Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax

En el contexto fisiopatológico de las infecciones mediadas por Plasmodium se ha documentado que la respuesta mediada por citoquinas proinflamatorias o antiinflamatorias contribuyen a la eliminación del parásito; sin embargo, una respuesta inmunológica exacerbada que puede favorecer el desarrollo de...

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Autores:
Tovar Acero, Catalina
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2021
Institución:
Universidad de Cartagena
Repositorio:
Repositorio Universidad de Cartagena
Idioma:
spa
OAI Identifier:
oai:repositorio.unicartagena.edu.co:11227/15502
Acceso en línea:
https://hdl.handle.net/11227/15502
http://dx.doi.org/10.57799/11227/144
Palabra clave:
Malaria
Parásito de la malaria
Plasmodium
Malaria - Epidemiologia
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openAccess
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Derechos Reservados - Universidad de Cartagena, 2021
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oai_identifier_str oai:repositorio.unicartagena.edu.co:11227/15502
network_acronym_str UCART2
network_name_str Repositorio Universidad de Cartagena
repository_id_str
dc.title.spa.fl_str_mv Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
title Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
spellingShingle Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
Malaria
Parásito de la malaria
Plasmodium
Malaria - Epidemiologia
title_short Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
title_full Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
title_fullStr Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
title_full_unstemmed Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
title_sort Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax
dc.creator.fl_str_mv Tovar Acero, Catalina
dc.contributor.advisor.none.fl_str_mv Yasnot Acosta, María Fernanda
dc.contributor.author.none.fl_str_mv Tovar Acero, Catalina
dc.subject.armarc.none.fl_str_mv Malaria
Parásito de la malaria
Plasmodium
Malaria - Epidemiologia
topic Malaria
Parásito de la malaria
Plasmodium
Malaria - Epidemiologia
description En el contexto fisiopatológico de las infecciones mediadas por Plasmodium se ha documentado que la respuesta mediada por citoquinas proinflamatorias o antiinflamatorias contribuyen a la eliminación del parásito; sin embargo, una respuesta inmunológica exacerbada que puede favorecer el desarrollo de cuadros complicados de la enfermedad. En los últimos años ha sido estudiado el papel de las citoquinas en la patogénesis de la malaria, así como su rol como biomarcadores capaces de pronosticar el desarrollo una complicación en pacientes que padecen esta enfermedad. Disponer de un biomarcador con estas características, es un insumo para generar herramientas diagnósticas que permitan de manera temprana dar un mejor enfoque clínico y terapéutico al paciente, por otra parte, es importante generar información que contribuya al conocimiento de la fisiopatología en las infecciones por Plasmodium vivax. Este estudio tuvo como finalidad evaluar del perfil de citoquinas de monocitos, linfocitosTh1 y linfocitos Treg en la malaria complicada por Plasmodium vivax en una zona endémica para la enfermedad en el noreste de Colombia. Se vincularon 156 individuos, conformando tres grupos de estudio, pacientes con malaria complicada, malaria no complicada y controles sanos. La trombocitopenia, la hipoglicemia, la disfunción hepática y renal fueron las complicaciones más frecuentes observadas en la malaria por P. vivax en la población de estudio. La evaluación de las citoquinas derivadas de los monocitos, Th1 y Treg, permitió identificar que la concentración plasmática de IL-6, IL-10 y IFN-γ marca un perfil diferenciador entre pacientes complicados y no complicados, la concentración aumentada de estas citoquinas mostró correlaciones con manifestaciones complicadas como la trombocitopenia severa, hipoglicemia, alteraciones hepáticas y renales. Adicionalmente, IL-6 mostró potencial para pronosticar el desarrollo de complicaciones en pacientes con infección por P. vivax. El TGF-β se postula como una citoquina moduladora de la inflamación en la infección por P. vivax, se encontró una mayor concentración de esta citoquina en el grupo control y en pacientes no complicados; sin embargo, las células Treg parecen estar suprimidas en pacientes complicados favoreciendo un ambiente proinflamatorio de citoquinas como IFN-γ e IL-6, que media las complicaciones observadas en los pacientes. El papel de la IL-10 parece estar asociado al desarrollo de complicaciones en la malaria por P. vivax, fue la citoquina con mayor concentración plasmática en pacientes con malaria complicada, y postulamos que la fuente de esta citoquina en el curso de esta infección proviene de fuentes celulares diferentes a Treg. Este es el primer estudio en Colombia que se realiza comparando grupos de pacientes con malaria vivax con diferentes formas clínicas y evalúa el comportamiento de las citoquinas en el curso de las infecciones, estas aproximaciones generan conocimiento de la inmunopatogénesis de este parásito que puede ser explorado en pronóstico de complicaciones o en blancos terapéuticos.
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spelling Yasnot Acosta, María FernandaTovar Acero, Catalina2022-07-28T13:57:31Z2022-07-28T13:57:31Z2021https://hdl.handle.net/11227/15502http://dx.doi.org/10.57799/11227/144En el contexto fisiopatológico de las infecciones mediadas por Plasmodium se ha documentado que la respuesta mediada por citoquinas proinflamatorias o antiinflamatorias contribuyen a la eliminación del parásito; sin embargo, una respuesta inmunológica exacerbada que puede favorecer el desarrollo de cuadros complicados de la enfermedad. En los últimos años ha sido estudiado el papel de las citoquinas en la patogénesis de la malaria, así como su rol como biomarcadores capaces de pronosticar el desarrollo una complicación en pacientes que padecen esta enfermedad. Disponer de un biomarcador con estas características, es un insumo para generar herramientas diagnósticas que permitan de manera temprana dar un mejor enfoque clínico y terapéutico al paciente, por otra parte, es importante generar información que contribuya al conocimiento de la fisiopatología en las infecciones por Plasmodium vivax. Este estudio tuvo como finalidad evaluar del perfil de citoquinas de monocitos, linfocitosTh1 y linfocitos Treg en la malaria complicada por Plasmodium vivax en una zona endémica para la enfermedad en el noreste de Colombia. Se vincularon 156 individuos, conformando tres grupos de estudio, pacientes con malaria complicada, malaria no complicada y controles sanos. La trombocitopenia, la hipoglicemia, la disfunción hepática y renal fueron las complicaciones más frecuentes observadas en la malaria por P. vivax en la población de estudio. La evaluación de las citoquinas derivadas de los monocitos, Th1 y Treg, permitió identificar que la concentración plasmática de IL-6, IL-10 y IFN-γ marca un perfil diferenciador entre pacientes complicados y no complicados, la concentración aumentada de estas citoquinas mostró correlaciones con manifestaciones complicadas como la trombocitopenia severa, hipoglicemia, alteraciones hepáticas y renales. Adicionalmente, IL-6 mostró potencial para pronosticar el desarrollo de complicaciones en pacientes con infección por P. vivax. El TGF-β se postula como una citoquina moduladora de la inflamación en la infección por P. vivax, se encontró una mayor concentración de esta citoquina en el grupo control y en pacientes no complicados; sin embargo, las células Treg parecen estar suprimidas en pacientes complicados favoreciendo un ambiente proinflamatorio de citoquinas como IFN-γ e IL-6, que media las complicaciones observadas en los pacientes. El papel de la IL-10 parece estar asociado al desarrollo de complicaciones en la malaria por P. vivax, fue la citoquina con mayor concentración plasmática en pacientes con malaria complicada, y postulamos que la fuente de esta citoquina en el curso de esta infección proviene de fuentes celulares diferentes a Treg. Este es el primer estudio en Colombia que se realiza comparando grupos de pacientes con malaria vivax con diferentes formas clínicas y evalúa el comportamiento de las citoquinas en el curso de las infecciones, estas aproximaciones generan conocimiento de la inmunopatogénesis de este parásito que puede ser explorado en pronóstico de complicaciones o en blancos terapéuticos.DoctoradoDoctor(a) en Medicina Tropicalapplication/pdfspaUniversidad de CartagenaFacultad de MedicinaCartagena de IndiasDoctorado en Medicina TropicalDerechos Reservados - Universidad de Cartagena, 2021https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivaxTrabajo de grado - Doctoradoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_db06Textinfo:eu-repo/semantics/doctoralThesishttps://purl.org/redcol/resource_type/TDhttp://purl.org/coar/version/c_970fb48d4fbd8a85MalariaParásito de la malariaPlasmodiumMalaria - EpidemiologiaAbbas, A. 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