Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi.
Chagas disease is endemic in some rural and tropical areas. Currently there are only two antiparasitics to treat this pathology, their efficacy varies according to the phase of the disease and reports show serious side effects in treated patients, which highlights the need for further research and d...
- Autores:
-
Sanabria Martínez, Yeimy Alejandra
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2023
- Institución:
- Universidad Antonio Nariño
- Repositorio:
- Repositorio UAN
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uan.edu.co:123456789/8335
- Acceso en línea:
- http://repositorio.uan.edu.co/handle/123456789/8335
- Palabra clave:
- Bioquimica
574
38.23 S197e
Biochemistry
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| title |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| spellingShingle |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. Bioquimica 574 38.23 S197e Biochemistry |
| title_short |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| title_full |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| title_fullStr |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| title_full_unstemmed |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| title_sort |
Evaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi. |
| dc.creator.fl_str_mv |
Sanabria Martínez, Yeimy Alejandra |
| dc.contributor.advisor.spa.fl_str_mv |
Bernal Rosas, Yuly Elien |
| dc.contributor.author.spa.fl_str_mv |
Sanabria Martínez, Yeimy Alejandra |
| dc.subject.es_ES.fl_str_mv |
Bioquimica |
| topic |
Bioquimica 574 38.23 S197e Biochemistry |
| dc.subject.ddc.es_ES.fl_str_mv |
574 38.23 S197e |
| dc.subject.keyword.es_ES.fl_str_mv |
Biochemistry |
| description |
Chagas disease is endemic in some rural and tropical areas. Currently there are only two antiparasitics to treat this pathology, their efficacy varies according to the phase of the disease and reports show serious side effects in treated patients, which highlights the need for further research and development of new treatments of vegetable origin, with molecules that contain biological potential and action, since their compounds contain important medicinal and phytochemical properties. |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-07-28T20:40:35Z |
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2023-07-28T20:40:35Z |
| dc.date.issued.spa.fl_str_mv |
2023-05-25 |
| dc.type.spa.fl_str_mv |
Trabajo de grado (Pregrado y/o Especialización) |
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http://repositorio.uan.edu.co/handle/123456789/8335 |
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Endalkachew Nibret and others, Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloidproducing plants of Ethiopia, Journal of Pharmacy and Pharmacology, Volume 61, Issue 6, June 2009, Pages 801–808, https://doi.org/10.1211/jpp.61.06.0014 Simoben, C. V., Ntie-Kang, F., Akone, S. H., & Sippl, W. (2018). Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. Natural products and bioprospecting, 8(3), 151–169. https://doi.org/10.1007/s13659-018-0165-y Gouhari, A. R., SAEIDNIA, S., HAJI, A. A., NAGHINEZHAD, A., & Yagura, T. (2008). Trypanocidal activity of some medicinal plants against the epimastigotes of Trypanosoma cruzi. Polonio, T., & Efferth, T. (2008). Leishmaniasis: drug resistance and natural products (review). International journal of molecular medicine, 22(3), 277–286. Catherine, A., & Neira, N. (n.d.). “Evaluación de la actividad tripanocida de extractos de plantas del género Piper en cultivos de Trypanosoma cruzi.” Edu.Co. Retrieved May 28, 2023, from https://repositorio.unal.edu.co/bitstream/handle/unal/82317/1032465907.%202022.pdf?sequence=4 Investigaciones Fármaco Bioquímicas, M. E. N. C. B. Y. B. I. (n.d.). UNIVERSIDAD MAYOR DE SAN ANDRES. Umsa.Bo. Retrieved May 28, 2023, from https://repositorio.umsa.bo/bitstream/handle/123456789/22719/TM-1951.pdf?sequence=1&isAllowed=y J. (n.d.). G r a d o e n F a r m a c i a. Ull.Es. Retrieved May 28, 2023, from https://riull.ull.es/xmlui/bitstream/handle/915/29019/Actividad%20tripanocida%20de%20compuestos%20 derivados%20de%20la%20Withaferina%20A.pdf?sequence=1&isAllowed=y J. (n.d.). G r a d o e n F a r m a c i a. Ull.Es. Retrieved May 28, 2023, from https://riull.ull.es/xmlui/bitstream/handle/915/29019/Actividad%20tripanocida%20de%20compuestos%20 derivados%20de%20la%20Withaferina%20A.pdf?sequence=1&isAllowed=y Fayed, M. A. A. (2021). Heliotropium; a genus rich in pyrrolizidine alkaloids: A systematic review following its phytochemistry and pharmacology. Phytomedicine plus: International Journal of Phytotherapy and Phytopharmacology, 1(2), 100036. https://doi.org/10.1016/j.phyplu.2021.100036 Fournet, A., & Muñoz, V. (2002). Natural products as trypanocidal, antileishmanial and antimalarial drugs. Current Topics in Medicinal Chemistry, 2(11), 1215–1237. https://doi.org/10.2174/1568026023393011 |
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Endalkachew Nibret and others, Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloidproducing plants of Ethiopia, Journal of Pharmacy and Pharmacology, Volume 61, Issue 6, June 2009, Pages 801–808, https://doi.org/10.1211/jpp.61.06.0014 Simoben, C. V., Ntie-Kang, F., Akone, S. H., & Sippl, W. (2018). Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. Natural products and bioprospecting, 8(3), 151–169. https://doi.org/10.1007/s13659-018-0165-y Gouhari, A. R., SAEIDNIA, S., HAJI, A. A., NAGHINEZHAD, A., & Yagura, T. (2008). Trypanocidal activity of some medicinal plants against the epimastigotes of Trypanosoma cruzi. Polonio, T., & Efferth, T. (2008). Leishmaniasis: drug resistance and natural products (review). International journal of molecular medicine, 22(3), 277–286. Catherine, A., & Neira, N. (n.d.). “Evaluación de la actividad tripanocida de extractos de plantas del género Piper en cultivos de Trypanosoma cruzi.” Edu.Co. Retrieved May 28, 2023, from https://repositorio.unal.edu.co/bitstream/handle/unal/82317/1032465907.%202022.pdf?sequence=4 Investigaciones Fármaco Bioquímicas, M. E. N. C. B. Y. B. I. (n.d.). UNIVERSIDAD MAYOR DE SAN ANDRES. Umsa.Bo. Retrieved May 28, 2023, from https://repositorio.umsa.bo/bitstream/handle/123456789/22719/TM-1951.pdf?sequence=1&isAllowed=y J. (n.d.). G r a d o e n F a r m a c i a. Ull.Es. Retrieved May 28, 2023, from https://riull.ull.es/xmlui/bitstream/handle/915/29019/Actividad%20tripanocida%20de%20compuestos%20 derivados%20de%20la%20Withaferina%20A.pdf?sequence=1&isAllowed=y J. (n.d.). G r a d o e n F a r m a c i a. Ull.Es. Retrieved May 28, 2023, from https://riull.ull.es/xmlui/bitstream/handle/915/29019/Actividad%20tripanocida%20de%20compuestos%20 derivados%20de%20la%20Withaferina%20A.pdf?sequence=1&isAllowed=y Fayed, M. A. A. (2021). Heliotropium; a genus rich in pyrrolizidine alkaloids: A systematic review following its phytochemistry and pharmacology. Phytomedicine plus: International Journal of Phytotherapy and Phytopharmacology, 1(2), 100036. https://doi.org/10.1016/j.phyplu.2021.100036 Fournet, A., & Muñoz, V. (2002). Natural products as trypanocidal, antileishmanial and antimalarial drugs. Current Topics in Medicinal Chemistry, 2(11), 1215–1237. https://doi.org/10.2174/1568026023393011 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ |
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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Bernal Rosas, Yuly ElienSanabria Martínez, Yeimy Alejandra118219271372023-07-28T20:40:35Z2023-07-28T20:40:35Z2023-05-25http://repositorio.uan.edu.co/handle/123456789/8335Endalkachew Nibret and others, Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloidproducing plants of Ethiopia, Journal of Pharmacy and Pharmacology, Volume 61, Issue 6, June 2009, Pages 801–808, https://doi.org/10.1211/jpp.61.06.0014Simoben, C. V., Ntie-Kang, F., Akone, S. H., & Sippl, W. (2018). Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. Natural products and bioprospecting, 8(3), 151–169. https://doi.org/10.1007/s13659-018-0165-yGouhari, A. R., SAEIDNIA, S., HAJI, A. A., NAGHINEZHAD, A., & Yagura, T. (2008). Trypanocidal activity of some medicinal plants against the epimastigotes of Trypanosoma cruzi.Polonio, T., & Efferth, T. (2008). Leishmaniasis: drug resistance and natural products (review). International journal of molecular medicine, 22(3), 277–286.Catherine, A., & Neira, N. (n.d.). “Evaluación de la actividad tripanocida de extractos de plantas del género Piper en cultivos de Trypanosoma cruzi.” Edu.Co. Retrieved May 28, 2023, from https://repositorio.unal.edu.co/bitstream/handle/unal/82317/1032465907.%202022.pdf?sequence=4Investigaciones Fármaco Bioquímicas, M. E. N. C. B. Y. B. I. (n.d.). UNIVERSIDAD MAYOR DE SAN ANDRES. Umsa.Bo. Retrieved May 28, 2023, from https://repositorio.umsa.bo/bitstream/handle/123456789/22719/TM-1951.pdf?sequence=1&isAllowed=yJ. (n.d.). G r a d o e n F a r m a c i a. Ull.Es. Retrieved May 28, 2023, from https://riull.ull.es/xmlui/bitstream/handle/915/29019/Actividad%20tripanocida%20de%20compuestos%20 derivados%20de%20la%20Withaferina%20A.pdf?sequence=1&isAllowed=yJ. (n.d.). G r a d o e n F a r m a c i a. Ull.Es. Retrieved May 28, 2023, from https://riull.ull.es/xmlui/bitstream/handle/915/29019/Actividad%20tripanocida%20de%20compuestos%20 derivados%20de%20la%20Withaferina%20A.pdf?sequence=1&isAllowed=yFayed, M. A. A. (2021). Heliotropium; a genus rich in pyrrolizidine alkaloids: A systematic review following its phytochemistry and pharmacology. Phytomedicine plus: International Journal of Phytotherapy and Phytopharmacology, 1(2), 100036. https://doi.org/10.1016/j.phyplu.2021.100036Fournet, A., & Muñoz, V. (2002). Natural products as trypanocidal, antileishmanial and antimalarial drugs. Current Topics in Medicinal Chemistry, 2(11), 1215–1237. https://doi.org/10.2174/1568026023393011instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/Chagas disease is endemic in some rural and tropical areas. Currently there are only two antiparasitics to treat this pathology, their efficacy varies according to the phase of the disease and reports show serious side effects in treated patients, which highlights the need for further research and development of new treatments of vegetable origin, with molecules that contain biological potential and action, since their compounds contain important medicinal and phytochemical properties.La enfermedad de Chagas es endémica en algunas áreas rurales y tropicales. En la actualidad solo se cuenta con dos antiparasitarios para tratar esta patología, su eficacia varía según la fase en que se encuentre la enfermedad y los reportes evidencian efectos secundarios graves en los pacientes tratados, lo que destaca la necesidad de una mayor investigación y desarrollo de nuevos tratamientos de origen vegetal, con moléculas que contengan potencial y acción biológica, ya que sus compuestos contienen propiedades medicinales, y fitoquímicas importantes. Heliotropium indicum es una planta herbácea de zonas tropicales de América que se caracteriza por su gran cantidad de alcaloides de pirrolizidina, flavonoides y terpenoides con actividad antibacteriana, antifúngica y antiparasitaria.Bioquímico(a)PregradoPresencialInvestigaciónspaUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - CircunvalarBioquimica57438.23 S197eBiochemistryEvaluación de la fracción de cloroformo de Heliotropium indicum sobre cultivo de epimastigotes y tripomastigotes de Trypanosoma cruzi.Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85GeneralORIGINAL2023_YeimyAlejandraSanabriaMartínez.pdf2023_YeimyAlejandraSanabriaMartínez.pdfapplication/pdf1008487https://repositorio.uan.edu.co/bitstreams/979950c1-a5d4-404c-957e-3c6affe9c5bb/download70a22ce5c9284bbe3a60b702ee81bb34MD512023_YeimyAlejandraSanabriaMartínez_Acta .pdf2023_YeimyAlejandraSanabriaMartínez_Acta .pdfapplication/pdf1616838https://repositorio.uan.edu.co/bitstreams/757ef6e2-269c-4597-8a4d-20ee828da922/download71d1b57733b6b30eebc1b8881a4624a7MD532023_YeimyAlejandraSanabriaMartínez_Autorizacion.pdf2023_YeimyAlejandraSanabriaMartínez_Autorizacion.pdfapplication/pdf1792256https://repositorio.uan.edu.co/bitstreams/6def5e2c-8375-4937-b4d4-365eceaaba75/download477571f935cf3f1288950b4e7b70a10fMD55CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.uan.edu.co/bitstreams/75075310-1fe8-4c14-ab37-cb7826ed3b76/download9868ccc48a14c8d591352b6eaf7f6239MD56123456789/8335oai:repositorio.uan.edu.co:123456789/83352024-10-09 22:39:52.9https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertoopen.accesshttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co |