Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue

Existen evidencias de la participación del estrés oxidativo en la patogénesis del dengue grave. Sin embargo, los referentes observacionales presentan ciertas limitaciones metodológicas, las cuales pueden afectar su validez interna y externa. Materiales y métodos. Estudio de casos y controles, con pa...

Full description

Autores:
Castro Orozco, Raimundo
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2018
Institución:
Universidad de Cartagena
Repositorio:
Repositorio Universidad de Cartagena
Idioma:
spa
OAI Identifier:
oai:repositorio.unicartagena.edu.co:11227/15527
Acceso en línea:
https://hdl.handle.net/11227/15527
http://dx.doi.org/10.57799/11227/145
Palabra clave:
Virus del dengue
Fiebre del dengue
Fiebre hemorrágica
Enfermedades por virus
Rights
openAccess
License
Derechos Reservados - Universidad de Cartagena, 2018
id UCART2_5ad9a61a6d20fcafe90fa978db9dc901
oai_identifier_str oai:repositorio.unicartagena.edu.co:11227/15527
network_acronym_str UCART2
network_name_str Repositorio Universidad de Cartagena
repository_id_str
dc.title.spa.fl_str_mv Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
title Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
spellingShingle Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
Virus del dengue
Fiebre del dengue
Fiebre hemorrágica
Enfermedades por virus
title_short Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
title_full Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
title_fullStr Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
title_full_unstemmed Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
title_sort Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengue
dc.creator.fl_str_mv Castro Orozco, Raimundo
dc.contributor.advisor.none.fl_str_mv Alvis Guzmán, Nelsón Rafael
dc.contributor.author.none.fl_str_mv Castro Orozco, Raimundo
dc.subject.armarc.none.fl_str_mv Virus del dengue
Fiebre del dengue
Fiebre hemorrágica
Enfermedades por virus
topic Virus del dengue
Fiebre del dengue
Fiebre hemorrágica
Enfermedades por virus
description Existen evidencias de la participación del estrés oxidativo en la patogénesis del dengue grave. Sin embargo, los referentes observacionales presentan ciertas limitaciones metodológicas, las cuales pueden afectar su validez interna y externa. Materiales y métodos. Estudio de casos y controles, con pacientes con dengue grave y dengue con signos de alarma, para examinar el comportamiento de los niveles séricos de carbonilos proteicos, hidroperóxidos lipídicos, superóxido dismutasa mitocondrial, citosólica y total, en pro de su evaluación como potenciales indicadores pronósticos de severidad en pacientes con diagnóstico de dengue, utilizando análisis de regresión logística binaria y probit binario, enmarcado en una estrategia de doble validación cruzada. Para tal fin, se seleccionó un grupo de derivación con muestras de suero de pacientes pediátricos procedentes de Barranquilla- Colombia y un grupo de validación externa con muestras de suero, de niños y adultos, remitidas al Instituto Nacional de Salud del Perú. Resultados. Los carbonilos proteicos fueron los únicos marcadores de estrés oxidativo que mostraron asociación con la severidad del dengue, tanto en niños como en adultos. En el grupo de derivación, el punto de corte óptimo fue estimado en 5,29 nmol/mg de proteína, y en el grupo de validación externa, fue de 5,77 nmol/mg de proteína. Conclusión. Los modelos pronósticos basados en estos dos umbrales diagnósticos presentaron una alta capacidad discriminatoria de severidad del dengue, reproducibilidad externa, transportabilidad geográfica y características de validez y seguridad diagnóstica, propias de las pruebas de cribado.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2022-08-16T21:06:45Z
dc.date.available.none.fl_str_mv 2022-08-16T21:06:45Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
status_str publishedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/11227/15527
http://dx.doi.org/10.57799/11227/145
url https://hdl.handle.net/11227/15527
http://dx.doi.org/10.57799/11227/145
dc.language.iso.spa.fl_str_mv spa
language spa
dc.rights.spa.fl_str_mv Derechos Reservados - Universidad de Cartagena, 2018
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.creativecommons.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
rights_invalid_str_mv Derechos Reservados - Universidad de Cartagena, 2018
https://creativecommons.org/licenses/by-nc/4.0/
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad de Cartagena
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Cartagena de Indias
dc.publisher.program.spa.fl_str_mv Doctorado en Medicina Tropical
institution Universidad de Cartagena
bitstream.url.fl_str_mv https://dspace7-unicartagena.metabuscador.org/bitstreams/353758c0-70f3-4181-b70e-eeaa8bb6cf44/download
https://dspace7-unicartagena.metabuscador.org/bitstreams/3a31815c-b5aa-4ecd-bdd7-c29a1a04ac14/download
https://dspace7-unicartagena.metabuscador.org/bitstreams/01670888-03dd-4319-8b01-b9318830fb71/download
https://dspace7-unicartagena.metabuscador.org/bitstreams/ae7d7775-99a3-4c58-a480-eb7c2b8745c8/download
https://dspace7-unicartagena.metabuscador.org/bitstreams/3fa81a0c-e329-41db-b30d-0358019a0639/download
https://dspace7-unicartagena.metabuscador.org/bitstreams/7474f862-a72a-485d-9403-b29859211987/download
https://dspace7-unicartagena.metabuscador.org/bitstreams/4f94ce68-533c-4400-9c4a-9547d36dd4fd/download
bitstream.checksum.fl_str_mv 1fadc15ae0ca8d831be2f60eaffcf932
cdd666f8b38f960b99848ed2b9def794
7b38fcee9ba3bc8639fa56f350c81be3
54e57ae75aad65c2c3bb18249b735102
1e6ec8585db79adb3ec82be0fb985191
a7e75e0467b968fd94cd9e89fe2ebbc4
e883f58a8b73686421cd70e59348ba6e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Biblioteca Digital Universidad de Cartagena
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814214042129006592
spelling Alvis Guzmán, Nelsón RafaelCastro Orozco, Raimundo2022-08-16T21:06:45Z2022-08-16T21:06:45Z2018https://hdl.handle.net/11227/15527http://dx.doi.org/10.57799/11227/145Existen evidencias de la participación del estrés oxidativo en la patogénesis del dengue grave. Sin embargo, los referentes observacionales presentan ciertas limitaciones metodológicas, las cuales pueden afectar su validez interna y externa. Materiales y métodos. Estudio de casos y controles, con pacientes con dengue grave y dengue con signos de alarma, para examinar el comportamiento de los niveles séricos de carbonilos proteicos, hidroperóxidos lipídicos, superóxido dismutasa mitocondrial, citosólica y total, en pro de su evaluación como potenciales indicadores pronósticos de severidad en pacientes con diagnóstico de dengue, utilizando análisis de regresión logística binaria y probit binario, enmarcado en una estrategia de doble validación cruzada. Para tal fin, se seleccionó un grupo de derivación con muestras de suero de pacientes pediátricos procedentes de Barranquilla- Colombia y un grupo de validación externa con muestras de suero, de niños y adultos, remitidas al Instituto Nacional de Salud del Perú. Resultados. Los carbonilos proteicos fueron los únicos marcadores de estrés oxidativo que mostraron asociación con la severidad del dengue, tanto en niños como en adultos. En el grupo de derivación, el punto de corte óptimo fue estimado en 5,29 nmol/mg de proteína, y en el grupo de validación externa, fue de 5,77 nmol/mg de proteína. Conclusión. Los modelos pronósticos basados en estos dos umbrales diagnósticos presentaron una alta capacidad discriminatoria de severidad del dengue, reproducibilidad externa, transportabilidad geográfica y características de validez y seguridad diagnóstica, propias de las pruebas de cribado.DoctoradoDoctor(a) en Medicina Tropicalapplication/pdfspaUniversidad de CartagenaFacultad de MedicinaCartagena de IndiasDoctorado en Medicina TropicalDerechos Reservados - Universidad de Cartagena, 2018https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2Biomarcadores de estrés oxidativo como indicadores pronósticos de severidad en pacientes con dengueTrabajo de grado - Doctoradoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_db06Textinfo:eu-repo/semantics/doctoralThesishttps://purl.org/redcol/resource_type/TDhttp://purl.org/coar/version/c_970fb48d4fbd8a85Virus del dengueFiebre del dengueFiebre hemorrágicaEnfermedades por virusBhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.Laughlin CA, Morens DM, Cassetti MC, Costero-Saint Denis A, San Martin JL, Whitehead SS, et al. Dengue research opportunities in the Americas. The Journal of infectious diseases. 2012;206(7):1121-7.Gurugama P, Garg P, Perera J, Wijewickrama A, Seneviratne SL. Dengue viral infections. Indian journal of dermatology. 2010;55(1):68-78.McBride WJ, Bielefeldt-Ohmann H. Dengue viral infections; pathogenesis and epidemiology. Microbes and infection / Institut Pasteur. 2000;2(9):1041-50.Mangold KA, Reynolds SL. A review of dengue fever: a resurging tropical disease. Pediatric emergency care. 2013;29(5):665-9; quiz 70-1.Kularatne SAM. Dengue fever. BMJ : British Medical Journal. 2015;351.Dhanoa A, Hassan SS, Ngim CF, Lau CF, Chan TS, Adnan NAA, et al. Impact of dengue virus (DENV) co-infection on clinical manifestations, disease severity and laboratory parameters. BMC infectious diseases. 2016;16(1):406.Venkatachalam RS, V. Homology and conservation of amino acids in E-protein sequences of dengue serotypes. Asian Pac J Trop Dis 2014;2(Suppl 2):5.Acosta EG, Castilla, V. and Damonte, E. B. Alternative infectious entry pathways for dengue virus serotypes into mammalian cells. Cellular microbiology. 2009;11(10):12.Noisakran S, Onlamoon N, Songprakhon P, Hsiao HM, Chokephaibulkit K, Perng GC. Cells in dengue virus infection in vivo. Advances in virology. 2010;2010:164878.Clyde K, Kyle JL, Harris E. Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. Journal of virology. 2006;80(23):11418-31.Guabiraba R, Ryffel B. Dengue virus infection: current concepts in immune mechanisms and lessons from murine models. Immunology. 2014;141(2):143-56.Costa VV, Fagundes CT, Souza DG, Teixeira MM. Inflammatory and Innate Immune Responses in Dengue Infection: Protection versus Disease Induction. The American journal of pathology. 2013;182(6):1950-61.Padilla JCR, D. P.; Sáenz-Gómez, R. Dengue en Colombia. Epidemiología de la reemergencia a la hiperendemia. Bogotá-Colombia: Los Autores; 2012. 249 pCafferata ML B, A, Rey-Ares, L, Alcaraz, A, Cormick, G, Gibbons, L, Romano, M. Cesaroni, S, Ruvinsky, S. Dengue Epidemiology and Burden of Disease in Latin America and the Caribbean: A Systematic Review of the Literature and Meta-Analysis. Value in Health Regional Issues. 2013;2:10.Tabor E. Emerging Viruses in Human Populations. Zuckerman AJM, I.K, editor: Elsevier Science; 2007 January 30, 2007. 374Torres J, Orduna, TA, Piña-Pozas, M, Vázquez-Vega, D, Sarti, E. Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature. Journal of tropical medicine. 2017;3:18Romero L. Informe final del evento dengue, año 2012. Instituto Nacional de Salud. Vigilancia y Control en Salud Pública. 2012:1-19Zea D, Osorio L. Situación del sistema de vigilancia de casos de Dengue en un municipio de Colombia. Revista de salud publica. 2011;13(5):785-95Salud INd. Boletin Epidemiológico Semanal. In: Pública SdVyCeS, editor. Semana Epidemiológica 51 de 20132013.Instituto Nacional de Salud. Boletin Epidemiológico Semanal. In: Pública SdVyCeS, editor. Semana Epidemiológica 53 de 20142014. p. 34.Instituto Nacional de Salud. Boletin Epidemiológico Semanal. In: Pública SdVyCeS, editor. Semana Epidemiológica 52 de 20152015. p. 72.Instituto Nacional de Salud. Boletin Epidemiológico Semanal. In: Pública SdVyCeS, editor. Semana Epidemiológica 52 de 20162016. p. 121.Instituto Nacional de Salud. Boletin Epidemiológico Semanal. In: Pública SdVyCeS, editor. Semana Epidemiológica 51 de 20132013. p. 25.Salud Md. Boletín Epidemiológico Semana Epidemiológica 13. In: Epidemiología DGd, editor. 2010. p. 234-56.Salud Md. Boletín Epidemiológico Semana Epidemiológica 52. In: Epidemiología DGd, editor. 2010. p. 1095-128.Salud Md. Anuario Estadístico 2014. In: Instituto Nacional de Salud, editor. 2014. p. 281.Instituto Nacional de Salud. Anuario Estadístico 2015. In: Salud Md, editor. 2015. p. 320Salud Md. Anuario Estadístico 2016. In: Instituto Nacional de Salud, editor. 2016. p. 330.Instituto Nacional de Salud. Anuario Estadístico 2017. In: Salud Md, editor. 2017. p. 305World Health Organization. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. WHO Guidelines Approved by the Guidelines Review Committee. Geneva2009. p. 147.Anders KL, Nguyet NM, Chau NV, Hung NT, Thuy TT, Lien le B, et al. Epidemiological factors associated with dengue shock syndrome and mortality in hospitalized dengue patients in Ho Chi Minh City, Vietnam. The American journal of tropical medicine and hygiene. 2011;84(1):127-34.Thai KT, Nishiura H, Hoang PL, Tran NT, Phan GT, Le HQ, et al. Age-specificity of clinical dengue during primary and secondary infections. PLoS neglected tropical diseases. 2011;5(6):e1180.Nguyen TH NT, Lei HY, Lin YS, Le BL, Huang KJ, Lin CF, Do QH, Vu TQ, Lam TM, Yeh TM, Huang JH, Liu CC, Halstead SB. Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene. 2005;72(4):370-4.Malavige GN, Fernando S, Fernando DJ, Seneviratne SL. Dengue viral infections. Postgraduate medical journal. 2004;80(948):588-601.Guzman MG, Kouri G. Dengue diagnosis, advances and challenges. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2004;8(2):69-80.Rahman T, Hosen I, Islam MMT, Shekhar HU. Oxidative stress and human health. Advances in Bioscience and Biotechnology. 2012;03(07):997-1019.Halliwell B. The wanderings of a free radical. Free radical biology & medicine. 2009;46(5):531-42.Halliwell B. Biochemistry of oxidative stress. Biochemical Society transactions. 2007;35(Pt 5):1147-50.Soundravally R, Sankar P, Hoti SL, Selvaraj N, Bobby Z, Sridhar MG. Oxidative stress induced changes in plasma protein can be a predictor of imminent severe dengue infection. Acta tropica. 2008;106(3):156-61.Gil L, Martinez G, Tapanes R, Castro O, Gonzalez D, Bernardo L, et al. Oxidative stress in adult dengue patients. The American journal of tropical medicine and hygiene. 2004;71(5):652-7.de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP. Biomarkers of free radical damage applications in experimental animals and in humans. Free radical biology & medicine. 1999;26(1-2):202-26.Noori S. An Overview of Oxidative Stress and Antioxidant Defensive System. Journal of Clinical & Cellular Immunology. 2012;01(08).Kohen R, Nyska A. Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification. Toxicologic Pathology. 2002;30(6):620-50.Rojas A, Figueroa H, Re L, Morales MA. Oxidative stress at the vascular wall. Mechanistic and pharmacological aspects. Archives of medical research. 2006;37(4):436- 48.Hamilton RT, Walsh ME, Van Remmen H. Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging. J Clin Exp Pathol. 2012;Suppl 4:S4:005.Tamari Y, Nawata H, Inoue E, Yoshimura A, Yoshii H, Kashino G, et al. Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Free radical research. 2013;47(1):1-7.Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, et al. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nature neuroscience. 1999;2(2):157-61.Didion SP, Kinzenbaw DA, Fegan PE, Didion LA, Faraci FM. Overexpression of CuZn-SOD Prevents Lipopolysaccharide-Induced Endothelial Dysfunction. Stroke; a journal of cerebral circulation. 2004;35(8):1963-7.Niki E. Biomarkers of lipid peroxidation in clinical material. Biochimica et Biophysica Acta (BBA) - General Subjects. 2014;1840(2):809-17.Katz R. Biomarkers and Surrogate Markers: An FDA Perspective. NeuroRX. 2004;1(2):189-95.Medicine Io. Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Micheel CM, Ball JR, editors. Washington, DC: The National Academies Press; 2010. 334 p.Rogowska-Wrzesinska A, Wojdyla K, Nedic O, Baron CP, Griffiths HR. Analysis of protein carbonylation--pitfalls and promise in commonly used methods. Free radical research. 2014;48(10):1145-62.Díaz-Acosta A, Membrillo-Hernández, J. Consecuencias fisiológicas de la oxidación de proteínas por carbonilación en diversos sistemas biológicos. Revista Especializada en Ciencias Químico-Biológicas. 2006;9(1):34-44.Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radicalmediated protein oxidation. The Biochemical journal. 1997;324 ( Pt 1):1-18.Fedorova M, Bollineni RC, Hoffmann R. Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies. Mass Spectrometry Reviews. 2014;33(2):79-97Semchyshyn HM. Reactive carbonyl species in vivo: generation and dual biological effects. TheScientificWorldJournal. 2014;2014:417842.Pamplona R. Advanced lipoxidation end-products. Chemico-biological interactions. 2011;192(1):14-20.Rabbani N, Thornalley PJ. Glycation research in amino acids: a place to call home. Amino acids. 2012;42(4):1087-96.Miller A-F. Superoxide dismutases: active sites that save, but a protein that kills. Current Opinion in Chemical Biology. 2004;8(2):162-8.Abreu IA, Cabelli DE. Superoxide dismutases—a review of the metal-associated mechanistic variations. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2010;1804(2):263-74.Miao L, St. Clair DK. Regulation of superoxide dismutase genes: Implications in disease. Free Radical Biology and Medicine. 2009;47(4):344-56.Miyamoto S, Ronsein GE, Prado FM, Uemi M, Corrêa TC, Toma IN, et al. Biological hydroperoxides and singlet molecular oxygen generation. IUBMB Life. 2007;59(4‐5):322-31.Castro-Orozco R, Pinzon-Redondo, H.S., Alvis-Guzman, N. A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis. Colombia Medica. 2015;46(3):135-43.Rasool M, Malik A, Khan KM, Qureshi MS, Shabbir B, Zahid S, et al. Assessment of biochemical and antioxidative status in patients suffering from dengue fever. Journal of Huazhong University of Science and Technology Medical sciences = Hua zhong ke ji da xue xue bao Yi xue Ying De wen ban = Huazhong keji daxue xuebao Yixue Yingdewen ban. 2015;35(3):411-8.Chandrasena LG, Peiris H, Kamani J, Wanigasuriya P, Jayaratne SD, Wijayasiri WA, et al. Antioxidants in patients with dengue viral infection. The Southeast Asian journal of tropical medicine and public health. 2014;45(5):1015-22Soundravally R, Hoti SL, Patil SA, Cleetus CC, Zachariah B, Kadhiravan T, et al. Association between proinflammatory cytokines and lipid peroxidation in patients with severe dengue disease around defervescence. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2014;18:68-72Matsuura C, Moraes TL, Barbosa JB, Moss MB, Siqueira MA, Mann GE, et al. Nitric oxide activity in platelets of dengue haemorrhagic fever patients: the apparent paradoxical role of ADMA and l-NMMA. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2012;106(3):174-9.Gil L, León OS, Pérez J, Milián LC, González I, Guevara M. Characterization of oxidative stress in different clinical conditions, using redox indexes of diagnostic value. Biotecnología Aplicada. 2012;29(3):175-83.Levy A, Valero N, Espina LM, Anez G, Arias J, Mosquera J. Increment of interleukin 6, tumour necrosis factor alpha, nitric oxide, C-reactive protein and apoptosis in dengue. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2010;104(1):16-23Seet RC, Lee CY, Lim EC, Quek AM, Yeo LL, Huang SH, et al. Oxidative damage in dengue fever. Free radical biology & medicine. 2009;47(4):375-80.Lee CY, Seet RC, Huang SH, Long LH, Halliwell B. Different patterns of oxidized lipid products in plasma and urine of dengue fever, stroke, and Parkinson's disease patients: cautions in the use of biomarkers of oxidative stress. Antioxidants & redox signaling. 2009;11(3):407-20.Rajendiran S, Lakshamanappa HS, Zachariah B, Nambiar S. Desialylation of plasma proteins in severe dengue infection: possible role of oxidative stress. The American journal of tropical medicine and hygiene. 2008;79(3):372-7.Soundravally R, Sankar P, Bobby Z, Hoti SL. Oxidative stress in severe dengue viral infection: association of thrombocytopenia with lipid peroxidation. Platelets. 2008;19(6):447- 54.Mendes-Ribeiro AC, Moss MB, Siqueira MA, Moraes TL, Ellory JC, Mann GE, et al. Dengue fever activates the L-arginine-nitric oxide pathway: an explanation for reduced aggregation of human platelets. Clinical and experimental pharmacology & physiology. 2008;35(10):1143-6.Rojas E, Díaz-Quijano FA, Coronel-Ruiz C, Martínez-Vega RA, Rueda E, VillarCenteno LA. Correlación entre los niveles de glutatión peroxidasa y presentación clínica del dengue. Revista Médica de Chile. 2007;135(6):743-50.Chareonsirisuthigul T, Kalayanarooj S, Ubol S. Dengue virus (DENV) antibodydependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells. The Journal of general virology. 2007;88(Pt 2):365-75.Trairatvorakul P, Chongsrisawat V, Ngamvasinont D, Asawarachun D, Nantasook J, Poovorawan Y. Serum nitric oxide in children with dengue infection. Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand. 2005;23(2-3):115-9Klassen P, Biesalski HK, Mazariegos M, Solomons NW, Furst P. Classic dengue fever affects levels of circulating antioxidants. Nutrition. 2004;20(6):542-7.Valero N, Espina LM, Anez G, Torres E, Mosquera JA. Short report: increased level of serum nitric oxide in patients with dengue. The American journal of tropical medicine and hygiene. 2002;66(6):762-4.Ray G, Kumar V, Kapoor AK, Dutta AK, Batra S. Status of antioxidants and other biochemical abnormalities in children with dengue fever. Journal of tropical pediatrics. 1999;45(1):4-7.Janero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radical Biology and Medicine. 1990;9(6):515-40.Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? British journal of pharmacology. 2004;142(2):231-55.Girotti AW. Lipid hydroperoxide generation, turnover, and effector action in biological systems. Journal of lipid research. 1998;39(8):1529-42.Levine RL, Wehr N, Williams JA, Stadtman ER, Shacter E. Determination of carbonyl groups in oxidized proteins. Methods in molecular biology. 2000;99:15-24.Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clinica Chimica Acta. 2003;329(1):23-38Mesquita CS, Oliveira R, Bento F, Geraldo D, Rodrigues JV, Marcos JC. Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins. Analytical biochemistry. 2014;458:69-71.Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Analytical biochemistry. 1989;179:8-18Zhang Y, Zhao W, Zhang HJ, Domann FE, Oberley LW. Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. Cancer research. 2002;62(4):1205-12.Lipid Oxidation: Measurement Methods. Bailey's Industrial Oil and Fat Products.Ibusuki D, Nakagawa K, Asai A, Oikawa S, Masuda Y, Suzuki T, et al. Preparation of pure lipid hydroperoxides. Journal of lipid research. 2008;49(12):2668-77Molyneux D. Neglected tropical diseases. Community eye health / International Centre for Eye Health. 2013;26(82):21-4.Morens DM, Folkers GK, Fauci AS. Dengue: the continual re-emergence of a centuries-old disease. EcoHealth. 2013;10(1):104-6.Tapia-Conyer R, Mendez-Galvan JF, Gallardo-Rincon H. The growing burden of dengue in Latin America. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2009;46 Suppl 2:S3-6.Zapata JC, Cox D, Salvato MS. The Role of Platelets in the Pathogenesis of Viral Hemorrhagic Fevers. PLoS neglected tropical diseases. 2014;8(6):e2858.Diaz-Quijano FA, Waldman EA. Factors associated with dengue mortality in Latin America and the Caribbean, 1995-2009: an ecological study. The American journal of tropical medicine and hygiene. 2012;86(2):328-34.San Martin JL, Brathwaite O, Zambrano B, Solorzano JO, Bouckenooghe A, Dayan GH, et al. The epidemiology of dengue in the americas over the last three decades: a worrisome reality. The American journal of tropical medicine and hygiene. 2010;82(1):128- 35.Murray NE, Quam MB, Wilder-Smith A. Epidemiology of dengue: past, present and future prospects. Clinical epidemiology. 2013;5:299-309.Hay SEa. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1260-344.Luz PM, Grinsztejn B, Galvani AP. Disability adjusted life years lost to dengue in Brazil. Tropical Medicine & International Health. 2009;14(2):237-46.Meltzer MR-P, JG; CLARK, GG; REITER, P; GUBLER, DJ. Using disability-adjusted life years to assess the economic impact of dengue in Puerto Rico: 1984–1994. American Journal of Tropical Medicine and Hygiene. 1998;59(2):265-71Shepard DS, Suaya JA, Halstead SB, Nathan MB, Gubler DJ, Mahoney RT, et al. Cost-effectiveness of a pediatric dengue vaccine. Vaccine. 2004;22(9):1275-80.Clark DM, MP; Nisalak, A; Puthimethee, V; Endy TP. Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. American Journal of Tropical Medicine and Hygiene. 2005;72(6):786-91.Undurraga EA, Betancourt-Cravioto M, Ramos-Castaneda J, Martinez-Vega R, Mendez-Galvan J, Gubler DJ, et al. Economic and disease burden of dengue in Mexico. PLoS neglected tropical diseases. 2015;9(3):e0003547.Shepard DS, Undurraga EA, Halasa YA. Economic and disease burden of dengue in Southeast Asia. PLoS neglected tropical diseases. 2013;7(2):e2055.Luh DL, Liu CC, Luo YR, Chen SC. Economic cost and burden of dengue during epidemics and non-epidemic years in Taiwan. Journal of infection and public health. 2018;11(2):215-23.Stanaway JD, Shepard DS, Undurraga EA, Halasa YA, Coffeng LE, Brady OJ, et al. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. The Lancet infectious diseases.16(6):712-23.Sarti E, L’Azou M, Mercado M, Kuri P, Siqueira JB, Solis E, et al. A comparative study on active and passive epidemiological surveillance for dengue in five countries of Latin America. International Journal of Infectious Diseases. 2016;44:44-9.Organization PAH. Number of reported cases of dengue and severe dengue (SD) in the Americas. World Health Organization, 2015.Organization PAH. Number of reported cases of dengue and severe dengue (SD) in the Americas. World Health Organization, 2016.Organization PAH. Number of reported cases of dengue and severe dengue (SD) in the Americas. World Health Organization, 2017.Castro-Orozco R, Alvis-Guzmán N, Gómez-Arias R. Diferencias y similitudes entre las estrategias de gestión integrada para la prevención y control del dengue en Colombia y Perú. 2015. 2015:7Sharp TM, Tomashek KM, Read JS, Margolis HS, Waterman SH. A New Look at an Old Disease: Recent Insights into the Global Epidemiology of Dengue. Current Epidemiology Reports. 2017;4(1):11-21.Leo YS, Gan VC, Ng EL, Hao Y, Ng LC, Pok KY, et al. Utility of warning signs in guiding admission and predicting severe disease in adult dengue. BMC infectious diseases. 2013;13:498.Thein TL, Gan VC, Lye DC, Yung CF, Leo YS. Utilities and limitations of the World Health Organization 2009 warning signs for adult dengue severity. PLoS neglected tropical diseases. 2013;7(1):e2023.Tsai CY, Lee IK, Lee CH, Yang KD, Liu JW. Comparisons of dengue illness classified based on the 1997 and 2009 World Health Organization dengue classification schemes. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2013;46(4):271-81.Srikiatkhachorn AR, A.L.; Gibbons, R.V.; Sittisombut, N.; Malasit, P.; Ennis, F.A.; Nimmannitya, S.; Kalayanarooj, S. Dengue--how best to classify it. Clinical Infectious Diseases. 2011;53(6):563-7.Setiati TE, Mairuhu AT, Koraka P, Supriatna M, Mac Gillavry MR, Brandjes DP, et al. Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system. BMC infectious diseases. 2007;7:22Bandyopadhyay SL, L.C.S.; Kroeger, A. Classiffying dengue: a review of the difficulties in using the WHO case classificaction for dengue haemorrhagic fever. Tropical Medicine and International Health. 2006;11(8):1238-55.Phuong CN, NT.; Kneen, R. Clinical diagnosis and assessment of severity of confirmed dengue infections in vietnamese children: is the World Health Organization classiffication system helpful? American Journal of Tropical Medicine and Hygiene. 2004;70(2):172-9.Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, et al. Early clinical and laboratory indicators of acute dengue illness. The Journal of infectious diseases. 1997;176(2):313-21.Halstead SB. Dengue: the syndromic basis to pathogenesis research. Inutility of the 2009 WHO case definition. The American journal of tropical medicine and hygiene. 2013;88(2):212-5.van de Weg CA, van Gorp EC, Supriatna M, Soemantri A, Osterhaus AD, Martina BE. Evaluation of the 2009 WHO dengue case classification in an Indonesian pediatric cohort. The American journal of tropical medicine and hygiene. 2012;86(1):166-70.Hadinegoro SR. The revised WHO dengue case classification: does the system need to be modified? Paediatr Int Child Health. 2012;32 Suppl 1(S1):33-8Alexander N, Balmaseda A, Coelho IC, Dimaano E, Hien TT, Hung NT, et al. Multicentre prospective study on dengue classification in four South-east Asian and three Latin American countries. Tropical medicine & international health : TM & IH. 2011;16(8):936-48.Dalrymple NA, Mackow ER. Roles for endothelial cells in dengue virus infection. Advances in virology. 2012;2012:840654.Srikiatkhachorn A. Plasma leakage in dengue haemorrhagic fever. Thromb Haemost. 2009;102(6):1042-9.Basu A, Chaturvedi UC. Vascular endothelium: the battlefield of dengue viruses. FEMS immunology and medical microbiology. 2008;53(3):287-99.Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC. Immunopathogenesis of dengue virus infection. Journal of biomedical science. 2001;8(5):377-88.Yacoub S, Wertheim H, Simmons CP, Screaton GR, Wills B. Microvascular and endothelial function for risk prediction in dengue: an observational study. The Lancet. 2015;385:S102.Silva BR, Pernomian L, Bendhack LM. Contribution of oxidative stress to endothelial dysfunction in hypertension. Frontiers in physiology. 2012;3:441.Gori T, Munzel T. Oxidative stress and endothelial dysfunction: therapeutic implications. Annals of medicine. 2011;43(4):259-72.Rodriguez-Manas L, El-Assar M, Vallejo S, Lopez-Doriga P, Solis J, Petidier R, et al. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging cell. 2009;8(3):226-38.Wadsworth RM. Oxidative stress and the endothelium. Experimental physiology. 2008;93(1):155-7.Pereira EC, Ferderbar S, Bertolami MC, Faludi AA, Monte O, Xavier HT, et al. Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus. Clinical biochemistry. 2008;41(18):1454-60.Zalba G, Fortuno A, San Jose G, Moreno MU, Beloqui O, Diez J. Oxidative stress, endothelial dysfunction and cerebrovascular disease. Cerebrovascular diseases. 2007;24 Suppl 1:24-9.Muller G, Goettsch C, Morawietz H. Oxidative stress and endothelial dysfunction. Hamostaseologie. 2007;27(1):5-12.Esper RJ, Nordaby RA, Vilarino JO, Paragano A, Cacharron JL, Machado RA. Endothelial dysfunction: a comprehensive appraisal. Cardiovascular diabetology. 2006;5:4.Parodi O, De Chiara B, Campolo J, Sedda V, Roubina E. [Endothelial dysfunction and oxidative stress in sepsis]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2006;23 Suppl 36:S69-73.Fayers KE, Cummings MH, Shaw KM, Laight DW. Nitrate tolerance and the links with endothelial dysfunction and oxidative stress. British journal of clinical pharmacology. 2003;56(6):620-8.Vallance P, Chan N. Endothelial function and nitric oxide: clinical relevance. Heart. 2001;85(3):342-50Bermudez V, Bermudez F, Acosta G, Acosta A, Anez J, Andara C, et al. Molecular mechanisms of endothelial dysfunction: from nitric oxide synthesis to ADMA inhibition. American journal of therapeutics. 2008;15(4):326-33.Badimón L, Martínez-González J. Disfunción endotelial. Revista Española de Cardiologia. 2006;6(Supl.A):21-30.Widlansky ME, Gokce N, Keaney JF, Jr., Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003;42(7):1149-60.Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circulation research. 2000;87(10):840-4.Levent G, Ali A, Ahmet A, Polat EC, Aytac C, Ayse E, et al. Oxidative stress and antioxidant defense in patients with chronic hepatitis C patients before and after pegylated interferon alfa-2b plus ribavirin therapy. Journal of translational medicine. 2006;4:25.Yang TC, Lai CC, Shiu SL, Chuang PH, Tzou BC, Lin YY, et al. Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells. Microbes and infection / Institut Pasteur. 2010;12(8-9):643-51.Kalugalage T, Rodrigo C, Vithanage T, Somaratne P, De Silva HJ, Handunnetti S, et al. Low serum total nitrite and nitrate levels in severe leptospirosis. BMC infectious diseases. 2013;13:206.Hosakote YM, Liu T, Castro SM, Garofalo RP, Casola A. Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes. American journal of respiratory cell and molecular biology. 2009;41(3):348-57.Fabbri C, de Cassia Mascarenhas-Netto R, Lalwani P, Melo GC, Magalhaes BM, Alexandre MA, et al. Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice. Malaria journal. 2013;12(1):315.Machado FS, Tanowitz HB, Ribeiro AL. Pathogenesis of chagas cardiomyopathy: role of inflammation and oxidative stress. Journal of the American Heart Association. 2013;2(5):e000539.Cunha GM, Silva VM, Bessa KD, Bitencourt MA, Macedo UB, Freire-Neto FP, et al. Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis. Acta parasitologica / Witold Stefanski Institute of Parasitology, Warszawa, Poland. 2012;57(2):160-6.Macdonald J, Galley HF, Webster NR. Oxidative stress and gene expression in sepsis. British journal of anaesthesia. 2003;90(2):221-32.Valyi-Nagy T, Dermody TS. Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histology and histopathology. 2005;20(3):957-67.Ubol S, Chareonsirisuthigul T, Kasisith J, Klungthong C. Clinical isolates of dengue virus with distinctive susceptibility to nitric oxide radical induce differential gene responses in THP-1 cells. Virology. 2008;376(2):290-6.Rabablert J, Wasi C, Kinney R, Kasisith J, Pitidhammabhorn D, Ubol S. Attenuating characteristics of DEN-2 PDK53 in flavivirus-naive peripheral blood mononuclear cells. Vaccine. 2007;25(19):3896-905.Moreno-Altamirano MM, Romano M, Legorreta-Herrera M, Sanchez-Garcia FJ, Colston MJ. Gene expression in human macrophages infected with dengue virus serotype2. Scandinavian journal of immunology. 2004;60(6):631-8.Cologna R, Rico-Hesse R. American genotype structures decrease dengue virus output from human monocytes and dendritic cells. Journal of virology. 2003;77(7):3929-38Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clinica chimica acta; international journal of clinical chemistry. 2003;329(1-2):23-38.Pawitan JA. Dengue virus infection: predictors for severe dengue. Acta medica Indonesiana. 2011;43(2):129-35.Martina BE, Koraka P, Osterhaus AD. Dengue virus pathogenesis: an integrated view. Clinical microbiology reviews. 2009;22(4):564-81.Atrasheuskaya A, Petzelbauer P, Fredeking TM, Ignatyev G. Anti-TNF antibody treatment reduces mortality in experimental dengue virus infection. FEMS immunology and medical microbiology. 2003;35(1):33-42.Wong GH, Goeddel DV. Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science. 1988;242(4880):941-4.Marikovsky M, Ziv V, Nevo N, Harris-Cerruti C, Mahler O. Cu/Zn Superoxide Dismutase Plays Important Role in Immune Response. The Journal of Immunology. 2003;170(6):2993-3001.van de Weg CAM, Pannuti CS, van den Ham H-J, de Araújo ESA, Boas LSV, Felix AC, et al. Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection. Journal of Clinical Virology.60(4):328-35.Katzelnick LC, Coloma J, Harris E. Dengue: knowledge gaps, unmet needs, and research priorities. The Lancet infectious diseases. 2017;17(3):e88-e100.Gil-Gonzalez D, Ruiz-Cantero MT, Alvarez-Dardet C. How political epidemiology research can address why the millennium development goals have not been achieved: developing a research agenda. Journal of epidemiology and community health. 2009;63(4):278-80.Moons KG, Royston P, Vergouwe Y, Grobbee DE, Altman DG. Prognosis and prognostic research: what, why, and how? Bmj. 2009;338:b375.Pang J, Thein TL, Leo YS, Lye DC. Early clinical and laboratory risk factors of intensive care unit requirement during 2004-2008 dengue epidemics in Singapore: a matched case-control study. BMC infectious diseases. 2014;14(1):649.Juneja D, Nasa P, Singh O, Javeri Y, Uniyal B, Dang R. Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with dengue. Journal of critical care. 2011;26(5):449-52.Kamath SR, Ranjit S. Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India. Indian journal of pediatrics. 2006;73(10):889-95.Vittinghoff E, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. American journal of epidemiology. 2007;165(6):710-8.Arguelles S, Gomez A, Machado A, Ayala A. A preliminary analysis of within-subject variation in human serum oxidative stress parameters as a function of time. Rejuvenation research. 2007;10(4):621-36.Perdomo Celis F, Perilla P, Salgado DM, Narváez CF. Detección y cuantificación de virus dengue 2 en lisado celular y plasma de niños por qPCR en tiempo real usando un estuche comercial y el equipo EcoTM System-Illumina. 2014. 2014;6(1):8.Bhoomiboonchoo P, Nisalak A, Chansatiporn N, Yoon I-K, Kalayanarooj S, Thipayamongkolgul M, et al. Sequential dengue virus infections detected in active and passive surveillance programs in Thailand, 1994–2010. BMC public health. 2015;15(1):250.Alera MT, Srikiatkhachorn A, Velasco JM, Tac-An IA, Lago CB, Clapham HE, et al. Incidence of Dengue Virus Infection in Adults and Children in a Prospective Longitudinal Cohort in the Philippines. PLoS neglected tropical diseases. 2016;10(2):e0004337.Méndez MR, Calisher CH, Kruger H, Sipan F, Sánchez S, Lazuick JS. A continuing focus of yellow fever in the Apurimac River Valley, Ayacucho, Peru, and the first isolation of yellow fever virus in that country. Bull Pan Am Hdh Organ 1984;18(2):172-9.CDC. Trioplex Real-time RT-PCR Assay For use under an Emergency Use Authorization only Instructions for Use. 2016.Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. Journal of clinical microbiology. 1992;30(3):545-51.Yap BW, Sim CH. Comparisons of various types of normality tests. Journal of Statistical Computation and Simulation. 2011;81(12):2141-55.Razali NY, BW. Power Comparisons of Shapiro-Wilk, Kolmogorov-Smirnov, Lilliefors and Anderson-Darling Tests. Journal of Statistical Modeling and Analytics. 2011;2(1):21-33.Gaskin CJ, Happell B. Power, effects, confidence, and significance: An investigation of statistical practices in nursing research. International Journal of Nursing Studies.51(5):795-806.Nuñez E, Steyerberg, E., Nuñez, J. Estrategias para la elaboración de modelos estadísticos de regresión. Revista Española de Cardiología. 2011;64(6):501-7.Swets J. Measuring the accuracy of diagnostic systems. Science. 1988;240(4857):1285-93.Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148(3):839-43.Sterne JA, Davey Smith G. Sifting the evidence-what's wrong with significance tests? Bmj. 2001;322(7280):226-31.Osborne JW. Prediction in Multiple Regression. Practical Assessment , Research & Evaluation. 2000;7(2):1-6.Carrasco LR, Leo YS, Cook AR, Lee VJ, Thein TL, Go CJ, et al. Predictive Tools for Severe Dengue Conforming to World Health Organization 2009 Criteria. PLoS neglected tropical diseases. 2014;8(7):e2972.Guzmán MG, Kouri G, Bravo J, Valdes L, Susana V, Halstead SB. Effect of age on outcome of secondary dengue 2 infections. International Journal of Infectious Diseases. 2002;6(2):118-24.Karunakaran A, Ilyas WM, Sheen SF, Jose NK, Nujum ZT. Risk factors of mortality among dengue patients admitted to a tertiary care setting in Kerala, India. Journal of infection and public health. 2014;7(2):114-20.Cavalcanti LP, Vilar D, Souza-Santos R, Teixeira MG. Change in Age Pattern of Persons with Dengue, Northeastern Brazil. Emerging infectious diseases. 2011;17(1):132- 4.Suárez-Ognio L, Arrasco, J, Casapía, M, Sihuincha, M, Ávila, J, Soto, G, Álvarez, C, Rodríguez, H. Factores asociados a dengue grave durante la epidemia de dengue en la ciudad de Iquitos, 2010 – 2011. Revista Peruana de Epidemiología 2011;15(1):17-23.Nunes PCG, Sampaio SAF, Costa NRd, Mendonça MCLd, Lima MdRQ, Araujo SEM, et al. Dengue severity associated with age and a new lineage of dengue virus‐type 2 during an outbreak in Rio De Janeiro, Brazil. Journal of medical virology. 2016;88(7):1130- 6.Burattini MN, Lopez LF, Coutinho FAB, Siqueira-Jr JB, Homsani S, Sarti E, et al. Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014. Clinics. 2016;71:455-63.de Souza LJB, L.; Carvalho, L.; Assed de Souza, L.; Barbosa, R; do Vale da Silveira, M.; Souto, J.T.D. Comparison of clinical and laboratory characteristics between children and adults with dengue. The Brazilian Journal of Infectious Diseases. 2013;17(1):27-31.Vicente CR, Cerutti Junior C, FrÖSchl G, Romano CM, Cabidelle ASA, Herbinger KH. Influence of demographics on clinical outcome of dengue: a cross-sectional study of 6703 confirmed cases in Vitória, Espírito Santo State, Brazil. Epidemiology and infection. 2016;145(1):46-53.Thomas L, Brouste Y, Najioullah F, Hochedez P, Hatchuel Y, Moravie V, et al. Predictors of severe manifestations in a cohort of adult dengue patients. Journal of Clinical Virology. 2010;48(2):96-9.Khan MIH, Anwar E, Agha A, Hassanien NSM, Ullah E, Syed IA, et al. Factors predicting severe dengue in patients with dengue Fever. Mediterr J Hematol Infect Dis. 2013;5(1):e2013014.Hsieh C-C, Cia C-T, Lee J-C, Sung J-M, Lee N-Y, Chen P-L, et al. A Cohort Study of Adult Patients with Severe Dengue in Taiwanese Intensive Care Units: The Elderly and APTT Prolongation Matter for Prognosis. PLoS neglected tropical diseases. 2017;11(1):e0005270.Huy NT, Van Giang T, Thuy DHD, Kikuchi M, Hien TT, Zamora J, et al. Factors Associated with Dengue Shock Syndrome: A Systematic Review and Meta-Analysis. PLoS neglected tropical diseases. 2013;7(9):e2412.Sun J, Lu L, Wu H, Yang J, Xu L, Sang S, et al. Epidemiological trends of dengue in mainland China, 2005–2015. International Journal of Infectious Diseases.57:86-91.Reyes-García SZ, Zambrano LI, Sierra M. Caracterización clínica y hematológica de pacientes pediátricos con Dengue en Honduras. Revista Médica de Risaralda. 2014;20:95- 100.Real JJR, S.G.; Gómez, M.D.; Roby, A.J.; Ordoñez, J.M. . Caracterización clínica del dengue con signos de alarma y grave, en hospitales de Guayaquil. . Revista científica INSPILIP. 2017;1(1):18.Talarico LB, Byrne AB, Amarilla S, Lovera D, Vázquez C, Chamorro G, et al. Characterization of type I interferon responses in dengue and severe dengue in children in Paraguay. Journal of Clinical Virology. 2017;97:10-7.Biswas HH, Gordon A, Nuñez A, Perez MA, Balmaseda A, Harris E. Lower LowDensity Lipoprotein Cholesterol Levels Are Associated with Severe Dengue Outcome. PLoS neglected tropical diseases. 2015;9(9):e0003904.G. NR. Interval estimation for the difference between independent proportions: comparison of eleven methods. Statistics in medicine. 1998;17(8):873-90.Ranganathan P, Pramesh C, Buyse M. Common pitfalls in statistical analysis: Clinical versus statistical significance. Perspectives in Clinical Research. 2015;6(2):116-7.Monterrey PG, C. Aplicación de las pruebas de hipótesis en la investigación en salud: ¿estamos en lo correcto? Universitas Medica. 2007;48(3):193-206Jayanthi HK, Tulasi SK. Correlation study between platelet count, leukocyte count, nonhemorrhagic complications, and duration of hospital stay in dengue fever with thrombocytopenia. Journal of Family Medicine and Primary Care. 2016;5(1):120-3.Thanachartwet V, Oer-areemitr N, Chamnanchanunt S, Sahassananda D, Jittmittraphap A, Suwannakudt P, et al. Identification of clinical factors associated with severe dengue among Thai adults: a prospective study. BMC infectious diseases. 2015;15(1):420.Fernandez E, Smieja M, Walter SD, Loeb M. A retrospective cohort study to predict severe dengue in Honduran patients. BMC infectious diseases. 2017;17(1):676.Londoño JO, J.M.; Casanova, M.E.; Muriel, A.J. Caracterización de pacientes con dengue y evaluación de biomarcadores de morbimortalidad en un centro de nivel III de Cali. Revista Colombiana Salud Libre. 2014;9(1):15-20.Lugo SM, L.; Bejarano, O.; Basualdo, W.; Pavlicich, V. Resumen. En dengue con signos de alarma ¿Podemos predecir evolución a grave desde la emergencia? Revista Chilena de Pediatría. 2015;86(4):305.Alvarado-Castro VM, Ramírez-Hernández E, Paredes-Solís S, Legorreta-Soberanis J, Saldaña-Herrera VG, Salas-Franco LS, et al. Clinical profile of dengue and predictive severity variables among children at a secondary care hospital of Chilpancingo, Guerrero, Mexico: case series. Boletín Médico Del Hospital Infantil de México (English Edition). 2016;73(4):237-42.Ledika MA, Setiabudi D, Dhamayanti M. Association between Clinical Profiles and Severe Dengue Infection in Children in Developing Country. American Journal of Epidemiology and Infectious Disease. 2015;3(3):45-9.Martínez Torres E. Dengue. Estudos Avançados. 2008;22:33-52Yacoub S, Trung TH, Lam PK, Thien VHN, Hai DHT, Phan TQ, et al. Cardiohaemodynamic assessment and venous lactate in severe dengue: Relationship with recurrent shock and respiratory distress. PLoS neglected tropical diseases. 2017;11(7):e0005740.Lum LCS, Thong MK, Cheah YK, Lam SK. Dengue-associated adult respiratory distress syndrome. Annals of tropical paediatrics. 1995;15(4):335-9.Yeh C-Y, Chen P-L, Chuang K-T, Shu Y-C, Chien Y-W, Perng GC, et al. Symptoms associated with adverse dengue fever prognoses at the time of reporting in the 2015 dengue outbreak in Taiwan. PLoS neglected tropical diseases. 2017;11(12):e0006091.Pothapregada S, Kamalakannan B, Thulasingham M, Sampath S. Clinically Profiling Pediatric Patients with Dengue. Journal of Global Infectious Diseases. 2016;8(3):115-20Noisakran S, Perng GC. Alternate hypothesis on the pathogenesis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in dengue virus infection. Experimental biology and medicine. 2008;233(4):401-8.Agudelo IYP, L.D.; Gonzalo, L.; Avendaño, E.; Bedoya, G.; Restrepo, B.N. Factores asociados a extravasación plasmática en pacientes con dengue de Antioquia y Chocó entre el 2000 y 2013. Colombia. CES Medicina. 2015;29:23-4Halstead SB. Controversies in dengue pathogenesis. Paediatrics and International Child Health. 2012;32(s1):5-9.Wang C-C, Lee I-K, Su M-C, Lin H-I, Huang Y-C, Liu S-F, et al. Differences in clinical and laboratory characteristics and disease severity between children and adults with dengue virus infection in Taiwan, 2002. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2009;103(9):871-7Sivathanu SM, K.; Sampath, S.; Nagaraj, P.; Sunder, S.K.; Pachaimuthu, R.A. To study the clinical profile of dengue fever and to evolve a prognostic marker based on hematological parameters for severe dengue. International Journal of Contemporary Pediatrics. 2017;4(2):538-42.Sridharan A, Chen Q, Tang KF, Ooi EE, Hibberd ML, Chen J. Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. Journal of virology. 2013;87(21):11648-58.Seneviratne SL, Malavige GN, de Silva HJ. Pathogenesis of liver involvement during dengue viral infections. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2006;100(7):608-14.Souza LJd, Nogueira RMR, Soares LC, Soares CEC, Ribas BF, Alves FP, et al. The impact of dengue on liver function as evaluated by aminotransferase levels. Brazilian Journal of Infectious Diseases. 2007;11:407-10.Lugo SP, V. Indicadores tempranos de dengue grave en pacientes hospitalizados. Pediatria. 2014;41(2).Soo K-M, Khalid B, Ching S-M, Chee H-Y. Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections. PloS one. 016;11(5):e0154760Khurram M, Qayyum W, Hassan SJu, Mumtaz S, Bushra HT, Umar M. Dengue hemorrhagic fever: Comparison of patients with primary and secondary infections. Journal of infection and public health.7(6):489-95.Santhosh NK, K.N.; Ramadas, D. Hepatic Proteins & Protein Oxidation - Role in Dengue Fever. International Journal of Biotechnology and Biochemistry. 2016;12(2):161-5Lushchak VI. Free radical oxidation of proteins and its relationship with functional state of organisms. Biochemistry (Moscow). 2007;72(8):809-27.Poyton RO, Ball KA, Castello PR. Mitochondrial generation of free radicals and hypoxic signaling. Trends in Endocrinology & Metabolism. 2009;20(7):332-40.Dirmeier R, O'Brien K, Engle M, Dodd A, Spears E, Poyton RO. Measurement of Oxidative Stress in Cells Exposed to Hypoxia and Other Changes in Oxygen Concentration. Methods in enzymology. 381: Academic Press; 2004. p. 589-603.Kim JJ, Lee SB, Park JK, Yoo YD. TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL. Cell Death And Differentiation. 2010;17:1420.Yen YT, Chen HC, Lin YD, Shieh CC, Wu-Hsieh BA. Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development. Journal of virology. 2008;82(24):12312- 24.Singh M, Kapoor A, Bhatnagar A. Oxidative and reductive metabolism of lipidperoxidation derived carbonyls. Chemico-biological interactions. 2015;234:261-73.Castro R, Pinzon HS, Alvis-Guzman N. A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis. Colomb Med (Cali). 2015;46(3):135-43.Castro R, Pinzon HS, Alvis-Guzman N. Oxidative-nitrosative stress and dengue disease: a systematic review of in vivo/in vitro studies. Revista cubana de medicina tropical. 2015;67(2):244-63.Cherupanakkal C, Ramachadrappa V, Kadhiravan T, Parameswaran N, Parija SC, Pillai AB, et al. A Study on Gene Expression Profile of Endogenous Antioxidant Enzymes: CAT, MnSOD and GPx in Dengue Patients. Indian Journal of Clinical Biochemistry. 2017;32(4):437-45Semrau F, Kühl RJ, Ritter S, Ritter K. Manganese superoxide dismutase (MnSOD) and autoantibodies against MnSOD in acute viral infections. Journal of medical virology. 1998;55(2):161-7Ritter K, Kühl RJ, Semrau F, Eiffert H, Kratzin HD, Thomssen R. Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection. The Journal of experimental medicine. 1994;180(5):1995-8.Dalpke AH, Thomssen R, Ritter K. Oxidative injury to endothelial cells due to Epstein‐ Barr virus‐induced autoantibodies against manganese superoxide dismutase. Journal of medical virology. 2003;71(3):408-16.Ho JCM, Zheng S, Comhair SAA, Erzurum SC, Farver C. Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer research. 2001;61(23):8578-85.Niki E. Lipid peroxidation: Physiological levels and dual biological effects. Free Radical Biology and Medicine. 2009;47(5):469-84.Soundravally R, Sherin J, Agieshkumar BP, Daiisy MS, Cleetus C, Narayanah P, et al. Serum levels of copper and iron in dengue fever. Revista do Instituto de Medicina Tropical de Sao Paulo. 2015;57:315-20.Wang Y, Oberley LW, Murhammer DW. Evidence of oxidative stress following the viral infection of two lepidopteran insect cell lines. Free Radical Biology and Medicine. 2001;31(11):1448-55.ALESSIO HM, HAGERMAN AE, FULKERSON BK, AMBROSE J, RICE RE, WILEY RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Medicine & Science in Sports & Exercise. 2000;32(9):1576-81.Dotan Y, Lichtenberg D, Pinchuk I. Lipid peroxidation cannot be used as a universal criterion of oxidative stress. Progress in lipid research. 2004;43(3):200-27.Burgueño MJ, García-Bastos JL, González-Buitrago JM. Las curvas ROC en la evaluación de las pruebas diagnósticas. Medicina clinica. 1995;104:661-70.Linnet K, Bossuyt PMM, Moons KGM, Reitsma JB. Quantifying the Accuracy of a Diagnostic Test or Marker. Clinical chemistry. 2012;58(9):1292-301.Metz CE. Receiver Operating Characteristic Analysis: A Tool for the Quantitative Evaluation of Observer Performance and Imaging Systems. Journal of the American College of Radiology.3(6):413-22.Bravo-Grau S, Cruz Q JP. Estudios de exactitud diagnóstica: Herramientas para su Interpretación. Revista chilena de radiología. 2015;21:158-64Terrin N, Schmid CH, Griffith JL, D'Agostino RB, Selker HP. External validity of predictive models: a comparison of logistic regression, classification trees, and neural networks. Journal of Clinical Epidemiology. 2003;56(8):721-9Steyerberg EW, Harrell FE, Borsboom GJJM, Eijkemans MJC, Vergouwe Y, Habbema JDF. Internal validation of predictive models: Efficiency of some procedures for logistic regression analysis. Journal of Clinical Epidemiology. 2001;54(8):774-81.Ranke MB, Lindberg A, Chatelain P, Wilton P, Cutfield W, Albertsson-Wikland K, et al. Derivation and Validation of a Mathematical Model for Predicting the Response to Exogenous Recombinant Human Growth Hormone (GH) in Prepubertal Children with Idiopathic GH Deficiency. The Journal of Clinical Endocrinology & Metabolism. 1999;84(4):1174-83.Lehmann ED, Hermanyi I, Deutsch T. Retrospective validation of a physiological model of glucose-insulin interaction in type 1 diabetes mellitus. Medical Engineering & Physics. 1994;16(3):193-202.Altmann A, Däumer M, Beerenwinkel N, Peres Y, Schülter E, Büch J, et al. Predicting the Response to Combination Antiretroviral Therapy: Retrospective Validation of geno2pheno-THEO on a Large Clinical Database. The Journal of infectious diseases. 2009;199(7):999-1006.de Vries Robbé M, de Vogel V, de Spa E. Protective Factors for Violence Risk in Forensic Psychiatric Patients: A Retrospective Validation Study of the SAPROF. International Journal of Forensic Mental Health. 2011;10(3):178-86.Goodacre S, Wilson R, Shephard N, Nicholl J. Derivation and validation of a risk adjustment model for predicting seven day mortality in emergency medical admissions: mixed prospective and retrospective cohort study. BMJ : British Medical Journal. 2012;344.Gómez M, Danglot, C., Huerta, S. G., García de la Torre, S. . El estudio de casos y controles. Su diseño, análisis e interpretación, en investigación clínica. Rev Mex Pediatr. 2003;70(5):257-63.Gómez M, Danglot, C., Huerta, S. G., García de la Torre, S. . El estudio de casos y controles. Su diseño, análisis e interpretación, en investigación clínica. Rev Mex Pediatr. 2003;70(5):257-63.PublicationORIGINALTesis Final Raimundo Castro Orozco.pdfTesis Final Raimundo Castro Orozco.pdfapplication/pdf1442024https://dspace7-unicartagena.metabuscador.org/bitstreams/353758c0-70f3-4181-b70e-eeaa8bb6cf44/download1fadc15ae0ca8d831be2f60eaffcf932MD51FORMATO CESION DE DERECHOS DE AUTOR.pdfFORMATO CESION DE DERECHOS DE AUTOR.pdfapplication/pdf169460https://dspace7-unicartagena.metabuscador.org/bitstreams/3a31815c-b5aa-4ecd-bdd7-c29a1a04ac14/downloadcdd666f8b38f960b99848ed2b9def794MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81756https://dspace7-unicartagena.metabuscador.org/bitstreams/01670888-03dd-4319-8b01-b9318830fb71/download7b38fcee9ba3bc8639fa56f350c81be3MD53TEXTTesis Final Raimundo Castro Orozco.pdf.txtTesis Final Raimundo Castro Orozco.pdf.txtExtracted texttext/plain244391https://dspace7-unicartagena.metabuscador.org/bitstreams/ae7d7775-99a3-4c58-a480-eb7c2b8745c8/download54e57ae75aad65c2c3bb18249b735102MD54FORMATO CESION DE DERECHOS DE AUTOR.pdf.txtFORMATO CESION DE DERECHOS DE AUTOR.pdf.txtExtracted texttext/plain2697https://dspace7-unicartagena.metabuscador.org/bitstreams/3fa81a0c-e329-41db-b30d-0358019a0639/download1e6ec8585db79adb3ec82be0fb985191MD56THUMBNAILTesis Final Raimundo Castro Orozco.pdf.jpgTesis Final Raimundo Castro Orozco.pdf.jpgGenerated Thumbnailimage/jpeg8610https://dspace7-unicartagena.metabuscador.org/bitstreams/7474f862-a72a-485d-9403-b29859211987/downloada7e75e0467b968fd94cd9e89fe2ebbc4MD55FORMATO CESION DE DERECHOS DE AUTOR.pdf.jpgFORMATO CESION DE DERECHOS DE AUTOR.pdf.jpgGenerated Thumbnailimage/jpeg15648https://dspace7-unicartagena.metabuscador.org/bitstreams/4f94ce68-533c-4400-9c4a-9547d36dd4fd/downloade883f58a8b73686421cd70e59348ba6eMD5711227/15527oai:dspace7-unicartagena.metabuscador.org:11227/155272024-08-28 17:04:51.244https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Cartagena, 2018open.accesshttps://dspace7-unicartagena.metabuscador.orgBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.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

Publicaciones similares