Estudio de captación y bioacumulación de compuestos farmacéuticamente activos en cultivo de Lactuca sativa y evaluación de sus posibles efectos en las características morfológicas de la planta

It has been shown that pharmaceutically active compounds released in agroecosystems are absorbed and accumulated in the edible parts of crop plants. Using a simulated culture under controlled conditions, the present study aimed to evaluate the absorption and bioaccumulation of three common pharmaceu...

Full description

Autores:
Carvajal Silva, Angie Valentina
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2021
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/6380
Acceso en línea:
http://repositorio.uan.edu.co/handle/123456789/6380
Palabra clave:
Compuestos farmacéuticamente activos
Absorción y bioacumulación
Diclofenaco
Lactuca sativa romana
540
Pharmaceutically active compounds
Absorption and bioaccumulation
Diclofenac
Lactuca sativa
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Description
Summary:It has been shown that pharmaceutically active compounds released in agroecosystems are absorbed and accumulated in the edible parts of crop plants. Using a simulated culture under controlled conditions, the present study aimed to evaluate the absorption and bioaccumulation of three common pharmaceutically active compounds (Diclofenac, Sulfamethoxazole and Losartan) applied individually and in mixture in Lactuca sativa roman crop, and the effects mediated by these compounds on the quality attributes of the leafs plant. Ultrasound assisted solid phase extraction technique and high-performance liquid chromatography was used identified and quantify these compounds in lettuce leaves. Absorption of sulfamethoxazole and losartan was not observed, while diclofenac was detected in concentrations of 0.0372 ng/g. The compounds evaluated and applied at different concentrations significatively affected (lower values) the attributes of the plant such as sugars, humidity, and chlorophyll. On the other hand, it is suggested to continue carrying out studies related with establishment the mobility of pharmaceutical compounds in the plant, their possible metabolization and the probable transformation products of the three pharmaceutical compounds used and of those that may be found in irrigation water samples in crops at field level.