Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas

The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is considered one of the major health problems in South America. Molecular studies exhibit this parasite has a wide genetic diversity, being classified into six discrete typing units (Tc I - VI) and other related to bats (T...

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Autores:: Rodríguez Acosta, Anyi Lorena

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2021

Institución:: Universidad Antonio Nariño

Repositorio:: Repositorio UAN

Idioma:: spa

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dc.title.es_ES.fl_str_mv	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
spellingShingle	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs). 540 Chagas disease Triatomines Trypanosoma cruzi Discrete typing unit (DTU)
title_short	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_full	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_fullStr	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_full_unstemmed	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
title_sort	Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de Chagas
dc.creator.fl_str_mv	Rodríguez Acosta, Anyi Lorena
dc.contributor.advisor.spa.fl_str_mv	Bernal Rosas, Yuly Elien Torres García, Orlando Alfredo
dc.contributor.author.spa.fl_str_mv	Rodríguez Acosta, Anyi Lorena
dc.subject.es_ES.fl_str_mv	Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs).
topic	Enfermedad de Chagas Triatominos Trypanosoma cruzi Unidades discretas de tipificación (UDTs). 540 Chagas disease Triatomines Trypanosoma cruzi Discrete typing unit (DTU)
dc.subject.ddc.es_ES.fl_str_mv	540
dc.subject.keyword.es_ES.fl_str_mv	Chagas disease Triatomines Trypanosoma cruzi Discrete typing unit (DTU)
description	The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is considered one of the major health problems in South America. Molecular studies exhibit this parasite has a wide genetic diversity, being classified into six discrete typing units (Tc I - VI) and other related to bats (T Bat). This parasite has a high clinical and genetic diversity; but its immunopathogenesis is still quite unknown. It should be noted that the pathogenicity of some strains differs in their mechanism of infection and spread according to the host, which makes it difficult to predict the results of the disease. Therefore, a bibliographic search was carried for evidence published in various information sources was carried out, during the period 2015 to 2021, in order to obtain the most up-to-date data on research advances related to the genetic variability of the parasite associated with its geographical distribution, vectors, reservoirs and finally the clinical manifestations in people. The findings of this bibliographic review allowed us to conclude that the great plasticity, virulence of the parasite and the immune response of the hosts are determinants that influence the distribution of the different discrete typing units and the presentation of clinical pictures.
publishDate	2021
dc.date.issued.spa.fl_str_mv	2021-11-23
dc.date.accessioned.none.fl_str_mv	2022-04-30T01:07:27Z
dc.date.available.none.fl_str_mv	2022-04-30T01:07:27Z
dc.type.spa.fl_str_mv	Trabajo de grado (Pregrado y/o Especialización)
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dc.identifier.uri.none.fl_str_mv	http://repositorio.uan.edu.co/handle/123456789/6377
dc.identifier.bibliographicCitation.spa.fl_str_mv	Abarca, H., Trubnykova, M., Chavesta, F., Ordoñez, M., & Rondón, E. (2021). Variantes en el número de copias en neonatos aneuploides. Biomedica, 41, 282–292. https://doi.org/10.7705/biomedica.5354 Abras, A., Muñoz, C., Juiz, N. A., Carlos, J., Cura, C. I., Tebar, S., Fernández-arévalo, A., Pinazo, M., De, L., Posada, E., Navarro, F., Espinal, P., Ballart, C., Gascón, J., & Schijman, A. G. (2017). Parasitology International Identi fi cation of Trypanosoma cruzi Discrete Typing Units ( DTUs ) in Latin-American migrants in Barcelona ( Spain ). Parasitology International, 66(2), 83–88. https://doi.org/10.1016/j.parint.2016.12.003 Almeida, L., Vasconcelos, S. De, Oliveira, J. C., Allan, G., Augusto, J., Guerra, D. O., Vale, G., & Guerra, B. (2021). Case Report Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute Chagas disease in a domiciliated dog in the western Amazon. Revista Da Sociedade Brasileira de Medicina Tropica, 54, 1–4. Andrés, R., Díaz, C., Forsyth, C., Alberto, O., Marchiol, A., Beltrán, M., Batista, C., Herazo, R., Javier, M., Pachon, E., Valencia-hernández, C. A., Carolina, A., & Sánchez, F. (2019). International Journal of Infectious Diseases Comparative evaluation of immunoassays to improve access to diagnosis for Chagas disease in Colombia. International Journal of Infectious Diseases, 87, 100–108. https://doi.org/10.1016/j.ijid.2019.07.022 Anónimo. (1999). Recommendations from a satellite meeting. Internartional Symposium to commemorate the 90th anniversary of the discovery of chagas disease, Rio de Janeiro,Brazil. Memorias Do Instituto Oswaldo Cruz, 94 Suppl 1, 429–432. Avispas, M. (2019). Control biológico de vectores de la enfermedad de Chagas con Microhimenopteros (Micro Avispas). 7, 85–93. Balouz, V., Camea, C. C., Cori, C., Kashiwagi, G. A., Gil, S. A., Paula, N., Macchiaverna, N. P., Cardinal, M. V., Guaimas, F., Lobo, M., Lederkremer, R. M., Gallo-rodriguez, C., & Buscaglia, C. A. (2019). Trypanosoma cruzi surface mucins are involved in the attachment to the Triatoma infestans rectal ampoule. 1–23. Barja, M. R., Rus, L. I., Boquete, T., Benito, A., & Hernández, T. B. (2021). Key Chagas disease missing knowledge among at ‑ risk population in Spain affecting diagnosis and treatment. Infectious Diseases of Poverty, 1–11. https://doi.org/10.1186/s40249-021- 00841-4 Barnabé, C., Mobarec, H. I., Jurado, M. R., Cortez, J. A., & Brenière, S. F. (2016). Reconsideration of the seven discrete typing units within the species Trypanosoma cruzi, a new proposal of three reliable mitochondrial clades. Infection, Genetics and Evolution, 39, 176–186. https://doi.org/10.1016/j.meegid.2016.01.029 Barros, J. H. S., Xavier, S. C. C., Bilac, D., Lima, V. S., Dario, M. A., & Jansen, A. M. (2017). Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV. Acta Tropica, 172(May), 173–179. https://doi.org/10.1016/j.actatropica.2017.05.003
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identifier_str_mv	Abarca, H., Trubnykova, M., Chavesta, F., Ordoñez, M., & Rondón, E. (2021). Variantes en el número de copias en neonatos aneuploides. Biomedica, 41, 282–292. https://doi.org/10.7705/biomedica.5354 Abras, A., Muñoz, C., Juiz, N. A., Carlos, J., Cura, C. I., Tebar, S., Fernández-arévalo, A., Pinazo, M., De, L., Posada, E., Navarro, F., Espinal, P., Ballart, C., Gascón, J., & Schijman, A. G. (2017). Parasitology International Identi fi cation of Trypanosoma cruzi Discrete Typing Units ( DTUs ) in Latin-American migrants in Barcelona ( Spain ). Parasitology International, 66(2), 83–88. https://doi.org/10.1016/j.parint.2016.12.003 Almeida, L., Vasconcelos, S. De, Oliveira, J. C., Allan, G., Augusto, J., Guerra, D. O., Vale, G., & Guerra, B. (2021). Case Report Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute Chagas disease in a domiciliated dog in the western Amazon. Revista Da Sociedade Brasileira de Medicina Tropica, 54, 1–4. Andrés, R., Díaz, C., Forsyth, C., Alberto, O., Marchiol, A., Beltrán, M., Batista, C., Herazo, R., Javier, M., Pachon, E., Valencia-hernández, C. A., Carolina, A., & Sánchez, F. (2019). International Journal of Infectious Diseases Comparative evaluation of immunoassays to improve access to diagnosis for Chagas disease in Colombia. International Journal of Infectious Diseases, 87, 100–108. https://doi.org/10.1016/j.ijid.2019.07.022 Anónimo. (1999). Recommendations from a satellite meeting. Internartional Symposium to commemorate the 90th anniversary of the discovery of chagas disease, Rio de Janeiro,Brazil. Memorias Do Instituto Oswaldo Cruz, 94 Suppl 1, 429–432. Avispas, M. (2019). Control biológico de vectores de la enfermedad de Chagas con Microhimenopteros (Micro Avispas). 7, 85–93. Balouz, V., Camea, C. C., Cori, C., Kashiwagi, G. A., Gil, S. A., Paula, N., Macchiaverna, N. P., Cardinal, M. V., Guaimas, F., Lobo, M., Lederkremer, R. M., Gallo-rodriguez, C., & Buscaglia, C. A. (2019). Trypanosoma cruzi surface mucins are involved in the attachment to the Triatoma infestans rectal ampoule. 1–23. Barja, M. R., Rus, L. I., Boquete, T., Benito, A., & Hernández, T. B. (2021). Key Chagas disease missing knowledge among at ‑ risk population in Spain affecting diagnosis and treatment. Infectious Diseases of Poverty, 1–11. https://doi.org/10.1186/s40249-021- 00841-4 Barnabé, C., Mobarec, H. I., Jurado, M. R., Cortez, J. A., & Brenière, S. F. (2016). Reconsideration of the seven discrete typing units within the species Trypanosoma cruzi, a new proposal of three reliable mitochondrial clades. Infection, Genetics and Evolution, 39, 176–186. https://doi.org/10.1016/j.meegid.2016.01.029 Barros, J. H. S., Xavier, S. C. C., Bilac, D., Lima, V. S., Dario, M. A., & Jansen, A. M. (2017). Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV. Acta Tropica, 172(May), 173–179. https://doi.org/10.1016/j.actatropica.2017.05.003 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/
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dc.publisher.spa.fl_str_mv	Universidad Antonio Nariño
dc.publisher.program.spa.fl_str_mv	Bioquímica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.campus.spa.fl_str_mv	Bogotá - Circunvalar
institution	Universidad Antonio Nariño
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spelling	Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Bernal Rosas, Yuly ElienTorres García, Orlando AlfredoRodríguez Acosta, Anyi Lorena118217110052022-04-30T01:07:27Z2022-04-30T01:07:27Z2021-11-23http://repositorio.uan.edu.co/handle/123456789/6377Abarca, H., Trubnykova, M., Chavesta, F., Ordoñez, M., & Rondón, E. (2021). Variantes en el número de copias en neonatos aneuploides. Biomedica, 41, 282–292. https://doi.org/10.7705/biomedica.5354Abras, A., Muñoz, C., Juiz, N. A., Carlos, J., Cura, C. I., Tebar, S., Fernández-arévalo, A., Pinazo, M., De, L., Posada, E., Navarro, F., Espinal, P., Ballart, C., Gascón, J., & Schijman, A. G. (2017). Parasitology International Identi fi cation of Trypanosoma cruzi Discrete Typing Units ( DTUs ) in Latin-American migrants in Barcelona ( Spain ). Parasitology International, 66(2), 83–88. https://doi.org/10.1016/j.parint.2016.12.003Almeida, L., Vasconcelos, S. De, Oliveira, J. C., Allan, G., Augusto, J., Guerra, D. O., Vale, G., & Guerra, B. (2021). Case Report Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute Chagas disease in a domiciliated dog in the western Amazon. Revista Da Sociedade Brasileira de Medicina Tropica, 54, 1–4.Andrés, R., Díaz, C., Forsyth, C., Alberto, O., Marchiol, A., Beltrán, M., Batista, C., Herazo, R., Javier, M., Pachon, E., Valencia-hernández, C. A., Carolina, A., & Sánchez, F. (2019). International Journal of Infectious Diseases Comparative evaluation of immunoassays to improve access to diagnosis for Chagas disease in Colombia. International Journal of Infectious Diseases, 87, 100–108. https://doi.org/10.1016/j.ijid.2019.07.022Anónimo. (1999). Recommendations from a satellite meeting. Internartional Symposium to commemorate the 90th anniversary of the discovery of chagas disease, Rio de Janeiro,Brazil. Memorias Do Instituto Oswaldo Cruz, 94 Suppl 1, 429–432.Avispas, M. (2019). Control biológico de vectores de la enfermedad de Chagas con Microhimenopteros (Micro Avispas). 7, 85–93.Balouz, V., Camea, C. C., Cori, C., Kashiwagi, G. A., Gil, S. A., Paula, N., Macchiaverna, N. P., Cardinal, M. V., Guaimas, F., Lobo, M., Lederkremer, R. M., Gallo-rodriguez, C., & Buscaglia, C. A. (2019). Trypanosoma cruzi surface mucins are involved in the attachment to the Triatoma infestans rectal ampoule. 1–23.Barja, M. R., Rus, L. I., Boquete, T., Benito, A., & Hernández, T. B. (2021). Key Chagas disease missing knowledge among at ‑ risk population in Spain affecting diagnosis and treatment. Infectious Diseases of Poverty, 1–11. https://doi.org/10.1186/s40249-021- 00841-4Barnabé, C., Mobarec, H. I., Jurado, M. R., Cortez, J. A., & Brenière, S. F. (2016). Reconsideration of the seven discrete typing units within the species Trypanosoma cruzi, a new proposal of three reliable mitochondrial clades. Infection, Genetics and Evolution, 39, 176–186. https://doi.org/10.1016/j.meegid.2016.01.029Barros, J. H. S., Xavier, S. C. C., Bilac, D., Lima, V. S., Dario, M. A., & Jansen, A. M. (2017). Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV. Acta Tropica, 172(May), 173–179. https://doi.org/10.1016/j.actatropica.2017.05.003instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is considered one of the major health problems in South America. Molecular studies exhibit this parasite has a wide genetic diversity, being classified into six discrete typing units (Tc I - VI) and other related to bats (T Bat). This parasite has a high clinical and genetic diversity; but its immunopathogenesis is still quite unknown. It should be noted that the pathogenicity of some strains differs in their mechanism of infection and spread according to the host, which makes it difficult to predict the results of the disease. Therefore, a bibliographic search was carried for evidence published in various information sources was carried out, during the period 2015 to 2021, in order to obtain the most up-to-date data on research advances related to the genetic variability of the parasite associated with its geographical distribution, vectors, reservoirs and finally the clinical manifestations in people. The findings of this bibliographic review allowed us to conclude that the great plasticity, virulence of the parasite and the immune response of the hosts are determinants that influence the distribution of the different discrete typing units and the presentation of clinical pictures.El protozoario Trypanosoma cruzi es el agente causal de la enfermedad de Chagas y se considera uno de los mayores problemas de salud en Sudamérica. Estudios moleculares han demostrado que este parásito presenta una amplia diversidad genética, clasificándose en seis unidades discretas de tipificación (Tc I – VI) y una más, relacionada con murciélagos (T Bat). Este parásito presenta una alta diversidad clínica y genética, pero su inmunopatogénesis aún es bastante desconocida. La patogenicidad de algunas cepas difiere en su mecanismo de infección y propagación según el hospedero, lo que dificulta la predicción de los resultados de la enfermedad. A partir de ello se realizó una búsqueda bibliográfica de evidencia publicada en diversas fuentes de información, durante el periodo 2015 a 2021, con el fin de obtener los datos más actualizados sobre los avances investigativos relacionados con la variabilidad genética del parásito relacionado a su distribución geográfica, vectores, reservorios y finalmente a las manifestaciones clínicas que presentan las personas infectadas. Los hallazgos de esta revisión bibliográfica permitieron concluir que la gran plasticidad, la virulencia del parásito y la respuesta inmune de los hospederos son determinantes que influyen en la distribución de las diferentes unidades discretas de tipificación y la presentación de los cuadros clínicos.Bioquímico(a)PregradoPresencialMonografíaspaUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - CircunvalarEnfermedad de ChagasTriatominosTrypanosoma cruziUnidades discretas de tipificación (UDTs).540Chagas diseaseTriatominesTrypanosoma cruziDiscrete typing unit (DTU)Relación entre Unidades Discretas de Tipificación de Trypanosoma cruzi y la enfermedad de ChagasTrabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85EspecializadaORIGINAL2021_AnyiLorenaRodriguezAcosta_Autorización.pdf2021_AnyiLorenaRodriguezAcosta_Autorización.pdfFormato de autorización de autoresapplication/pdf1200061https://repositorio.uan.edu.co/bitstreams/90e952a4-75b2-422a-af91-ce6a1f576048/downloadff1280f30e335fac57841a2eb4cb4bb6MD512021_AnyiLorenaRodriguezAcosta.pdf2021_AnyiLorenaRodriguezAcosta.pdfTrabajo de gradoapplication/pdf1158662https://repositorio.uan.edu.co/bitstreams/cb0a0a26-ac65-4255-bb8c-ffd407f1524a/downloade4dda635be9071f40625e0aa06d7e6c1MD522021_AnyiLorenaRodriguezAcosta_Acta.pdf2021_AnyiLorenaRodriguezAcosta_Acta.pdfActa de sustentaciónapplication/pdf515923https://repositorio.uan.edu.co/bitstreams/49530f54-a839-4797-b5ec-5941fdbf2962/download266282d79b8dc669429a01d8d8cb1a04MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.uan.edu.co/bitstreams/75235fe5-6a31-448a-8300-995db8c8a4b9/download9868ccc48a14c8d591352b6eaf7f6239MD54123456789/6377oai:repositorio.uan.edu.co:123456789/63772024-10-09 22:58:25.822https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertorestrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co

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