Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.
Propia
- Autores:
-
Campeón Recio, Luisa Maria
García Cuadrado, Daniel Felipe
Zuluaga Solarte, Valeria
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2020
- Institución:
- Universidad Antonio Nariño
- Repositorio:
- Repositorio UAN
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uan.edu.co:123456789/3200
- Acceso en línea:
- http://repositorio.uan.edu.co/handle/123456789/3200
- Palabra clave:
- Selladores biocerámicos premezclados
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
Propiedades fisicoquímicas
Bioactividad
Biocompatibilidad
Premixed bioceramic sealers
TotalFill BC Sealer
EndoSequence BC Sealer
IRoot SP
Bio-C Sealer
Sealer Plus BC
Endoseal MTA
physicochemical properties
bioactivity
biocompatibility
- Rights
- openAccess
- License
- Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
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oai:repositorio.uan.edu.co:123456789/3200 |
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UAntonioN2 |
network_name_str |
Repositorio UAN |
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|
dc.title.es_ES.fl_str_mv |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
title |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
spellingShingle |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. Selladores biocerámicos premezclados TotalFill BC Sealer EndoSequence BC Sealer IRoot SP Bio-C Sealer Sealer Plus BC Endoseal MTA Propiedades fisicoquímicas Bioactividad Biocompatibilidad Premixed bioceramic sealers TotalFill BC Sealer EndoSequence BC Sealer IRoot SP Bio-C Sealer Sealer Plus BC Endoseal MTA physicochemical properties bioactivity biocompatibility |
title_short |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
title_full |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
title_fullStr |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
title_full_unstemmed |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
title_sort |
Comparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática. |
dc.creator.fl_str_mv |
Campeón Recio, Luisa Maria García Cuadrado, Daniel Felipe Zuluaga Solarte, Valeria |
dc.contributor.advisor.spa.fl_str_mv |
Reyes Gallego, Ana Carolina |
dc.contributor.author.spa.fl_str_mv |
Campeón Recio, Luisa Maria García Cuadrado, Daniel Felipe Zuluaga Solarte, Valeria |
dc.subject.es_ES.fl_str_mv |
Selladores biocerámicos premezclados TotalFill BC Sealer EndoSequence BC Sealer IRoot SP Bio-C Sealer Sealer Plus BC Endoseal MTA Propiedades fisicoquímicas Bioactividad Biocompatibilidad |
topic |
Selladores biocerámicos premezclados TotalFill BC Sealer EndoSequence BC Sealer IRoot SP Bio-C Sealer Sealer Plus BC Endoseal MTA Propiedades fisicoquímicas Bioactividad Biocompatibilidad Premixed bioceramic sealers TotalFill BC Sealer EndoSequence BC Sealer IRoot SP Bio-C Sealer Sealer Plus BC Endoseal MTA physicochemical properties bioactivity biocompatibility |
dc.subject.keyword.es_ES.fl_str_mv |
Premixed bioceramic sealers TotalFill BC Sealer EndoSequence BC Sealer IRoot SP Bio-C Sealer Sealer Plus BC Endoseal MTA physicochemical properties bioactivity biocompatibility |
description |
Propia |
publishDate |
2020 |
dc.date.issued.spa.fl_str_mv |
2020-11-27 |
dc.date.accessioned.none.fl_str_mv |
2021-03-11T15:19:21Z |
dc.date.available.none.fl_str_mv |
2021-03-11T15:19:21Z |
dc.type.spa.fl_str_mv |
Trabajo de grado (Pregrado y/o Especialización) |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
format |
http://purl.org/coar/resource_type/c_7a1f |
dc.identifier.uri.none.fl_str_mv |
http://repositorio.uan.edu.co/handle/123456789/3200 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
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Properties of calcium silicate-monobasic calcium phosphate materials for endodontics containing tantalum pentoxide and zirconium oxide. Clinical Oral Investigations, 23(1), 445-457. https://doi.org/10.1007/s00784-018-2453-7 Zhang, W., Li, Z., & Peng, B. (2010). Ex vivo cytotoxicity of a new calcium silicate-based canal filling material. International Endodontic Journal, 43(9), 769-774. https://doi.org/10.1111/j.1365-2591.2010.01733.x Zhang, Wei, Li, Z., & Peng, B. (2010). Effects of iRoot SP on mineralization-related genes expression in MG63 Cells. Journal of Endodontics, 36(12), 1978-1982. https://doi.org/10.1016/j.joen.2010.08.038 Zhou, H. M., Du, T. F., Shen, Y., Wang, Z. J., Zheng, Y. F., & Haapasalo, M. (2015). In Vitro Cytotoxicity of Calcium Silicate-containing Endodontic Sealers. Journal of Endodontics, 41(1), 56-61. https://doi.org/10.1016/j.joen.2014.09.012 Zhou, H. M., Shen, Y., Zheng, W., Li, L., Zheng, Y. F., & Haapasalo, M. (2013). Physical properties of 5 root canal sealers. Journal of Endodontics, 39(10), 1281-1286. https://doi.org/10.1016/j.joen.2013.06.012 Zordan-Bronzel, C. L., Tanomaru-Filho, M., Rodrigues, E. M., Chávez-Andrade, G. M., Faria, G., & Guerreiro-Tanomaru, J. M. (2019). Cytocompatibility, bioactive potential and antimicrobial activity of an experimental calcium silicate-based endodontic sealer. International Endodontic Journal, 52(7), 979-986. https://doi.org/10.1111/iej.13086 Zordan-Bronzel, Christian L, Ferrari Esteves, F., Tanomaru Torres, M. F., Andrade Chavez, M. G., & Martelo, Roberta Bosso Guerreiro Tanomaru, J. M. (2018). Evaluation of Physicochemical Properties of a New Calcium Silicate–based Sealer, Bio-C Sealer. Journal of Endodontics, 45(10), 1248-1252. https://doi.org/10.1016/j.joen.2019.07.006 Zoufan, K., Jiang, J., Komabayashi, T., Wang, Y. H., Safavi, K. E., & Zhu, Q. (2011). Cytotoxicity evaluation of Gutta Flow and Endo Sequence BC sealers. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 112(5), 657-661. https://doi.org/10.1016/j.tripleo.2011.03.050 Zunic, B., & Peter, S. (2018). World ’ s largest Science , Technology & Medicine Open Access book publisher. (2016), 267-322. https://doi.org/10.5772/18475 |
url |
http://repositorio.uan.edu.co/handle/123456789/3200 |
identifier_str_mv |
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Properties of calcium silicate-monobasic calcium phosphate materials for endodontics containing tantalum pentoxide and zirconium oxide. Clinical Oral Investigations, 23(1), 445-457. https://doi.org/10.1007/s00784-018-2453-7 Zhang, W., Li, Z., & Peng, B. (2010). Ex vivo cytotoxicity of a new calcium silicate-based canal filling material. International Endodontic Journal, 43(9), 769-774. https://doi.org/10.1111/j.1365-2591.2010.01733.x Zhang, Wei, Li, Z., & Peng, B. (2010). Effects of iRoot SP on mineralization-related genes expression in MG63 Cells. Journal of Endodontics, 36(12), 1978-1982. https://doi.org/10.1016/j.joen.2010.08.038 Zhou, H. M., Du, T. F., Shen, Y., Wang, Z. J., Zheng, Y. F., & Haapasalo, M. (2015). In Vitro Cytotoxicity of Calcium Silicate-containing Endodontic Sealers. Journal of Endodontics, 41(1), 56-61. https://doi.org/10.1016/j.joen.2014.09.012 Zhou, H. M., Shen, Y., Zheng, W., Li, L., Zheng, Y. F., & Haapasalo, M. (2013). Physical properties of 5 root canal sealers. Journal of Endodontics, 39(10), 1281-1286. https://doi.org/10.1016/j.joen.2013.06.012 Zordan-Bronzel, C. L., Tanomaru-Filho, M., Rodrigues, E. M., Chávez-Andrade, G. M., Faria, G., & Guerreiro-Tanomaru, J. M. (2019). Cytocompatibility, bioactive potential and antimicrobial activity of an experimental calcium silicate-based endodontic sealer. International Endodontic Journal, 52(7), 979-986. https://doi.org/10.1111/iej.13086 Zordan-Bronzel, Christian L, Ferrari Esteves, F., Tanomaru Torres, M. F., Andrade Chavez, M. G., & Martelo, Roberta Bosso Guerreiro Tanomaru, J. M. (2018). Evaluation of Physicochemical Properties of a New Calcium Silicate–based Sealer, Bio-C Sealer. Journal of Endodontics, 45(10), 1248-1252. https://doi.org/10.1016/j.joen.2019.07.006 Zoufan, K., Jiang, J., Komabayashi, T., Wang, Y. H., Safavi, K. E., & Zhu, Q. (2011). Cytotoxicity evaluation of Gutta Flow and Endo Sequence BC sealers. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 112(5), 657-661. https://doi.org/10.1016/j.tripleo.2011.03.050 Zunic, B., & Peter, S. (2018). World ’ s largest Science , Technology & Medicine Open Access book publisher. (2016), 267-322. https://doi.org/10.5772/18475 |
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Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Reyes Gallego, Ana CarolinaCampeón Recio, Luisa MariaGarcía Cuadrado, Daniel FelipeZuluaga Solarte, Valeria109497042610983374351094970381246061172021-03-11T15:19:21Z2021-03-11T15:19:21Z2020-11-27http://repositorio.uan.edu.co/handle/123456789/3200Abu Zeid, S. T., Mokeem Saleh, A. A., Khafagi, M. G. E. D., & Abou Neel, E. A. (2018). Setting reaction of new bioceramic root canal sealers. Spectroscopy Letters, 51(8), 426-430. https://doi.org/10.1080/00387010.2018.1485703Al-Haddad, A., & Aziz, Z. A. C. A. (2016). Bioceramic-Based Root Canal Sealers: A Review. International Journal of Biomaterials, 2016. https://doi.org/10.1155/2016/9753210Balceros, L. J. S. (2016). Descripción del ph, liberación de calcio y citotoxicidad de algunos cementos selladores en endodoncia: mta, bioaggregate, iroot y endosequence. Revisión narrativa de la literatura.Baraba, A., Pezelj-Ribarić, S., Roguljić, M., & Miletić, I. (2016). Citotoksičnost dvaju bioaktivnih materijala za punjenje korijenskih kanala. Acta Stomatologica Croatica, 50(1), 8-13. https://doi.org/10.15644/asc50/1/2Becerra Suarez, J. C., & Amado Espinosa, S. (2018). Desarrollo De Un Sistema De Control De Temperatura Y Monitoreo De pH Y Humedad Del Proceso Spin Coating. Universidad Autónoma De Occidente, 1-137. https://doi.org/10.1017/CBO9781107415324.004Benetti, F., de Azevedo Queiroz, Í. O., de Oliveira, P. H. C., Conti, L. C., Azuma, M. M., de Oliveira, S. H. P., & Cintra, L. T. A. (2019). Cytotoxicity and biocompatibility of a new bioceramic endodontic sealer containing calcium hydroxide. Brazilian Oral Research, 33, 1-9. https://doi.org/10.1590/1807-3107BOR-2019.VOL33.0042Bonde, K., Beri, L., Bhargava, K., Mulay, S., Mastud, S., & Kumar, T. (2019). Comparative evaluation of the antibacterial and physicochemical properties of bioceramic apexit plus sealer mixed with cationic nanoparticles. - In vitro study. Pravara Medical Review, 11(2), 40-44.Borges, R. P., Sousa-Neto, M. D., Versiani, M. A., Rached-Júnior, F. A., De-Deus, G., Miranda, C. E. S., & Pécora, J. D. (2012). Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test. International Endodontic Journal, 45(5), 419-428. https://doi.org/10.1111/j.1365-2591.2011.01992.xBraun, A. Y. (2015). Revista de la Sociedad de Endodoncia de Chile No 31 Abril 2015. Homenaje Dra. Ada Reti M. Página 32.Camilleri, J. (2017). Will Bioceramics be the Future Root Canal Filling Materials? Current Oral Health Reports, 4(3), 228-238. https://doi.org/10.1007/s40496-017-0147-xCandeiro, G., Moura-Netto, C., D’Almeida-Couto, R. S., Azambuja-Júnior, N., Marques, M. M., Cai, S., & Gavini, G. (2016). Cytotoxicity, genotoxicity and antibacterial effectiveness of a bioceramic endodontic sealer. International Endodontic Journal, 49(9), 858-864. https://doi.org/10.1111/iej.12523Candeiro, Miranda, G. T. D. C., Campelo, F., Duarte, M. A. H., Ribeiro-Siqueira, D. C., & Gavini, G. (2012). Evaluation of radiopacity, pH, release of calcium ions, and flow of a bioceramic root canal sealer. Journal of Endodontics, 38(6), 842-845. https://doi.org/10.1016/j.joen.2012.02.029Carvalho, C. N., Grazziotin-Soares, R., De Miranda Candeiro, G. T., Martinez, L. G., De Souza, J. P., Oliveira, P. S., … Gavini, G. (2017). Micro push-out bond strength and bioactivity analysis of a bioceramic root canal sealer. Iranian Endodontic Journal, 12(3), 343-348. https://doi.org/10.22037/iej.v12i3.16091Chang, S. W., Lee, S. Y., Kang, S. K., Kum, K. Y., & Kim, E. C. (2014). In vitro biocompatibility, inflammatory response, and osteogenic potential of 4 root canal sealers: Sealapex, sankin apatite root sealer, MTA Fillapex, and iroot SP root canal sealer. Journal of Endodontics, 40(10), 1642-1648. https://doi.org/10.1016/j.joen.2014.04.006Chen, B., Haapasalo, M., Mobuchon, C., Li, X., Ma, J., & Shen, Y. (2020). Cytotoxicity and the Effect of Temperature on Physical Properties and Chemical Composition of a New Calcium Silicate–based Root Canal Sealer. Journal of Endodontics, 46(4), 531-538. https://doi.org/10.1016/j.joen.2019.12.009Cintra, L. T. A., Benetti, F., de Azevedo Queiroz, Í. O., Ferreira, L. L., Massunari, L., Bueno, C. R. E., … Gomes-Filho, J. E. (2017). Evaluation of the Cytotoxicity and Biocompatibility of New Resin Epoxy–based Endodontic Sealer Containing Calcium Hydroxide. 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Reciamuc, Vol. 4, pp. 253-266. https://doi.org/10.26820/reciamuc/4.(1).enero.2020.253-266Pamukçu Güven, E., Yalvaç, M. E., Kayahan, M. B., Sunay, H., ŞahIn, F., & Bayirli, G. (2013). Human tooth germ stem cell response to calciumsilicate based endodontic cements. Journal of Applied Oral Science, 21(4), 351-357. https://doi.org/10.1590/1679-775720130047Poggio, C., Dagna, A., Ceci, M., Meravini, M. V., Colombo, M., & Pietrocola, G. (2017). Solubility and pH of bioceramic root canal sealers: A comparative study. Journal of Clinical and Experimental Dentistry, 9(10), e1189-e1194. https://doi.org/10.4317/jced.54040Poggio, C., Riva, P., Chiesa, M., Colombo, M., & Pietrocola, G. (2017). Comparative cytotoxicity evaluation of eight root canal sealers. Journal of Clinical and Experimental Dentistry, 9(4), e574-e578. https://doi.org/10.4317/jced.53724Qu, W., Bai, W., Liang, Y. H., & Gao, X. J. (2016). Influence of Warm Vertical Compaction Technique on Physical Properties of Root Canal Sealers. 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G., & Martelo, Roberta Bosso Guerreiro Tanomaru, J. M. (2018). Evaluation of Physicochemical Properties of a New Calcium Silicate–based Sealer, Bio-C Sealer. Journal of Endodontics, 45(10), 1248-1252. https://doi.org/10.1016/j.joen.2019.07.006Zoufan, K., Jiang, J., Komabayashi, T., Wang, Y. H., Safavi, K. E., & Zhu, Q. (2011). Cytotoxicity evaluation of Gutta Flow and Endo Sequence BC sealers. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 112(5), 657-661. https://doi.org/10.1016/j.tripleo.2011.03.050Zunic, B., & Peter, S. (2018). World ’ s largest Science , Technology & Medicine Open Access book publisher. (2016), 267-322. https://doi.org/10.5772/18475PropiaIntroduction: The endodontic treatment is composed of different sequential stages, including sealing of the canal. This comprises a set of procedures performed in an ordered sequence, which involve the use of an endodontic sealant with ideal properties that promote a hermetic, three-dimensional and stable seal. Among endodontic sealants are bioceramic sealants, which in turn are subdivided into premixed bioceramics that are stored in hermetic syringes, they are new formulations that seek to solve problems of handling, intraduct placement, working time, low biocompatibility and bioactivity presented by other sealants. Methodology: Four electronic databases PubMed, Scopus, Web of Science and Google Scholar were used; The systematized search was carried out considering PICO criteria, mesh and non-mesh terms. Exclusion was made by title, abstract and methodological quality, for a consolidated of 63 articles included. Results: Bioceramics premixed sealants showed adequate chemical composition, radiopacity and setting time met ISO 6876 requirements except for solubility. Sealants proved to be alkaline, presented favorable bioactivity and biocompatibility. Conclusions: The premixed bioceramic sealants showed adequate physicochemical properties such as pH, setting time, radiopacity, bioactive potential and favorable biocompatibility. However, multiple studies indicate that TotalFill BC, Iroot SP, Bio-C and Sealer Plus BC sealants show solubility values higher than those required by ISO 6876/2012 specification number 57 ANSI / ADA. Without ignoring that the literature reports various limitations regarding the methodologies to evaluate the solubility of these materials.Introducción: El tratamiento endodóntico está compuesto por diferentes etapas secuenciales, entre ellas, el sellado del conducto. Esta comprende de un conjunto de procedimientos realizados en una secuencia ordenada, que implican el uso de un sellador endodóntico con propiedades idóneas que promuevan un selle hermético, tridimensional y estable. Dentro de los selladores endodónticos se encuentran, los selladores biocerámicos, los cuales a su vez se subdividen en biocerámicos premezclados que vienen almacenados en jeringas herméticas, son nuevas formulaciones que buscan solventar problemas de manipulación, colocación intraconducto, tiempo de trabajo, baja biocompatibilidad y bioactividad que presentan otros selladores. Metodología: Se utilizaron cuatro bases de datos electrónicas PubMed, Scopus, Web of Science y GoogleScholar; se realizó la búsqueda sistematizada considerando criterios PICO, términos mesh y no mesh. Se realizó exclusión por título, resumen y calidad metodológica, para un consolidado de 63 artículos incluidos. Resultados: Los selladores premezclados biocerámicos mostraron composición química adecuada, la radiopacidad y tiempo de fraguado cumplieron los requisitos ISO 6876 a excepción de la solubilidad. Los selladores evidenciaron ser alcalinos, presentaron bioactividad y biocompatibilidad favorables. Conclusiones: Los selladores biocerámicos premezclados mostraron propiedades fisicoquímicas adecuadas como pH, tiempo de fraguado, radiopacidad, potencial bioactivo y biocompatibilidad favorable. Sin embargo, múltiples estudios apuntan que los selladores TotalFill BC, Iroot SP, Bio-C y Sealer PlusBC muestran valores de solubilidad superiores a los requeridos por la normas ISO 6876/2012 especificación número 57 ANSI/ADA. Sin desconocer que la literatura reporta diversas limitaciones en cuanto a las metodologías para evaluar la solubilidad de estos materiales.Odontólogo(a)PregradoPresencialspaUniversidad Antonio NariñoOdontologíaFacultad de OdontologíaArmeniaSelladores biocerámicos premezcladosTotalFill BC SealerEndoSequence BC SealerIRoot SPBio-C SealerSealer Plus BCEndoseal MTAPropiedades fisicoquímicasBioactividadBiocompatibilidadPremixed bioceramic sealersTotalFill BC SealerEndoSequence BC SealerIRoot SPBio-C SealerSealer Plus BCEndoseal MTAphysicochemical propertiesbioactivitybiocompatibilityComparación de las propiedades fisicoquímicas y biológicas de 6 selladores endodónticos biocerámicos premezclados. Una revisión sistemática.Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINAL2020_LuisaMariaCampeonRecio.pdf2020_LuisaMariaCampeonRecio.pdfTrabajo de gradoapplication/pdf2446755https://repositorio.uan.edu.co/bitstreams/39f81bf5-127a-4660-99c9-aaac1072cfc4/download78fe2613ecee348b706f83781bec2b9dMD512020_LuisaMariaCampeonRecio_Autorización.pdf2020_LuisaMariaCampeonRecio_Autorización.pdfAutorización de autoresapplication/pdf1631516https://repositorio.uan.edu.co/bitstreams/b5bf7f5b-dd39-41e7-977b-03ab939687fe/download13afcbd659fd3cd09c8db3106f636da9MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.uan.edu.co/bitstreams/24d0f9fd-9811-42b3-917a-93bfe3ce2fef/download5812a2eee99d5585fc0c26f0033099bbMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-82710https://repositorio.uan.edu.co/bitstreams/ac7654aa-0055-4b9a-bde6-343d7978d528/download2e388663398085f69421c9e4c5fcf235MD54123456789/3200oai:repositorio.uan.edu.co:123456789/32002024-10-09 23:30:00.342https://creativecommons.org/licenses/by-nd/4.0/Acceso abiertoopen.accesshttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.coQWwgaW5jbHVpciBpbmZvcm1hY2nDs24gZW4gZWwgUmVwb3NpdG9yaW8gSW5zdGl0dWNpb25hbCBkZSBsYSAgVU5JVkVSU0lEQUQgQU5UT05JTyBOQVJJw5FPLCBlbCBhdXRvcihlcykgYXV0b3JpemEgYWwgU2lzdGVtYSBOYWNpb25hbCBkZSBCaWJsaW90ZWNhcyBwYXJhIGFsbWFjZW5hciB5IG1hbnRlbmVyIGxhIGluZm9ybWFjacOzbiAsIGNvbiBmaW5lcyBhY2Fkw6ltaWNvcyB5IGRlIG1hbmVyYSBncmF0dWl0YSwgIHBvbmdhIGEgZGlzcG9zaWNpw7NuIGRlIGxhIGNvbXVuaWRhZCBzdXMgY29udGVuaWRvcyBkw6FuZG9sZSB2aXNpYmlsaWRhZCBhIGxvcyBtaXNtb3MsIHNlIGVudGllbmRlIHF1ZSBlbChsb3MpIGF1dG9yKGVzKSBhY2VwdGEobik6IAoKMS4JUXVlIGxvcyB1c3VhcmlvcyBpbnRlcm5vcyB5IGV4dGVybm9zIGRlIGxhIEluc3RpdHVjacOzbiBwdWVkYW4gY29uc3VsdGFyIGVsIGNvbnRlbmlkbyBkZSBlc3RlIHRyYWJham8gZW4gbG9zIHNpdGlvcyB3ZWIgcXVlIGFkbWluaXN0cmEgbGEgVW5pdmVyc2lkYWQgQW50b25pbyBOYXJpw7FvLCBlbiBCYXNlIGRlIERhdG9zLCBlbiBvdHJvcyBDYXTDoWxvZ29zIHkgZW4gb3Ryb3Mgc2l0aW9zIFdlYiwgUmVkZXMgeSBTaXN0ZW1hcyBkZSBJbmZvcm1hY2nDs24gbmFjaW9uYWxlcyBlIGludGVybmFjaW9uYWxlcyDigJxPcGVuIEFjY2Vzc+KAnSB5IGVuIGxhcyByZWRlcyBkZSBpbmZvcm1hY2nDs24gZGVsIHBhw61zIHkgZGVsIGV4dGVyaW9yLCBjb24gbGFzIGN1YWxlcyB0ZW5nYSBjb252ZW5pbyBsYSBVbml2ZXJzaWRhZCBBbnRvbmlvIE5hcmnDsW8uCgoyLglRdWUgc2UgcGVybWl0ZSBsYSBjb25zdWx0YSBhIGxvcyB1c3VhcmlvcyBpbnRlcmVzYWRvcyBlbiBlbCBjb250ZW5pZG8gZGUgZXN0ZSB0cmFiYWpvLCBjb24gZmluYWxpZGFkIGFjYWTDqW1pY2EsIG51bmNhIHBhcmEgdXNvcyBjb21lcmNpYWxlcywgc2llbXByZSB5IGN1YW5kbyBtZWRpYW50ZSBsYSBjb3JyZXNwb25kaWVudGUgY2l0YSBiaWJsaW9ncsOhZmljYSBzZSBsZSBkw6kgY3LDqWRpdG8gYWwgdHJhYmFqbyB5IGEgc3UgYXV0b3IuIEVzdG8gaW5jbHV5ZSBjdWFscXVpZXIgZm9ybWF0byBkaXNwb25pYmxlIGNvbm9jaWRvIG8gcG9yIGNvbm9jZXIuCgozLglRdWUgbG9zIGRlcmVjaG9zIHNvYnJlIGxvcyBkb2N1bWVudG9zIHNvbiBwcm9waWVkYWQgZGVsIGF1dG9yIG8gZGUgbG9zIGF1dG9yZXMgeSB0aWVuZW4gc29icmUgc3Ugb2JyYSwgZW50cmUgb3Ryb3MsIGxvcyBkZXJlY2hvcyBtb3JhbGVzIGEgcXVlIGhhY2VuIHJlZmVyZW5jaWEgY29uc2VydmFuZG8gbG9zIGNvcnJlc3BvbmRpZW50ZXMgZGVyZWNob3Mgc2luIG1vZGlmaWNhY2nDs24gbyByZXN0cmljY2nDs24gYWxndW5hIHB1ZXN0byBxdWUsIGRlIGFjdWVyZG8gY29uIGxhIGxlZ2lzbGFjacOzbiBjb2xvbWJpYW5hIGFwbGljYWJsZSwgZWwgcHJlc2VudGUgZXMgdW5hIGF1dG9yaXphY2nDs24gcXVlIGVuIG5pbmfDum4gY2FzbyBjb25sbGV2YSBsYSBlbmFqZW5hY2nDs24gZGVsIGRlcmVjaG8gZGUgYXV0b3IgeSBzdXMgY29uZXhvcy4KCjQuCVF1ZSBlbCBTaXN0ZW1hIE5hY2lvbmFsIGRlIEJpYmxpb3RlY2FzIGRlIGxhIFVuaXZlcnNpZGFkIEFudG9uaW8gTmFyacOxbyBwdWVkYSBjb252ZXJ0aXIgZWwgZG9jdW1lbnRvIGEgY3VhbHF1aWVyIG1lZGlvIG8gZm9ybWF0byBwYXJhIHByb3DDs3NpdG9zIGRlIHByZXNlcnZhY2nDs24gZGlnaXRhbC4gRGUgY29uZm9ybWlkYWQgY29uIGxvIGVzdGFibGVjaWRvIGVuIGxhIExleSAyMyBkZSAxOTgyLCBMZXkgNDQgZGUgMTk5MywgRGVjaXNpw7NuIEFuZGluYSAzNTEgZGUgMTk5MywgRGVjcmV0byA0NjAgZGUgMTk5NSB5IGRlbcOhcyBub3JtYXMgZ2VuZXJhbGVzIHNvYnJlIGxhIG1hdGVyaWEsIHV0aWxpY2UgeSB1c2UgZW4gdG9kYXMgc3VzIGZvcm1hcywgbG9zIGRlcmVjaG9zIHBhdHJpbW9uaWFsZXMgZGUgcmVwcm9kdWNjacOzbiwgY29tdW5pY2FjacOzbiBww7pibGljYSwgdHJhbnNmb3JtYWNpw7NuIHkgZGlzdHJpYnVjacOzbiBkZSBsYSBpbmZvcm1hY2nDs24gaW5jbHVpZGEgZW4gZXN0ZSByZXBvc2l0b3Jpby4KCjUuCVF1ZSBsYSBvYnJhIG9iamV0byBkZSBsYSBwcmVzZW50ZSBhdXRvcml6YWNpw7NuIGVzIG9yaWdpbmFsIHkgbGEgcmVhbGl6w7Mgc2luIHZpb2xhciBvIHVzdXJwYXIgZGVyZWNob3MgZGUgYXV0b3IgZGUgdGVyY2Vyb3MsIHBvciBsbyB0YW50byBsYSBvYnJhIGVzIGRlIHN1IGV4Y2x1c2l2YSBhdXRvcsOtYSB5IHRpZW5lIGxhIHRpdHVsYXJpZGFkIHNvYnJlIGxhIG1pc21hLiBFbiBjYXNvIGRlIHByZXNlbnRhcnNlIGN1YWxxdWllciByZWNsYW1hY2nDs24gbyBhY2Npw7NuIHBvciBwYXJ0ZSBkZSB1biB0ZXJjZXJvIGVuIGN1YW50byBhIGxvcyBkZXJlY2hvcyBkZSBhdXRvciBzb2JyZSBsYSBvYnJhIGVuIGN1ZXN0acOzbiwgRUwgQVVUT1IsIGFzdW1pcsOhIHRvZGEgbGEgcmVzcG9uc2FiaWxpZGFkLCB5IHNhbGRyw6EgZW4gZGVmZW5zYSBkZSBsb3MgZGVyZWNob3MgYXF1w60gYXV0b3JpemFkb3M7IHBhcmEgdG9kb3MgbG9zIGVmZWN0b3MgbGEgVW5pdmVyc2lkYWQgYWN0w7phIGNvbW8gdW4gdGVyY2VybyBkZSBidWVuYSBmZTsgYXPDrSBtaXNtbyBlbCBhY8OhIGZpcm1hbnRlIGRlamFyw6EgaW5kZW1uZSBhIGxhIFVuaXZlcnNpZGFkIGRlIGN1YWxxdWllciByZWNsYW1hY2nDs24gbyBwZXJqdWljaW8uCg== |