Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19
Introducción: en diciembre 2019, se reportó en China la presencia de un nuevo coronavirus que, se clasificó y denominó como Síndrome Respiratorio Agudo Severo-Coronavirus 2 (SARS-CoV-2), causante de la enfermedad pandémica Covid-19. Este virus es capaz de producir daño adicional en el sistema nervio...
- Autores:
-
Gaya, Jose
Puentes Corrales, Odalys
Alonso Rodríguez, Iliana
Leyva Medrano, Liliam
Valero Sanchez, Adonisbel Mario
Del Pozo Burgos, Yoelvis Cesar
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Cartagena
- Repositorio:
- Repositorio Universidad de Cartagena
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicartagena.edu.co:11227/15846
- Acceso en línea:
- https://doi.org/10.32997/rcb-2022-3778
- Palabra clave:
- Covid-19
Coronaviruses
SARS-CoV-2
Neurological Manifestations
Neurological Symptoms
Covid-19
Coronavirus
SARS-CoV-2
Manifestaciones Neurológicas
Síntomas Neurológicos
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0
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UCART2 |
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| dc.title.spa.fl_str_mv |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| dc.title.translated.eng.fl_str_mv |
Pathophysiological mechanisms involved in neurological damage by Covid-19 |
| title |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| spellingShingle |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 Covid-19 Coronaviruses SARS-CoV-2 Neurological Manifestations Neurological Symptoms Covid-19 Coronavirus SARS-CoV-2 Manifestaciones Neurológicas Síntomas Neurológicos |
| title_short |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| title_full |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| title_fullStr |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| title_full_unstemmed |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| title_sort |
Mecanismos fisiopatológicos asociados al daño neurológico por Covid-19 |
| dc.creator.fl_str_mv |
Gaya, Jose Puentes Corrales, Odalys Alonso Rodríguez, Iliana Leyva Medrano, Liliam Valero Sanchez, Adonisbel Mario Del Pozo Burgos, Yoelvis Cesar |
| dc.contributor.author.spa.fl_str_mv |
Gaya, Jose Puentes Corrales, Odalys Alonso Rodríguez, Iliana Leyva Medrano, Liliam Valero Sanchez, Adonisbel Mario Del Pozo Burgos, Yoelvis Cesar |
| dc.subject.eng.fl_str_mv |
Covid-19 Coronaviruses SARS-CoV-2 Neurological Manifestations Neurological Symptoms |
| topic |
Covid-19 Coronaviruses SARS-CoV-2 Neurological Manifestations Neurological Symptoms Covid-19 Coronavirus SARS-CoV-2 Manifestaciones Neurológicas Síntomas Neurológicos |
| dc.subject.spa.fl_str_mv |
Covid-19 Coronavirus SARS-CoV-2 Manifestaciones Neurológicas Síntomas Neurológicos |
| description |
Introducción: en diciembre 2019, se reportó en China la presencia de un nuevo coronavirus que, se clasificó y denominó como Síndrome Respiratorio Agudo Severo-Coronavirus 2 (SARS-CoV-2), causante de la enfermedad pandémica Covid-19. Este virus es capaz de producir daño adicional en el sistema nervioso y provocar síntomas y complicaciones neurológicas. Objetivo: describir los principales mecanismos fisiopatológicos que explican el daño neurológico reportado en la enfermedad Covid-19. Métodos: se realizó una selección de artículos científicos publicados entre 2019 y 2021, utilizando el repositorio electrónico de PubMed/ScienceDirect (y artículos de libre acceso en las Bases/Datos de Scopus, MedLine, Scielo y LILACs) según las recomendaciones del tesauro DeCS (Descriptores en Ciencias de la Salud) para operadores lógicos y descriptores sobre esta temática. Resultados: aunque, se considera una enfermedad típicamente respiratoria, se han descrito una serie de manifestaciones extra-pulmonares como posibles síntomas de presentación y/o complicaciones, en pacientes con Covid-19. El coronavirus SARS-CoV-2, tiene propiedades neuroinvasivas, neurotrópicas y pro-inflamatorias capaces de exacerbar el proceso neurodegenerativo que provoca la enfermedad. Se ha reportado que entre 30-80% de los pacientes con Covid-19 suelen presentar síntomas neurológicos. Conclusión: esta revisión describe los principales fundamentos fisiopatológicos invocados para intentan explicar los mecanismos que determinan la generación de enfermedad y complicaciones neurológicas en la infección por Covid-19. Las manifestaciones neurológicas reportadas en los pacientes infectados pueden deberse a invasión viral directa (propiedades neurotrópicas) o mecanismos indirectos (derivados del estado infeccioso post-inflamatorio, alteraciones metabólicas y desregulaciones de la respuesta inmune). |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-07-15 00:00:00 |
| dc.date.available.none.fl_str_mv |
2022-07-15 00:00:00 |
| dc.date.issued.none.fl_str_mv |
2022-07-15 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_dcae04bc |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.local.eng.fl_str_mv |
Journal article |
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http://purl.org/redcol/resource_type/ARTREV |
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http://purl.org/coar/resource_type/c_6501 |
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2215-7840 |
| dc.identifier.doi.none.fl_str_mv |
10.32997/rcb-2022-3778 |
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2389-7252 |
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https://doi.org/10.32997/rcb-2022-3778 |
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https://doi.org/10.32997/rcb-2022-3778 |
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spa |
| language |
spa |
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Revista Ciencias Biomédicas |
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https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3778/3262 |
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Núm. 3 , Año 2022 |
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237 |
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3 |
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223 |
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11 |
| dc.relation.references.spa.fl_str_mv |
Cui J, Li F, Shi Z. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019; 17(2): 181-92. doi: 10.1038/s41579-018-0118-9 Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270–3. doi: 10.1038/s41586-020-2012-7 Zhong NS, Zheng BJ, Li YM, Poon LLM, ZH, Xie ZH, Chan KH, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China. Lancet. 2003; 362 (8667):1353-8. doi: 10.1016/S0140-6736(03)14630-2 Zaki AM, Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from man with pneumonia in Saudi Arabia. N Engl J Med. 2012; 367(7): 1814-20. doi: 10.1056/NEJMoa1211721 Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al (China Novel Coronavirus Investigating and Research Team). A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2019; 24(1): 1017-20. doi: 10.1056/NEJMoa2001017 Sohrabi C, Alsafi Z, O´Neill N, Khan M, Kerwan A, Al-Jabir A, et al. WHO declares global emergency: A review of 2019 novel coronavirus (COVID-19). Int J Surg. 2020; 76(1): 71-6. doi: 10.1016/j.ijsu.2020.02.034 Conferencia de Prensa del MINSAP: Actualización sobre la situación epidemiológica de la COVID-19 en Cuba (31.01.2020). Disponible en: http://www//CubaPorLaVida; www//COVID19. Berger JR. COVID-19 and the nervous system. J Neurovirol. 2020; 26(2): 143-8. doi: 10.1007/s13365-020-00840-5 Butala N. Neurological aspects of Coronavirus Infectious Disease 2019 (COVID-19). Innov Clin Neurosci. 2020; 17(4-6): 13-15. Disponible en: PMID: 32802586 Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with COVID-19 in Wuhan, China. Lancet. 2020; 395 (10223): 497-506. doi: 10.1016/S0140-6736(20)30183-5 Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020; 77(6): 683-90. doi: 10.1016/j.clineuro.2020.105921 Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin Neurol Neurosurg. 2020; 194: 105921. doi: 10.1016/j.clineuro.2020.105921 Niazkar HR, Zibaee B, Nasimi A, Bahri N. The neurological manifestations of COVID-19: a review article. Neurol Sci. 2020; 41(7): 1667-71. doi: 10.1007/s10072-020-04486-3 Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020; 143(10): 3104-20. doi: 10.1093/brain/awaa240 Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020; 1(2): 357-63. doi: 10.1016/j.bbi.2020.03.031 Zhou M, Zhang X, Qu J. Coronavirus disease 2019 (COVID-19): A clinical update. Front Med. 2020; 127: 10436. doi: 10.1007/s11684-020-0767-8 Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020; 382(23): 2268-70. doi: 10.1056/NEJMc2008597 Liotta EM, Batra A, Clark JR, Shlobin NA, Hoffman SC, Orban ZS, et al. Frequent neurologic manifestations and encephalopathy-associated morbidity in COVID-19 patients. Ann Clin Transl Neurol. 2020; 7(11): 2221-30. doi: 10.1002/acn3.51210 Chen Y, Liu Q, Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol. 2020; 92: 418-23. doi.org/10.1002/jmv.25681 Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019; 16: 69 (1-22). doi: 10.1186/s12985-019-1182-0 Paules CI, Marston HD, Fauci AS. Coronavirus infections: more than just the common cold. J Am Med Assoc. 2020; 323(8): 707-8. doi: 10.1001/jama.2020.0757 Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, et al. Immunology of COVID-19: current state of the science. Immunity. 2020; 52: 910-41. doi: 10.1016/j.immuni.2020.05.002 Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, Evaluation and Treatment of Coronavirus (COVID-19). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK554776 Krett JD, Jewett GA, Elton-Lacasse C, Fonseca K, Hahn C, Au S, et al. Hemorrhagic encephalopathy associated with COVID-19. J Neuroimmunol. 2020; 577326 (1-4). doi: 10.1016/j.jneuroim.2020.577326 Verdecchia P, Cavallini C, Spanevello A, Angeli F. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. Eur J Intern Med. 2020; 20(2): 3151-5. doi: 10.1016/j.ejim.2020.04.037 Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: Tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020; 11(7): 995-8. doi: 10.1021/acschemneuro.0c00122 Bender del Busto J, León-Castellón R, Mendieta-Pedroso M, Rodríguez-Labrada R, Velázquez-Pérez L. Infección por el SARS-CoV-2: de los mecanismos neuroinvasivos a las manifestaciones neurológicas. Anales ACC. 2020; 10(2): e855. Disponible en: http://www.revistaccuba.cu/index.php/revacc/article/view/855 Machado C. Cómo el SARS-CoV-2 ataca al Sistema Nervioso?. Trabajo para optar por el Premio Anual de la Academia de Ciencias de Cuba. La Habana, 2020. Machado C, DeFina P. Covid-19: Anosmia and Ageusia might be initial or unique symptoms. SF J Clin Neurol Brain. 2020; 1(1): 1002 (1-7). Disponible en: https://doi.org/10.20944/preprints202004.0272.v1 Weir EM, Reed DR, Pepino MY, Veldhuizen MG, Hayes JE. Massively collaborative crowdsourced research on COVID19 and the chemical senses: insights and outcomes. Food Quality & Preference. 2022; 97: 104483 (1-8). doi: 10.1016/j.foodqual.2021.104483 Zahra SA, Iddawela S, Pillai K, Choudhury RY, Harky A. Can symptoms of anosmia and dysgeusia be diagnostic for COVID‐19?. Brain Behav. 2020; 10(11): e011839. doi.org/10.1002/BRB3.1839 Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020; 27(2): 1564-7. doi: 10.1056/NEJMc2004973 Tang A, Tong ZD, Wang HL, Dai YX, Li KF, Liu JN, et al. Detection of novel coronavirus by RT-PCR in stool specimen, China. Emerg Infect Dis. 2020; 26(6): 110-8. doi: 10.3201/eid2606.200301 Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020; 135(23): 2033-40. doi: 10.1182/blood.2020006000 Machado C. Silent or 'Happy' Hypoxemia: An urgent dilemma for COVID-19 patient care. MEDICC Rev. 2020; 22:85-86. doi: 10.37757/MR2020.V22.N4.9 Machado C. Severe COVID-19 cases: Is respiratory distress partially explained by CNS involvement?. MEDICC Rev. 2020; 22(2): 38-9. doi: 10.37757/MR2020.V22.N2.10 Orsini A, Corsi M, Santangelo A, Riva A, Peroni D, Foiadelli T, et al. Challenges and management of neurological and psychiatric manifestations in SARS-Cov-2 (COVID-19) patients. Neurol Sci. 2020; 41(9): 2353-40. doi: 10.1007/s10072-020-04544-w Zou L, Dai L, Zhang Y, Fu W, Gao Y, Zhang Z, et al. Clinical characteristics and risk factors for disease severity and death in patients with COVID-19 in Wuhan, China. Front Med. 2020; 7(1): 532-41. doi: 10.3389/fmed.2020.00532 Michalicova A, Bhide K, Bhide M, Kovac A. How viruses infiltrate the central nervous system. Acta Virol. 2017; 61: 393-400. doi: 10.4149/av_2017_401 He Q, Liu H, Huang C, Wang R, Luo M, Lu W. Herpes simplex virus 1-induced Blood-Brain Barrier damage involves apoptosis associated with GM130-mediated Golgi stress. Front Mol Neurosci. 2020; 13: 2 (1-16). doi: 10.3389/fnmol.2020.00002 Tian J, Shi R, Liu T, She R, Wu Q, An J, et al. Brain infection by Hepatitis E virus probably via damage of the blood-brain barrier due to alteration of tight junction proteins. Front Cell Infect Microbiol. 2020; 9: 52. doi: 10.3389/fcimb.2019.00052 Padrón AA, González C, Dorta A. Empleo del Reibergrama en manifestaciones neurológicas del dengue. Rev Hab Cienc Med. 2017; 16(5): 711-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2017000500005 Rodríguez JA, Pérez V, Mirabal A, Padrón AA, Castillo W, Gonzalez, et al. Epstein-Barr virus and Multiple Sclerosis. FASEB J. 2018; 32(1): 617-20. Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/868/892 Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Sarnelli G. Can the enteric nervous system be an alternative entrance door in SARS-CoV-2 neuroinvasion?. Brain Behav Immum. 2020; 87(2): 93-4. doi: 10.1016/j.bbi.2020.04.060 Skinner D, Marro BS, Lane TE. Chemokine CXCL10 and coronavirus induced neurologic disease. Viral Inmunol. 2019; 32(1): 25-37. doi: 10.1089/vim.2018.0073 Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. 2020; 19(5): 383-4. doi: 10.1016/S1474-4422(20)30109-5 Céspedes HR, Rodríguez DJ, Céspedes HA, Céspedes RA. Mecanismos neuroinvasivos y daño neurológico en infecciones por coronavirus. Rev Cub Ped. 2020; 92 (Suppl.): e1203. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1203 Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol. 2020; 19(9): 767-83. doi: 10.1016/S1474-4422(20)30221-0 Cilia R, Bonvegna S, Straccia G, Andreasi NG, Elia AE, Romito LM, et al. Effects of COVID-19 on Parkinson's disease clinical features: a community-based case-control study. Mov Disord. 2020; 35(8): 1287-92. doi: 10.1002/mds.28170 Brown EG, Chahine LM, Goldman SM, Korell M, Mann E, Kinel DR, et al. The effect of the COVID-19 pandemic on people with Parkinson's disease. J Parkinson's Dis. 2020; 10(4): 1365-77. doi: 10.3233/JPD-202249 Berger JR, Brandstadter R, Bar-Or A. COVID-19 and MS disease-modifying therapies. Neurol Neuroimmunol Neuroinflamm. 2020; 7(4): e761 (1-8). doi: 10.1212/NXI.0000000000000761 COViMS Registry. The COViMS database public data update. Disponible en: https://www.COViMS.org Padrón AA, Dorta A. Patogenia de las manifestaciones neurológicas asociadas al SARS-CoV-2. Rev Cub Inv Biomedicas. 2020; 39(3): e868. Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/868 Aschman T, Schneider J, Greuel S, Meinhardt J, Streit S, Goebel HH, et al. Association between SARS-CoV-2 infection and immune-mediated myopathy in patients who have died. JAMA Neurol. 2021;78(8): 948-60. doi: 10.1001/jamaneurol.2021.2004 Machado C, Brock B, Schift A. Reader Response: Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19. Neurology. 2021; 97(18): 881-2. doi: 10.1212/WNL.0000000000012790 Mughal MS, Kaur IP, Alhashemi R, Rehman R, Du D. Acute viral myositis complicated by rhabdomyolysis: a sole manifestation of COVID-19 infection. J Community Hosp Intern Med Perspect. 2021; 11(2): 289-91. doi: 10.1080/20009666.2021.1878601 Paliwal VK, Garg RK, Gupta A, Tejan N. Neuromuscular presentations in patients with COVID-19. Neurol Sci. 2020; 41(11): 3039-56. doi: 10.1007/s10072-020-04708-8 Suh J, Mukerji SS, Collens SI, Padera RF, Pinkus GS, Amato AA, et al. Skeletal muscle and peripheral nerve histopathology in COVID-19. Neurology. 2021; 97(8): e849-e858. doi: 10.1212/WNL.0000000000012344 Carod-Artal FJ. Complicaciones neurológicas por coronavirus y COVID-19. Rev Neurol. 2020; 70(3): 311-22. doi: 10.33588/rn.7009.2020179 Cortés ME. Enfermedad por coronavirus 2019 (COVID-19): importancia de sus potenciales efectos neurológicos. Rev Ecuatoriana Neurol. 2020; 29(1): 16-7. Disponible en: http://revecuatneurol.com/wp-content/uploads/2020/05/2631-2581-rneuro-29-01-00016.pdf Machado C, DeFina PA, Chinchilla M, Machado Y, Machado Y. Brainstem dysfunction in SARS-COV-2 infection can be a potential cause of respiratory distress. Neurol India. 2020; 68(5): 989-93. doi: 10.4103/0028-3886.299165 Casez O, Willaume G, Grand S, Nemoz B, Lupo J, Kahane P, et al. Teaching NeuroImages: SARS-CoV-2−Related Encephalitis: MRI pattern of olfactory tract involvement. Neurology. 2021; 96: e645-e646. doi: 10.1212/WNL.0000000000011150 Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020; 71(15): 762-8. doi: 10.1093/cid/ciaa248 Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, et al. High risk of thrombosis in severe SARS-Cov-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020; 46(6): 1089-98. doi: 10.1007/s00134-020-06062-x García-Azorín D, Martínez-Pías E, Trigo J, Hernandez-Perez I, Valle-Peñacoba G, Talavera B, et al. Neurological comorbidity is a predictor of death in COVID-19 disease: a cohort study on 576 patients. Front Neurol. 2020; 11 (3): 781 (1-8). doi.org/10.3389/fneur.2020.00781 Romagnolo A, Balestrino R, Imbalzano G, Ciccone G, Riccardini F, Artusi CA, et al. Neurological comorbidity and severity of COVID-19. J Neurol. 2021; 268(3): 762-9. doi: 10.1007/s00415-020-10123-y World Health Organization. Tracking SARS-CoV-2 variants. World Health Organization, 2021. Disponible en: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/ Papanikolaou V, Chrysovergis A, Ragos V, Tsiambas E, Katsinis S, Manoli A, et al. From delta to Omicron: S1- RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants. Gene. 2022; 814: 146134 (1-5). doi: 10.1016/j.gene.2021.146134 Karim SSA, Karim QA. Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic. Lancet. 2021; 398: 2126-8. doi: 10.1016/S0140-6736(21)02758-6 Abdullah F, Myers J, Basu D, Tintinger G, Ueckermann V, Mathebula M, et al. Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in Tshwane, South Africa. Int J Infect Dis. 2021; 116(1): 38-42. doi: 10.1016/j.ijid.2021.12.357 Tureček P, Kleisner K. Symptomic mimicry between SARS-CoV-2 and the Common Cold Complex. Biosemiotics. 2022; 10(1): 1-6. doi: 10.1007/s12304-021-09472-6 Zhang L, Li Q, Liang Z, Li T, Liu S, Qiangian C, et al. The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron. Emerg Microbes Infect. 2022; 11(1): 1-5. doi: 10.1080/22221751.2021.2017757 Borrelli M, Corcione A, Castellano F, Fiori Nastro F, Santamaria F. Coronavirus disease 2019 in children. Front Pediatr. 2021; 28(9): 668484. doi: 10.3389/fped.2021.668484 Castillo-Martínez M, Castillo M, Ferrer M, González-Peris S. Depresión infanto-juvenil y otros aspectos de salud mental durante el confinamiento y la pandemia por SARS-CoV-2/COVID-19: encuesta en contexto escolar. An Pediatr (Barc). 2022; 96(1): 61-4. doi: 10.1016/j.anpedi.2020.09.013 Golberstein E, Wen H, Miller BF. Coronavirus Disease 2019 (COVID19) and mental health for children and adolescents. JAMA Pediatr. 2020; 174(9): 819-20. doi: 10.1001/jamapediatrics.2020.1456 Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020; 53(3): 371-2. doi: 10.1016/j.jmii.2020.02.011 Carsetti R, Quintarelli C, Quinti I, Mortari E, Zumla A, Ippolito G, et al. The immune system of children: the key to understanding SARS-CoV-2 susceptibility? Lancet Child Adolesc Health. 2020; 4(6): 414-6. doi: 10.1016/S2352-4642(20)30135-8 González P, Pérez-Moneo Agapito B, Albi MS, Aizpurúa P, Rodrigo MA, Fernández MM, et al (Grupo de Trabajo de Pediatría Basada en la Evidencia de la AEP y AEPap). COVID-19 en Pediatría: valoración crítica de la evidencia. An Pediatr (Barc). 2021; 95(3): e1-e13. doi:10.1016/j.anpedi.2021.05.019 Callard F, Perego E. How and Why patients made Long-Covid? Soc Sci Med. 2021; 268: 113426 (1-5). doi: 10.1016/j.socscimed.2020.113426 Iqbal FM, Lam K, Sounderajah V, Clarke JM, Ashrafian H, Darzi A. Characteristics and predictors of acute and chronic post-Covid syndrome: a systematic review and meta-analysis. EClinical Medicine. 2021; 36: 100899 (1-13). doi: 10.1016/j.eclinm.2021.100899 Liu YH, Chen Y, Wang QH, Wang LR, Jiang L, Yang Y, et al. One-Year trajectory of cognitive changes in older survivors of COVID-19 in Wuhan, China: A longitudinal cohort study. JAMA Neurol. 2022; e220461 (e1-e10). doi: 10.1001/jamaneurol.2022.0461 Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022; s41586. doi: 10.1038/s41586-022-04569-5 Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. 6-month neurological and psychiatric outcomes in 236.379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry. 2021; 8(5): 416-27. doi: https://doi.org/10.1101/2021.01.16.21249950 |
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Gaya, JosePuentes Corrales, OdalysAlonso Rodríguez, IlianaLeyva Medrano, LiliamValero Sanchez, Adonisbel MarioDel Pozo Burgos, Yoelvis Cesar2022-07-15 00:00:002022-07-15 00:00:002022-07-152215-784010.32997/rcb-2022-37782389-7252https://doi.org/10.32997/rcb-2022-3778Introducción: en diciembre 2019, se reportó en China la presencia de un nuevo coronavirus que, se clasificó y denominó como Síndrome Respiratorio Agudo Severo-Coronavirus 2 (SARS-CoV-2), causante de la enfermedad pandémica Covid-19. Este virus es capaz de producir daño adicional en el sistema nervioso y provocar síntomas y complicaciones neurológicas. Objetivo: describir los principales mecanismos fisiopatológicos que explican el daño neurológico reportado en la enfermedad Covid-19. Métodos: se realizó una selección de artículos científicos publicados entre 2019 y 2021, utilizando el repositorio electrónico de PubMed/ScienceDirect (y artículos de libre acceso en las Bases/Datos de Scopus, MedLine, Scielo y LILACs) según las recomendaciones del tesauro DeCS (Descriptores en Ciencias de la Salud) para operadores lógicos y descriptores sobre esta temática. Resultados: aunque, se considera una enfermedad típicamente respiratoria, se han descrito una serie de manifestaciones extra-pulmonares como posibles síntomas de presentación y/o complicaciones, en pacientes con Covid-19. El coronavirus SARS-CoV-2, tiene propiedades neuroinvasivas, neurotrópicas y pro-inflamatorias capaces de exacerbar el proceso neurodegenerativo que provoca la enfermedad. Se ha reportado que entre 30-80% de los pacientes con Covid-19 suelen presentar síntomas neurológicos. Conclusión: esta revisión describe los principales fundamentos fisiopatológicos invocados para intentan explicar los mecanismos que determinan la generación de enfermedad y complicaciones neurológicas en la infección por Covid-19. Las manifestaciones neurológicas reportadas en los pacientes infectados pueden deberse a invasión viral directa (propiedades neurotrópicas) o mecanismos indirectos (derivados del estado infeccioso post-inflamatorio, alteraciones metabólicas y desregulaciones de la respuesta inmune).Introduction: On December 2019, it was reported in China a novel human coronavirus that was classified and named as Severe Acute Respiratory Syndrome by Coronavirus 2 (SARS-CoV-2) that caused Coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 is being able to affect the nervous system and cause neurological symptoms and complications. Objective: to oescribe the main pathogenesis mechanisms of neurological manifestations in patients with Covid-19. Methods: a review was conducted of international updated bibliography. The search was carried out in Central PubMed electronic database (and open access papers were consulted in Scopus, MedLine, Scielo and LILACs) from February, 2019 to August, 2021. The search terms which addressed about the clinical neurological manifestations and pathogenesis mechanisms of Covid-19 in compliance with the Health Sciences Descriptors. Results: although SARS-CoV-2 infection is considered a typically respiratory illness have been described a series of extra-pulmonary manifestations as possible symptoms of presentation or complications. During the Covid-19 pandemic have been reported central, peripheral and musculoskeletal neurological manifestations by hematogenous, lymphatic, trans-synaptic retrograde routes and viruses immune-mediated local dissemination or by dysfunction of hematoencephalic barrier. Some research suggests that 30-80% of patients with Covid-19 has neurological symptoms. Conclusions: this review of literature shows the magnitude and breadth of neurological conditions associated with the Covid-19. SARS-CoV-2 attack the nervous system, both directly (neuroinvasive and neurotropic) and indirectly (inflammatory, metabolic and immunological causes) through a wide range of underlying pathophysiological mechanisms providing varied neurological outcomes in infected patients.application/pdfspaUniversidad de CartagenaRevista Ciencias Biomédicashttps://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3778/3262Núm. 3 , Año 2022237322311Cui J, Li F, Shi Z. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019; 17(2): 181-92. doi: 10.1038/s41579-018-0118-9Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270–3. doi: 10.1038/s41586-020-2012-7Zhong NS, Zheng BJ, Li YM, Poon LLM, ZH, Xie ZH, Chan KH, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China. Lancet. 2003; 362 (8667):1353-8. doi: 10.1016/S0140-6736(03)14630-2Zaki AM, Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from man with pneumonia in Saudi Arabia. N Engl J Med. 2012; 367(7): 1814-20. doi: 10.1056/NEJMoa1211721Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al (China Novel Coronavirus Investigating and Research Team). A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2019; 24(1): 1017-20. doi: 10.1056/NEJMoa2001017Sohrabi C, Alsafi Z, O´Neill N, Khan M, Kerwan A, Al-Jabir A, et al. WHO declares global emergency: A review of 2019 novel coronavirus (COVID-19). Int J Surg. 2020; 76(1): 71-6. doi: 10.1016/j.ijsu.2020.02.034Conferencia de Prensa del MINSAP: Actualización sobre la situación epidemiológica de la COVID-19 en Cuba (31.01.2020). Disponible en: http://www//CubaPorLaVida; www//COVID19.Berger JR. COVID-19 and the nervous system. J Neurovirol. 2020; 26(2): 143-8. doi: 10.1007/s13365-020-00840-5Butala N. Neurological aspects of Coronavirus Infectious Disease 2019 (COVID-19). Innov Clin Neurosci. 2020; 17(4-6): 13-15. Disponible en: PMID: 32802586Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with COVID-19 in Wuhan, China. Lancet. 2020; 395 (10223): 497-506. doi: 10.1016/S0140-6736(20)30183-5Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020; 77(6): 683-90. doi: 10.1016/j.clineuro.2020.105921Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin Neurol Neurosurg. 2020; 194: 105921. doi: 10.1016/j.clineuro.2020.105921Niazkar HR, Zibaee B, Nasimi A, Bahri N. The neurological manifestations of COVID-19: a review article. Neurol Sci. 2020; 41(7): 1667-71. doi: 10.1007/s10072-020-04486-3Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020; 143(10): 3104-20. doi: 10.1093/brain/awaa240Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020; 1(2): 357-63. doi: 10.1016/j.bbi.2020.03.031Zhou M, Zhang X, Qu J. Coronavirus disease 2019 (COVID-19): A clinical update. Front Med. 2020; 127: 10436. doi: 10.1007/s11684-020-0767-8Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020; 382(23): 2268-70. doi: 10.1056/NEJMc2008597Liotta EM, Batra A, Clark JR, Shlobin NA, Hoffman SC, Orban ZS, et al. Frequent neurologic manifestations and encephalopathy-associated morbidity in COVID-19 patients. Ann Clin Transl Neurol. 2020; 7(11): 2221-30. doi: 10.1002/acn3.51210Chen Y, Liu Q, Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol. 2020; 92: 418-23. doi.org/10.1002/jmv.25681Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019; 16: 69 (1-22). doi: 10.1186/s12985-019-1182-0Paules CI, Marston HD, Fauci AS. Coronavirus infections: more than just the common cold. J Am Med Assoc. 2020; 323(8): 707-8. doi: 10.1001/jama.2020.0757Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, et al. Immunology of COVID-19: current state of the science. Immunity. 2020; 52: 910-41. doi: 10.1016/j.immuni.2020.05.002Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, Evaluation and Treatment of Coronavirus (COVID-19). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK554776Krett JD, Jewett GA, Elton-Lacasse C, Fonseca K, Hahn C, Au S, et al. Hemorrhagic encephalopathy associated with COVID-19. J Neuroimmunol. 2020; 577326 (1-4). doi: 10.1016/j.jneuroim.2020.577326Verdecchia P, Cavallini C, Spanevello A, Angeli F. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. Eur J Intern Med. 2020; 20(2): 3151-5. doi: 10.1016/j.ejim.2020.04.037Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: Tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020; 11(7): 995-8. doi: 10.1021/acschemneuro.0c00122Bender del Busto J, León-Castellón R, Mendieta-Pedroso M, Rodríguez-Labrada R, Velázquez-Pérez L. Infección por el SARS-CoV-2: de los mecanismos neuroinvasivos a las manifestaciones neurológicas. Anales ACC. 2020; 10(2): e855. Disponible en: http://www.revistaccuba.cu/index.php/revacc/article/view/855Machado C. Cómo el SARS-CoV-2 ataca al Sistema Nervioso?. Trabajo para optar por el Premio Anual de la Academia de Ciencias de Cuba. La Habana, 2020.Machado C, DeFina P. Covid-19: Anosmia and Ageusia might be initial or unique symptoms. SF J Clin Neurol Brain. 2020; 1(1): 1002 (1-7). Disponible en: https://doi.org/10.20944/preprints202004.0272.v1Weir EM, Reed DR, Pepino MY, Veldhuizen MG, Hayes JE. Massively collaborative crowdsourced research on COVID19 and the chemical senses: insights and outcomes. Food Quality & Preference. 2022; 97: 104483 (1-8). doi: 10.1016/j.foodqual.2021.104483Zahra SA, Iddawela S, Pillai K, Choudhury RY, Harky A. Can symptoms of anosmia and dysgeusia be diagnostic for COVID‐19?. Brain Behav. 2020; 10(11): e011839. doi.org/10.1002/BRB3.1839Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020; 27(2): 1564-7. doi: 10.1056/NEJMc2004973Tang A, Tong ZD, Wang HL, Dai YX, Li KF, Liu JN, et al. Detection of novel coronavirus by RT-PCR in stool specimen, China. Emerg Infect Dis. 2020; 26(6): 110-8. doi: 10.3201/eid2606.200301Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020; 135(23): 2033-40. doi: 10.1182/blood.2020006000Machado C. Silent or 'Happy' Hypoxemia: An urgent dilemma for COVID-19 patient care. MEDICC Rev. 2020; 22:85-86. doi: 10.37757/MR2020.V22.N4.9Machado C. Severe COVID-19 cases: Is respiratory distress partially explained by CNS involvement?. MEDICC Rev. 2020; 22(2): 38-9. doi: 10.37757/MR2020.V22.N2.10Orsini A, Corsi M, Santangelo A, Riva A, Peroni D, Foiadelli T, et al. Challenges and management of neurological and psychiatric manifestations in SARS-Cov-2 (COVID-19) patients. Neurol Sci. 2020; 41(9): 2353-40. doi: 10.1007/s10072-020-04544-wZou L, Dai L, Zhang Y, Fu W, Gao Y, Zhang Z, et al. Clinical characteristics and risk factors for disease severity and death in patients with COVID-19 in Wuhan, China. Front Med. 2020; 7(1): 532-41. doi: 10.3389/fmed.2020.00532Michalicova A, Bhide K, Bhide M, Kovac A. How viruses infiltrate the central nervous system. Acta Virol. 2017; 61: 393-400. doi: 10.4149/av_2017_401He Q, Liu H, Huang C, Wang R, Luo M, Lu W. Herpes simplex virus 1-induced Blood-Brain Barrier damage involves apoptosis associated with GM130-mediated Golgi stress. Front Mol Neurosci. 2020; 13: 2 (1-16). doi: 10.3389/fnmol.2020.00002Tian J, Shi R, Liu T, She R, Wu Q, An J, et al. Brain infection by Hepatitis E virus probably via damage of the blood-brain barrier due to alteration of tight junction proteins. Front Cell Infect Microbiol. 2020; 9: 52. doi: 10.3389/fcimb.2019.00052Padrón AA, González C, Dorta A. Empleo del Reibergrama en manifestaciones neurológicas del dengue. Rev Hab Cienc Med. 2017; 16(5): 711-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2017000500005Rodríguez JA, Pérez V, Mirabal A, Padrón AA, Castillo W, Gonzalez, et al. Epstein-Barr virus and Multiple Sclerosis. FASEB J. 2018; 32(1): 617-20. Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/868/892Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Sarnelli G. Can the enteric nervous system be an alternative entrance door in SARS-CoV-2 neuroinvasion?. Brain Behav Immum. 2020; 87(2): 93-4. doi: 10.1016/j.bbi.2020.04.060Skinner D, Marro BS, Lane TE. Chemokine CXCL10 and coronavirus induced neurologic disease. Viral Inmunol. 2019; 32(1): 25-37. doi: 10.1089/vim.2018.0073Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. 2020; 19(5): 383-4. doi: 10.1016/S1474-4422(20)30109-5Céspedes HR, Rodríguez DJ, Céspedes HA, Céspedes RA. Mecanismos neuroinvasivos y daño neurológico en infecciones por coronavirus. Rev Cub Ped. 2020; 92 (Suppl.): e1203. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1203Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol. 2020; 19(9): 767-83. doi: 10.1016/S1474-4422(20)30221-0Cilia R, Bonvegna S, Straccia G, Andreasi NG, Elia AE, Romito LM, et al. Effects of COVID-19 on Parkinson's disease clinical features: a community-based case-control study. Mov Disord. 2020; 35(8): 1287-92. doi: 10.1002/mds.28170Brown EG, Chahine LM, Goldman SM, Korell M, Mann E, Kinel DR, et al. The effect of the COVID-19 pandemic on people with Parkinson's disease. J Parkinson's Dis. 2020; 10(4): 1365-77. doi: 10.3233/JPD-202249Berger JR, Brandstadter R, Bar-Or A. COVID-19 and MS disease-modifying therapies. Neurol Neuroimmunol Neuroinflamm. 2020; 7(4): e761 (1-8). doi: 10.1212/NXI.0000000000000761COViMS Registry. The COViMS database public data update. Disponible en: https://www.COViMS.orgPadrón AA, Dorta A. Patogenia de las manifestaciones neurológicas asociadas al SARS-CoV-2. Rev Cub Inv Biomedicas. 2020; 39(3): e868. Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/868Aschman T, Schneider J, Greuel S, Meinhardt J, Streit S, Goebel HH, et al. Association between SARS-CoV-2 infection and immune-mediated myopathy in patients who have died. JAMA Neurol. 2021;78(8): 948-60. doi: 10.1001/jamaneurol.2021.2004Machado C, Brock B, Schift A. Reader Response: Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19. Neurology. 2021; 97(18): 881-2. doi: 10.1212/WNL.0000000000012790Mughal MS, Kaur IP, Alhashemi R, Rehman R, Du D. Acute viral myositis complicated by rhabdomyolysis: a sole manifestation of COVID-19 infection. J Community Hosp Intern Med Perspect. 2021; 11(2): 289-91. doi: 10.1080/20009666.2021.1878601Paliwal VK, Garg RK, Gupta A, Tejan N. Neuromuscular presentations in patients with COVID-19. Neurol Sci. 2020; 41(11): 3039-56. doi: 10.1007/s10072-020-04708-8Suh J, Mukerji SS, Collens SI, Padera RF, Pinkus GS, Amato AA, et al. Skeletal muscle and peripheral nerve histopathology in COVID-19. Neurology. 2021; 97(8): e849-e858. doi: 10.1212/WNL.0000000000012344Carod-Artal FJ. Complicaciones neurológicas por coronavirus y COVID-19. Rev Neurol. 2020; 70(3): 311-22. doi: 10.33588/rn.7009.2020179Cortés ME. Enfermedad por coronavirus 2019 (COVID-19): importancia de sus potenciales efectos neurológicos. Rev Ecuatoriana Neurol. 2020; 29(1): 16-7. Disponible en: http://revecuatneurol.com/wp-content/uploads/2020/05/2631-2581-rneuro-29-01-00016.pdfMachado C, DeFina PA, Chinchilla M, Machado Y, Machado Y. Brainstem dysfunction in SARS-COV-2 infection can be a potential cause of respiratory distress. Neurol India. 2020; 68(5): 989-93. doi: 10.4103/0028-3886.299165Casez O, Willaume G, Grand S, Nemoz B, Lupo J, Kahane P, et al. Teaching NeuroImages: SARS-CoV-2−Related Encephalitis: MRI pattern of olfactory tract involvement. Neurology. 2021; 96: e645-e646. doi: 10.1212/WNL.0000000000011150Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020; 71(15): 762-8. doi: 10.1093/cid/ciaa248Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, et al. High risk of thrombosis in severe SARS-Cov-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020; 46(6): 1089-98. doi: 10.1007/s00134-020-06062-xGarcía-Azorín D, Martínez-Pías E, Trigo J, Hernandez-Perez I, Valle-Peñacoba G, Talavera B, et al. Neurological comorbidity is a predictor of death in COVID-19 disease: a cohort study on 576 patients. Front Neurol. 2020; 11 (3): 781 (1-8). doi.org/10.3389/fneur.2020.00781Romagnolo A, Balestrino R, Imbalzano G, Ciccone G, Riccardini F, Artusi CA, et al. Neurological comorbidity and severity of COVID-19. J Neurol. 2021; 268(3): 762-9. doi: 10.1007/s00415-020-10123-yWorld Health Organization. Tracking SARS-CoV-2 variants. World Health Organization, 2021. Disponible en: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/Papanikolaou V, Chrysovergis A, Ragos V, Tsiambas E, Katsinis S, Manoli A, et al. From delta to Omicron: S1- RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants. Gene. 2022; 814: 146134 (1-5). doi: 10.1016/j.gene.2021.146134Karim SSA, Karim QA. Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic. Lancet. 2021; 398: 2126-8. doi: 10.1016/S0140-6736(21)02758-6Abdullah F, Myers J, Basu D, Tintinger G, Ueckermann V, Mathebula M, et al. Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in Tshwane, South Africa. Int J Infect Dis. 2021; 116(1): 38-42. doi: 10.1016/j.ijid.2021.12.357Tureček P, Kleisner K. Symptomic mimicry between SARS-CoV-2 and the Common Cold Complex. Biosemiotics. 2022; 10(1): 1-6. doi: 10.1007/s12304-021-09472-6Zhang L, Li Q, Liang Z, Li T, Liu S, Qiangian C, et al. The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron. Emerg Microbes Infect. 2022; 11(1): 1-5. doi: 10.1080/22221751.2021.2017757Borrelli M, Corcione A, Castellano F, Fiori Nastro F, Santamaria F. Coronavirus disease 2019 in children. Front Pediatr. 2021; 28(9): 668484. doi: 10.3389/fped.2021.668484Castillo-Martínez M, Castillo M, Ferrer M, González-Peris S. Depresión infanto-juvenil y otros aspectos de salud mental durante el confinamiento y la pandemia por SARS-CoV-2/COVID-19: encuesta en contexto escolar. An Pediatr (Barc). 2022; 96(1): 61-4. doi: 10.1016/j.anpedi.2020.09.013Golberstein E, Wen H, Miller BF. Coronavirus Disease 2019 (COVID19) and mental health for children and adolescents. JAMA Pediatr. 2020; 174(9): 819-20. doi: 10.1001/jamapediatrics.2020.1456Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020; 53(3): 371-2. doi: 10.1016/j.jmii.2020.02.011Carsetti R, Quintarelli C, Quinti I, Mortari E, Zumla A, Ippolito G, et al. The immune system of children: the key to understanding SARS-CoV-2 susceptibility? Lancet Child Adolesc Health. 2020; 4(6): 414-6. doi: 10.1016/S2352-4642(20)30135-8González P, Pérez-Moneo Agapito B, Albi MS, Aizpurúa P, Rodrigo MA, Fernández MM, et al (Grupo de Trabajo de Pediatría Basada en la Evidencia de la AEP y AEPap). COVID-19 en Pediatría: valoración crítica de la evidencia. An Pediatr (Barc). 2021; 95(3): e1-e13. doi:10.1016/j.anpedi.2021.05.019Callard F, Perego E. How and Why patients made Long-Covid? Soc Sci Med. 2021; 268: 113426 (1-5). doi: 10.1016/j.socscimed.2020.113426Iqbal FM, Lam K, Sounderajah V, Clarke JM, Ashrafian H, Darzi A. Characteristics and predictors of acute and chronic post-Covid syndrome: a systematic review and meta-analysis. EClinical Medicine. 2021; 36: 100899 (1-13). doi: 10.1016/j.eclinm.2021.100899Liu YH, Chen Y, Wang QH, Wang LR, Jiang L, Yang Y, et al. One-Year trajectory of cognitive changes in older survivors of COVID-19 in Wuhan, China: A longitudinal cohort study. JAMA Neurol. 2022; e220461 (e1-e10). doi: 10.1001/jamaneurol.2022.0461Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022; s41586. doi: 10.1038/s41586-022-04569-5Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. 6-month neurological and psychiatric outcomes in 236.379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry. 2021; 8(5): 416-27. doi: https://doi.org/10.1101/2021.01.16.21249950Jose Gaya, Odalys Puentes Corrales, Iliana Alonso Rodríguez, Liliam Leyva Medrano, Adonisbel Mario Valero Sanchez, Yoelvis Cesar Del Pozo Burgos - 2022https://creativecommons.org/licenses/by-nc-sa/4.0http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/view/3778Covid-19CoronavirusesSARS-CoV-2Neurological ManifestationsNeurological SymptomsCovid-19CoronavirusSARS-CoV-2Manifestaciones NeurológicasSíntomas NeurológicosMecanismos fisiopatológicos asociados al daño neurológico por Covid-19Pathophysiological mechanisms involved in neurological damage by Covid-19Artículo de revistainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTREVPublicationOREORE.xmltext/xml2812https://repositorio.unicartagena.edu.co/bitstreams/387d186c-831b-4861-a415-5266060faa0e/downloadcde79e877e87bf2c3884468a519998ccMD5111227/15846oai:repositorio.unicartagena.edu.co:11227/158462024-09-05 15:30:42.191https://creativecommons.org/licenses/by-nc-sa/4.0Jose Gaya, Odalys Puentes Corrales, Iliana Alonso Rodríguez, Liliam Leyva Medrano, Adonisbel Mario Valero Sanchez, Yoelvis Cesar Del Pozo Burgos - 2022metadata.onlyhttps://repositorio.unicartagena.edu.coBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.com |