Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos
Ilustraciones, fotografías, gráficas
- Autores:
-
Marulanda Marín, Daniel Gustavo
- Tipo de recurso:
- Masters Thesis
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Caldas
- Repositorio:
- Repositorio U. de Caldas
- Idioma:
- eng
spa
- OAI Identifier:
- oai:repositorio.ucaldas.edu.co:ucaldas/16731
- Acceso en línea:
- https://repositorio.ucaldas.edu.co/handle/ucaldas/16731
https://repositorio.ucaldas.edu.co/
- Palabra clave:
- Cirugía veterinaria
Patología veterinaria
Coagulación
Fibrina
Fibrina rica en plaquetas
Coágulo
Bioandamio
Caninos
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
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| dc.title.spa.fl_str_mv |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| title |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| spellingShingle |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos Cirugía veterinaria Patología veterinaria Coagulación Fibrina Fibrina rica en plaquetas Coágulo Bioandamio Caninos |
| title_short |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| title_full |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| title_fullStr |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| title_full_unstemmed |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| title_sort |
Evaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninos |
| dc.creator.fl_str_mv |
Marulanda Marín, Daniel Gustavo |
| dc.contributor.advisor.none.fl_str_mv |
Silva Molano, Raul Fernando |
| dc.contributor.author.none.fl_str_mv |
Marulanda Marín, Daniel Gustavo |
| dc.subject.lemb.none.fl_str_mv |
Cirugía veterinaria Patología veterinaria Coagulación |
| topic |
Cirugía veterinaria Patología veterinaria Coagulación Fibrina Fibrina rica en plaquetas Coágulo Bioandamio Caninos |
| dc.subject.proposal.spa.fl_str_mv |
Fibrina Fibrina rica en plaquetas Coágulo Bioandamio Caninos |
| description |
Ilustraciones, fotografías, gráficas |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2021-06-23T22:23:41Z |
| dc.date.available.none.fl_str_mv |
2021-06-23T22:23:41Z |
| dc.date.issued.none.fl_str_mv |
2021-06-23 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
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Text |
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info:eu-repo/semantics/masterThesis |
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https://repositorio.ucaldas.edu.co/handle/ucaldas/16731 |
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Universidad de Caldas |
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Repositorio Institucional Universidad de Caldas |
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https://repositorio.ucaldas.edu.co/ |
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https://repositorio.ucaldas.edu.co/handle/ucaldas/16731 https://repositorio.ucaldas.edu.co/ |
| identifier_str_mv |
Universidad de Caldas Repositorio Institucional Universidad de Caldas |
| dc.language.iso.spa.fl_str_mv |
eng spa |
| language |
eng spa |
| dc.relation.references.spa.fl_str_mv |
Ahmed, Tamer A.E., Emma V. Dare, and Max Hincke. 2008. “Fibrin: A Versatile Scaffold for Tissue Engineering Applications.” Tissue Engineering Part B: Reviews 14(2): 199– 215. http://www.liebertonline.com/doi/abs/10.1089/ten.teb.2007.0435. Bölükbaşi, Nilüfer, Sinem Yeniyol, Merva Soluk Tekkesin, and Kemal Altunatmaz. 2013. “The Use of Platelet-Rich Fibrin in Combination With Biphasic Calcium Phosphate in the Treatment of Bone Defects: A Histologic and Histomorphometric Study.” Current Therapeutic Research - Clinical and Experimental 75: 15–21. Can, Mehmet Erol et al. 2016. “Urgent Therapeutic Grafting of Platelet-Rich Fibrin Membrane in Descemetocele.” Cornea 35(9): 1245–49. http://www.ncbi.nlm.nih.gov/pubmed/27362878%5Cnhttp://content.wkhealth.com/lin kback/openurl?sid=WKPTLP:landingpage&an=00003226-201609000-00017. Carmona, J U, P Martı, E Bach, and M Prades. 2006. “Evaluation of Single and Double Centrifugation Tube Methods for Concentrating Equine Platelets.” 81: 237–45. Chatterjee, Anirban, Prerna Agarwal, and Shobha Krishna Subbaiah. 2014. “Platelet Rich Fibrin: An Autologous Bioactive Membrane.” Apollo Medicine 11(1): 24–26. http://linkinghub.elsevier.com/retrieve/pii/S0976001614000088. Dar, Manzoor et al. 2016. “Use of Autologous Platelet-Rich Fibrin in Osseous Regeneration after Cystic Enucleation: A Clinical Study.” Journal of Oral Biology and Craniofacial Research 6: S29–32. Dohan, David M. et al. 2006a. “Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part I: Technological Concepts and Evolution.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 101(3). Dohan, David M. 2006b. “Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part II: Platelet-Related Biologic Features.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 101(3). Dohan, David M. 2006c. “Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part III: Leucocyte Activation: A New Feature for Platelet Concentrates?” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 101(3). Dohan Ehrenfest, David M. et al. 2010. “Three-Dimensional Architecture and Cell Composition of a Choukroun’s Platelet-Rich Fibrin Clot and Membrane.” Journal of Periodontology 81(4): 546–55. http://www.joponline.org/doi/10.1902/jop.2009.090531. Gassling, Volker et al. 2010. “Platelet-Rich Fibrin Membranes as Scaffolds for Periosteal Tissue Engineering.” Clinical Oral Implants Research 21(5): 543–49. Gorlero, Franco et al. 2012. “New Approach in Vaginal Prolapse Repair: Mini-Invasive Surgery Associated with Application of Platelet-Rich Fibrin.” International Urogynecology Journal 23(6): 715–22. Guinot, A. et al. 2014. “Preliminary Experience with the Use of an Autologous Platelet-Rich Fibrin Membrane for Urethroplasty Coverage in Distal Hypospadias Surgery.” Journal of Pediatric Urology 10(2): 300–305. http://dx.doi.org/10.1016/j.jpurol.2013.09.026. De Hingh, I. H J T et al. 2009. “Mesh Fixation with Autologous Platelet-Rich Fibrin Sealant in Inguinal Hernia Repair.” European Surgical Research 43(3): 306–9. Jiménez-Aristizabal, Román F. et al. 2017. “Long-Term Cytokine and Growth Factor Release from Equine Platelet-Rich Fibrin Clots Obtained with Two Different Centrifugation Protocols.” Cytokine 97(26): 149–55. http://dx.doi.org/10.1016/j.cyto.2017.06.011. K., Murray Robert et al. 2010. Harper. Bioquímica Ilustrada. Kuffler, Damien P., Onix Reyes, Ivan J. Sosa, and Jose Santiago-Figueroa. 2011. “Neurological Recovery across a 12-Cm-Long Ulnar Nerve Gap Repaired 3.25 Years Post Trauma: Case Report.” Neurosurgery 69(6): 1321–26. De la Puente, Pilar, and Dolores Ludeña. 2014. “Cell Culture in Autologous Fibrin Scaffolds for Applications in Tissue Engineering.” Experimental Cell Research 322(1): 1–11. http://dx.doi.org/10.1016/j.yexcr.2013.12.017. Lansdown, Drew A, and Lisa A Fortier. 2017. “Platelet-Rich Plasma : Formulations , Preparations , Constituents , and Their Effects.” Operative Techniques in Sports Medicine 25(1): 7–12. http://dx.doi.org/10.1053/j.otsm.2016.12.002. Litvinov, Rustem I., and John W. Weisel. 2017. “Fibrin Mechanical Properties and Their Structural Origins.” Matrix Biology 60–61: 110–23. http://dx.doi.org/10.1016/j.matbio.2016.08.003. Miron, Richard J. et al. 2017. “Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review.” Tissue Engineering Part B: Reviews 23(1): 83–99. http://online.liebertpub.com/doi/10.1089/ten.teb.2016.0233. Mohanty, Sujata, Himani Pathak, and Jitender Dabas. 2014. “Platelet Rich Fibrin: A New Covering Material for Oral Mucosal Defects.” Journal of Oral Biology and Craniofacial Research 4(2): 144–46. http://dx.doi.org/10.1016/j.jobcr.2014.03.003. Mosesson, M. W. 2005. “Fibrinogen and Fibrin Structure and Functions.” Journal of Thrombosis and Haemostasis 3(8): 1894–1904. Mosesson, Michael W., Kevin R. Siebenlist, and David A. Meh. 2006. “The Structure and Biological Features of Fibrinogen and Fibrin.” Annals of the New York Academy of Sciences 936(1): 11–30. http://doi.wiley.com/10.1111/j.1749-6632.2001.tb03491.x. Mvz, Catalina López, and Jorge U Carmona Mvz. 2014. “Journal of Equine Veterinary Science Platelet-Rich Plasma as an Adjunctive Therapy for the Management of a Severe Chronic Distal Limb Wound in a Foal.” Journal of Equine Veterinary Science 34(9): 1128–33. http://dx.doi.org/10.1016/j.jevs.2014.06.007. Nanditha, S., Balamanikandasrinivasan Chandrasekaran, Senthilkumar Muthusamy, and Kavitha Muthu. 2017. “Apprising the Diverse Facets of Platelet Rich Fibrin in Surgery through a Systematic Review.” International Journal of Surgery 46: 186–94. http://dx.doi.org/10.1016/j.ijsu.2017.08.558. Parra Castro, Estefanía, Andrea Vergara, and Fernando Silva Molano. 2017. “Author ’ S Accepted Manuscript.” Topics in Companion Animal Medicine. http://dx.doi.org/10.1053/j.tcam.2017.05.001. Paul, Ducheyne. 2011. 1 Comprehensive Biomaterials. R. F. Silva, J. U. Carmona, and C. M. F. Rezende. 2013. “Use of Intra-Articular Autologous Platelet Concentrates as Coadjutants in the Surgical Arthroscopy Treatment of Elbow Dysplasia in a Bitch Uso Intra-Articular de Concentrados Autólogos de Plaquetas Como Coadyuvantes En El Tratamiento Artroscópico de Una D.” Archivos de Medicina Veterinaria, Universidad Austral de Chile 45(2): 213–17. Roseti, Livia et al. 2017. “Scaffolds for Bone Tissue Engineering: State of the Art and New Perspectives.” Materials Science and Engineering C 78: 1246–62. http://dx.doi.org/10.1016/j.msec.2017.05.017. Sheu, S. Y. et al. 2017. “The Effect of Platelet-Rich Fibrin on Autologous Osteochondral Transplantation: An in Vivo Porcine Model.” Knee: 1–10. Shirvan, Maliheh Keshvari, Daryoush Hamidi Alamdari, and Alireza Ghoreifi. 2013. “A Novel Method for Iatrogenic Vesicovaginal Fistula Treatment: Autologous Platelet Rich Plasma Injection and Platelet Rich Fibrin Glue Interposition.” Journal of Urology 189(6): 2125–29. http://dx.doi.org/10.1016/j.juro.2012.12.064. Silva, R F, C M F Rezende, and J U Carmona. 2011. “Uso de Concentrados Autólogos de Plaquetas Intraarticulares Como Coadyuvantes En El Tratamiento Quirúrgico de La Rotura Del Ligamento Cruzado Anterior En Una Perra Use of Intra-Articular Autologous Platelet Concentrates as Coadjutants in the Surgical Treatment of a Cranial Cruciate Ligament Rupture in a Bitch.” 316: 313–16. Silva, R F, C M F Rezende, F O Paes-leme, and J U Carmona. 2011a. “Evaluación Del Método Del Tubo Para Concentrar Plaquetas Caninas : Estudio Celular Evaluation of the Tube Method for Concentrating Canine Platelets : Cellular Study.” 98: 95–98 Silva, R F, C M F Rezende, 2011b. “Evaluación Del Método Del Tubo Para Concentrar Plaquetas Felinas : Estudio Celular Evaluation of the Tube Method for Concentrating Feline Platelets : Cellular Study.” 190: 187–90. Soyer, Tutku et al. 2013. “Use of Autologous Platelet Rich Fibrin in Urethracutaneous Fistula Repair: Preliminary Report.” International Wound Journal 10(3): 345–47. Standeven, Kristina F., Robert A S Ariëns, and Peter J. Grant. 2005. “The Molecular Physiology and Pathology of Fibrin Structure/function.” Blood Reviews 19(5): 275–88. Weisel, John W. 2004. “The Mechanical Properties of Fibrin for Basic Scientists and Clinicians.” Biophysical Chemistry 112(2–3 SPEC. ISS.): 267–76 Wu, Peter I-kung, Robert Diaz, and Joanne Borg-stein. 2016. “P L a T E L E T - R I c H Pl a S M a.” 27: 825–53. |
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Silva Molano, Raul Fernando7c85c585171ee8cf1ad28a585c3103c7Marulanda Marín, Daniel Gustavo8b332a202db20cacfc3ee0334788da352021-06-23T22:23:41Z2021-06-23T22:23:41Z2021-06-23https://repositorio.ucaldas.edu.co/handle/ucaldas/16731Universidad de CaldasRepositorio Institucional Universidad de Caldashttps://repositorio.ucaldas.edu.co/Ilustraciones, fotografías, gráficasspa: El propósito de este estudio fue estandarizar y describir un método para la formación de un coagulo o malla de fibrina rica en plaquetas en caninos que fuera estable molecularmente para su caracterización y posible aplicación clínica. Se emplearon 13 perros adultos, de ambos sexos, clínicamente sanos con edades entre 2 y 7 años y un peso igual o superior a 20kg. Estos ingresaron al área de clínica quirúrgica del Hospital Veterinario de la Universidad de Caldas para un procedimiento electivo. A cada canino se le tomó una muestra de 34 ml de sangre entera divida en seis tubos; uno con anticoagulante EDTA que fue empleado para realizar conteo celular basal y cinco tubos sin anticoagulante, pero con sílice micronizado que fueron a su vez divididas en tres grupos los cuales recibieron diferentes tipos de procesos y fueron llamados protocolo de centrifugación Nº1 (2 tubos) a 410g durante 10 minutos, descrito por Dohan et al. para obtener fibrina rica en plaquetas en la especie humana, protocolo de centrifugación Nº2 (2 tubos) a 191g durante 6 minutos, protocolo descrito por Silva et al. para obtener concentrado autólogo de plaquetas en la especie canina; y el denominado control (1 tubo) que fue dejado en reposo para obtener una comparación posterior entre estos mediante microscopia electrónica de barrido y un conteo automatizado del sobrenadante residual de cada tubo. Evaluar la distribución celular dentro del coágulo no fue posible debido a la característica gelatinosa que presenta la estructura y que envuelve las células, en este caso solo se pudo comprobar su presencia por visualización directa de cuerpos celulares parcialmente atrapados o adheridos a la superficie del coagulo. Sin embargo, al realizar conteo hematológico al sobrenadante de cada tubo se pudo determinar que existe una diferencia estadísticamente significativa del coagulo generado en reposo también denominado control, respecto a los coágulos generados por los protocolos 1 y 2 en términos de eritrocitos. El análisis de las demás estructuras celulares demostró que no existe una diferencia estadísticamente significativa entre estos. Por otro lado La manipulación de la sangre mediante los dos tipos de protocolos si permitió la obtención de un coagulo y una malla estable y resistente, con características visco elásticas deseables al momento de una aplicabilidad clínica. Sin embargo, el tamaño del coagulo generado con el protocolo Nº1 logra una estructura de 1cm a 1.5cm más largo, siendo este tipo de estructura más deseable cuando se enfrentan lesiones de gran tamaño o con grandes pérdidas de tejido.eng: The purpose of this study was to standardize and describe a method for the formation of a platelet-rich fibrin clot or mesh in canines that was molecularly stable for characterization and possible clinical application. Thirteen adult dogs, of both sexes, we`re used clinically healthy with ages between 2 and 7 years and a weight equal to or greater than 20 kg. These entered the surgical clinic area of the Veterinary Hospital of the University of Caldas for an elective procedure. Each canine is taken a 34 ml sample of whole blood divided into six tubes; one with EDTA anticoagulant that was used to perform a basal cell count and five tubes without anticoagulant, but with micronized silica that were in turn divided into three groups which had different types of processes and were called centrifugation protocols Nº1 (2 tubes) at 410 g for 10 minutes, described by Dohan et al. to obtain platelet-rich fibrin in the human species, centrifugation protocol Nº2 (2 tubes) at 191g for 6 minutes, protocol labeled by Silva et al. to obtain autologous platelet concentrate in the canine species; and the so-called control (1 tube) that was left to rest to obtain a subsequent comparison between these using scanning electron microscopy and an automated count of the residual supernatant of each tube. Evaluating the cellular distribution within the clot was not possible due to the gelatinous characteristic that the structure presents and that surrounds the cells. In this case, its presence could only be detected by direct visualization of the cell bodies trapped or adhering to the surface of the clot. However, by performing a hematological count on the supernatant of each tube, it was possible to determine that there is a statistically significant difference between the resting clot, also called control, with respect to the clots generated by protocols 1 and 2 in terms of erythrocytes. The analysis of the other mobile structures showed that there is no statistically significant difference between them. On the other hand, the manipulation of the blood by means of the two types of protocols if obtaining a clot and a stable and resistant mesh, with desirable elastic visual characteristics at the time of clinical applicability. However, the size of the generating clot with protocol No. 1 achieves a structure of 1 cm to 1.5 cm longer, this type of structure being more desirable when large lesions are present or with large tissue losses.Resumen / Abstract/ Introducción/ Marco teórico. / Estructura/ Propiedades / Uso de FRP en pérdidas de tejidos blandos/ Uso de FRP en tejidos óseo / Técnicas de obtención de FRP/ Materiales y métodos/ Discusión/ Conclusiones/ Referencias bibliográficas.MaestríaMagister en Ciencias Veterinariasapplication/pdfengspaEvaluación ultraestructural de coágulos de fibrina rica en plaquetas (FRP) de caninosTrabajo de grado - Maestríahttp://purl.org/coar/resource_type/c_bdccTextinfo:eu-repo/semantics/masterThesishttp://purl.org/coar/version/c_970fb48d4fbd8a85Facultad de Ciencias AgropecuariasManizalesMaestría en Ciencias VeterinariasAhmed, Tamer A.E., Emma V. Dare, and Max Hincke. 2008. “Fibrin: A Versatile Scaffold for Tissue Engineering Applications.” Tissue Engineering Part B: Reviews 14(2): 199– 215. http://www.liebertonline.com/doi/abs/10.1089/ten.teb.2007.0435.Bölükbaşi, Nilüfer, Sinem Yeniyol, Merva Soluk Tekkesin, and Kemal Altunatmaz. 2013. “The Use of Platelet-Rich Fibrin in Combination With Biphasic Calcium Phosphate in the Treatment of Bone Defects: A Histologic and Histomorphometric Study.” Current Therapeutic Research - Clinical and Experimental 75: 15–21.Can, Mehmet Erol et al. 2016. “Urgent Therapeutic Grafting of Platelet-Rich Fibrin Membrane in Descemetocele.” Cornea 35(9): 1245–49. http://www.ncbi.nlm.nih.gov/pubmed/27362878%5Cnhttp://content.wkhealth.com/lin kback/openurl?sid=WKPTLP:landingpage&an=00003226-201609000-00017.Carmona, J U, P Martı, E Bach, and M Prades. 2006. “Evaluation of Single and Double Centrifugation Tube Methods for Concentrating Equine Platelets.” 81: 237–45.Chatterjee, Anirban, Prerna Agarwal, and Shobha Krishna Subbaiah. 2014. “Platelet Rich Fibrin: An Autologous Bioactive Membrane.” Apollo Medicine 11(1): 24–26. http://linkinghub.elsevier.com/retrieve/pii/S0976001614000088.Dar, Manzoor et al. 2016. “Use of Autologous Platelet-Rich Fibrin in Osseous Regeneration after Cystic Enucleation: A Clinical Study.” Journal of Oral Biology and Craniofacial Research 6: S29–32.Dohan, David M. et al. 2006a. “Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part I: Technological Concepts and Evolution.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 101(3).Dohan, David M. 2006b. “Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part II: Platelet-Related Biologic Features.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 101(3).Dohan, David M. 2006c. “Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part III: Leucocyte Activation: A New Feature for Platelet Concentrates?” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 101(3).Dohan Ehrenfest, David M. et al. 2010. “Three-Dimensional Architecture and Cell Composition of a Choukroun’s Platelet-Rich Fibrin Clot and Membrane.” Journal of Periodontology 81(4): 546–55. http://www.joponline.org/doi/10.1902/jop.2009.090531.Gassling, Volker et al. 2010. “Platelet-Rich Fibrin Membranes as Scaffolds for Periosteal Tissue Engineering.” Clinical Oral Implants Research 21(5): 543–49.Gorlero, Franco et al. 2012. “New Approach in Vaginal Prolapse Repair: Mini-Invasive Surgery Associated with Application of Platelet-Rich Fibrin.” International Urogynecology Journal 23(6): 715–22.Guinot, A. et al. 2014. “Preliminary Experience with the Use of an Autologous Platelet-Rich Fibrin Membrane for Urethroplasty Coverage in Distal Hypospadias Surgery.” Journal of Pediatric Urology 10(2): 300–305. http://dx.doi.org/10.1016/j.jpurol.2013.09.026.De Hingh, I. H J T et al. 2009. “Mesh Fixation with Autologous Platelet-Rich Fibrin Sealant in Inguinal Hernia Repair.” European Surgical Research 43(3): 306–9.Jiménez-Aristizabal, Román F. et al. 2017. “Long-Term Cytokine and Growth Factor Release from Equine Platelet-Rich Fibrin Clots Obtained with Two Different Centrifugation Protocols.” Cytokine 97(26): 149–55. http://dx.doi.org/10.1016/j.cyto.2017.06.011.K., Murray Robert et al. 2010. Harper. Bioquímica Ilustrada.Kuffler, Damien P., Onix Reyes, Ivan J. Sosa, and Jose Santiago-Figueroa. 2011. “Neurological Recovery across a 12-Cm-Long Ulnar Nerve Gap Repaired 3.25 Years Post Trauma: Case Report.” Neurosurgery 69(6): 1321–26.De la Puente, Pilar, and Dolores Ludeña. 2014. “Cell Culture in Autologous Fibrin Scaffolds for Applications in Tissue Engineering.” Experimental Cell Research 322(1): 1–11. http://dx.doi.org/10.1016/j.yexcr.2013.12.017.Lansdown, Drew A, and Lisa A Fortier. 2017. “Platelet-Rich Plasma : Formulations , Preparations , Constituents , and Their Effects.” Operative Techniques in Sports Medicine 25(1): 7–12. http://dx.doi.org/10.1053/j.otsm.2016.12.002.Litvinov, Rustem I., and John W. Weisel. 2017. “Fibrin Mechanical Properties and Their Structural Origins.” Matrix Biology 60–61: 110–23. http://dx.doi.org/10.1016/j.matbio.2016.08.003.Miron, Richard J. et al. 2017. “Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review.” Tissue Engineering Part B: Reviews 23(1): 83–99. http://online.liebertpub.com/doi/10.1089/ten.teb.2016.0233.Mohanty, Sujata, Himani Pathak, and Jitender Dabas. 2014. “Platelet Rich Fibrin: A New Covering Material for Oral Mucosal Defects.” Journal of Oral Biology and Craniofacial Research 4(2): 144–46. http://dx.doi.org/10.1016/j.jobcr.2014.03.003.Mosesson, M. W. 2005. “Fibrinogen and Fibrin Structure and Functions.” Journal of Thrombosis and Haemostasis 3(8): 1894–1904.Mosesson, Michael W., Kevin R. Siebenlist, and David A. Meh. 2006. “The Structure and Biological Features of Fibrinogen and Fibrin.” Annals of the New York Academy of Sciences 936(1): 11–30. http://doi.wiley.com/10.1111/j.1749-6632.2001.tb03491.x.Mvz, Catalina López, and Jorge U Carmona Mvz. 2014. “Journal of Equine Veterinary Science Platelet-Rich Plasma as an Adjunctive Therapy for the Management of a Severe Chronic Distal Limb Wound in a Foal.” Journal of Equine Veterinary Science 34(9): 1128–33. http://dx.doi.org/10.1016/j.jevs.2014.06.007.Nanditha, S., Balamanikandasrinivasan Chandrasekaran, Senthilkumar Muthusamy, and Kavitha Muthu. 2017. “Apprising the Diverse Facets of Platelet Rich Fibrin in Surgery through a Systematic Review.” International Journal of Surgery 46: 186–94. http://dx.doi.org/10.1016/j.ijsu.2017.08.558.Parra Castro, Estefanía, Andrea Vergara, and Fernando Silva Molano. 2017. “Author ’ S Accepted Manuscript.” Topics in Companion Animal Medicine. http://dx.doi.org/10.1053/j.tcam.2017.05.001.Paul, Ducheyne. 2011. 1 Comprehensive Biomaterials.R. F. Silva, J. U. Carmona, and C. M. F. Rezende. 2013. “Use of Intra-Articular Autologous Platelet Concentrates as Coadjutants in the Surgical Arthroscopy Treatment of Elbow Dysplasia in a Bitch Uso Intra-Articular de Concentrados Autólogos de Plaquetas Como Coadyuvantes En El Tratamiento Artroscópico de Una D.” Archivos de Medicina Veterinaria, Universidad Austral de Chile 45(2): 213–17.Roseti, Livia et al. 2017. “Scaffolds for Bone Tissue Engineering: State of the Art and New Perspectives.” Materials Science and Engineering C 78: 1246–62. http://dx.doi.org/10.1016/j.msec.2017.05.017.Sheu, S. Y. et al. 2017. “The Effect of Platelet-Rich Fibrin on Autologous Osteochondral Transplantation: An in Vivo Porcine Model.” Knee: 1–10.Shirvan, Maliheh Keshvari, Daryoush Hamidi Alamdari, and Alireza Ghoreifi. 2013. “A Novel Method for Iatrogenic Vesicovaginal Fistula Treatment: Autologous Platelet Rich Plasma Injection and Platelet Rich Fibrin Glue Interposition.” Journal of Urology 189(6): 2125–29. http://dx.doi.org/10.1016/j.juro.2012.12.064.Silva, R F, C M F Rezende, and J U Carmona. 2011. “Uso de Concentrados Autólogos de Plaquetas Intraarticulares Como Coadyuvantes En El Tratamiento Quirúrgico de La Rotura Del Ligamento Cruzado Anterior En Una Perra Use of Intra-Articular Autologous Platelet Concentrates as Coadjutants in the Surgical Treatment of a Cranial Cruciate Ligament Rupture in a Bitch.” 316: 313–16.Silva, R F, C M F Rezende, F O Paes-leme, and J U Carmona. 2011a. “Evaluación Del Método Del Tubo Para Concentrar Plaquetas Caninas : Estudio Celular Evaluation of the Tube Method for Concentrating Canine Platelets : Cellular Study.” 98: 95–98Silva, R F, C M F Rezende, 2011b. “Evaluación Del Método Del Tubo Para Concentrar Plaquetas Felinas : Estudio Celular Evaluation of the Tube Method for Concentrating Feline Platelets : Cellular Study.” 190: 187–90.Soyer, Tutku et al. 2013. “Use of Autologous Platelet Rich Fibrin in Urethracutaneous Fistula Repair: Preliminary Report.” International Wound Journal 10(3): 345–47.Standeven, Kristina F., Robert A S Ariëns, and Peter J. Grant. 2005. “The Molecular Physiology and Pathology of Fibrin Structure/function.” Blood Reviews 19(5): 275–88.Weisel, John W. 2004. “The Mechanical Properties of Fibrin for Basic Scientists and Clinicians.” Biophysical Chemistry 112(2–3 SPEC. ISS.): 267–76Wu, Peter I-kung, Robert Diaz, and Joanne Borg-stein. 2016. “P L a T E L E T - R I c H Pl a S M a.” 27: 825–53.info:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbCirugía veterinariaPatología veterinariaCoagulaciónFibrinaFibrina rica en plaquetasCoáguloBioandamioCaninosORIGINALDanielGustavo_MarulandaMarin_2021.pdfDanielGustavo_MarulandaMarin_2021.pdfArchivo principal tesis evaluación ultraestructural coágulos FRP en caninosapplication/pdf2195156https://repositorio.ucaldas.edu.co/bitstream/ucaldas/16731/1/DanielGustavo_MarulandaMarin_2021.pdf2d7e890fbcf7f077993b132ccc154defMD51Acta - Daniel Gustavo.pdfActa - Daniel Gustavo.pdfActa de sustentación de tesisapplication/pdf188779https://repositorio.ucaldas.edu.co/bitstream/ucaldas/16731/3/Acta%20-%20Daniel%20Gustavo.pdfcaac7855c2e426b6c5ed54e5c893e3c2MD53Carta Autorización Publicación de Contenidos Repositorio.pdfCarta Autorización Publicación de Contenidos Repositorio.pdfCarta autorización publicación 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Thumbnailimage/jpeg11071https://repositorio.ucaldas.edu.co/bitstream/ucaldas/16731/12/Carta%20Autorizaci%c3%b3n%20Publicaci%c3%b3n%20de%20Contenidos%20Repositorio.pdf.jpgd43dd856bbac5e69e6fbc96ae6afb604MD512ucaldas/16731oai:repositorio.ucaldas.edu.co:ucaldas/167312021-06-24 03:00:27.996Repositorio Digital de la Universidad de 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