Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.

Autores:: Mendoza Carmona, Laura Marcela
Marrugo Ortiz, Ariel Camilo
Payares Florez, Sebastian David

Tipo de recurso:: Article of journal

Fecha de publicación:: 2021

Institución:: Universidad de Cartagena

Repositorio:: Repositorio Universidad de Cartagena

Idioma:: spa

id	UCART2_54762ee966b99f80cd1829ccebcc5964
oai_identifier_str	oai:repositorio.unicartagena.edu.co:11227/13452
network_acronym_str	UCART2
network_name_str	Repositorio Universidad de Cartagena
repository_id_str
dc.title.spa.fl_str_mv	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
dc.title.translated.eng.fl_str_mv	Macroscopic and microscopic findings in the respiratory system in patients with covid-19.
title	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
spellingShingle	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19. SARS-COV-2 COVID-19 Respiratory epithelium Histopathology Lung Diffuse alveolar damage Acute respiratory distress syndrome SARS-COV-2 COVID-19 Epitelio respiratorio Histopatologia Pulmon Daño alveolar difuso Sindrome de dificultad respiratoria aguda
title_short	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
title_full	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
title_fullStr	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
title_full_unstemmed	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
title_sort	Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.
dc.creator.fl_str_mv	Mendoza Carmona, Laura Marcela Marrugo Ortiz, Ariel Camilo Payares Florez, Sebastian David
dc.contributor.author.spa.fl_str_mv	Mendoza Carmona, Laura Marcela Marrugo Ortiz, Ariel Camilo Payares Florez, Sebastian David
dc.subject.eng.fl_str_mv	SARS-COV-2 COVID-19 Respiratory epithelium Histopathology Lung Diffuse alveolar damage Acute respiratory distress syndrome
topic	SARS-COV-2 COVID-19 Respiratory epithelium Histopathology Lung Diffuse alveolar damage Acute respiratory distress syndrome SARS-COV-2 COVID-19 Epitelio respiratorio Histopatologia Pulmon Daño alveolar difuso Sindrome de dificultad respiratoria aguda
dc.subject.spa.fl_str_mv	SARS-COV-2 COVID-19 Epitelio respiratorio Histopatologia Pulmon Daño alveolar difuso Sindrome de dificultad respiratoria aguda
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-07-15 00:00:00
dc.date.available.none.fl_str_mv	2021-07-15 00:00:00
dc.date.issued.none.fl_str_mv	2021-07-15
dc.type.spa.fl_str_mv	Artículo de revista
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_dcae04bc http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.coarversion.spa.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.content.spa.fl_str_mv	Text
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/article
dc.type.local.eng.fl_str_mv	Journal article
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/ARTREV
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.issn.none.fl_str_mv	2215-7840
dc.identifier.doi.none.fl_str_mv	10.32997/rcb-2021-3334
dc.identifier.eissn.none.fl_str_mv	2389-7252
dc.identifier.url.none.fl_str_mv	https://doi.org/10.32997/rcb-2021-3334
identifier_str_mv	2215-7840 10.32997/rcb-2021-3334 2389-7252
url	https://doi.org/10.32997/rcb-2021-3334
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.ispartofjournal.spa.fl_str_mv	Revista Ciencias Biomédicas
dc.relation.bitstream.none.fl_str_mv	https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3334/2946
dc.relation.citationedition.spa.fl_str_mv	Núm. 3 , Año 2021
dc.relation.citationendpage.none.fl_str_mv	188
dc.relation.citationissue.spa.fl_str_mv	3
dc.relation.citationstartpage.none.fl_str_mv	172
dc.relation.citationvolume.spa.fl_str_mv	10
dc.relation.references.spa.fl_str_mv	Ye ZW, Yuan S, Yuen KS, Fung SY, Chan CP, Jin DY. Zoonotic origins of human coronaviruses. Int J Biol Sci. 2020; 16(10): 1686-97. https://doi.org/10.7150/ijbs.45472 Chan JFW, Kok KH, Zhu Z, Chu H, To KKW, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020; 9(1): 221-36. https://doi.org/10.1080/22221751.2020.1719902 Polak SB, Van Gool IC, Cohen D, von der Thüsen JH, van Paassen J. A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression. Mod Pathol [Internet]. 2020; 33(11): 2128-38. Disponible en: https://doi.org/10.1038/s41379-020-0603-3 Menter T, Haslbauer JD, Nienhold R, Savic S, Hopfer H, Deigendesch N, et al. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020; 77(2): 198-209. https://doi.org/10.1111/his.14134 Shi Y, Wang G, Cai X peng, Deng J wen, Zheng L, Zhu H hong, et al. An overview of COVID-19. J Zhejiang Univ Sci B. 2020; 21(5): 343-60. https://doi.org/10.1631/jzus.B2000083 Calabrese F, Pezzuto F, Fortarezza F, Hofman P, Kern I, Panizo A, et al. Pulmonary pathology and COVID- 19: lessons from autopsy. The experience of European Pulmonary Pathologists. Virchows Arch. 2020; 477(3): 359-72. https://doi.org/10.1007/s00428-020-02886-6 Woo PCY, Lau SKP, Chu C, Chan K, Tsoi H, Huang Y, et al. Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1 , from Patients with Pneumonia. 2005; 79(2): 884-95. https://doi.org/10.1128/JVI.79.2.884-895.2005 Martines RB, Ritter JM, Matkovic E, Gary J, Bollweg BC, Bullock H, et al. Pathology and pathogenesis of SARS-CoV-2 associated with fatal coronavirus disease, united states. Emerg Infect Dis. 2020; 26(9): 2005-15. https://doi.org/10.3201/eid2609.202095 Lax SF, Skok K, Zechner P, Kessler HH, Kaufmann N, Koelblinger C, et al. Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome : Results From a Prospective, Single-Center, Clinicopathologic Case Series. Ann Intern Med. 2020; 173(5): 350-61. https://doi.org/10.7326/M20-2566 Cipolloni L, Sessa F, Bertozzi G, Baldari B, Cantatore S, Testi R, et al. Preliminary post-mortem COVID-19 evidence of endothelial injury and factor VIII hyperexpression. Diagnostics. 2020; 10(8): 1-16. https://doi.org/10.3390/diagnostics10080575 Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R, et al. Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience. 2020. https://doi.org/10.1101/2020.05.18.20099960 Fox SE, Akmatbekov A, Harbert JL, Li G, Brown JQ. not peer reviewed Pulmonary and Cardiac Pathology in Covid-19: The First Autopsy Series from New Orleans 1) Department of Pathology, LSU Health Sciences Center, New Orleans 2) Pathology and Laboratory Medicine Service, Southeast Louisiana V eterans. medRxiv [Internet]. 2020; 2020.04.06.20050575. Disponible en: https://doi.org/10.1101/2020.04.06.20050575 Grosse C, Grosse A, Salzer HJF, Dünser MW, Motz R, Langer R. Analysis of cardiopulmonary findings in COVID-19 fatalities: High incidence of pulmonary artery thrombi and acute suppurative bronchopneumonia. Cardiovasc Pathol. 2020; 49 (January). https://doi.org/10.1016/j.carpath.2020.107263 Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID- 19: A Prospective Cohort Study. Ann Intern Med. 2020; 173(4): 268-77. https://doi.org/10.7326/M20-2003 Nasr A, Rossi RS, Pellegrinelli A, Zerbi P, Rech R. Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy Since December 2019, an outbreak caused by a new coronavirus infection (severe acute respiratory syndrome coronavirus 2 , SARS-CoV-2) disease was reported, starting. 2020; 1-11. Bradley BT, Maioli H, Johnston R, Chaudhry I, Fink SL, Xu H, et al. Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections. medRxiv. 2020. https://doi.org/10.1101/2020.04.17.20058545 Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020; 383(2): 120-8. https://doi.org/10.1056/NEJMoa2015432 Edler C, Schröder AS, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, et al. Erratum: Correction to: Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany (International journal of legal medicine (2020) 134 4 (1275-1284). Int J Legal Med. 2020; 134(5): 1977. https://doi.org/10.1007/s00414-020-02336-7 Nicholson AG, Osborn M, Devaraj A, Wells AU. COVID-19 related lung pathology: old patterns in new clothing? Histopathology. 2020; 77(2): 169-72. https://doi.org/10.1111/his.14162 Copin MC, Parmentier E, Duburcq T, Poissy J, Mathieu D, Caplan M, etal. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med [Internet]. 2020; 46(6): 1124-6. Disponible en: https://doi.org/10.1007/s00134-020-06057-8 Barton LM, Duval EJ, Stroberg E, Ghosh S, Mukhopadhyay S. COVID-19 Autopsies, Oklahoma, USA. Am J Clin Pathol. 2020; 153(6): 725-33. https://doi.org/10.1093/ajcp/aqaa062 Borczuk AC, Salvatore SP , Seshan S V ., Patel SS, Bussel JB, Mostyka M, et al. COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City. Mod Pathol [Internet]. 2020; 33(11): 2156-68. Disponible en: https://doi.org/10.1038/s41379-020-00661-1 Adachi T, Chong JM, Nakajima N, Sano M, Yamazaki J, Miyamoto I, et al. Clinicopathologic and immunohistochemical findings from autopsy of patient with COVID-19, Japan. Emerg Infect Dis. 2020; 26(9): 2157-61. https://doi.org/10.3201/eid2609.201353 Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, et al. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect , the company' s public news and information. 2020; (January). Suess C, Hausmann R. Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation. Int J Legal Med. 2020; 134(4): 1285-90. https://doi.org/10.1007/s00414-020-02319-8 Falasca L, Nardacci R, Colombo D, Lalle E, Di Caro A, Nicastri E, et al. Postmortem Findings in Italian Patients With COVID-19: A Descriptive Full Autopsy Study of Cases With and Without Comorbidities. J Infect Dis. 2020; 222(11): 1807-15. https://doi.org/10.1093/infdis/jiaa578 Del Nonno F, Colombo D, Nardacci R, Falasca L. Fatal pulmonary arterial thrombosis in a COVID-19 patient, with asymptomatic history, occurred after swab negativization. Thromb J. 2021; 19(1): 1. https://doi.org/10.1186/s12959-020-00255-6 Stoyanov GS, Petkova L, Dzhenkov DL, Sapundzhiev NR, Todorov I. Gross and Histopathology of COVID-19 With First Histology Report of Olfactory Bulb Changes. Cureus. 2020; 12(12). https://doi.org/10.7759/cureus.11912 Bösmüller H, Traxler S, Bitzer M, Häberle H, Raiser W, Nann D, etal. The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation. Virchows Arch. 2020; 477(3): 349-57. https://doi.org/10.1007/s00428-020-02881-x Scendoni. Histopath 2 oncology COVIDs. Diagn Pathol. 2020; 1-4. Bian X. Autopsy of COVID-19 patients in China. 2020. Aguiar D, Lobrinus JA, Schibler M, Fracasso T, Lardi C. Inside the lungs of COVID-19 disease. Int J Legal Med. 2020; 134(4): 1271-4. https://doi.org/10.1007/s00414-020-02318-9 Konopka KE, Wilson A, Myers JL. Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019. Chest. 2020; 158(3): e99-101. https://doi.org/10.1016/j.chest.2020.04.032 Chmielik E, Jazowiecka-Rakus J, Dyduch G, Nasierowska-Guttmejer A, Michalowski L, Sochanik A, et al. COVID-19 Autopsies: A Case Series from Poland. Pathobiology. 2020. https://doi.org/10.1159/000512768 Ducloyer M, Gaborit B, Toquet C, Castain L, Bal A, Arrigoni PP, et al. Complete post-mortem data in a fatal case of COVID-19: clinical, radiological and pathological correlations. Int J Legal Med. 2020; 134(6): 2209-14. https://doi.org/10.1007/s00414-020-02390-1 Remmelink M, De Mendonça R, D'Haene N, De Clercq S, Verocq C, Lebrun L, et al. Unspecific post- mortem findings despite multiorgan viral spread in COVID-19 patients. Crit Care. 2020; 24(1): 1-10. https://doi.org/10.1186/s13054-020-03218-5 Buja LM, Wolf D, Zhao B, Akkanti B, McDonald M, Lelenwa L, etal. The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities. Cardiovasc Pathol [Internet]. 2020; 48: 107233. Disponible en: https://doi.org/10.1016/j.carpath.2020.107233 Sauter JL, Baine MK, Butnor KJ, Buonocore DJ, Chang JC, Jungbluth AA, etal. Insights into pathogenesis of fatal COVID-19 pneumonia from histopathology with immunohistochemical and viral RNA studies. Histopathology. 2020; 77(6): 915-25. https://doi.org/10.1111/his.14201 Calvin M, Cletus T, Madala N. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information. 2020; (January). Okudela K, Hayashi H, Yoshimura Y, Sasaki H, Horiuchi H, Miyata N, et al. A Japanese case of COVID-19: An autopsy report. Pathol Int. 2020; 70(10): 820-4. https://doi.org/10.1111/pin.13002 ZengZ, XuL, XieXY, YanHL, XieBJ, XuWZ, et al. Pulmonary pathology of early-phase COVID-19 pneumonia in a patient with a benign lung lesion. Histopathology. 2020; 77(5): 823-31. https://doi.org/10.1111/his.14138 Flikweert AW, Grootenboers MJJH, Yick DCY, du Mée AWF, van der Meer NJM, Rettig TCD, et al. Late histopathologic characteristics of critically ill COVID- 19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series. J Crit Care [Internet]. 2020; 59: 149-55. Disponible en: https://doi.org/10.1016/j.jcrc.2020.07.002 Rubin JE, Crowe SE. Annals of internal medicine®. Ann Intern Med. 2020; 172(1): ITC1-14. https://doi.org/10.7326/AITC202001070 Beigmohammadi MT, Jahanbin B, Safaei M, Amoozadeh L, Khoshavi M, Mehrtash V , et al. Pathological Findings of Postmortem Biopsies From Lung, Heart, and Liver of 7 Deceased COVID-19 Patients. Int J Surg Pathol. 2020; 1-11. https://doi.org/10.1177/1066896920935195 YaoX, LiT, HeZ, PingY, LiuH, YuS, et al. Histopathological Study of New Coronavirus Pneumonia (COVID-19) in Three Patients. Chinese J Pathol. 2020; 49 DOI: https://doi.org/10.3760/cma.j.cn112151-20200312-00193 Recalde-Zamacona B, García-Tobar L, Argueta A, Álvarez L, De Andrea CE, Fernández Alonso M, et al. Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: Preliminary experience from a series of 10 Spanish patients. Thorax. 2020; 75(12): 1116-8. https://doi.org/10.1136/thoraxjnl-2020-215577 Xu Z, Shi L, Wang Y et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome [published correction appears in Lancet Respir Med. 2020 Feb 25;:]. Lancet Respir Med. 2020. 8(4): 420-422. doi: 10.1016/S2213-2600(20)30076-X Lancet Respir Med [Internet]. 2020;8(feb 25):420-2. Disponible en: https://doi.org/10.1016/S2213-2600(20)30076-X Ding M, Zhang Q, Li Q, Wu T, Huang Y. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information. 2020; (January). Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD. Acute fibrinous and organizing pneumonia: A histologic pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 2002; 126(9): 1064-70. https://doi.org/10.5858/2002-126-1064-AFAOP Valdivia-Mazeyra MF, Salas C, Nieves-Alonso JM, Martín-Fragueiro L, Bárcena C, Muñoz-Hernández P , et al. Increased number of pulmonary megakaryocytes in COVID-19 patients with diffuse alveolar damage: an autopsy study with clinical correlation and review of the literature. Virchows Arch. 2020. https://doi.org/10.21203/rs.3.rs-49093/v1 Schaefer IM, Padera RF, Solomon IH, Kanjilal S, Hammer MM, Hornick JL, et al. In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19. Mod Pathol [Internet]. 2020; 33(11): 2104-14. Disponible en: https://doi.org/10.1038/s41379-020-0595-z Barisione E, Grillo F, Ball L, Bianchi R, Grosso M, Morbini P, et al. Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems. Virchows Arch. 2020. https://doi.org/10.1007/s00428-020-02934-1 Pernazza A, Mancini M, Rullo E, Bassi M, De Giacomo T, Rocca C Della, et al. Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen. Virchows Arch. 2020; 477(5): 743-8. https://doi.org/10.1007/s00428-020-02829-1 Elsoukkary SS, Mostyka M, Dillard A, Berman DR, Ma LX, Chadburn A, et al. Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience. Pathobiology. 2020. https://doi.org/10.1159/000511325 Sociedade Chinesa de Medicina de Reabilitação, Comitê de Reabilitação Respiratória da Associação Chinesa de Medicina de Reabilitação G de RC do R de MFeRdaAMC,QianxueM,HaoD,YinZ,HongZ, Hospital T. Nova Orientação para Reabilitação Respiratória de Coronavírus Pneumonia (Segunda Edição). 2020; 44: 1-8. Mac Dowall MP, Barrionuevo-Poquet A, Carnero- Fuentes O, Pareja-Begazo G, Coayla-Cano C, Gallo- Lopez A, et al. Clinical-pathological characterization, viral genotipification and genetic heterogeneity as risk determinants in COVID-19: Study design and initial findings. Rev la Fac Med Humana. 2020; 20(3): 433- 43. https://doi.org/10.25176/RFMH.v20i3.3040 Wang XX, Shao C, Huang XJ, Sun L, Meng LJ, Liu H, et al. Histopathological features of multiorgan percutaneous tissue core biopsy in patients with COVID-19. J Clin Pathol. 2020; 1-6. https://doi.org/10.1136/jclinpath-2020-206623 Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, etal. 3D Virtual Pathohistology of Lung Tissue From Covid-19 Patients Based on Phase Contrast X-Ray Tomography. Elife. 2020; 9: 1-25. https://doi.org/10.7554/eLife.60408 Kommoss FKF, Schwab C, Tavernar L, Schreck J, Wagner WL, Merle U, et al. Pathologie der schweren COVID-19-bedingten Lungenschädigung. Dtsch Arztebl Int. 2020; 117 (29-30): 500-6. Ochoa Salmorán H, Martínez Martínez I, Díaz Greene EJ. Ventilación mecánica en pacientes con COVID-19 de acuerdo a los fenotipos de Gattinoni. Acta Médica Grup Ángeles. 2020; 18(3): 336-40. https://doi.org/10.35366/95421 LengL,CaoR,MaJ,MouD,ZhuY,LiW,etal. Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther [Internet]. 2020; 5(1): 1-9. Disponible en: https://doi.org/10.1038/s41392-020-00355-9 COAGULOPATÍA EN PACIENTES CON COVID- 19 [Internet]. [citado 27 de enero de 2021]. Disponible en: https://www.siicsalud.com/dato/resiiccompleto.php/163612 Comino-Trinidad O, Calvo A, Ojeda A, Mercadal J, Cornellas L, Ferrando C. Disseminated intravascular coagulation as a form of presentation of coronavirus- 19 disease. Clinical case. Rev Esp Anestesiol Reanim. 1 de enero de 202; 68(1): 41-5. https://doi.org/10.1016/j.redare.2020.05.014 Iba T, Levy JH. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. J Thromb Haemost. 2018; 16(2): 231-41. https://doi.org/10.1111/jth.13911 Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost [Internet]. 1 de abril de 2020 [citado 27 de enero de 2021]; 18(4): 844-7. Disponible en: /pmc/articles/PMC7166509/?report=abstract ; https://doi.org/10.1111/jth.14768 Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID‐19. J Thromb Haemost [Internet]. 21 de septiembre de 2020 [citado 27 de enero de 2021]; 18(9):2 103-9. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.14975 ; https://doi.org/10.1111/jth.14975 Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 1 de junio de 2020; 127: 104362. https://doi.org/10.1016/j.jcv.2020.104362
dc.rights.spa.fl_str_mv	Laura Marcela Mendoza Carmona, Ariel Camilo Marrugo Ortiz, Sebastian David Payares Florez - 2021
dc.rights.uri.spa.fl_str_mv	https://creativecommons.org/licenses/by-nc-sa/4.0
dc.rights.coar.spa.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Laura Marcela Mendoza Carmona, Ariel Camilo Marrugo Ortiz, Sebastian David Payares Florez - 2021 https://creativecommons.org/licenses/by-nc-sa/4.0 http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	Universidad de Cartagena
dc.source.spa.fl_str_mv	https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/view/3334
institution	Universidad de Cartagena
bitstream.url.fl_str_mv	https://repositorio.unicartagena.edu.co/bitstreams/c26a5db5-e63b-4cbc-a942-c96cd75dd97e/download
bitstream.checksum.fl_str_mv	786121460933148cdc9a57bca57874d3
bitstream.checksumAlgorithm.fl_str_mv	MD5
repository.name.fl_str_mv	Biblioteca Digital Universidad de Cartagena
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814214088338702336
spelling	Mendoza Carmona, Laura MarcelaMarrugo Ortiz, Ariel CamiloPayares Florez, Sebastian David2021-07-15 00:00:002021-07-15 00:00:002021-07-152215-784010.32997/rcb-2021-33342389-7252https://doi.org/10.32997/rcb-2021-3334application/pdfspaUniversidad de CartagenaRevista Ciencias Biomédicashttps://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/download/3334/2946Núm. 3 , Año 2021188317210Ye ZW, Yuan S, Yuen KS, Fung SY, Chan CP, Jin DY. Zoonotic origins of human coronaviruses. Int J Biol Sci. 2020; 16(10): 1686-97. https://doi.org/10.7150/ijbs.45472Chan JFW, Kok KH, Zhu Z, Chu H, To KKW, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020; 9(1): 221-36. https://doi.org/10.1080/22221751.2020.1719902Polak SB, Van Gool IC, Cohen D, von der Thüsen JH, van Paassen J. A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression. Mod Pathol [Internet]. 2020; 33(11): 2128-38. Disponible en: https://doi.org/10.1038/s41379-020-0603-3Menter T, Haslbauer JD, Nienhold R, Savic S, Hopfer H, Deigendesch N, et al. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020; 77(2): 198-209. https://doi.org/10.1111/his.14134Shi Y, Wang G, Cai X peng, Deng J wen, Zheng L, Zhu H hong, et al. An overview of COVID-19. J Zhejiang Univ Sci B. 2020; 21(5): 343-60. https://doi.org/10.1631/jzus.B2000083Calabrese F, Pezzuto F, Fortarezza F, Hofman P, Kern I, Panizo A, et al. Pulmonary pathology and COVID- 19: lessons from autopsy. The experience of European Pulmonary Pathologists. Virchows Arch. 2020; 477(3): 359-72. https://doi.org/10.1007/s00428-020-02886-6Woo PCY, Lau SKP, Chu C, Chan K, Tsoi H, Huang Y, et al. Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1 , from Patients with Pneumonia. 2005; 79(2): 884-95. https://doi.org/10.1128/JVI.79.2.884-895.2005Martines RB, Ritter JM, Matkovic E, Gary J, Bollweg BC, Bullock H, et al. Pathology and pathogenesis of SARS-CoV-2 associated with fatal coronavirus disease, united states. Emerg Infect Dis. 2020; 26(9): 2005-15. https://doi.org/10.3201/eid2609.202095Lax SF, Skok K, Zechner P, Kessler HH, Kaufmann N, Koelblinger C, et al. Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome : Results From a Prospective, Single-Center, Clinicopathologic Case Series. Ann Intern Med. 2020; 173(5): 350-61. https://doi.org/10.7326/M20-2566Cipolloni L, Sessa F, Bertozzi G, Baldari B, Cantatore S, Testi R, et al. Preliminary post-mortem COVID-19 evidence of endothelial injury and factor VIII hyperexpression. Diagnostics. 2020; 10(8): 1-16. https://doi.org/10.3390/diagnostics10080575Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R, et al. Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience. 2020. https://doi.org/10.1101/2020.05.18.20099960Fox SE, Akmatbekov A, Harbert JL, Li G, Brown JQ. not peer reviewed Pulmonary and Cardiac Pathology in Covid-19: The First Autopsy Series from New Orleans 1) Department of Pathology, LSU Health Sciences Center, New Orleans 2) Pathology and Laboratory Medicine Service, Southeast Louisiana V eterans. medRxiv [Internet]. 2020; 2020.04.06.20050575. Disponible en: https://doi.org/10.1101/2020.04.06.20050575Grosse C, Grosse A, Salzer HJF, Dünser MW, Motz R, Langer R. Analysis of cardiopulmonary findings in COVID-19 fatalities: High incidence of pulmonary artery thrombi and acute suppurative bronchopneumonia. Cardiovasc Pathol. 2020; 49 (January). https://doi.org/10.1016/j.carpath.2020.107263Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID- 19: A Prospective Cohort Study. Ann Intern Med. 2020; 173(4): 268-77. https://doi.org/10.7326/M20-2003Nasr A, Rossi RS, Pellegrinelli A, Zerbi P, Rech R. Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy Since December 2019, an outbreak caused by a new coronavirus infection (severe acute respiratory syndrome coronavirus 2 , SARS-CoV-2) disease was reported, starting. 2020; 1-11.Bradley BT, Maioli H, Johnston R, Chaudhry I, Fink SL, Xu H, et al. Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections. medRxiv. 2020. https://doi.org/10.1101/2020.04.17.20058545Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020; 383(2): 120-8. https://doi.org/10.1056/NEJMoa2015432Edler C, Schröder AS, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, et al. Erratum: Correction to: Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany (International journal of legal medicine (2020) 134 4 (1275-1284). Int J Legal Med. 2020; 134(5): 1977. https://doi.org/10.1007/s00414-020-02336-7Nicholson AG, Osborn M, Devaraj A, Wells AU. COVID-19 related lung pathology: old patterns in new clothing? Histopathology. 2020; 77(2): 169-72. https://doi.org/10.1111/his.14162Copin MC, Parmentier E, Duburcq T, Poissy J, Mathieu D, Caplan M, etal. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med [Internet]. 2020; 46(6): 1124-6. Disponible en: https://doi.org/10.1007/s00134-020-06057-8Barton LM, Duval EJ, Stroberg E, Ghosh S, Mukhopadhyay S. COVID-19 Autopsies, Oklahoma, USA. Am J Clin Pathol. 2020; 153(6): 725-33. https://doi.org/10.1093/ajcp/aqaa062Borczuk AC, Salvatore SP , Seshan S V ., Patel SS, Bussel JB, Mostyka M, et al. COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City. Mod Pathol [Internet]. 2020; 33(11): 2156-68. Disponible en: https://doi.org/10.1038/s41379-020-00661-1Adachi T, Chong JM, Nakajima N, Sano M, Yamazaki J, Miyamoto I, et al. Clinicopathologic and immunohistochemical findings from autopsy of patient with COVID-19, Japan. Emerg Infect Dis. 2020; 26(9): 2157-61. https://doi.org/10.3201/eid2609.201353Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, et al. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect , the company' s public news and information. 2020; (January).Suess C, Hausmann R. Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation. Int J Legal Med. 2020; 134(4): 1285-90. https://doi.org/10.1007/s00414-020-02319-8Falasca L, Nardacci R, Colombo D, Lalle E, Di Caro A, Nicastri E, et al. Postmortem Findings in Italian Patients With COVID-19: A Descriptive Full Autopsy Study of Cases With and Without Comorbidities. J Infect Dis. 2020; 222(11): 1807-15. https://doi.org/10.1093/infdis/jiaa578Del Nonno F, Colombo D, Nardacci R, Falasca L. Fatal pulmonary arterial thrombosis in a COVID-19 patient, with asymptomatic history, occurred after swab negativization. Thromb J. 2021; 19(1): 1. https://doi.org/10.1186/s12959-020-00255-6Stoyanov GS, Petkova L, Dzhenkov DL, Sapundzhiev NR, Todorov I. Gross and Histopathology of COVID-19 With First Histology Report of Olfactory Bulb Changes. Cureus. 2020; 12(12). https://doi.org/10.7759/cureus.11912Bösmüller H, Traxler S, Bitzer M, Häberle H, Raiser W, Nann D, etal. The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation. Virchows Arch. 2020; 477(3): 349-57. https://doi.org/10.1007/s00428-020-02881-xScendoni. Histopath 2 oncology COVIDs. Diagn Pathol. 2020; 1-4.Bian X. Autopsy of COVID-19 patients in China. 2020.Aguiar D, Lobrinus JA, Schibler M, Fracasso T, Lardi C. Inside the lungs of COVID-19 disease. Int J Legal Med. 2020; 134(4): 1271-4. https://doi.org/10.1007/s00414-020-02318-9Konopka KE, Wilson A, Myers JL. Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019. Chest. 2020; 158(3): e99-101. https://doi.org/10.1016/j.chest.2020.04.032Chmielik E, Jazowiecka-Rakus J, Dyduch G, Nasierowska-Guttmejer A, Michalowski L, Sochanik A, et al. COVID-19 Autopsies: A Case Series from Poland. Pathobiology. 2020. https://doi.org/10.1159/000512768Ducloyer M, Gaborit B, Toquet C, Castain L, Bal A, Arrigoni PP, et al. Complete post-mortem data in a fatal case of COVID-19: clinical, radiological and pathological correlations. Int J Legal Med. 2020; 134(6): 2209-14. https://doi.org/10.1007/s00414-020-02390-1Remmelink M, De Mendonça R, D'Haene N, De Clercq S, Verocq C, Lebrun L, et al. Unspecific post- mortem findings despite multiorgan viral spread in COVID-19 patients. Crit Care. 2020; 24(1): 1-10. https://doi.org/10.1186/s13054-020-03218-5Buja LM, Wolf D, Zhao B, Akkanti B, McDonald M, Lelenwa L, etal. The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities. Cardiovasc Pathol [Internet]. 2020; 48: 107233. Disponible en: https://doi.org/10.1016/j.carpath.2020.107233Sauter JL, Baine MK, Butnor KJ, Buonocore DJ, Chang JC, Jungbluth AA, etal. Insights into pathogenesis of fatal COVID-19 pneumonia from histopathology with immunohistochemical and viral RNA studies. Histopathology. 2020; 77(6): 915-25. https://doi.org/10.1111/his.14201Calvin M, Cletus T, Madala N. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information. 2020; (January).Okudela K, Hayashi H, Yoshimura Y, Sasaki H, Horiuchi H, Miyata N, et al. A Japanese case of COVID-19: An autopsy report. Pathol Int. 2020; 70(10): 820-4. https://doi.org/10.1111/pin.13002ZengZ, XuL, XieXY, YanHL, XieBJ, XuWZ, et al. Pulmonary pathology of early-phase COVID-19 pneumonia in a patient with a benign lung lesion. Histopathology. 2020; 77(5): 823-31. https://doi.org/10.1111/his.14138Flikweert AW, Grootenboers MJJH, Yick DCY, du Mée AWF, van der Meer NJM, Rettig TCD, et al. Late histopathologic characteristics of critically ill COVID- 19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series. J Crit Care [Internet]. 2020; 59: 149-55. Disponible en: https://doi.org/10.1016/j.jcrc.2020.07.002Rubin JE, Crowe SE. Annals of internal medicine®. Ann Intern Med. 2020; 172(1): ITC1-14. https://doi.org/10.7326/AITC202001070Beigmohammadi MT, Jahanbin B, Safaei M, Amoozadeh L, Khoshavi M, Mehrtash V , et al. Pathological Findings of Postmortem Biopsies From Lung, Heart, and Liver of 7 Deceased COVID-19 Patients. Int J Surg Pathol. 2020; 1-11. https://doi.org/10.1177/1066896920935195YaoX, LiT, HeZ, PingY, LiuH, YuS, et al. Histopathological Study of New Coronavirus Pneumonia (COVID-19) in Three Patients. Chinese J Pathol. 2020; 49 DOI: https://doi.org/10.3760/cma.j.cn112151-20200312-00193Recalde-Zamacona B, García-Tobar L, Argueta A, Álvarez L, De Andrea CE, Fernández Alonso M, et al. Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: Preliminary experience from a series of 10 Spanish patients. Thorax. 2020; 75(12): 1116-8. https://doi.org/10.1136/thoraxjnl-2020-215577Xu Z, Shi L, Wang Y et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome [published correction appears in Lancet Respir Med. 2020 Feb 25;:]. Lancet Respir Med. 2020.8(4): 420-422. doi: 10.1016/S2213-2600(20)30076-X Lancet Respir Med [Internet]. 2020;8(feb 25):420-2. Disponible en: https://doi.org/10.1016/S2213-2600(20)30076-XDing M, Zhang Q, Li Q, Wu T, Huang Y. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information. 2020; (January).Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD. Acute fibrinous and organizing pneumonia: A histologic pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 2002; 126(9): 1064-70. https://doi.org/10.5858/2002-126-1064-AFAOPValdivia-Mazeyra MF, Salas C, Nieves-Alonso JM, Martín-Fragueiro L, Bárcena C, Muñoz-Hernández P , et al. Increased number of pulmonary megakaryocytes in COVID-19 patients with diffuse alveolar damage: an autopsy study with clinical correlation and review of the literature. Virchows Arch. 2020. https://doi.org/10.21203/rs.3.rs-49093/v1Schaefer IM, Padera RF, Solomon IH, Kanjilal S, Hammer MM, Hornick JL, et al. In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19. Mod Pathol [Internet]. 2020; 33(11): 2104-14. Disponible en: https://doi.org/10.1038/s41379-020-0595-zBarisione E, Grillo F, Ball L, Bianchi R, Grosso M, Morbini P, et al. Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems. Virchows Arch. 2020. https://doi.org/10.1007/s00428-020-02934-1Pernazza A, Mancini M, Rullo E, Bassi M, De Giacomo T, Rocca C Della, et al. Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen. Virchows Arch. 2020; 477(5): 743-8. https://doi.org/10.1007/s00428-020-02829-1Elsoukkary SS, Mostyka M, Dillard A, Berman DR, Ma LX, Chadburn A, et al. Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience. Pathobiology. 2020. https://doi.org/10.1159/000511325Sociedade Chinesa de Medicina de Reabilitação, Comitê de Reabilitação Respiratória da Associação Chinesa de Medicina de Reabilitação G de RC do R de MFeRdaAMC,QianxueM,HaoD,YinZ,HongZ, Hospital T. Nova Orientação para Reabilitação Respiratória de Coronavírus Pneumonia (Segunda Edição). 2020; 44: 1-8.Mac Dowall MP, Barrionuevo-Poquet A, Carnero- Fuentes O, Pareja-Begazo G, Coayla-Cano C, Gallo- Lopez A, et al. Clinical-pathological characterization, viral genotipification and genetic heterogeneity as risk determinants in COVID-19: Study design and initial findings. Rev la Fac Med Humana. 2020; 20(3): 433- 43. https://doi.org/10.25176/RFMH.v20i3.3040Wang XX, Shao C, Huang XJ, Sun L, Meng LJ, Liu H, et al. Histopathological features of multiorgan percutaneous tissue core biopsy in patients with COVID-19. J Clin Pathol. 2020; 1-6. https://doi.org/10.1136/jclinpath-2020-206623Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, etal. 3D Virtual Pathohistology of Lung Tissue From Covid-19 Patients Based on Phase Contrast X-Ray Tomography. Elife. 2020; 9: 1-25. https://doi.org/10.7554/eLife.60408Kommoss FKF, Schwab C, Tavernar L, Schreck J, Wagner WL, Merle U, et al. Pathologie der schweren COVID-19-bedingten Lungenschädigung. Dtsch Arztebl Int. 2020; 117 (29-30): 500-6.Ochoa Salmorán H, Martínez Martínez I, Díaz Greene EJ. Ventilación mecánica en pacientes con COVID-19 de acuerdo a los fenotipos de Gattinoni. Acta Médica Grup Ángeles. 2020; 18(3): 336-40. https://doi.org/10.35366/95421LengL,CaoR,MaJ,MouD,ZhuY,LiW,etal. Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther [Internet]. 2020; 5(1): 1-9. Disponible en: https://doi.org/10.1038/s41392-020-00355-9COAGULOPATÍA EN PACIENTES CON COVID- 19 [Internet]. [citado 27 de enero de 2021]. Disponible en: https://www.siicsalud.com/dato/resiiccompleto.php/163612Comino-Trinidad O, Calvo A, Ojeda A, Mercadal J, Cornellas L, Ferrando C. Disseminated intravascular coagulation as a form of presentation of coronavirus- 19 disease. Clinical case. Rev Esp Anestesiol Reanim. 1 de enero de 202; 68(1): 41-5. https://doi.org/10.1016/j.redare.2020.05.014Iba T, Levy JH. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. J Thromb Haemost. 2018; 16(2): 231-41. https://doi.org/10.1111/jth.13911Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost [Internet]. 1 de abril de 2020 [citado 27 de enero de 2021]; 18(4): 844-7. Disponible en: /pmc/articles/PMC7166509/?report=abstract ; https://doi.org/10.1111/jth.14768Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID‐19. J Thromb Haemost [Internet]. 21 de septiembre de 2020 [citado 27 de enero de 2021]; 18(9):2 103-9. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.14975 ; https://doi.org/10.1111/jth.14975Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 1 de junio de 2020; 127: 104362. https://doi.org/10.1016/j.jcv.2020.104362Laura Marcela Mendoza Carmona, Ariel Camilo Marrugo Ortiz, Sebastian David Payares Florez - 2021https://creativecommons.org/licenses/by-nc-sa/4.0http://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.https://revistas.unicartagena.edu.co/index.php/cbiomedicas/article/view/3334SARS-COV-2COVID-19Respiratory epitheliumHistopathologyLungDiffuse alveolar damageAcute respiratory distress syndromeSARS-COV-2COVID-19Epitelio respiratorioHistopatologiaPulmonDaño alveolar difusoSindrome de dificultad respiratoria agudaHallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.Macroscopic and microscopic findings in the respiratory system in patients with covid-19.Artículo de revistainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTREVPublicationOREORE.xmltext/xml2729https://repositorio.unicartagena.edu.co/bitstreams/c26a5db5-e63b-4cbc-a942-c96cd75dd97e/download786121460933148cdc9a57bca57874d3MD5111227/13452oai:repositorio.unicartagena.edu.co:11227/134522024-09-05 15:30:31.32https://creativecommons.org/licenses/by-nc-sa/4.0Laura Marcela Mendoza Carmona, Ariel Camilo Marrugo Ortiz, Sebastian David Payares Florez - 2021metadata.onlyhttps://repositorio.unicartagena.edu.coBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.com

Hallazgos macroscópicos y microscópicos en el sistema respiratorio en autopsias de pacientes con covid-19.

Publicaciones similares