Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.

Autores:: Benedetti Padron, Inés
Lecompte Osorio, Paola
Barrios Garcia, Lía

Tipo de recurso:: Article of journal

Fecha de publicación:: 2021

Institución:: Universidad de Cartagena

Repositorio:: Repositorio Universidad de Cartagena

Idioma:: eng

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repository_id_str
dc.title.spa.fl_str_mv	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
dc.title.translated.eng.fl_str_mv	Expression of Osteopontin and Cyclooxygenase-2 in relation to cellular proliferation, in non-tumor colonic mucosa, colonic adenomas and colon adenocarcinoma.
title	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
spellingShingle	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon. Colorectal cancer Osteopontin Cyclooxygenase-2 Cáncer colorrectal Osteopontina Ciclooxigenasa-2
title_short	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
title_full	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
title_fullStr	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
title_full_unstemmed	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
title_sort	Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.
dc.creator.fl_str_mv	Benedetti Padron, Inés Lecompte Osorio, Paola Barrios Garcia, Lía
dc.contributor.author.spa.fl_str_mv	Benedetti Padron, Inés Lecompte Osorio, Paola Barrios Garcia, Lía
dc.subject.eng.fl_str_mv	Colorectal cancer Osteopontin Cyclooxygenase-2
topic	Colorectal cancer Osteopontin Cyclooxygenase-2 Cáncer colorrectal Osteopontina Ciclooxigenasa-2
dc.subject.spa.fl_str_mv	Cáncer colorrectal Osteopontina Ciclooxigenasa-2
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-01-15 00:00:00
dc.date.available.none.fl_str_mv	2021-01-15 00:00:00
dc.date.issued.none.fl_str_mv	2021-01-15
dc.type.spa.fl_str_mv	Artículo de revista
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dc.identifier.issn.none.fl_str_mv	2215-7840
dc.identifier.doi.none.fl_str_mv	10.32997/rcb-2021-3232
dc.identifier.eissn.none.fl_str_mv	2389-7252
dc.identifier.url.none.fl_str_mv	https://doi.org/10.32997/rcb-2021-3232
identifier_str_mv	2215-7840 10.32997/rcb-2021-3232 2389-7252
url	https://doi.org/10.32997/rcb-2021-3232
dc.language.iso.eng.fl_str_mv	eng
language	eng
dc.relation.ispartofjournal.spa.fl_str_mv	Revista Ciencias Biomédicas
dc.relation.bitstream.none.fl_str_mv	https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3232/2745
dc.relation.citationedition.spa.fl_str_mv	Núm. 1 , Año 2021
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dc.relation.references.eng.fl_str_mv	Ferlay J CM, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019; 144(8): 1941-53. https://doi.org/10.1002/ijc.31937 Campo-Sánchez S, Camargo-Trillos J, Calle-Ramírez J, Gómez-Wolff L, Sánchez-Patiño L, García-García H. Supervivencia de cáncer colorrectal en un centro oncológico de Colombia. Estudio de cohorte histórica. Revista de Gastroenterología de México. 2018. https://doi.org/10.1016/j.rgmx.2018.04.002 Giráldez MD. Avances en la etiopatogenia, identificación y manejo clínico de las formas hereditarias y familiares de cáncer colorrectal. Gastroenterología y Hepatología. 2011; 34: 70-5. https://doi.org/10.1016/S0210-5705(11)70011-5 Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990; 61(5): 759-67. https://doi.org/10.1016/0092-8674(90)90186-I Marmol I, Sanchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int J Mol Sci. 2017; 18(1). https://doi.org/10.3390/ijms18010197 Armaghany T, Wilson JD, Chu Q, Mills G. Genetic alterations in colorectal cancer. Gastrointestinal cancer research: GCR. 2012; 5(1): 19. Niitsu H, Hinoi T, Kawaguchi Y, Sentani K, Yuge R, Kitadai Y, et al. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer. Oncogenesis. 2016; 5(8): e253. https://doi.org/10.1038/oncsis.2016.47 Leslie A, Carey F, Pratt N, Steele R. The colorectal adenoma-carcinoma sequence. British Journal of Surgery. 2002; 89(7): 845-60. https://doi.org/10.1046/j.1365-2168.2002.02120.x Benedetti-Padrón I, Becerra-Mejía D. Expresión de Ciclooxigenasa-2 en carcinoma colorrectal, una revisión narrativa. Iatreia. 2019; 32(1): 52-63. https://doi.org/10.17533/udea.iatreia.v32n1a06 Koehne C-H, Dubois RN, editors. COX-2 inhibition and colorectal cancer. Seminars in oncology; 2004: Elsevier. https://doi.org/10.1053/j.seminoncol.2004.03.041 Soslow RA, Dannenberg AJ, Rush D, Woerner B, Khan KN, Masferrer J, et al. COX‐2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer. 2000; 89(12): 2637-45. https://doi.org/10.1002/1097-0142(20001215)89:122637::AID-CNCR173.0.CO;2-B Di Bartolomeo M, Pietrantonio F, Pellegrinelli A, Martinetti A, Mariani L, Daidone MG, et al. Osteopontin, E-cadherin, and β-catenin expression as prognostic biomarkers in patients with radically resected gastric cancer. Gastric cancer. 2016; 19(2): 412-20. https://doi.org/10.1007/s10120-015-0495-y Wei R, Wong JPC, Lyu P, Xi X, Tong O, Zhang SD, et al. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Journal of Cellular and Molecular Medicine. 2018; 22(9): 4097-105. https://doi.org/10.1111/jcmm.13686 Becerra D, Benedetti I. OSTEOPONTINA, UNA PROTEÍNA INVOLUCRADA EN LA PROGRESIÓN TUMORAL, Y SU PARTICIPACIÓN EN EL DESARROLLO DEL CARCINOMA COLORRECTAL. Revista Ciencias Biomédicas. 2019; 8(1): 15-21. https://doi.org/10.32997/rcb-2018-2711 Zubiaurre L, de Pierola LBF. Aspirina en la prevención del cáncer colorrectal. Gastroenterología y Hepatología. 2011; 34(5): 337-45. https://doi.org/10.1016/j.gastrohep.2011.01.004 Kale S, Raja R, Thorat D, Soundararajan G, Patil TV, Kundu GC. Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via alpha9beta1 integrin. Oncogene. 2014; 33(18): 2295-306. https://doi.org/10.1038/onc.2013.184 Jain S, Chakraborty G, Kundu GC. The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. Cancer Res. 2006; 66(13): 6638-48. https://doi.org/10.1158/0008-5472.CAN-06-0661 Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D. Expression of cyclooxygenase-2 in colonic polyps. Pol Arch Med Wewn. 2010; 120(9): 313-20. https://doi.org/10.20452/pamw.955 Li J, Yang G-Z, Zhu Z-M, Zhou Z-Y, Li L. Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. Experimental and therapeutic medicine. 2012; 3(4): 621-4. https://doi.org/10.3892/etm.2012.465 Petrişor O, Giuşcă SE, Sajin M, Dobrescu G, Căruntu I-D. Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma. Rom J Morphol Embryol. 2008; 49(2): 163-71. Melling N, Kowitz CM, Simon R, Bokemeyer C, Terracciano L, Sauter G, et al. High Ki67 expression is an independent good prognostic marker in colorectal cancer. Journal of clinical pathology. 2016; 69(3): 209-14. https://doi.org/10.1136/jclinpath-2015-202985 Ávila FP, Ortega GC, García RM. Marcadores inmunohistoquímicos p53 y Ki67: utilización diagnóstica y pronóstica en el cáncer de colon. Revista andaluza de patología digestiva. 2012; 35(3): 173-8. Mesina C, Stoean LC, Stoean R, Sandita VA, Gruia CL, Foarfa MC, et al. Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps. Bucharest. 2018; 69: 419. https://doi.org/10.37358/RC.18.2.6120 Li L, Wang J, Jian'gang Li ZW, Ma P. Expression of Ki-67 and pAKT in colorectal cancer tissues and their clinical significance. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE. 2018; 11(5): 4623-30. Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, et al. Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). The American journal of surgical pathology. 2008; 32(1): 21-9. https://doi.org/10.1097/PAS.0b013e318157f002 Sakuma K, Fujimori T, Hirabayashi K, Terano A. Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. Journal of gastroenterology. 1999; 34(2): 189-94. https://doi.org/10.1007/s005350050242 Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, Dubois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994; 107(4): 1183-8. https://doi.org/10.1016/0016-5085(94)90246-1 Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, et al. Expression of cyclooxygenase-1 and-2 in human colorectal cancer. Cancer research. 1995; 55(17): 3785-9. https://doi.org/10.1016/0928-4680(94)90594-0 Lim SC, Lee TB, Choi CH, Ryu SY, Min YD, Kim KJ. Prognostic significance of cyclooxygenase‐2 expression and nuclear p53 accumulation in patients with colorectal cancer. Journal of surgical oncology. 2008; 97(1): 51-6. https://doi.org/10.1002/jso.20907 Yamac D, Celenkoglu G, Coskun U, Akyurek N, Akcali Z, Dursun A, et al. Prognostic importance of COX-2 expression in patients with colorectal cancer. Pathology-Research and Practice. 2005; 201(7): 497-502. https://doi.org/10.1016/j.prp.2005.04.006 Sobolewski C, Cerella C, Dicato M, Ghibelli L, Diederich M. The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. International journal of cell biology. 2010; 2010. https://doi.org/10.1155/2010/215158 Lamort AS, Giopanou I, Psallidas I, Stathopoulos GT. Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight. Cells. 2019; 8(8). https://doi.org/10.3390/cells8080815 Hao C, Cui Y, Owen S, Li W, Cheng S, Jiang WG. Human osteopontin: Potential clinical applications in cancer (Review). Int J Mol Med. 2017; 39(6): 1327-37. https://doi.org/10.3892/ijmm.2017.2964 Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, Chambers AF, et al. Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clinical cancer research. 2004; 10(1): 184-90. https://doi.org/10.1158/1078-0432.CCR-1405-2 Wei R, Wong JPC, Kwok HF. Osteopontin--a promising biomarker for cancer therapy. Journal of Cancer. 2017; 8(12): 2173. https://doi.org/10.7150/jca.20480 Youssef NS, Osman WM. Relationship between osteopontin and β-catenin immunohistochemical expression and prognostic parameters of colorectal carcinoma. International journal of clinical and experimental pathology. 2015; 8(2): 1503. Cheng Y, Wen G, Sun Y, Shen Y, Zeng Y, Du M, et al. Osteopontin Promotes Colorectal Cancer Cell Invasion and the Stem Cell-Like Properties through the PI3K-AKT-GSK/3beta-beta/Catenin Pathway. Med Sci Monit. 2019; 25: 3014-25. https://doi.org/10.12659/MSM.913185
dc.rights.eng.fl_str_mv	Inés Benedetti Padron - 2021
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spelling	Benedetti Padron, Inés212ebbef4817e55347c4f1f69129aabaLecompte Osorio, Paola6f93c13aab633200474b13804701a206Barrios Garcia, Lía3ea84501a2af5a6719c4a17303c8dee32021-01-15 00:00:002021-01-15 00:00:002021-01-152215-784010.32997/rcb-2021-32322389-7252https://doi.org/10.32997/rcb-2021-3232application/pdfengUniversidad de CartagenaRevista Ciencias Biomédicashttps://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3232/2745Núm. 1 , Año 2021151310Ferlay J CM, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019; 144(8): 1941-53. https://doi.org/10.1002/ijc.31937Campo-Sánchez S, Camargo-Trillos J, Calle-Ramírez J, Gómez-Wolff L, Sánchez-Patiño L, García-García H. Supervivencia de cáncer colorrectal en un centro oncológico de Colombia. Estudio de cohorte histórica. Revista de Gastroenterología de México. 2018. https://doi.org/10.1016/j.rgmx.2018.04.002Giráldez MD. Avances en la etiopatogenia, identificación y manejo clínico de las formas hereditarias y familiares de cáncer colorrectal. Gastroenterología y Hepatología. 2011; 34: 70-5. https://doi.org/10.1016/S0210-5705(11)70011-5Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990; 61(5): 759-67. https://doi.org/10.1016/0092-8674(90)90186-IMarmol I, Sanchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int J Mol Sci. 2017; 18(1). https://doi.org/10.3390/ijms18010197Armaghany T, Wilson JD, Chu Q, Mills G. Genetic alterations in colorectal cancer. Gastrointestinal cancer research: GCR. 2012; 5(1): 19.Niitsu H, Hinoi T, Kawaguchi Y, Sentani K, Yuge R, Kitadai Y, et al. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer. Oncogenesis. 2016; 5(8): e253. https://doi.org/10.1038/oncsis.2016.47Leslie A, Carey F, Pratt N, Steele R. The colorectal adenoma-carcinoma sequence. British Journal of Surgery. 2002; 89(7): 845-60. https://doi.org/10.1046/j.1365-2168.2002.02120.xBenedetti-Padrón I, Becerra-Mejía D. Expresión de Ciclooxigenasa-2 en carcinoma colorrectal, una revisión narrativa. Iatreia. 2019; 32(1): 52-63. https://doi.org/10.17533/udea.iatreia.v32n1a06Koehne C-H, Dubois RN, editors. COX-2 inhibition and colorectal cancer. Seminars in oncology; 2004: Elsevier. https://doi.org/10.1053/j.seminoncol.2004.03.041Soslow RA, Dannenberg AJ, Rush D, Woerner B, Khan KN, Masferrer J, et al. COX‐2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer. 2000; 89(12): 2637-45. https://doi.org/10.1002/1097-0142(20001215)89:122637::AID-CNCR173.0.CO;2-BDi Bartolomeo M, Pietrantonio F, Pellegrinelli A, Martinetti A, Mariani L, Daidone MG, et al. Osteopontin, E-cadherin, and β-catenin expression as prognostic biomarkers in patients with radically resected gastric cancer. Gastric cancer. 2016; 19(2): 412-20. https://doi.org/10.1007/s10120-015-0495-yWei R, Wong JPC, Lyu P, Xi X, Tong O, Zhang SD, et al. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Journal of Cellular and Molecular Medicine. 2018; 22(9): 4097-105. https://doi.org/10.1111/jcmm.13686Becerra D, Benedetti I. OSTEOPONTINA, UNA PROTEÍNA INVOLUCRADA EN LA PROGRESIÓN TUMORAL, Y SU PARTICIPACIÓN EN EL DESARROLLO DEL CARCINOMA COLORRECTAL. Revista Ciencias Biomédicas. 2019; 8(1): 15-21. https://doi.org/10.32997/rcb-2018-2711Zubiaurre L, de Pierola LBF. Aspirina en la prevención del cáncer colorrectal. Gastroenterología y Hepatología. 2011; 34(5): 337-45. https://doi.org/10.1016/j.gastrohep.2011.01.004Kale S, Raja R, Thorat D, Soundararajan G, Patil TV, Kundu GC. Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via alpha9beta1 integrin. Oncogene. 2014; 33(18): 2295-306. https://doi.org/10.1038/onc.2013.184Jain S, Chakraborty G, Kundu GC. The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. Cancer Res. 2006; 66(13): 6638-48. https://doi.org/10.1158/0008-5472.CAN-06-0661Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D. Expression of cyclooxygenase-2 in colonic polyps. Pol Arch Med Wewn. 2010; 120(9): 313-20. https://doi.org/10.20452/pamw.955Li J, Yang G-Z, Zhu Z-M, Zhou Z-Y, Li L. Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. Experimental and therapeutic medicine. 2012; 3(4): 621-4. https://doi.org/10.3892/etm.2012.465Petrişor O, Giuşcă SE, Sajin M, Dobrescu G, Căruntu I-D. Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma. Rom J Morphol Embryol. 2008; 49(2): 163-71.Melling N, Kowitz CM, Simon R, Bokemeyer C, Terracciano L, Sauter G, et al. High Ki67 expression is an independent good prognostic marker in colorectal cancer. Journal of clinical pathology. 2016; 69(3): 209-14. https://doi.org/10.1136/jclinpath-2015-202985Ávila FP, Ortega GC, García RM. Marcadores inmunohistoquímicos p53 y Ki67: utilización diagnóstica y pronóstica en el cáncer de colon. Revista andaluza de patología digestiva. 2012; 35(3): 173-8.Mesina C, Stoean LC, Stoean R, Sandita VA, Gruia CL, Foarfa MC, et al. Immunohistochemical Expression of CD8, CDX2, P53, D2-40 and KI 67 in Colorectal Adenocarcinoma, Conventional and Malignant Colo-rectal Polyps. Bucharest. 2018; 69: 419. https://doi.org/10.37358/RC.18.2.6120Li L, Wang J, Jian'gang Li ZW, Ma P. Expression of Ki-67 and pAKT in colorectal cancer tissues and their clinical significance. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE. 2018; 11(5): 4623-30.Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, et al. Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). The American journal of surgical pathology. 2008; 32(1): 21-9. https://doi.org/10.1097/PAS.0b013e318157f002Sakuma K, Fujimori T, Hirabayashi K, Terano A. Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. Journal of gastroenterology. 1999; 34(2): 189-94. https://doi.org/10.1007/s005350050242Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, Dubois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994; 107(4): 1183-8. https://doi.org/10.1016/0016-5085(94)90246-1Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, et al. Expression of cyclooxygenase-1 and-2 in human colorectal cancer. Cancer research. 1995; 55(17): 3785-9. https://doi.org/10.1016/0928-4680(94)90594-0Lim SC, Lee TB, Choi CH, Ryu SY, Min YD, Kim KJ. Prognostic significance of cyclooxygenase‐2 expression and nuclear p53 accumulation in patients with colorectal cancer. Journal of surgical oncology. 2008; 97(1): 51-6. https://doi.org/10.1002/jso.20907Yamac D, Celenkoglu G, Coskun U, Akyurek N, Akcali Z, Dursun A, et al. Prognostic importance of COX-2 expression in patients with colorectal cancer. Pathology-Research and Practice. 2005; 201(7): 497-502. https://doi.org/10.1016/j.prp.2005.04.006Sobolewski C, Cerella C, Dicato M, Ghibelli L, Diederich M. The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. International journal of cell biology. 2010; 2010. https://doi.org/10.1155/2010/215158Lamort AS, Giopanou I, Psallidas I, Stathopoulos GT. Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight. Cells. 2019; 8(8). https://doi.org/10.3390/cells8080815Hao C, Cui Y, Owen S, Li W, Cheng S, Jiang WG. Human osteopontin: Potential clinical applications in cancer (Review). Int J Mol Med. 2017; 39(6): 1327-37. https://doi.org/10.3892/ijmm.2017.2964Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, Chambers AF, et al. Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clinical cancer research. 2004; 10(1): 184-90. https://doi.org/10.1158/1078-0432.CCR-1405-2Wei R, Wong JPC, Kwok HF. Osteopontin--a promising biomarker for cancer therapy. Journal of Cancer. 2017; 8(12): 2173. https://doi.org/10.7150/jca.20480Youssef NS, Osman WM. Relationship between osteopontin and β-catenin immunohistochemical expression and prognostic parameters of colorectal carcinoma. International journal of clinical and experimental pathology. 2015; 8(2): 1503.Cheng Y, Wen G, Sun Y, Shen Y, Zeng Y, Du M, et al. Osteopontin Promotes Colorectal Cancer Cell Invasion and the Stem Cell-Like Properties through the PI3K-AKT-GSK/3beta-beta/Catenin Pathway. Med Sci Monit. 2019; 25: 3014-25. https://doi.org/10.12659/MSM.913185Inés Benedetti Padron - 2021https://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/view/3232Colorectal cancerOsteopontinCyclooxygenase-2Cáncer colorrectalOsteopontinaCiclooxigenasa-2Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.Expression of Osteopontin and Cyclooxygenase-2 in relation to cellular proliferation, in non-tumor colonic mucosa, colonic adenomas and colon adenocarcinoma.Artículo de revistainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articleOREORE.xmltext/xml2688https://repositorio.unicartagena.edu.co/bitstream/11227/13442/1/ORE.xml73060a4a9ce6e5b2f97f708f673dae0eMD51open access11227/13442oai:repositorio.unicartagena.edu.co:11227/134422023-03-27 12:59:05.167An error occurred on the license name.\|\|\|https://creativecommons.org/licenses/by-nc-sa/4.0/metadata only accessBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.com

Expresión de Osteopontina y Ciclooxigenasa-2 en relación con la proliferación celular, en mucosa colónica no tumoral, adenomas y adenocarcinoma de colon.

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