In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia
Revista Ciencias Biomédicas Vol.9, Núm.1 (2020) Pag. 4 - 14
- Autores:
-
Bohórquez Moreno, Cristina
Duran Lengua, Marlene
Alviz Amador, Antistio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Cartagena
- Repositorio:
- Repositorio Universidad de Cartagena
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unicartagena.edu.co:11227/11678
- Acceso en línea:
- https://hdl.handle.net/11227/11678
https://doi.org/10.32997/rcb-2020-3038
- Palabra clave:
- HMG-CoA reductasa
Antidiabético
Antioxidantes
Hipolipemiante
- Rights
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
| id |
UCART2_373087f1f9ed21079b12d5e1d43b3e68 |
|---|---|
| oai_identifier_str |
oai:repositorio.unicartagena.edu.co:11227/11678 |
| network_acronym_str |
UCART2 |
| network_name_str |
Repositorio Universidad de Cartagena |
| repository_id_str |
|
| dc.title.es.fl_str_mv |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| title |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| spellingShingle |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia HMG-CoA reductasa Antidiabético Antioxidantes Hipolipemiante |
| title_short |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| title_full |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| title_fullStr |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| title_full_unstemmed |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| title_sort |
In vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha Gossypifolia |
| dc.creator.fl_str_mv |
Bohórquez Moreno, Cristina Duran Lengua, Marlene Alviz Amador, Antistio |
| dc.contributor.author.none.fl_str_mv |
Bohórquez Moreno, Cristina Duran Lengua, Marlene Alviz Amador, Antistio |
| dc.subject.es.fl_str_mv |
HMG-CoA reductasa Antidiabético Antioxidantes Hipolipemiante |
| topic |
HMG-CoA reductasa Antidiabético Antioxidantes Hipolipemiante |
| description |
Revista Ciencias Biomédicas Vol.9, Núm.1 (2020) Pag. 4 - 14 |
| publishDate |
2020 |
| dc.date.issued.none.fl_str_mv |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2021-03-30T15:16:57Z |
| dc.date.available.none.fl_str_mv |
2021-03-30T15:16:57Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a320 |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.local.eng.fl_str_mv |
Journal article |
| format |
http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.issn.spa.fl_str_mv |
2215-7840 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/11227/11678 |
| dc.identifier.doi.spa.fl_str_mv |
10.32997/rcb-2020-3038 |
| dc.identifier.eissn.spa.fl_str_mv |
2389-7252 |
| dc.identifier.url.spa.fl_str_mv |
https://doi.org/10.32997/rcb-2020-3038 |
| identifier_str_mv |
2215-7840 10.32997/rcb-2020-3038 2389-7252 |
| url |
https://hdl.handle.net/11227/11678 https://doi.org/10.32997/rcb-2020-3038 |
| dc.language.iso.es.fl_str_mv |
spa |
| language |
spa |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Revista Ciencias Biomédicas |
| dc.relation.citationedition.spa.fl_str_mv |
(2020) |
| dc.relation.citationendpage.none.fl_str_mv |
14 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
| dc.relation.citationstartpage.none.fl_str_mv |
4 |
| dc.relation.citationvolume.spa.fl_str_mv |
9 |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.uri.es.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.access.es.fl_str_mv |
openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf237 |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess http://purl.org/coar/access_right/c_abf237 http://purl.org/coar/access_right/c_abf2 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.es.fl_str_mv |
Universidad de Cartagena |
| institution |
Universidad de Cartagena |
| bitstream.url.fl_str_mv |
https://dspace7-unicartagena.metabuscador.org/bitstreams/08eb6ecd-7ba3-4117-85f8-09ddd1b92c5e/download https://dspace7-unicartagena.metabuscador.org/bitstreams/b4e77a92-df60-4a87-b9a1-40d819bd7912/download https://dspace7-unicartagena.metabuscador.org/bitstreams/6563877e-fc80-40be-bf79-adfae0add2c7/download https://dspace7-unicartagena.metabuscador.org/bitstreams/97c2e840-3059-4e33-8259-d1b8e41f06de/download |
| bitstream.checksum.fl_str_mv |
b4c6e50f39c220ef0c5b9d1d85661b2f 7b38fcee9ba3bc8639fa56f350c81be3 44aa374498b716b841002214e2e322db 06e04d639b76075d0400ef241ef9e5f1 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Biblioteca Digital Universidad de Cartagena |
| repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
| _version_ |
1814214137507479552 |
| spelling |
Bohórquez Moreno, CristinaDuran Lengua, MarleneAlviz Amador, Antistio2021-03-30T15:16:57Z2021-03-30T15:16:57Z20202215-7840https://hdl.handle.net/11227/1167810.32997/rcb-2020-30382389-7252https://doi.org/10.32997/rcb-2020-3038Revista Ciencias Biomédicas Vol.9, Núm.1 (2020) Pag. 4 - 14Introducción: la Jatropha gossypifolia es una planta tradicionalmente utilizada como agente antidiabético e hipolipemiante. Por tanto, es importante evaluar la actividad antioxidante e inhibidora de la enzima HMG CoA reductasa, para validar su uso tradicional. Objetivo: determinar la actividad inhibidora in vitro de la enzima reductasa HMGCoA y la actividad antioxidante del extracto metanólico de Jatropha gossypifolia. Metodología: se evaluó la inhibición de la 3-hidroxi-3-metilglutaril-coenzima A reductasa (HMG-CoA) usando el kit de ensayo HMG-CoA reductasa (HMGR) de sigma Aldrich, la actividad antioxidante se realizó mediante la inhibición de hemólisis de los glóbulos rojos expuestos a H2O2. Los resultados se analizaron mediante análisis de varianza, aceptando significancia estadística con p <0,05. Resultados: el extracto metanólico total de Jatropha gossypifolia a diferentes concentraciones inhibió la enzima HMG-coA reductasa, especialmente a la concentración de 0.001 ppm, donde inhibió alrededor del 76.5% podría estar asociado a metabolitos secundarios de alta polaridad. Además, se evidenció que una concentración de 0.1 ppm de extracto inhibió el 96.6% de la hemólisis en eritrocitos humanos inducida por H2O2 (p <0.001). Conclusiones: el extracto de metanol total de Jatropha gossypifolia a diferentes concentraciones inhibe la enzima HMG-coA reductasa y tiene actividad antioxidante a bajas concentraciones.application/pdfspaUniversidad de CartagenaRevista Ciencias Biomédicas(2020)14149https://creativecommons.org/licenses/by-nc-nd/4.0/openAccesshttp://purl.org/coar/access_right/c_abf237http://purl.org/coar/access_right/c_abf2HMG-CoA reductasaAntidiabéticoAntioxidantesHipolipemianteIn vitro antioxidant and inhibitory activity of enzyme HMG-CoA reductase from the methanol extract of Jatropha GossypifoliaArtículo de revistahttp://purl.org/coar/version/c_970fb48d4fbd8a320http://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlePublicationORIGINALybarriosh-1.-bohorquez.pdfybarriosh-1.-bohorquez.pdfapplication/pdf1138603https://dspace7-unicartagena.metabuscador.org/bitstreams/08eb6ecd-7ba3-4117-85f8-09ddd1b92c5e/downloadb4c6e50f39c220ef0c5b9d1d85661b2fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81756https://dspace7-unicartagena.metabuscador.org/bitstreams/b4e77a92-df60-4a87-b9a1-40d819bd7912/download7b38fcee9ba3bc8639fa56f350c81be3MD52TEXTybarriosh-1.-bohorquez.pdf.txtybarriosh-1.-bohorquez.pdf.txtExtracted texttext/plain32266https://dspace7-unicartagena.metabuscador.org/bitstreams/6563877e-fc80-40be-bf79-adfae0add2c7/download44aa374498b716b841002214e2e322dbMD53THUMBNAILybarriosh-1.-bohorquez.pdf.jpgybarriosh-1.-bohorquez.pdf.jpgGenerated Thumbnailimage/jpeg15352https://dspace7-unicartagena.metabuscador.org/bitstreams/97c2e840-3059-4e33-8259-d1b8e41f06de/download06e04d639b76075d0400ef241ef9e5f1MD5411227/11678oai:dspace7-unicartagena.metabuscador.org:11227/116782024-08-28 17:29:46.022https://creativecommons.org/licenses/by-nc-nd/4.0/open.accesshttps://dspace7-unicartagena.metabuscador.orgBiblioteca Digital Universidad de Cartagenabdigital@metabiblioteca.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 |