Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.

In the ocular microbiota there are bacteria of the genera Staphylococcus, Corynebacterium spp., Bacillus spp., Neisseria spp., Moraxella spp. And Streptococcus spp (1). However, it has been described that the composition of the communities fluctuates according to factors such as temperature, age, se...

Full description

Autores:
Castrillón Suárez, Karen Juliet
Gutiérrez Chica, Carlos Andrés
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2021
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/4563
Acceso en línea:
http://repositorio.uan.edu.co/handle/123456789/4563
Palabra clave:
conjuntiva
microbiota
lentes de contacto
ojo
conjunctiva
microbiota
contact lenses
eye
Rights
closedAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
id UAntonioN2_e78a8804d76ba1107353d337b7c1858d
oai_identifier_str oai:repositorio.uan.edu.co:123456789/4563
network_acronym_str UAntonioN2
network_name_str Repositorio UAN
repository_id_str
dc.title.es_ES.fl_str_mv Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
title Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
spellingShingle Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
conjuntiva
microbiota
lentes de contacto
ojo
conjunctiva
microbiota
contact lenses
eye
title_short Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
title_full Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
title_fullStr Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
title_full_unstemmed Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
title_sort Influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.
dc.creator.fl_str_mv Castrillón Suárez, Karen Juliet
Gutiérrez Chica, Carlos Andrés
dc.contributor.advisor.spa.fl_str_mv Reyes Clavijo, Ligia Soraya
Vásquez Melo, Eliana Carolina
dc.contributor.author.spa.fl_str_mv Castrillón Suárez, Karen Juliet
Gutiérrez Chica, Carlos Andrés
dc.subject.es_ES.fl_str_mv conjuntiva
microbiota
lentes de contacto
ojo
topic conjuntiva
microbiota
lentes de contacto
ojo
conjunctiva
microbiota
contact lenses
eye
dc.subject.keyword.es_ES.fl_str_mv conjunctiva
microbiota
contact lenses
eye
description In the ocular microbiota there are bacteria of the genera Staphylococcus, Corynebacterium spp., Bacillus spp., Neisseria spp., Moraxella spp. And Streptococcus spp (1). However, it has been described that the composition of the communities fluctuates according to factors such as temperature, age, sex, environmental exposure and exposure to foreign bodies (1,2). Aspects such as prolonged use, the lack of asepsis of both the contact lens and the case where they are deposited, and the state of the cleaning fluids have been identified. These aspects lead to the identification of the use of contact lenses as a factor of risk for the development of eye disorders (1,2). Objective: To determine the influence of the use of contact lenses on the human ocular bacterial microbiota. Methodology: bibliographic review, ocular surface, cornea and contact lenses. A search of published articles of the last 10 years was carried out; taking into account the inclusion and exclusion criteria. Results: the bacteria with the highest frequency in the normal ocular microbiota were identified, which were Staphylococcus, Streptococcus, bacillus, and those with the highest frequency in contact lenses were: Staphylococcus aureus, Staphylococcus epidermis, Klepsiella pneumonide and Citrobacter diversus. Conclution:
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-08-10T14:57:44Z
dc.date.available.none.fl_str_mv 2021-08-10T14:57:44Z
dc.date.issued.spa.fl_str_mv 2021-05-25
dc.type.spa.fl_str_mv Trabajo de grado (Pregrado y/o Especialización)
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv http://repositorio.uan.edu.co/handle/123456789/4563
dc.identifier.bibliographicCitation.spa.fl_str_mv Martín Algarra V, Jaimes Niño V, Rodríguez Álvarez MF. Caracterización de la microbiota conjuntival transitoria y residente de adultos jóvenes. Ciencia Tecnol para la Salud Vis y Ocul. 2017;15(1):37.https://ciencia.lasalle.edu.co/svo/vol15/iss1/4/
Sankaridurg PR, Markoulli M, De La Jara PL, Harmis N, Varghese T, Willcox MDP, et al. Lid and conjunctival microbiota during contact lens wear in children. Optom Vis Sci. 2009;86(4):312– 7. https://pubmed.ncbi.nlm.nih.gov/19348019/
Dang and Lovellc. Reviews-2015-Dang-91. full. Am Soc Microbiol. 2015;80(1):91–138. https://sci-hub.se/10.1128/mmbr.00037-15
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474(11):1823–36.https://pubmed.ncbi.nlm.nih.gov/28512250/
Boost M, Cho P, Wang Z. Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome. Clin Exp Optom. 2017;100(5):459– 72. https://pubmed.ncbi.nlm.nih.gov/28771841/
Boost M V., Cho P. Microbial flora of tears of orthokeratology patients, and microbial contamination of contact lenses and contact lens accessories. Optom Vis Sci. 2005;82(6):451–8. file:///C:/Users/Usuario/Desktop/Alteraciones%20oculares%20relacionadas %20con%20la%20contaminaci%C3%B3n%20del%20aire%20art_files/Micro bial%20flora%20of%20tears%20of%20orthokeratology%20patients,%20and %20microbial%20contamination%20of%20contact%20le
Retuerto MA, Szczotka-Flynn L, Mukherjee PK, Debanne S, Iyengar SK, Richardson B, et al. Diversity of Ocular Surface Bacterial Microbiome Adherent to Worn Contact Lenses and Bacterial Communities Associated With Care Solution Use. Eye Contact Lens. 2019;45(5):331–9. file:///C:/Users/Usuario/Downloads/Diversity%20of%20Ocular%20Surface% 20Bacterial%20Microbiome%20Adherent%20to.is.es.pdf
Shin H, Price K, Albert L, Dodick J, Park L, Dominguez-Belloa MG. Changes in the eye microbiota associated with contact lens wearing. MBio. 2016;7(2):1– 6. file:///C:/Users/Usuario/Desktop/Alteraciones%20oculares%20relacionad as%20con%20la%20contaminaci%C3%B3n%20del%20aire%20art_files/art 9.pdf
Dorrepaal SJ, Gale J, El-Defrawy S, Sharma S. Resistance of ocular flora to gatifloxacin in patients undergoing intravitreal injections. Can J Ophthalmol [Internet]. 2014;49(1):66–71. Available from: http://dx.doi.org/10.1016/j.jcjo.2013.09.008
Willcox MDP. Characterization of the normal microbiota of the ocular surface. Exp Eye Res [Internet]. 2013;117:99–105. Available from: http://dx.doi.org/10.1016/j.exer.2013.06.003
dc.identifier.instname.spa.fl_str_mv instname:Universidad Antonio Nariño
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UAN
dc.identifier.repourl.spa.fl_str_mv repourl:https://repositorio.uan.edu.co/
url http://repositorio.uan.edu.co/handle/123456789/4563
identifier_str_mv Martín Algarra V, Jaimes Niño V, Rodríguez Álvarez MF. Caracterización de la microbiota conjuntival transitoria y residente de adultos jóvenes. Ciencia Tecnol para la Salud Vis y Ocul. 2017;15(1):37.https://ciencia.lasalle.edu.co/svo/vol15/iss1/4/
Sankaridurg PR, Markoulli M, De La Jara PL, Harmis N, Varghese T, Willcox MDP, et al. Lid and conjunctival microbiota during contact lens wear in children. Optom Vis Sci. 2009;86(4):312– 7. https://pubmed.ncbi.nlm.nih.gov/19348019/
Dang and Lovellc. Reviews-2015-Dang-91. full. Am Soc Microbiol. 2015;80(1):91–138. https://sci-hub.se/10.1128/mmbr.00037-15
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474(11):1823–36.https://pubmed.ncbi.nlm.nih.gov/28512250/
Boost M, Cho P, Wang Z. Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome. Clin Exp Optom. 2017;100(5):459– 72. https://pubmed.ncbi.nlm.nih.gov/28771841/
Boost M V., Cho P. Microbial flora of tears of orthokeratology patients, and microbial contamination of contact lenses and contact lens accessories. Optom Vis Sci. 2005;82(6):451–8. file:///C:/Users/Usuario/Desktop/Alteraciones%20oculares%20relacionadas %20con%20la%20contaminaci%C3%B3n%20del%20aire%20art_files/Micro bial%20flora%20of%20tears%20of%20orthokeratology%20patients,%20and %20microbial%20contamination%20of%20contact%20le
Retuerto MA, Szczotka-Flynn L, Mukherjee PK, Debanne S, Iyengar SK, Richardson B, et al. Diversity of Ocular Surface Bacterial Microbiome Adherent to Worn Contact Lenses and Bacterial Communities Associated With Care Solution Use. Eye Contact Lens. 2019;45(5):331–9. file:///C:/Users/Usuario/Downloads/Diversity%20of%20Ocular%20Surface% 20Bacterial%20Microbiome%20Adherent%20to.is.es.pdf
Shin H, Price K, Albert L, Dodick J, Park L, Dominguez-Belloa MG. Changes in the eye microbiota associated with contact lens wearing. MBio. 2016;7(2):1– 6. file:///C:/Users/Usuario/Desktop/Alteraciones%20oculares%20relacionad as%20con%20la%20contaminaci%C3%B3n%20del%20aire%20art_files/art 9.pdf
Dorrepaal SJ, Gale J, El-Defrawy S, Sharma S. Resistance of ocular flora to gatifloxacin in patients undergoing intravitreal injections. Can J Ophthalmol [Internet]. 2014;49(1):66–71. Available from: http://dx.doi.org/10.1016/j.jcjo.2013.09.008
Willcox MDP. Characterization of the normal microbiota of the ocular surface. Exp Eye Res [Internet]. 2013;117:99–105. Available from: http://dx.doi.org/10.1016/j.exer.2013.06.003
instname:Universidad Antonio Nariño
reponame:Repositorio Institucional UAN
repourl:https://repositorio.uan.edu.co/
dc.language.iso.spa.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv Acceso a solo metadatos
dc.rights.license.spa.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_14cb
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Acceso a solo metadatos
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
dc.publisher.spa.fl_str_mv Universidad Antonio Nariño
dc.publisher.program.spa.fl_str_mv Optometría
dc.publisher.faculty.spa.fl_str_mv Facultad de Optometría
dc.publisher.campus.spa.fl_str_mv Medellín
institution Universidad Antonio Nariño
bitstream.url.fl_str_mv https://repositorio.uan.edu.co/bitstreams/5c91dda1-472c-4eec-815e-81eeb9406ec9/download
https://repositorio.uan.edu.co/bitstreams/41d5b03f-e24f-4a8c-aa54-026b55ed6ae9/download
https://repositorio.uan.edu.co/bitstreams/58fed481-a633-4b66-91d3-9496681b2734/download
https://repositorio.uan.edu.co/bitstreams/c5dd1749-d570-41cf-bb57-cb5b26c456c3/download
https://repositorio.uan.edu.co/bitstreams/a78c438e-3979-4e8c-a10a-95cf7de008ac/download
bitstream.checksum.fl_str_mv 71601891374e413e87f109ad67cfe1e7
b28f8ef4936d48651d22bf8abebed0cb
51e3a533b44bfa10dadc3ce4a142ca2e
9868ccc48a14c8d591352b6eaf7f6239
c3b2cdca800aa01c6175488b1291697a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional UAN
repository.mail.fl_str_mv alertas.repositorio@uan.edu.co
_version_ 1812928333898317824
spelling Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso a solo metadatoshttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbReyes Clavijo, Ligia SorayaVásquez Melo, Eliana CarolinaCastrillón Suárez, Karen JulietGutiérrez Chica, Carlos Andrés20271629523. Karen Castrillon20271626845. Carlos Gutierrez2021-08-10T14:57:44Z2021-08-10T14:57:44Z2021-05-25http://repositorio.uan.edu.co/handle/123456789/4563Martín Algarra V, Jaimes Niño V, Rodríguez Álvarez MF. Caracterización de la microbiota conjuntival transitoria y residente de adultos jóvenes. Ciencia Tecnol para la Salud Vis y Ocul. 2017;15(1):37.https://ciencia.lasalle.edu.co/svo/vol15/iss1/4/Sankaridurg PR, Markoulli M, De La Jara PL, Harmis N, Varghese T, Willcox MDP, et al. Lid and conjunctival microbiota during contact lens wear in children. Optom Vis Sci. 2009;86(4):312– 7. https://pubmed.ncbi.nlm.nih.gov/19348019/Dang and Lovellc. Reviews-2015-Dang-91. full. Am Soc Microbiol. 2015;80(1):91–138. https://sci-hub.se/10.1128/mmbr.00037-15Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474(11):1823–36.https://pubmed.ncbi.nlm.nih.gov/28512250/Boost M, Cho P, Wang Z. Disturbing the balance: effect of contact lens use on the ocular proteome and microbiome. Clin Exp Optom. 2017;100(5):459– 72. https://pubmed.ncbi.nlm.nih.gov/28771841/Boost M V., Cho P. Microbial flora of tears of orthokeratology patients, and microbial contamination of contact lenses and contact lens accessories. Optom Vis Sci. 2005;82(6):451–8. file:///C:/Users/Usuario/Desktop/Alteraciones%20oculares%20relacionadas %20con%20la%20contaminaci%C3%B3n%20del%20aire%20art_files/Micro bial%20flora%20of%20tears%20of%20orthokeratology%20patients,%20and %20microbial%20contamination%20of%20contact%20leRetuerto MA, Szczotka-Flynn L, Mukherjee PK, Debanne S, Iyengar SK, Richardson B, et al. Diversity of Ocular Surface Bacterial Microbiome Adherent to Worn Contact Lenses and Bacterial Communities Associated With Care Solution Use. Eye Contact Lens. 2019;45(5):331–9. file:///C:/Users/Usuario/Downloads/Diversity%20of%20Ocular%20Surface% 20Bacterial%20Microbiome%20Adherent%20to.is.es.pdfShin H, Price K, Albert L, Dodick J, Park L, Dominguez-Belloa MG. Changes in the eye microbiota associated with contact lens wearing. MBio. 2016;7(2):1– 6. file:///C:/Users/Usuario/Desktop/Alteraciones%20oculares%20relacionad as%20con%20la%20contaminaci%C3%B3n%20del%20aire%20art_files/art 9.pdfDorrepaal SJ, Gale J, El-Defrawy S, Sharma S. Resistance of ocular flora to gatifloxacin in patients undergoing intravitreal injections. Can J Ophthalmol [Internet]. 2014;49(1):66–71. Available from: http://dx.doi.org/10.1016/j.jcjo.2013.09.008Willcox MDP. Characterization of the normal microbiota of the ocular surface. Exp Eye Res [Internet]. 2013;117:99–105. Available from: http://dx.doi.org/10.1016/j.exer.2013.06.003instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/In the ocular microbiota there are bacteria of the genera Staphylococcus, Corynebacterium spp., Bacillus spp., Neisseria spp., Moraxella spp. And Streptococcus spp (1). However, it has been described that the composition of the communities fluctuates according to factors such as temperature, age, sex, environmental exposure and exposure to foreign bodies (1,2). Aspects such as prolonged use, the lack of asepsis of both the contact lens and the case where they are deposited, and the state of the cleaning fluids have been identified. These aspects lead to the identification of the use of contact lenses as a factor of risk for the development of eye disorders (1,2). Objective: To determine the influence of the use of contact lenses on the human ocular bacterial microbiota. Methodology: bibliographic review, ocular surface, cornea and contact lenses. A search of published articles of the last 10 years was carried out; taking into account the inclusion and exclusion criteria. Results: the bacteria with the highest frequency in the normal ocular microbiota were identified, which were Staphylococcus, Streptococcus, bacillus, and those with the highest frequency in contact lenses were: Staphylococcus aureus, Staphylococcus epidermis, Klepsiella pneumonide and Citrobacter diversus. Conclution:En la microbiota ocular se encuentran bacterias de los géneros Staphylococcus, Corynebacterium spp., Bacillus spp., Neisseria spp., Moraxella spp. Y Streptococcus spp (1,2). Sin embargo, se ha descrito que la composición de las comunidades fluctúa según factores como la temperatura, la edad, sexo, exposición ambiental y por exposición a cuerpos extraños (1,2). Se han identificado aspectos como, el uso prolongado, la falta de asepsia tanto del lente de contacto como del estuche donde se depositan y el estado de los líquidos de limpieza, dichos aspectos hacen que se identifique el uso de lentes de contacto como un factor de riesgo para el desarrollo de afecciones oculares (2). Objetivo: Determinar la influencia del uso de lentes de contacto en la microbiota bacteriana ocular humana. Metodología: revisión bibliográfica, de superficie ocular, córnea y lentes de contacto, Se realizó una búsqueda de artículos publicados, de los últimos 10 años; teniendo en cuenta los criterios de inclusión y exclusión. Resultados: se identificaron las bacterias con mayor frecuencia en la microbiota ocular normal las cuales fueron, Staphylococcus, Streptococcus, bacillus y las de mayor frecuencia en lentes de contacto fueron: Staphylococcus aureus, Staphylococcus epidermis, Klepsiella pneumonide y Citrobacter diversus.OptómetraPregradoPresencialspaUniversidad Antonio NariñoOptometríaFacultad de OptometríaMedellínconjuntivamicrobiotalentes de contactoojoconjunctivamicrobiotacontact lenseseyeInfluencia del uso de lentes de contacto en la microbiota bacteriana ocular humana.Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85GeneralORIGINAL2021_KarenJulietCastrillónSuárez.pdf2021_KarenJulietCastrillónSuárez.pdfapplication/pdf774903https://repositorio.uan.edu.co/bitstreams/5c91dda1-472c-4eec-815e-81eeb9406ec9/download71601891374e413e87f109ad67cfe1e7MD512021_KarenJulietCastrillónSuárez_Autorización.pdf2021_KarenJulietCastrillónSuárez_Autorización.pdfapplication/pdf3508634https://repositorio.uan.edu.co/bitstreams/41d5b03f-e24f-4a8c-aa54-026b55ed6ae9/downloadb28f8ef4936d48651d22bf8abebed0cbMD522021_KarenJulietCastrillónSuárez_Acta.pdf2021_KarenJulietCastrillónSuárez_Acta.pdfapplication/pdf162548https://repositorio.uan.edu.co/bitstreams/58fed481-a633-4b66-91d3-9496681b2734/download51e3a533b44bfa10dadc3ce4a142ca2eMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.uan.edu.co/bitstreams/c5dd1749-d570-41cf-bb57-cb5b26c456c3/download9868ccc48a14c8d591352b6eaf7f6239MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-83747https://repositorio.uan.edu.co/bitstreams/a78c438e-3979-4e8c-a10a-95cf7de008ac/downloadc3b2cdca800aa01c6175488b1291697aMD55123456789/4563oai:repositorio.uan.edu.co:123456789/45632024-10-09 23:35:31.912https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso a solo metadatosrestrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.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