Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.

Uterine cervical cancer (UCC) is the fourth most common cancer and the third leading cause of mortality in women worldwide. Currently, treatments are limited and/or have side effects; however, natural therapies, with less invasive activity and residual effect, have great potential. It is necessary t...

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Autores:: Lopez Castellanos, Angela Verónica

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2022

Institución:: Universidad Antonio Nariño

Repositorio:: Repositorio UAN

Idioma:: spa

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dc.title.es_ES.fl_str_mv	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
title	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
spellingShingle	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro. Revisión sistemática Metabolito secundario Cáncer cervical In vitro Vías apoptóticas Mecanismo de acción Systematic review Secondary metabolite Cervical cancer In vitro Apoptotic pathways Mechanism of action
title_short	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
title_full	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
title_fullStr	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
title_full_unstemmed	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
title_sort	Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.
dc.creator.fl_str_mv	Lopez Castellanos, Angela Verónica
dc.contributor.advisor.spa.fl_str_mv	Torres García, Orlando Alfredo Bernal Rosas, Yuly Elien
dc.contributor.author.spa.fl_str_mv	Lopez Castellanos, Angela Verónica
dc.subject.es_ES.fl_str_mv	Revisión sistemática Metabolito secundario Cáncer cervical In vitro Vías apoptóticas Mecanismo de acción
topic	Revisión sistemática Metabolito secundario Cáncer cervical In vitro Vías apoptóticas Mecanismo de acción Systematic review Secondary metabolite Cervical cancer In vitro Apoptotic pathways Mechanism of action
dc.subject.keyword.es_ES.fl_str_mv	Systematic review Secondary metabolite Cervical cancer In vitro Apoptotic pathways Mechanism of action
description	Uterine cervical cancer (UCC) is the fourth most common cancer and the third leading cause of mortality in women worldwide. Currently, treatments are limited and/or have side effects; however, natural therapies, with less invasive activity and residual effect, have great potential. It is necessary to investigate the main secondary metabolites of herbal extracts with potential in the treatment of UCC. The aim of this study was to perform a systematic review of the secondary metabolites that show regulate the intrinsic and extrinsic apoptotic pathways in UCC cell lines. A standardized methodology based on PRISMA guidelines was used, executing a Boolean search algorithm in different specialized databases. A total of 16 studies met the inclusion criteria of this systematic review with a low-to-medium risk of bias. For the evaluation of the anticancer effect of herbal extracts and secondary metabolites were used as cell models HeLa, SiHa, ME-180 and CaSki. After convergence analysis, several secondary metabolites with antioxidant effect (terpenoids, flavonoids, alkaloids and caffeic acids) were found to exhibit regulatory effects on apoptotic pathways (intrinsic as well as extrinsic) in different HCC cell models. Further translational research is required to evaluate their potential use as a treatment for HCC.
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2022-10-11T22:23:36Z
dc.date.available.none.fl_str_mv	2022-10-11T22:23:36Z
dc.date.issued.spa.fl_str_mv	2022-07-06
dc.type.spa.fl_str_mv	Trabajo de grado (Pregrado y/o Especialización)
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dc.identifier.bibliographicCitation.spa.fl_str_mv	Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. (2017). Molecular biology of the cell (J. Wilson & T. Hunt, Eds.). Garland Science. https://doi.org/10.1201/9781315735368 Ali, B. (2021). Salicylic acid: An efficient elicitor of secondary metabolite production in plants. Biocatalysis and Agricultural Biotechnology, 31, 101884. https://doi.org/10.1016/j.bcab.2020.101884 American Cancer Society. (2020, October 26). ¿Qué es el cáncer? https://www.cancer.org/es/tratamiento/como-comprender-su-diagnostico/que-es-el-cancer.html Arbyn, M., Castellsagué, X., de Sanjosé, S., Bruni, L., Saraiya, M., Bray, F., & Ferlay, J. (2011). Worldwide burden of cervical cancer in 2008. Annals of Oncology, 22(12), 2675–2686. https://doi.org/10.1093/annonc/mdr015 Asociación Española Contra el Cáncer. (2020). Cáncer de cuello uterino o cérvix ¿Qué es?\| AECC. https://www.aecc.es/es/todo-sobre-cancer/tipos-cancer/cancer-cuello-uterino-cervix Baker, C. C., Phelps, W. C., Lindgren, V., Braun, M. J., Gonda, M. A., & Howley, P. M. (1987). Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. Journal of Virology, 61(4), 962–971. https://doi.org/10.1128/JVI.61.4.962-971.1987 Benitez-Restrepo, C. C., Arias-Ortiz, N. E., & Arboleda-Ruiz, W. A. (2020). Cervical cancer incidence and patient survival in Manizales, Colombia, 2008-2012. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 438–445. https://doi.org/10.17843/rpmesp.2020.373.4838 Bermedo-Carrasco, S., & Waldner, C. L. (2016). The role of socio-demographic factors in premature cervical cancer mortality in Colombia. BMC Public Health, 16, 981. https://doi.org/10.1186/s12889016-3645-1 Beronius, A., Hanberg, A., Zilliacus, J., Ågerstrand, M., & Rudén, C. (2014). The SciRAP tool for evaluating the qualityof in vitro studies. Science in Risk Assessment and Policy. http://www.scirap.org/Page/Index/ee9102de-4b17-4c3a-86b6-e3e70d6ca3d1/evaluate-reliability-andrelevance Bhattacharya, A. (2019). High-Temperature Stress and Metabolism of Secondary Metabolites in Plants. In Effect of high temperature on crop productivity and metabolism of macro molecules (pp. 391–484). Elsevier. https://doi.org/10.1016/B978-0-12-817562-0.00005-7 Bourgioti, C., Chatoupis, K., & Moulopoulos, L. A. (2016). Current imaging strategies for the evaluation of uterine cervical cancer. World Journal of Radiology, 8(4), 342–354. https://doi.org/10.4329/wjr.v8.i4.342 Carrasco, D., Espinoza, R., Alejandro, G., Martínez, J., Santamaría-Aguirre, J., Zúñiga, F., Endara, P., & Terán, R. (2020). Evaluation of the microbiological quality of natural processed products for medicinal use marketed in Quito, Ecuador. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 431–437. https://doi.org/10.17843/rpmesp.2020.373.4889
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identifier_str_mv	Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. (2017). Molecular biology of the cell (J. Wilson & T. Hunt, Eds.). Garland Science. https://doi.org/10.1201/9781315735368 Ali, B. (2021). Salicylic acid: An efficient elicitor of secondary metabolite production in plants. Biocatalysis and Agricultural Biotechnology, 31, 101884. https://doi.org/10.1016/j.bcab.2020.101884 American Cancer Society. (2020, October 26). ¿Qué es el cáncer? https://www.cancer.org/es/tratamiento/como-comprender-su-diagnostico/que-es-el-cancer.html Arbyn, M., Castellsagué, X., de Sanjosé, S., Bruni, L., Saraiya, M., Bray, F., & Ferlay, J. (2011). Worldwide burden of cervical cancer in 2008. Annals of Oncology, 22(12), 2675–2686. https://doi.org/10.1093/annonc/mdr015 Asociación Española Contra el Cáncer. (2020). Cáncer de cuello uterino o cérvix ¿Qué es?\| AECC. https://www.aecc.es/es/todo-sobre-cancer/tipos-cancer/cancer-cuello-uterino-cervix Baker, C. C., Phelps, W. C., Lindgren, V., Braun, M. J., Gonda, M. A., & Howley, P. M. (1987). Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. Journal of Virology, 61(4), 962–971. https://doi.org/10.1128/JVI.61.4.962-971.1987 Benitez-Restrepo, C. C., Arias-Ortiz, N. E., & Arboleda-Ruiz, W. A. (2020). Cervical cancer incidence and patient survival in Manizales, Colombia, 2008-2012. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 438–445. https://doi.org/10.17843/rpmesp.2020.373.4838 Bermedo-Carrasco, S., & Waldner, C. L. (2016). The role of socio-demographic factors in premature cervical cancer mortality in Colombia. BMC Public Health, 16, 981. https://doi.org/10.1186/s12889016-3645-1 Beronius, A., Hanberg, A., Zilliacus, J., Ågerstrand, M., & Rudén, C. (2014). The SciRAP tool for evaluating the qualityof in vitro studies. Science in Risk Assessment and Policy. http://www.scirap.org/Page/Index/ee9102de-4b17-4c3a-86b6-e3e70d6ca3d1/evaluate-reliability-andrelevance Bhattacharya, A. (2019). High-Temperature Stress and Metabolism of Secondary Metabolites in Plants. In Effect of high temperature on crop productivity and metabolism of macro molecules (pp. 391–484). Elsevier. https://doi.org/10.1016/B978-0-12-817562-0.00005-7 Bourgioti, C., Chatoupis, K., & Moulopoulos, L. A. (2016). Current imaging strategies for the evaluation of uterine cervical cancer. World Journal of Radiology, 8(4), 342–354. https://doi.org/10.4329/wjr.v8.i4.342 Carrasco, D., Espinoza, R., Alejandro, G., Martínez, J., Santamaría-Aguirre, J., Zúñiga, F., Endara, P., & Terán, R. (2020). Evaluation of the microbiological quality of natural processed products for medicinal use marketed in Quito, Ecuador. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 431–437. https://doi.org/10.17843/rpmesp.2020.373.4889 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/
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dc.publisher.spa.fl_str_mv	Universidad Antonio Nariño
dc.publisher.program.spa.fl_str_mv	Bioquímica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.campus.spa.fl_str_mv	Bogotá - Circunvalar
institution	Universidad Antonio Nariño
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spelling	Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Torres García, Orlando AlfredoBernal Rosas, Yuly ElienLopez Castellanos, Angela Verónica118216277212022-10-11T22:23:36Z2022-10-11T22:23:36Z2022-07-06http://repositorio.uan.edu.co/handle/123456789/7079Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. (2017). Molecular biology of the cell (J. Wilson & T. Hunt, Eds.). Garland Science. https://doi.org/10.1201/9781315735368Ali, B. (2021). Salicylic acid: An efficient elicitor of secondary metabolite production in plants. Biocatalysis and Agricultural Biotechnology, 31, 101884. https://doi.org/10.1016/j.bcab.2020.101884 American Cancer Society. (2020, October 26). ¿Qué es el cáncer? https://www.cancer.org/es/tratamiento/como-comprender-su-diagnostico/que-es-el-cancer.html Arbyn, M., Castellsagué, X., de Sanjosé, S., Bruni, L., Saraiya, M., Bray, F., & Ferlay, J. (2011).Worldwide burden of cervical cancer in 2008. Annals of Oncology, 22(12), 2675–2686. https://doi.org/10.1093/annonc/mdr015Asociación Española Contra el Cáncer. (2020). Cáncer de cuello uterino o cérvix ¿Qué es?\| AECC. https://www.aecc.es/es/todo-sobre-cancer/tipos-cancer/cancer-cuello-uterino-cervixBaker, C. C., Phelps, W. C., Lindgren, V., Braun, M. J., Gonda, M. A., & Howley, P. M. (1987). Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. Journal of Virology, 61(4), 962–971. https://doi.org/10.1128/JVI.61.4.962-971.1987Benitez-Restrepo, C. C., Arias-Ortiz, N. E., & Arboleda-Ruiz, W. A. (2020). Cervical cancer incidence and patient survival in Manizales, Colombia, 2008-2012. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 438–445. https://doi.org/10.17843/rpmesp.2020.373.4838Bermedo-Carrasco, S., & Waldner, C. L. (2016). The role of socio-demographic factors in premature cervical cancer mortality in Colombia. BMC Public Health, 16, 981. https://doi.org/10.1186/s12889016-3645-1Beronius, A., Hanberg, A., Zilliacus, J., Ågerstrand, M., & Rudén, C. (2014). The SciRAP tool for evaluating the qualityof in vitro studies. Science in Risk Assessment and Policy. http://www.scirap.org/Page/Index/ee9102de-4b17-4c3a-86b6-e3e70d6ca3d1/evaluate-reliability-andrelevanceBhattacharya, A. (2019). High-Temperature Stress and Metabolism of Secondary Metabolites in Plants. In Effect of high temperature on crop productivity and metabolism of macro molecules (pp. 391–484). Elsevier. https://doi.org/10.1016/B978-0-12-817562-0.00005-7Bourgioti, C., Chatoupis, K., & Moulopoulos, L. A. (2016). Current imaging strategies for the evaluation of uterine cervical cancer. World Journal of Radiology, 8(4), 342–354. https://doi.org/10.4329/wjr.v8.i4.342Carrasco, D., Espinoza, R., Alejandro, G., Martínez, J., Santamaría-Aguirre, J., Zúñiga, F., Endara, P., & Terán, R. (2020). Evaluation of the microbiological quality of natural processed products for medicinal use marketed in Quito, Ecuador. Revista Peruana de Medicina Experimental y Salud Publica, 37(3), 431–437. https://doi.org/10.17843/rpmesp.2020.373.4889instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/Uterine cervical cancer (UCC) is the fourth most common cancer and the third leading cause of mortality in women worldwide. Currently, treatments are limited and/or have side effects; however, natural therapies, with less invasive activity and residual effect, have great potential. It is necessary to investigate the main secondary metabolites of herbal extracts with potential in the treatment of UCC. The aim of this study was to perform a systematic review of the secondary metabolites that show regulate the intrinsic and extrinsic apoptotic pathways in UCC cell lines. A standardized methodology based on PRISMA guidelines was used, executing a Boolean search algorithm in different specialized databases. A total of 16 studies met the inclusion criteria of this systematic review with a low-to-medium risk of bias. For the evaluation of the anticancer effect of herbal extracts and secondary metabolites were used as cell models HeLa, SiHa, ME-180 and CaSki. After convergence analysis, several secondary metabolites with antioxidant effect (terpenoids, flavonoids, alkaloids and caffeic acids) were found to exhibit regulatory effects on apoptotic pathways (intrinsic as well as extrinsic) in different HCC cell models. Further translational research is required to evaluate their potential use as a treatment for HCC.A nivel mundial, el cáncer de cuello uterino (CCU) es el cuarto cáncer más común y la tercera causa de mortalidad en mujeres. Actualmente, los tratamientos están limitados y presentan efectos secundarios; sin embargo, las terapias naturales con menor actividad invasiva y efecto residual, presentan un gran potencial. De esta manera, se hace necesario investigar los principales metabolitos secundarios de los extractos herbales con potencial efecto en el tratamiento del CCU. El objetivo del presente estudio fue realizar una revisión sistemática de los metabolitos secundarios que muestren regular las rutas apoptóticas intrínseca y extrínseca en líneas celulares del CCU. Se utilizó una metodología estandarizada basada en las guías PRISMA, ejecutando un algoritmo Booleano de búsqueda en diferentes bases de datos especializadas. Un total de 16 estudios cumplieron los criterios de inclusión de esta revisión sistemática con un riesgo de sesgo bajo-medio. Para la evaluación del efecto anticancerígeno de extractos herbales y metabolitos secundarios se emplearon como modelos celulares HeLa, SiHa, ME-180 y CaSki. Luego del análisis de convergencia, se encontró que varios metabolitos secundarios con efecto antioxidante (terpenoides, flavonoides, alcaloides y ácidos cafeicos), presentan efectos reguladores sobre vías apoptóticas (intrínseca como extrínseca) en diferentes modelos celulares del CCU. Se requiere más investigación traslacional para evaluar su posible uso como tratamiento del CCU.Bioquímico(a)PregradoPresencialMonografíaspaUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - CircunvalarRevisión sistemáticaMetabolito secundarioCáncer cervicalIn vitroVías apoptóticasMecanismo de acciónSystematic reviewSecondary metaboliteCervical cancerIn vitroApoptotic pathwaysMechanism of actionMetabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85EspecializadaORIGINAL6. Trabajo de grado-López Castellanos Ángela Verónica (2).pdf6. 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Metabolitos secundarios presentes en extractos herbales promisorios para el tratamiento del cáncer cervical: una revisión sistemática de estudios in vitro.

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