, Andrews DW, Benitez RP, Downes MB, Werner-Wasik M, Rosenstock J, et al. Fractionated stereotactic radiotherapy for the treatment of large arteriovenous malformations with or without previous partial embolization. Neurosurgery. 2008 Feb; 62 Suppl 2: 763-75. https://doi.org/10.1227/01.neu.0000316280.99500.99 Chang SD, Marcellus ML, Marks MP, Levy RP, Do HM, Steinberg GK. Multimodality treatment of giant intracranial arteriovenous malformations. Neurosurgery. 2003; 53: 1-11. https://doi.org/10.1227/01.NEU.0000068700.68238.84 Chung WY, Shiau CY, Wu HM, Liu KD, Guo WY, Wang LW, Pan DH. Staged radiosurgery for extra-large cerebral arteriovenous malformations: method, implementation, and results. J Neurosurg. 2008; 109(sup- pl): 65-72. https://doi.org/10.3171/JNS/2008/109/12/S11 Unkelbach, J., Bussière, M. R., Chapman, P. H., Loeffler, J. S., & Shih, H. A. Spatiotemporal Fractionation Schemes for Irradiating Large Cerebral Arteriovenous Malformations. International journal of radiation oncology, biology, physics. 2016; 95(3): 1067-1074. https://doi.org/10.1016/j.ijrobp.2016.02.001
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spelling	Ricagni, LeandroRivero Fuentes, MilexysAguiar, SergioSallabanda, Kita2021-07-15 00:00:002021-07-15 00:00:002021-07-152215-784010.32997/rcb-2021-32142389-7252https://doi.org/10.32997/rcb-2021-3214application/pdfspaUniversidad de CartagenaRevista Ciencias Biomédicashttps://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3214/2948Núm. 3 , Año 2021197318910Vlaskou Badra E, Ermiş E, Mordasini P, Herrmann E. Radiosurgery and radiotherapy for arteriovenous malformations: outcome predictors and review of the literature. J neurosurgical sci. 2018; 62(4): 490-504. DOI: https://doi.org/10.23736/S0390-5616.18.04406-5Brown, R. D., Jr, Wiebers, D. O., Forbes, G., O'Fallon, W. M., Piepgras, D. G., Marsh, W. R., & Maciunas, R. J. The natural history of unruptured intracranial arteriovenous malformations. J Neurosurg. 1988; 68(3): 352-357. https://doi.org/10.3171/jns.1988.68.3.0352Van Beijnum J, Lovelock CE, Cordonnier C, Rothwell PM, Klijn CJ, Salman RA. Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies. Brain. 2009; 132(Pt 2): 537-543. https://doi.org/10.1093/brain/awn318Laakso, A., Dashti, R., Seppänen, J., Juvela, S., Väärt, K., Niemelä, M., et.al. Long-term excess mortality in 623 patients with brain arteriovenous malformations. Neurosurgery. 2008; 63(2): 244-53. https://doi.org/10.1227/01.NEU.0000320439.27895.24Hernesniemi JA, Dashti R, Juvela S, Vaart K, Niemela M, Laakso A. Natural history of brain arteriovenous malformations: a long-term follow-up study of risk of hemorrhage in 238 patients. Neurosurgery. 2008; 63(5): 823-831. https://doi.org/10.1227/01.NEU.0000330401.82582.5EStapf, C., Mast, H., Sciacca, R. R., Choi, J. H., Khaw, A. V., Connolly, E. S., et.al.. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology. 2006; 66(9): 1350-5. https://doi.org/10.1212/01.wnl.0000210524.68507.87Stapf C, Mohr JP, Pile-Spellman J, Sciacca RR, Hartmann A, Schumacher HC, et al. Concurrent arterial aneurysms in brain arteriovenous malformations with haemorrhagic presentation. J Neurol Neurosurg Psychiatry. 2002; 73(3), 294-298. https://doi.org/10.1136/jnnp.73.3.294Pollock BE, Lunsford LD. A call to define stereotactic radiosurgery. Neurosurgery. 2004; 55: 1371-1373. https://doi.org/10.1227/01.NEU.0000143613.13759.D4Sallabanda K, Ley Urzaiz L, Lorenzana Honrado L. Radiocirugía en las Malformaciones Arterio Venosas. En: Samblas J, Sallabanda K, Martínez R, Calvo F. Radiocirugía: fundamentos, avances tecnológicos, indicaciones y resultados. Madrid: Aran; 2012. p. 319-334.Guo, W. Y., Lee, S. M., Chang, Y. C., & Pan, H. C. The impact of arteriovenous malformation radiosurgery on the brain: From morphology and perfusion to neurocognition. Stereotactic and functional neurosurgery. 2006; 84(4), 162-169. https://doi.org/10.1159/000094955Nataf F, Schlienger M, Bayram M, Ghossoub M, George B, Roux FX. Microsurgery or radiosurgery for cerebral arteriovenous malformations? A study of two paired series. Neurosurgery. 2007; 61(1): 39-50. https://doi.org/10.1227/01.neu.0000279722.60155.d3Yen, C. P., Ding, D., Cheng, C. H., Starke, R. M., Shaffrey, M., & Sheehan, J. Gamma Knife surgery for incidental cerebral arteriovenous malformations. Journal of neurosurgery. 2014; 121(5), 1015-1021. https://doi.org/10.3171/2014.7.JNS131397Kim, B. S., Yeon, J. Y., Kim, J. S., Hong, S. C., Shin, H. J., & Lee, J. I. Gamma Knife Radiosurgery for ARUBA-Eligible Patients with Unruptured Brain Arteriovenous Malformations. Journal of Korean medical science. 2019; 34(36), e232. https://doi.org/10.3346/jkms.2019.34.e232Ding, D., Yen, C. P., Xu, Z., Starke, R. M., & Sheehan, J. P. Radiosurgery for patients with unruptured intracranial arteriovenous malformations. J Neurosurgery. 2013; 118(5): 958-966. https://doi.org/10.3171/2013.2.JNS121239Ding, D., Starke, R. M., Kano, H., Mathieu, D., Huang, P., Kondziolka, et.al. Radiosurgery for Cerebral Arteriovenous Malformations in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)-Eligible Patients: A Multicenter Study. Stroke. 2016; 47(2), 342-349. https://doi.org/10.1161/STROKEAHA.115.011400Han, J. H., Kim, D. G., Chung, H. T., Park, C. K., Paek, S. H., Kim, J. E., et. al. Clinical and neuroimaging outcome of cerebral arteriovenous malformations after Gamma Knife surgery: analysis of the radiation injury rate depending on the arteriovenous malformation volume. Journal of neurosurgery. 2008; 109(2), 191-198. https://doi.org/10.3171/JNS/2008/109/8/0191Hanakita, S., Shin, M., Koga, T., Igaki, H., & Saito, N. Risk Reduction of Cerebral Stroke After Stereotactic Radiosurgery for Small Unruptured Brain Arteriovenous Malformations. Stroke. 2016; 47(5), 1247-1252. https://doi.org/10.1161/STROKEAHA.116.013132Javalkar V, Pillai P, Vannemreddy P, Caldito G, Ampil F, Nanda A. Gamma knife radiosurgery for arteriovenous malformations located in eloquent regions of the brain. Neurol India. 2009; 57: 617-21. https://www.neurologyindia.com/text.asp?2009/57/5/617/57818 ; https://doi.org/10.4103/0028-3886.57818Flickinger JC, Pollock BE, Kondziolka D, Lunsford LD. A dose-response analysis of arteriovenous malformation obliteration after radiosurgery. Int J Radiat Oncol Biol Phys. 1996; 36(4): 873-879. https://doi.org/10.1016/S0360-3016(96)00316-1Donald A. Ross, Howard M. Sandler, James M. Balter, James A. Hayman, John Deveikis, Donna L. Auer. Stereotactic Radiosurgery of Cerebral Arteriovenous Malformations with a Multileaf Collimator and a Single Isocenter, Neurosurgery. 2000; 47(1): 123-130. https://doi.org/10.1097/00006123-200007000-00026Yen, C. P., Sheehan, J. P., Schwyzer, L., & Schlesinger, D. Hemorrhage risk of cerebral arteriovenous malformations before and during the latency period after GAMMA knife radiosurgery. Stroke. 2011; 42(6), 1691-1696. https://doi.org/10.1161/STROKEAHA.110.602706Maruyama, K., Kawahara, N., Shin, M., Tago, M., Kishimoto, J., Kurita, H., et.al. The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations. The New England journal of medicine. 2005; 352(2), 146-153. https://doi.org/10.1056/NEJMoa040907Wang YC, Huang YC, Chen HC, Wei KC, Chang CN, Lee ST, et. al. Linear accelerator stereotactic radiosurgery in the management of intracranial arteriovenous malformations: long-term outcome. 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International journal of radiation oncology, biology, physics. 2016; 95(3): 1067-1074. https://doi.org/10.1016/j.ijrobp.2016.02.001Revista Ciencias Biomédicas - 2021https://creativecommons.org/licenses/by-nc-sa/4.0http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/view/3214Malformaciones arteriovenosasRadiocirugíaCirugíaEmbolización terapéuticaHemorragiaArteriovenous malformationsRadiosurgerySurgeryTherapeutic embolizationHemorrhagePapel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.Role of the radiosurgery in the treatment of cerebral arterio- venous malformations : review of the literature and analysis of results.Artículo de revistainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTREVPublicationOREORE.xmltext/xml2813https://repositorio.unicartagena.edu.co/bitstreams/829a9025-5cbb-4ed8-b05d-6ad10412787d/download8bc7383a72b45bb03a4ec96e500d09a7MD5111227/13440oai:repositorio.unicartagena.edu.co:11227/134402024-09-05 15:30:47.989https://creativecommons.org/licenses/by-nc-sa/4.0Revista Ciencias Biomédicas - 2021metadata.onlyhttps://repositorio.unicartagena.edu.coBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.com

Papel de la radiocirugía en el tratamiento de malformaciones arterio-venosas cerebrales : revisión de la literatura y análisis de resultados.

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