Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata
- Autores:
-
Benedetti Padrón, Inés
Barrios García, Lía
Segovia Fuentes, Javier
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Cartagena
- Repositorio:
- Repositorio Universidad de Cartagena
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicartagena.edu.co:11227/13421
- Acceso en línea:
- https://hdl.handle.net/11227/13421
https://doi.org/10.32997/rcb-2012-3168
- Palabra clave:
- Próstata
Adenocarcinoma prostático
Puntaje de Gleason
Antígeno prostático específico (PSA)
Densidad de antígeno prostático específico (DPSA).
- Rights
- openAccess
- License
- Revista Ciencias Biomédicas - 2020
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dc.title.spa.fl_str_mv |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
dc.title.translated.eng.fl_str_mv |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
title |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
spellingShingle |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata Próstata Adenocarcinoma prostático Puntaje de Gleason Antígeno prostático específico (PSA) Densidad de antígeno prostático específico (DPSA). |
title_short |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
title_full |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
title_fullStr |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
title_full_unstemmed |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
title_sort |
Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstata |
dc.creator.fl_str_mv |
Benedetti Padrón, Inés Barrios García, Lía Segovia Fuentes, Javier |
dc.contributor.author.spa.fl_str_mv |
Benedetti Padrón, Inés Barrios García, Lía Segovia Fuentes, Javier |
dc.subject.spa.fl_str_mv |
Próstata Adenocarcinoma prostático Puntaje de Gleason Antígeno prostático específico (PSA) Densidad de antígeno prostático específico (DPSA). |
topic |
Próstata Adenocarcinoma prostático Puntaje de Gleason Antígeno prostático específico (PSA) Densidad de antígeno prostático específico (DPSA). |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-12-28 00:00:00 |
dc.date.available.none.fl_str_mv |
2020-12-28 00:00:00 |
dc.date.issued.none.fl_str_mv |
2020-12-28 |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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Journal article |
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2215-7840 |
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https://hdl.handle.net/11227/13421 |
dc.identifier.doi.none.fl_str_mv |
10.32997/rcb-2012-3168 |
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2389-7252 |
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https://doi.org/10.32997/rcb-2012-3168 |
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Revista Ciencias Biomédicas |
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https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3168/2695 |
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Núm. 1 , Año 2012 |
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Globocan 2008, cancer fact sheet, Prostate cancer Incidence and mortality worldwide in 2008. http://globocan.iarc.fr/factsheets/cancers/prostate.asp consultado, 9-diciembre 2010. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: A Cancer J for Clinicians. 2011;61:69-90. Instituto Nacional de Cancerología, El cáncer en cifras, incidencia. http://www.cancer.gov.co/documentos/Incidencia/Tabla%2087.pdf consultado, 9-diciembre 2010. Instituto Nacional de Cancerología, El cáncer en cifras, mortalidad. http://www.cancer.gov.co/documentos/Mortalidad/Mortalidad%20nacional%20por%20tipo%20de%20c%C3%A1ncer%202000-2006%20.pdf consultado, 9-diciembre 2010. Routh JC, Leibovich BC. Adenocarcinoma of the prostate: epidemiological trends, screening, diagnosis, and surgical management of localized disease. Mayo ClinProc. 2005;80:899–907. Chodak G. Prostate cancer: epidemiology, screening and biomarkers. Rev Urology. 2006;8(suppl 2):S3-S8. Shah RB, Zhou M, LeBlanc S, Rubin MA. Comparison of the basal cell-specific markers, 34betaE12 and p63 in the diagnosis of prostate cancer. Am J Surg Pathol. 2002;26:1161-1168. Humphrey PA. Diagnosis of adenocarcinoma in prostate needle biopsy tissue. J Clin Pathol. 2007;60:34-42. Humphrey PA. Gleason grading and prognostic factors in carcinoma of the prostate. Modern Pathology. 2004;17:292-306. Gleason DF. Classification of prostatic carcinomas. Cancer Chemother Rep. 1966;50:125-128. Bostwick DG. Grading prostate cancer. Am J Clin Pathol. 1994;102:S38-56. Eggener SE. Scardino PT. Walsh PC. Han M; Partin AW. et al, Predicting 15-Year Prostate Cancer Specific Mortality After Radical Prostatectomy. Journal of Urology. 2011;185:869-875. Chikezie O. Madu and Yi Lu. Novel diagnostic biomarkers for prostate cancer. J of Cancer. 2010;1:150-177. Jansen FH, Roobol M, Jenster G, Schroder FH, Bangma C. Screening for Prostate Cancer in 2008 II: The Importance of Molecular Subforms of Prostate-Specific Antigen and Tissue Kallikreins. European Urology. 2009;55(3):563-574. Stephan C, Cammann H, Meyer H, Lein M, Jung K. PSA and new biomarkers within multivariate models to improve early detection of prostate cancer. Cancer Letters. 2007;249:18-29. Smith DS, Catalona WJ, Herschman JC. Longitudinal screening for prostate cancer with prostate specific antigen. JAMA. 1996;276:1309-1315. Babaian RJ, Fritsche HA, Evans RB. Prostate specific antigen and the prostate gland volume: correlation and clinical application. J Clin Lab Anal.1990;4:135-137. Scott G, Cavallo C, Lowe F. Evidence suggesting PSA cutpoint of 2.5 ng/ml for prompting prostate biopsy: review of 36,316 biopsies. Urology. 2005;65:549-553. D’Amico AV, Chen MH, Roehl KA, et al. Preoperative PSA velocity and the risk of death from prostate cancer after radical prostatectomy. N Engl J Med. 2004;351:125-135. Catalona WJ, Smith DS, Ratliff TL, et al. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med. 1991;324:1156-1161. Lokner DH, Crawforded RE, Miller GJ. Prostate-specific antigen and prostate-specific antigen density in cases of pathologically proven prostate cancer. J Urol. 1993;149:414-420. Brawer MK, Aramburu D, Chen GL. The inability of prostate-specificantigen index to enhance the predictive value of prostate-specific antigen in the diagnosis of prostatic carcinoma. J urol. 1993; 150(2p):369-373. Rodríguez A, González A. Importancia de la velocidad y la densidad de PSA en la predicción de cáncer de próstata en la pieza de RTU o adenomectomía de pacientes con biopsia prostática previa negativa. Actas Urol Esp. 2008;32:779-786. Al-Azab R, Toi A, Lockwood G, Kulkarni G, Fleshner N. Prostate volume is strongest predictor of cancer diagnosis at transrectal ultrasound-Guided prostate biopsy with prostate-specific antigen values between 2.0 and 9.0 ng/mL. Urology. 2007;69:103-107. Klein LT, Lowe FC. The effects of prostatic manipulation on prostate-specific antigen levels. Urol Clin North Am. 1997;24:293-297. Stamey TA, Caldwell M, McNeal JE, Nolley R, Hemenez M, Downs J. The prostate specific antigen era in the United States is over for prostate cancer: what happened in the last 20 years? J Urol. 2004;172:1297-1301. Reis L O, Zani E L, Alonso J.C, Simões F A, Rejowski R F, Ferreira U. ¿Impacta el criterio para indicar la biopsia prostática sobre su exactitud? Estudio prospectivo llevado a cabo sobre una población de pacientes ambulantes. Actas Urológicas Españolas. 2011;35:10-14. Catalona WJ, Richie JP, Ahmann FR, et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol. 1994;151:1283–1290. Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP, et al. EAU guidelines on prostate cancer. Acta Urol Esp. 2009;33:113-126. Piovesan AC, de Campos Freire G, Miranda FC, Cordeiro P, Yamada R, Srougi M. Incidence of Histological Prostatitis And Its Correlation With PSA Density. Clinics. 2009;64:1049-1051. Seaman EK, Whang IS, Cooner W, Olsson CA, Benson MC. Predictive value of prostate-specific antigen density for the presence of micrometastatic carcinoma of the prostate. Urology. 1994;43:645-648. Benson MC, Whang IH, Olsson CA, McMahon DJ, and Cooner WH. The use of prostatic specific antigen density to enhance the predictive value of intermediate levels of serum prostatic specific antigen. J Urol. 1992;147:817-821. Lodeta B, Benko G, Car S, Filipan Z, Stajcar D, Dujmović T. Prostate specific antigen density can help avoid unnecessary prostate biopsies at prostate specific antigen range of 4-10 ng/ml Acta Clin Croat. 2009; 48:153-155. Catalona WJ, Richie JP, deKernion JB, Ahmann FR, Ratliff TL, Dalkin BL, et al. Comparison of prostate specific antigen concentration versus prostate specific antigen density in the early detection of prostate cancer: receiver operating characteristic curves. J Urol. 1994;152: 2031-2036. Catalona WJ, Southwick PC, Slawin KM, Partin AW, Brawer MK, Flanigan RC, et al. Comparison of percent free PSA, PSA density, and age-specific PSA cutoffs for prostate cancer detection and staging. Urology. 2000;56:255-260. Stamey TA, Johnstone IM, McNeal JE, et al. Preoperative serum prostate specific antigen levels between 2 and 22 ng/ml. Correlate poorly with post-radical prostatectomy cancer morphology: prostate specific antigen cure rates appear constant between 2 and 9 ng/ml. J Urol. 2002;167:103-111. Bazinet M, Meshref AW, Trudel C, Aronson S, Peloquin F, Nachabe M, Begin LR, and Elhilali MM. Prospective evaluation of prostate-specific antigen density and systematic biopsies for early detection of prostatic carcinoma. Urology. 1994;43:44-52. Uzzo R G,Wei J T,Waldbaum et al. The influence of prostate size in cáncer detection, Urology. 1995;46:831-836. Keetch DW, Catalona WJ, Smith DS. Serial prostatic biopsies in men with persistently elevated serum PSA values. J Urol. 1994;151:1571- 1574. Kundu S.D, Roehl K.A, Yu X, Antenor JA, Suarez BK, Catalona WJ. Prostate Specific Antigen Density Correlates with Features of Prostate Cancer Aggressiveness. J Urology. 2007;177:505- 509. Moussa AS, Li J, Soriano M, et al. Prostate biopsy clinical and pathologic variables that predict significant grading changes in patients with intermediate and high grade prostate cancer. BJU Int. 2009;103:43-48. Tilki D, Schlenker B, John M, et al. Clinical and pathologic predictors of Gleason sum upgrading in patients after radical prostatectomy: Results from a single institution series. Urologic Oncology: Seminars and Original Investigations, 2009;29(5):508-514. Gyasi-Sarpong K, Boateng K, Aboah K, Opoku P, Adu Gyamfi M. Correlation of Pre-operative Prostate Specific Antigen (PSA) With Gleason Grading in Prostate Cancer Diagnosis. Urology 2008:72 (suppl):S122-S123. Al Shakarchi J A, Wasfi D. Audit of PSA and Gleason scoring in prostatic carcinoma. European Urology Supplements. 2009;8:567. Giannarini G, Scott C A, Moro U, Pertoldi B, Beltrami C A, Selli C. Are PSA density and PSA density of the transition zone more accurate than PSA in predicting the pathological stage of clinically localized prostate cancer? Urologic Oncolo. 2008;24(4):353-360. Ohori J, Dunn K P, Scardino P. Is Prostate-Specific Antigen Density More Useful Than Prostate-Specific Antigen Levels In The Diagnosis Of Prostate Cancer? Urology. 1995;46:666-671. |
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Benedetti Padrón, InésBarrios García, LíaSegovia Fuentes, Javier2020-12-28 00:00:002020-12-28 00:00:002020-12-282215-7840https://hdl.handle.net/11227/1342110.32997/rcb-2012-31682389-7252https://doi.org/10.32997/rcb-2012-3168application/pdfspaUniversidad de CartagenaRevista Ciencias Biomédicashttps://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3168/2695Núm. 1 , Año 2012681583Globocan 2008, cancer fact sheet, Prostate cancer Incidence and mortality worldwide in 2008. http://globocan.iarc.fr/factsheets/cancers/prostate.asp consultado, 9-diciembre 2010.Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: A Cancer J for Clinicians. 2011;61:69-90.Instituto Nacional de Cancerología, El cáncer en cifras, incidencia. http://www.cancer.gov.co/documentos/Incidencia/Tabla%2087.pdf consultado, 9-diciembre 2010.Instituto Nacional de Cancerología, El cáncer en cifras, mortalidad. http://www.cancer.gov.co/documentos/Mortalidad/Mortalidad%20nacional%20por%20tipo%20de%20c%C3%A1ncer%202000-2006%20.pdf consultado, 9-diciembre 2010.Routh JC, Leibovich BC. Adenocarcinoma of the prostate: epidemiological trends, screening, diagnosis, and surgical management of localized disease. Mayo ClinProc. 2005;80:899–907.Chodak G. Prostate cancer: epidemiology, screening and biomarkers. Rev Urology. 2006;8(suppl 2):S3-S8.Shah RB, Zhou M, LeBlanc S, Rubin MA. Comparison of the basal cell-specific markers, 34betaE12 and p63 in the diagnosis of prostate cancer. Am J Surg Pathol. 2002;26:1161-1168.Humphrey PA. Diagnosis of adenocarcinoma in prostate needle biopsy tissue. J Clin Pathol. 2007;60:34-42.Humphrey PA. Gleason grading and prognostic factors in carcinoma of the prostate. Modern Pathology. 2004;17:292-306.Gleason DF. Classification of prostatic carcinomas. Cancer Chemother Rep. 1966;50:125-128.Bostwick DG. Grading prostate cancer. Am J Clin Pathol. 1994;102:S38-56.Eggener SE. Scardino PT. Walsh PC. Han M; Partin AW. et al, Predicting 15-Year Prostate Cancer Specific Mortality After Radical Prostatectomy. Journal of Urology. 2011;185:869-875.Chikezie O. Madu and Yi Lu. Novel diagnostic biomarkers for prostate cancer. J of Cancer. 2010;1:150-177.Jansen FH, Roobol M, Jenster G, Schroder FH, Bangma C. Screening for Prostate Cancer in 2008 II: The Importance of Molecular Subforms of Prostate-Specific Antigen and Tissue Kallikreins. European Urology. 2009;55(3):563-574.Stephan C, Cammann H, Meyer H, Lein M, Jung K. PSA and new biomarkers within multivariate models to improve early detection of prostate cancer. Cancer Letters. 2007;249:18-29.Smith DS, Catalona WJ, Herschman JC. Longitudinal screening for prostate cancer with prostate specific antigen. JAMA. 1996;276:1309-1315.Babaian RJ, Fritsche HA, Evans RB. Prostate specific antigen and the prostate gland volume: correlation and clinical application. J Clin Lab Anal.1990;4:135-137.Scott G, Cavallo C, Lowe F. Evidence suggesting PSA cutpoint of 2.5 ng/ml for prompting prostate biopsy: review of 36,316 biopsies. Urology. 2005;65:549-553.D’Amico AV, Chen MH, Roehl KA, et al. Preoperative PSA velocity and the risk of death from prostate cancer after radical prostatectomy. N Engl J Med. 2004;351:125-135.Catalona WJ, Smith DS, Ratliff TL, et al. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med. 1991;324:1156-1161.Lokner DH, Crawforded RE, Miller GJ. Prostate-specific antigen and prostate-specific antigen density in cases of pathologically proven prostate cancer. J Urol. 1993;149:414-420.Brawer MK, Aramburu D, Chen GL. The inability of prostate-specificantigen index to enhance the predictive value of prostate-specific antigen in the diagnosis of prostatic carcinoma. J urol. 1993; 150(2p):369-373.Rodríguez A, González A. Importancia de la velocidad y la densidad de PSA en la predicción de cáncer de próstata en la pieza de RTU o adenomectomía de pacientes con biopsia prostática previa negativa. Actas Urol Esp. 2008;32:779-786.Al-Azab R, Toi A, Lockwood G, Kulkarni G, Fleshner N. Prostate volume is strongest predictor of cancer diagnosis at transrectal ultrasound-Guided prostate biopsy with prostate-specific antigen values between 2.0 and 9.0 ng/mL. Urology. 2007;69:103-107.Klein LT, Lowe FC. The effects of prostatic manipulation on prostate-specific antigen levels. Urol Clin North Am. 1997;24:293-297.Stamey TA, Caldwell M, McNeal JE, Nolley R, Hemenez M, Downs J. The prostate specific antigen era in the United States is over for prostate cancer: what happened in the last 20 years? J Urol. 2004;172:1297-1301.Reis L O, Zani E L, Alonso J.C, Simões F A, Rejowski R F, Ferreira U. ¿Impacta el criterio para indicar la biopsia prostática sobre su exactitud? Estudio prospectivo llevado a cabo sobre una población de pacientes ambulantes. Actas Urológicas Españolas. 2011;35:10-14.Catalona WJ, Richie JP, Ahmann FR, et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol. 1994;151:1283–1290.Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP, et al. EAU guidelines on prostate cancer. Acta Urol Esp. 2009;33:113-126.Piovesan AC, de Campos Freire G, Miranda FC, Cordeiro P, Yamada R, Srougi M. Incidence of Histological Prostatitis And Its Correlation With PSA Density. Clinics. 2009;64:1049-1051.Seaman EK, Whang IS, Cooner W, Olsson CA, Benson MC. Predictive value of prostate-specific antigen density for the presence of micrometastatic carcinoma of the prostate. Urology. 1994;43:645-648.Benson MC, Whang IH, Olsson CA, McMahon DJ, and Cooner WH. The use of prostatic specific antigen density to enhance the predictive value of intermediate levels of serum prostatic specific antigen. J Urol. 1992;147:817-821.Lodeta B, Benko G, Car S, Filipan Z, Stajcar D, Dujmović T. Prostate specific antigen density can help avoid unnecessary prostate biopsies at prostate specific antigen range of 4-10 ng/ml Acta Clin Croat. 2009; 48:153-155.Catalona WJ, Richie JP, deKernion JB, Ahmann FR, Ratliff TL, Dalkin BL, et al. Comparison of prostate specific antigen concentration versus prostate specific antigen density in the early detection of prostate cancer: receiver operating characteristic curves. J Urol. 1994;152: 2031-2036.Catalona WJ, Southwick PC, Slawin KM, Partin AW, Brawer MK, Flanigan RC, et al. Comparison of percent free PSA, PSA density, and age-specific PSA cutoffs for prostate cancer detection and staging. Urology. 2000;56:255-260.Stamey TA, Johnstone IM, McNeal JE, et al. Preoperative serum prostate specific antigen levels between 2 and 22 ng/ml. Correlate poorly with post-radical prostatectomy cancer morphology: prostate specific antigen cure rates appear constant between 2 and 9 ng/ml. J Urol. 2002;167:103-111.Bazinet M, Meshref AW, Trudel C, Aronson S, Peloquin F, Nachabe M, Begin LR, and Elhilali MM. Prospective evaluation of prostate-specific antigen density and systematic biopsies for early detection of prostatic carcinoma. Urology. 1994;43:44-52.Uzzo R G,Wei J T,Waldbaum et al. The influence of prostate size in cáncer detection, Urology. 1995;46:831-836.Keetch DW, Catalona WJ, Smith DS. Serial prostatic biopsies in men with persistently elevated serum PSA values. J Urol. 1994;151:1571- 1574.Kundu S.D, Roehl K.A, Yu X, Antenor JA, Suarez BK, Catalona WJ. Prostate Specific Antigen Density Correlates with Features of Prostate Cancer Aggressiveness. J Urology. 2007;177:505- 509.Moussa AS, Li J, Soriano M, et al. Prostate biopsy clinical and pathologic variables that predict significant grading changes in patients with intermediate and high grade prostate cancer. BJU Int. 2009;103:43-48.Tilki D, Schlenker B, John M, et al. Clinical and pathologic predictors of Gleason sum upgrading in patients after radical prostatectomy: Results from a single institution series. Urologic Oncology: Seminars and Original Investigations, 2009;29(5):508-514.Gyasi-Sarpong K, Boateng K, Aboah K, Opoku P, Adu Gyamfi M. Correlation of Pre-operative Prostate Specific Antigen (PSA) With Gleason Grading in Prostate Cancer Diagnosis. Urology 2008:72 (suppl):S122-S123.Al Shakarchi J A, Wasfi D. Audit of PSA and Gleason scoring in prostatic carcinoma. European Urology Supplements. 2009;8:567.Giannarini G, Scott C A, Moro U, Pertoldi B, Beltrami C A, Selli C. Are PSA density and PSA density of the transition zone more accurate than PSA in predicting the pathological stage of clinically localized prostate cancer? Urologic Oncolo. 2008;24(4):353-360.Ohori J, Dunn K P, Scardino P. Is Prostate-Specific Antigen Density More Useful Than Prostate-Specific Antigen Levels In The Diagnosis Of Prostate Cancer? Urology. 1995;46:666-671.Revista Ciencias Biomédicas - 2020https://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttps://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/view/3168PróstataAdenocarcinoma prostáticoPuntaje de GleasonAntígeno prostático específico (PSA)Densidad de antígeno prostático específico (DPSA).Asociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstataAsociación entre puntaje de gleason, nivel de psa, dpsa y volumen prostático en una serie de pacientes con adenocarcinoma de próstataArtículo de revistainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlePublicationOREORE.xmltext/xml2646https://repositorio.unicartagena.edu.co/bitstreams/7c952ef1-307f-4c38-aaac-fc067853f8b6/download3cc951580381998c46117fda4ac9f227MD5111227/13421oai:repositorio.unicartagena.edu.co:11227/134212024-09-05 15:30:36.818https://creativecommons.org/licenses/by-nc-sa/4.0/Revista Ciencias Biomédicas - 2020metadata.onlyhttps://repositorio.unicartagena.edu.coBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.com |