Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.

Propia

Autores:
Campeón Recio, Luisa Maria
García Cuadrado, Daniel Felipe
Zuluaga Solarte, Valeria
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2020
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/3200
Acceso en línea:
http://repositorio.uan.edu.co/handle/123456789/3200
Palabra clave:
Selladores biocerámicos premezclados
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
Propiedades fisicoquímicas
Bioactividad
Biocompatibilidad
Premixed bioceramic sealers
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
physicochemical properties
bioactivity
biocompatibility
Rights
openAccess
License
Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
id UAntonioN2_f5023fb5d1369caa1ae83808cb7e2ad1
oai_identifier_str oai:repositorio.uan.edu.co:123456789/3200
network_acronym_str UAntonioN2
network_name_str Repositorio UAN
repository_id_str
dc.title.es_ES.fl_str_mv Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
title Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
spellingShingle Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
Selladores biocerámicos premezclados
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
Propiedades fisicoquímicas
Bioactividad
Biocompatibilidad
Premixed bioceramic sealers
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
physicochemical properties
bioactivity
biocompatibility
title_short Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
title_full Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
title_fullStr Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
title_full_unstemmed Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
title_sort Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
dc.creator.fl_str_mv Campeón Recio, Luisa Maria
García Cuadrado, Daniel Felipe
Zuluaga Solarte, Valeria
dc.contributor.advisor.spa.fl_str_mv Reyes Gallego, Ana Carolina
dc.contributor.author.spa.fl_str_mv Campeón Recio, Luisa Maria
García Cuadrado, Daniel Felipe
Zuluaga Solarte, Valeria
dc.subject.es_ES.fl_str_mv Selladores biocerámicos premezclados
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
Propiedades fisicoquímicas
Bioactividad
Biocompatibilidad
topic Selladores biocerámicos premezclados
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
Propiedades fisicoquímicas
Bioactividad
Biocompatibilidad
Premixed bioceramic sealers
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
physicochemical properties
bioactivity
biocompatibility
dc.subject.keyword.es_ES.fl_str_mv Premixed bioceramic sealers
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
physicochemical properties
bioactivity
biocompatibility
description Propia
publishDate 2020
dc.date.issued.spa.fl_str_mv 2020-11-27
dc.date.accessioned.none.fl_str_mv 2021-03-11T15:19:21Z
dc.date.available.none.fl_str_mv 2021-03-11T15:19:21Z
dc.type.spa.fl_str_mv Trabajo de grado (Pregrado y/o Especialización)
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv http://repositorio.uan.edu.co/handle/123456789/3200
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spelling Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Reyes Gallego, Ana CarolinaCampeón Recio, Luisa MariaGarcía Cuadrado, Daniel FelipeZuluaga Solarte, Valeria109497042610983374351094970381246061172021-03-11T15:19:21Z2021-03-11T15:19:21Z2020-11-27http://repositorio.uan.edu.co/handle/123456789/3200Abu Zeid, S. T., Mokeem Saleh, A. A., Khafagi, M. G. E. D., & Abou Neel, E. A. (2018). Setting reaction of new bioceramic root canal sealers. Spectroscopy Letters, 51(8), 426-430. https://doi.org/10.1080/00387010.2018.1485703Al-Haddad, A., & Aziz, Z. A. C. A. (2016). Bioceramic-Based Root Canal Sealers: A Review. International Journal of Biomaterials, 2016. https://doi.org/10.1155/2016/9753210Balceros, L. J. S. (2016). Descripción del ph, liberación de calcio y citotoxicidad de algunos cementos selladores en endodoncia: mta, bioaggregate, iroot y endosequence. Revisión narrativa de la literatura.Baraba, A., Pezelj-Ribarić, S., Roguljić, M., & Miletić, I. (2016). Citotoksičnost dvaju bioaktivnih materijala za punjenje korijenskih kanala. Acta Stomatologica Croatica, 50(1), 8-13. https://doi.org/10.15644/asc50/1/2Becerra Suarez, J. C., & Amado Espinosa, S. (2018). Desarrollo De Un Sistema De Control De Temperatura Y Monitoreo De pH Y Humedad Del Proceso Spin Coating. Universidad Autónoma De Occidente, 1-137. https://doi.org/10.1017/CBO9781107415324.004Benetti, F., de Azevedo Queiroz, Í. O., de Oliveira, P. H. C., Conti, L. C., Azuma, M. M., de Oliveira, S. H. P., & Cintra, L. T. A. (2019). Cytotoxicity and biocompatibility of a new bioceramic endodontic sealer containing calcium hydroxide. Brazilian Oral Research, 33, 1-9. https://doi.org/10.1590/1807-3107BOR-2019.VOL33.0042Bonde, K., Beri, L., Bhargava, K., Mulay, S., Mastud, S., & Kumar, T. (2019). Comparative evaluation of the antibacterial and physicochemical properties of bioceramic apexit plus sealer mixed with cationic nanoparticles. - In vitro study. Pravara Medical Review, 11(2), 40-44.Borges, R. P., Sousa-Neto, M. D., Versiani, M. A., Rached-Júnior, F. A., De-Deus, G., Miranda, C. E. S., & Pécora, J. D. (2012). Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test. International Endodontic Journal, 45(5), 419-428. https://doi.org/10.1111/j.1365-2591.2011.01992.xBraun, A. Y. (2015). Revista de la Sociedad de Endodoncia de Chile No 31 Abril 2015. Homenaje Dra. Ada Reti M. Página 32.Camilleri, J. (2017). Will Bioceramics be the Future Root Canal Filling Materials? Current Oral Health Reports, 4(3), 228-238. https://doi.org/10.1007/s40496-017-0147-xCandeiro, G., Moura-Netto, C., D’Almeida-Couto, R. S., Azambuja-Júnior, N., Marques, M. M., Cai, S., & Gavini, G. (2016). Cytotoxicity, genotoxicity and antibacterial effectiveness of a bioceramic endodontic sealer. International Endodontic Journal, 49(9), 858-864. https://doi.org/10.1111/iej.12523Candeiro, Miranda, G. T. D. C., Campelo, F., Duarte, M. A. H., Ribeiro-Siqueira, D. C., & Gavini, G. (2012). Evaluation of radiopacity, pH, release of calcium ions, and flow of a bioceramic root canal sealer. Journal of Endodontics, 38(6), 842-845. https://doi.org/10.1016/j.joen.2012.02.029Carvalho, C. N., Grazziotin-Soares, R., De Miranda Candeiro, G. T., Martinez, L. G., De Souza, J. P., Oliveira, P. S., … Gavini, G. (2017). Micro push-out bond strength and bioactivity analysis of a bioceramic root canal sealer. Iranian Endodontic Journal, 12(3), 343-348. https://doi.org/10.22037/iej.v12i3.16091Chang, S. W., Lee, S. Y., Kang, S. K., Kum, K. Y., & Kim, E. C. (2014). In vitro biocompatibility, inflammatory response, and osteogenic potential of 4 root canal sealers: Sealapex, sankin apatite root sealer, MTA Fillapex, and iroot SP root canal sealer. Journal of Endodontics, 40(10), 1642-1648. https://doi.org/10.1016/j.joen.2014.04.006Chen, B., Haapasalo, M., Mobuchon, C., Li, X., Ma, J., & Shen, Y. (2020). Cytotoxicity and the Effect of Temperature on Physical Properties and Chemical Composition of a New Calcium Silicate–based Root Canal Sealer. Journal of Endodontics, 46(4), 531-538. https://doi.org/10.1016/j.joen.2019.12.009Cintra, L. T. A., Benetti, F., de Azevedo Queiroz, Í. O., Ferreira, L. L., Massunari, L., Bueno, C. R. E., … Gomes-Filho, J. E. (2017). Evaluation of the Cytotoxicity and Biocompatibility of New Resin Epoxy–based Endodontic Sealer Containing Calcium Hydroxide. 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Journal of Endodontics, 42(12), 1829-1833. https://doi.org/10.1016/j.joen.2016.08.014Reszka, P., Grocholewicz, K., Droździk, A., & Lipski, M. (2019). Evaluation of the radiopacity of selected calcium-silicate root canal sealers. Pomeranian Journal of Life Sciences, 65(4), 17-24. https://doi.org/10.21164/pomjlifesci.628Rodríguez-Lozano, F. J., García-Bernal, D., Oñate-Sánchez, R. E., Ortolani-Seltenerich, P. S., Forner, L., & Moraleda, J. M. (2017). Evaluation of cytocompatibility of calcium silicate-based endodontic sealers and their effects on the biological responses of mesenchymal dental stem cells. International Endodontic Journal, 50(1), 67-76. https://doi.org/10.1111/iej.12596Seltenerich, P. S. O. (2015). Evaluación del efecto de los selladores con base de biosilicatos en células madre de origen dental_. Ekp, 13(3), 1576-1580.Seo, D. G., Lee, D., Kim, Y. M., Song, D., & Kim, S. Y. (2019). 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G., & Martelo, Roberta Bosso Guerreiro Tanomaru, J. M. (2018). Evaluation of Physicochemical Properties of a New Calcium Silicate–based Sealer, Bio-C Sealer. Journal of Endodontics, 45(10), 1248-1252. https://doi.org/10.1016/j.joen.2019.07.006Zoufan, K., Jiang, J., Komabayashi, T., Wang, Y. H., Safavi, K. E., & Zhu, Q. (2011). Cytotoxicity evaluation of Gutta Flow and Endo Sequence BC sealers. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 112(5), 657-661. https://doi.org/10.1016/j.tripleo.2011.03.050Zunic, B., & Peter, S. (2018). World ’ s largest Science , Technology & Medicine Open Access book publisher. (2016), 267-322. https://doi.org/10.5772/18475PropiaIntroduction: The endodontic treatment is composed of different sequential stages, including sealing of the canal. This comprises a set of procedures performed in an ordered sequence, which involve the use of an endodontic sealant with ideal properties that promote a hermetic, three-dimensional and stable seal. Among endodontic sealants are bioceramic sealants, which in turn are subdivided into premixed bioceramics that are stored in hermetic syringes, they are new formulations that seek to solve problems of handling, intraduct placement, working time, low biocompatibility and bioactivity presented by other sealants. Methodology: Four electronic databases PubMed, Scopus, Web of Science and Google Scholar were used; The systematized search was carried out considering PICO criteria, mesh and non-mesh terms. Exclusion was made by title, abstract and methodological quality, for a consolidated of 63 articles included. Results: Bioceramics premixed sealants showed adequate chemical composition, radiopacity and setting time met ISO 6876 requirements except for solubility. Sealants proved to be alkaline, presented favorable bioactivity and biocompatibility. Conclusions: The premixed bioceramic sealants showed adequate physicochemical properties such as pH, setting time, radiopacity, bioactive potential and favorable biocompatibility. However, multiple studies indicate that TotalFill BC, Iroot SP, Bio-C and Sealer Plus BC sealants show solubility values ​​higher than those required by ISO 6876/2012 specification number 57 ANSI / ADA. Without ignoring that the literature reports various limitations regarding the methodologies to evaluate the solubility of these materials.Introducción: El tratamiento endodóntico está compuesto por diferentes etapas secuenciales, entre ellas, el sellado del conducto. Esta comprende de un conjunto de procedimientos realizados en una secuencia ordenada, que implican el uso de un sellador endodóntico con propiedades idóneas que promuevan un selle hermético, tridimensional y estable. Dentro de los selladores endodónticos se encuentran, los selladores biocerámicos, los cuales a su vez se subdividen en biocerámicos premezclados que vienen almacenados en jeringas herméticas, son nuevas formulaciones que buscan solventar problemas de manipulación, colocación intraconducto, tiempo de trabajo, baja biocompatibilidad y bioactividad que presentan otros selladores. Metodología: Se utilizaron cuatro bases de datos electrónicas PubMed, Scopus, Web of Science y GoogleScholar; se realizó la búsqueda sistematizada considerando criterios PICO, términos mesh y no mesh. Se realizó exclusión por título, resumen y calidad metodológica, para un consolidado de 63 artículos incluidos. Resultados: Los selladores premezclados biocerámicos mostraron composición química adecuada, la radiopacidad y tiempo de fraguado cumplieron los requisitos ISO 6876 a excepción de la solubilidad. Los selladores evidenciaron ser alcalinos, presentaron bioactividad y biocompatibilidad favorables. Conclusiones: Los selladores biocerámicos premezclados mostraron propiedades fisicoquímicas adecuadas como pH, tiempo de fraguado, radiopacidad, potencial bioactivo y biocompatibilidad favorable. Sin embargo, múltiples estudios apuntan que los selladores TotalFill BC, Iroot SP, Bio-C y Sealer PlusBC muestran valores de solubilidad superiores a los requeridos por la normas ISO 6876/2012 especificación número 57 ANSI/ADA. Sin desconocer que la literatura reporta diversas limitaciones en cuanto a las metodologías para evaluar la solubilidad de estos materiales.Odontólogo(a)PregradoPresencialspaUniversidad Antonio NariñoOdontologíaFacultad de OdontologíaArmeniaSelladores biocerámicos premezcladosTotalFill BC SealerEndoSequence BC SealerIRoot SPBio-C SealerSealer Plus BCEndoseal MTAPropiedades fisicoquímicasBioactividadBiocompatibilidadPremixed bioceramic sealersTotalFill BC SealerEndoSequence BC SealerIRoot SPBio-C SealerSealer Plus BCEndoseal MTAphysicochemical propertiesbioactivitybiocompatibilityComparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINAL2020_LuisaMariaCampeonRecio.pdf2020_LuisaMariaCampeonRecio.pdfTrabajo de gradoapplication/pdf2446755https://repositorio.uan.edu.co/bitstreams/39f81bf5-127a-4660-99c9-aaac1072cfc4/download78fe2613ecee348b706f83781bec2b9dMD512020_LuisaMariaCampeonRecio_Autorización.pdf2020_LuisaMariaCampeonRecio_Autorización.pdfAutorización de autoresapplication/pdf1631516https://repositorio.uan.edu.co/bitstreams/b5bf7f5b-dd39-41e7-977b-03ab939687fe/download13afcbd659fd3cd09c8db3106f636da9MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.uan.edu.co/bitstreams/24d0f9fd-9811-42b3-917a-93bfe3ce2fef/download5812a2eee99d5585fc0c26f0033099bbMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-82710https://repositorio.uan.edu.co/bitstreams/ac7654aa-0055-4b9a-bde6-343d7978d528/download2e388663398085f69421c9e4c5fcf235MD54123456789/3200oai:repositorio.uan.edu.co:123456789/32002024-10-09 23:30:00.342https://creativecommons.org/licenses/by-nd/4.0/Acceso abiertoopen.accesshttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.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