Efectos adversos corneales del uso de los AINES oculares

Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that combine therapeutic effects and adverse effects; contributing analgesic, anti-inflammatory and antipyretic properties (1). They are formulated after surgical procedures such as keratoplasty, cataract extraction, refractive surgery, and for the control of inflammatory-type ocular surface disorders. Furthermore, his activity anti-inflammatory lies in the inhibition of the enzyme cyclooxygenase (COX) in its isoforms like COX-1 and COX-2, the first is a physiological form that is found naturally common in the kidney, intestinal tract, monocytes/macrophages and platelets. It is expressed in formation of essential prostaglandins (2). The action of NSAIDs is to generate a reversible inhibition of these enzymes in order to to slow down the formation of prostaglandins whose action is to mediate the processes inflammatory. In contrast, COX-2 is almost undetectable in normal tissues, its manifestation is given by the release of some inflammatory-type prostaglandins, which lead to the appearance of inflammatory mechanisms and the amplification of signals painful in the inflamed areas(3).

• Autores: Panesso Palacios, Nardy Kamerlin; Jaramillo Salazar, Stefania; Montoya Herrera, Sandra Milena
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2021
• Institución: Universidad Antonio Nariño
• Repositorio: Repositorio UAN
• Idioma: spa
• OAI Identifier: oai:repositorio.uan.edu.co:123456789/6541
• Acceso en línea: http://repositorio.uan.edu.co/handle/123456789/6541
• Palabra clave: Ketorolaco; Diclofenaco; Bromfenaco,; Superficie ocular; Efectos adversos; Antiinflamatorios no esteroideos; Cirugia de catarata; Ketorolac; Diclofenac; Bromfenac; Ocular surface; Adverse effects; Non-steroidal anti-inflammatory drugs; Cataract surgery
• Rights: openAccess
• License: Attribution 4.0 International (CC BY 4.0)