Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo

Tesis (Doctor en Ciencias). -- Universidad de Cartagena. Facultad de Ciencias Exactas y Naturales, 2017

Autores:
Gueto Tettay, Carlos Alberto
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad de Cartagena
Repositorio:
Repositorio Universidad de Cartagena
Idioma:
spa
OAI Identifier:
oai:repositorio.unicartagena.edu.co:11227/9039
Acceso en línea:
https://hdl.handle.net/11227/9039
http://dx.doi.org/10.57799/11227/77
Palabra clave:
Biotecnología
Inhibidores de enzima - Ensayo
Inhibidores de enzima
Inhibidores de enzima - Métodos de simulación
Enzimas - Métodos de simulación
Enzimas - Hidrogenólisis - Métodos de simulación
Rights
License
https://creativecommons.org/licenses/by-nc-nd/4.0
id UCART2_8e643f056ec9c0725039e5dec16fe057
oai_identifier_str oai:repositorio.unicartagena.edu.co:11227/9039
network_acronym_str UCART2
network_name_str Repositorio Universidad de Cartagena
repository_id_str
dc.title.es.fl_str_mv Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
title Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
spellingShingle Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
Biotecnología
Inhibidores de enzima - Ensayo
Inhibidores de enzima
Inhibidores de enzima - Métodos de simulación
Enzimas - Métodos de simulación
Enzimas - Hidrogenólisis - Métodos de simulación
title_short Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
title_full Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
title_fullStr Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
title_full_unstemmed Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
title_sort Exploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempo
dc.creator.fl_str_mv Gueto Tettay, Carlos Alberto
dc.contributor.advisor.none.fl_str_mv Drosos Ramírez, Juan Carlos
dc.contributor.author.none.fl_str_mv Gueto Tettay, Carlos Alberto
dc.subject.es.fl_str_mv Biotecnología
Inhibidores de enzima - Ensayo
Inhibidores de enzima
Inhibidores de enzima - Métodos de simulación
Enzimas - Métodos de simulación
Enzimas - Hidrogenólisis - Métodos de simulación
topic Biotecnología
Inhibidores de enzima - Ensayo
Inhibidores de enzima
Inhibidores de enzima - Métodos de simulación
Enzimas - Métodos de simulación
Enzimas - Hidrogenólisis - Métodos de simulación
description Tesis (Doctor en Ciencias). -- Universidad de Cartagena. Facultad de Ciencias Exactas y Naturales, 2017
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2019-08-13T19:33:36Z
dc.date.available.none.fl_str_mv 2019-08-13T19:33:36Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.identifier.citation.es.fl_str_mv TD660.6 / G938
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11227/9039
http://dx.doi.org/10.57799/11227/77
identifier_str_mv TD660.6 / G938
url https://hdl.handle.net/11227/9039
http://dx.doi.org/10.57799/11227/77
dc.language.iso.es.fl_str_mv spa
language spa
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
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dc.format.medium.none.fl_str_mv application/pdf
dc.publisher.es.fl_str_mv Universidad de Cartagena
institution Universidad de Cartagena
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spelling Drosos Ramírez, Juan CarlosGueto Tettay, Carlos Alberto2019-08-13T19:33:36Z2019-08-13T19:33:36Z2017TD660.6 / G938https://hdl.handle.net/11227/9039http://dx.doi.org/10.57799/11227/77Tesis (Doctor en Ciencias). -- Universidad de Cartagena. Facultad de Ciencias Exactas y Naturales, 2017Dentro de esta investigación, se busca explorar el mecanismo inhibitorio de la b-secretasa por parte de los hidroxietilaminos empleando técnicas de modelado molecular asistido por computadorasapplication/pdfspaUniversidad de Cartagenahttps://creativecommons.org/licenses/by-nc-nd/4.0http://purl.org/coar/access_right/c_abf2BiotecnologíaInhibidores de enzima - EnsayoInhibidores de enzimaInhibidores de enzima - Métodos de simulaciónEnzimas - Métodos de simulaciónEnzimas - Hidrogenólisis - Métodos de simulaciónExploración "in silico" del proceso inhibitorio de la ß-Secretasa por hidroxietilaminas: Una aproximación geométrica y energética en el tiempoTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06Abraham, M. J., Murtola, T., Schulz, R., Páll, S., Smith, J. C., Hess, B. & Lindahl, E. (2015). 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J Mol Model 15: 765- 805.PublicationORIGINALCarlosGuetoTesisPhD_Final.pdfCarlosGuetoTesisPhD_Final.pdfapplication/pdf53934971https://dspace7-unicartagena.metabuscador.org/bitstreams/02d7f31a-fdab-4678-8858-3ce20a3a3f8e/download16fbc59a27de2341fa46e5db6f9f016bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81739https://dspace7-unicartagena.metabuscador.org/bitstreams/0bd65ec1-eda9-49d5-8e7f-77ab4549c444/download80f4fab81256c9c749645bab750e44eaMD52TEXTCarlosGuetoTesisPhD_Final.pdf.txtCarlosGuetoTesisPhD_Final.pdf.txtExtracted texttext/plain519459https://dspace7-unicartagena.metabuscador.org/bitstreams/28018b7c-5fe9-4a6f-8324-e9b9f7364e0b/download1088dfeda4aee676bbd6dc09d3723e72MD53THUMBNAILCarlosGuetoTesisPhD_Final.pdf.jpgCarlosGuetoTesisPhD_Final.pdf.jpgGenerated Thumbnailimage/jpeg6456https://dspace7-unicartagena.metabuscador.org/bitstreams/8181848f-edf2-445d-b96b-d353132510ff/download5801a8c84b260cc75bfff56b0d4f5daaMD5411227/9039oai:dspace7-unicartagena.metabuscador.org:11227/90392024-08-28 17:05:49.002https://creativecommons.org/licenses/by-nc-nd/4.0open.accesshttps://dspace7-unicartagena.metabuscador.orgBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.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