Protein fibrillation: the good, the bad and the ugly

Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays...

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Autores:
Segura, Karen
Malagón, Edwin Andres
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/4438
Acceso en línea:
http://revistas.uan.edu.co/index.php/saywa/article/view/674
http://repositorio.uan.edu.co/handle/123456789/4438
Palabra clave:
Rights
openAccess
License
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
id UAntonioN2_aa6f6b13fecbb048de7dae04f5f12809
oai_identifier_str oai:repositorio.uan.edu.co:123456789/4438
network_acronym_str UAntonioN2
network_name_str Repositorio UAN
repository_id_str
spelling Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Segura, KarenMalagón, Edwin Andres2021-06-16T13:59:56Z2021-06-16T13:59:56Z2020-03-20http://revistas.uan.edu.co/index.php/saywa/article/view/674http://repositorio.uan.edu.co/handle/123456789/4438Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins.Los procesos de fibrilación de proteínas se refieren a la unión de cadenas ligeramente modificadas en su estructura nativa, formando pequeñas fibras. Se conoce poco acerca del mecanismo que conduce a estas conformaciones, una hipótesis difundida y aceptada es la del cono entrópico, según la cual una estructura pre-desplegada es crucial en el crecimiento de fibras. La fibrilación puede presentar ventajas en cuanto a que las proteínas así conformadas tienen cualidades aprovechables tecnológicamente. Por otra parte, si el proceso ocurre en tejidos podría generar enfermedades conocidas como amiloidosis. En la Universidad Antonio Nariño se han estudiado moléculas macrocíclicas tipo resorcinareno capaces de inhibir la fibrilación de algunas proteínas.application/pdfspaUniversidad Antonio Nariñohttp://revistas.uan.edu.co/index.php/saywa/article/view/674/5742711-1571REVISTA SAYWA; Vol. 1 Núm. 1 (2019)Protein fibrillation: the good, the bad and the uglyFibrilación de proteínas: Lo bueno, lo malo y lo feoDivulgación científicainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85123456789/4438oai:repositorio.uan.edu.co:123456789/44382024-10-09 22:43:50.966https://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertometadata.onlyhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co
dc.title.en-US.fl_str_mv Protein fibrillation: the good, the bad and the ugly
dc.title.es-ES.fl_str_mv Fibrilación de proteínas: Lo bueno, lo malo y lo feo
title Protein fibrillation: the good, the bad and the ugly
spellingShingle Protein fibrillation: the good, the bad and the ugly
title_short Protein fibrillation: the good, the bad and the ugly
title_full Protein fibrillation: the good, the bad and the ugly
title_fullStr Protein fibrillation: the good, the bad and the ugly
title_full_unstemmed Protein fibrillation: the good, the bad and the ugly
title_sort Protein fibrillation: the good, the bad and the ugly
dc.creator.fl_str_mv Segura, Karen
Malagón, Edwin Andres
dc.contributor.author.spa.fl_str_mv Segura, Karen
Malagón, Edwin Andres
description Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins.
publishDate 2020
dc.date.issued.spa.fl_str_mv 2020-03-20
dc.date.accessioned.none.fl_str_mv 2021-06-16T13:59:56Z
dc.date.available.none.fl_str_mv 2021-06-16T13:59:56Z
dc.type.spa.fl_str_mv Divulgación científica
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.none.fl_str_mv http://revistas.uan.edu.co/index.php/saywa/article/view/674
dc.identifier.uri.none.fl_str_mv http://repositorio.uan.edu.co/handle/123456789/4438
url http://revistas.uan.edu.co/index.php/saywa/article/view/674
http://repositorio.uan.edu.co/handle/123456789/4438
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://revistas.uan.edu.co/index.php/saywa/article/view/674/574
dc.rights.none.fl_str_mv Acceso abierto
dc.rights.license.spa.fl_str_mv Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Acceso abierto
https://creativecommons.org/licenses/by-nc-sa/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Antonio Nariño
dc.source.none.fl_str_mv 2711-1571
dc.source.es-ES.fl_str_mv REVISTA SAYWA; Vol. 1 Núm. 1 (2019)
institution Universidad Antonio Nariño
repository.name.fl_str_mv Repositorio Institucional UAN
repository.mail.fl_str_mv alertas.repositorio@uan.edu.co
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