Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA
Propia
- Autores:
-
Aguilar Niño, Johann Sebastian
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 0024
- Institución:
- Universidad Antonio Nariño
- Repositorio:
- Repositorio UAN
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uan.edu.co:123456789/10295
- Acceso en línea:
- https://repositorio.uan.edu.co/handle/123456789/10295
- Palabra clave:
- Recepctores NMDA
Peptidos
Electrofisiología
Antagonistas
Agonistas
NMDA receptor
Peptides
Electrophysiology
Antagonists
Agonists
- Rights
- restrictedAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| title |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| spellingShingle |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA Recepctores NMDA Peptidos Electrofisiología Antagonistas Agonistas NMDA receptor Peptides Electrophysiology Antagonists Agonists |
| title_short |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| title_full |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| title_fullStr |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| title_full_unstemmed |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| title_sort |
Péptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDA |
| dc.creator.fl_str_mv |
Aguilar Niño, Johann Sebastian |
| dc.contributor.advisor.none.fl_str_mv |
Reyes Guzman, Edwin Alfredo Forero Vivas , Maria Elisa Forero Vivas, Maria Elisa |
| dc.contributor.author.none.fl_str_mv |
Aguilar Niño, Johann Sebastian |
| dc.subject.none.fl_str_mv |
Recepctores NMDA Peptidos Electrofisiología Antagonistas Agonistas |
| topic |
Recepctores NMDA Peptidos Electrofisiología Antagonistas Agonistas NMDA receptor Peptides Electrophysiology Antagonists Agonists |
| dc.subject.keyword.none.fl_str_mv |
NMDA receptor Peptides Electrophysiology Antagonists Agonists |
| description |
Propia |
| publishDate |
0024 |
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0024-06-11 |
| dc.date.accessioned.none.fl_str_mv |
2024-10-07T21:22:28Z |
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2024-10-07T21:22:28Z |
| dc.date.issued.none.fl_str_mv |
2024-10-04 |
| dc.type.document.none.fl_str_mv |
Estudio exploratorio |
| dc.type.version.none.fl_str_mv |
Versión original del autor, Borrador, Manuscrito |
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http://purl.org/coar/resource_type/c_7a1f |
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http://purl.org/redcol/resource_type/PID |
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http://purl.org/coar/version/c_b1a7d7d4d402bcce |
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Tesis/Trabajo de grado - Monografía - Pregrado |
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https://repositorio.uan.edu.co/handle/123456789/10295 |
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https://repositorio.uan.edu.co/handle/123456789/10295 |
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spa |
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spa |
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Acceso restringido |
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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/restrictedAccess |
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restrictedAccess |
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Bioquímica |
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Facultad de Ciencias |
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Bogotá - Circunvalar |
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reponame:Repositorio Institucional UAN |
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Universidad Antonio Nariño |
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Andrade, C. (2017). Memantine as an Augmentation Treatment for Schizophrenia: Limitations of MetaAnalysis for Evidence-Based Evaluation of Research. The Journal of Clinical Psychiatry, 78(9), 11569. https://doi.org/10.4088/JCP.17F11998 Bermudez, S and Reyes-Guzman EA. (2020). Tesis de pregrado. Evaluation of the effect of the Pb53a, a synthetic peptide obtained from toxins of the spider Phoneutria boliviensis on the cell viability of the HEK-293 line. Bleich, S., Römer, K., Wiltfang, J., & Kornhuber, J. (2003). Glutamate and the glutamate receptor system: a target for drug action. International Journal of Geriatric Psychiatry, 18(S1), S33–S40. https://doi.org/10.1002/GPS.933 Bogin, O. (2005). Venom Peptides and their Mimetics as Potential Drugs | Alomone Labs. Modulator. https://www.alomone.com/article/venom-peptides-mimetics-potential-drugs Carvajal, J and Reyes-Guzman EA. (2020). Tesis de pregrado. In silico analysis of the interactión of peptides derived from the Ctenitoxin-Pb48 and Ctenitoxin-Pb53 toxins of the Colombian spider Phoneutria boliviensis with the NMDA receptor Chang, C. H., Lane, H. Y., Tseng, P. T., Chen, S. J., Liu, C. Y., & Lin, C. H. (2019). Effect of N-methyl-Daspartate-receptor-enhancing agents on cognition in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials. Https://Doi.Org/10.1177/0269881118822157, 33(4), 436–448. https://doi.org/10.1177/0269881118822157 Chen, R., Robinson, A., & Chung, S. H. (2012). Binding of Hanatoxin to the Voltage Sensor of Kv2.1. Toxins 2012, Vol. 4, Pages 1552-1564, 4(12), 1552–1564. https://doi.org/10.3390/TOXINS4121552 Cristina, D. I., & Madera, P. (2014). Epidemiología de las enfermedades cerebrovasculares de origen extracraneal Epidemiology of the cerebrovascular diseases of extracranial origin. Revista Cubana de Angiología y Cirugía Vascular, 15(2), 66–74. http://scielo.sld.cuhttp://scielo.sld.cu Feigin, V. L., Brainin, M., Norrving, B., Martins, S., Sacco, R. L., Hacke, W., Fisher, M., Pandian, J., & Lindsay, P. (2022). World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. International Journal of Stroke, 17(1), 18–29. https://doi.org/10.1177/17474930211065917 Flores-Soto, M. E., Chaparro-Huerta, V., Escoto-Delgadillo, M., Vazquez-Valls, E., González-Castañeda, R. E., & Beas-Zarate, C. (2012). NEUROLOGÍA Estructura y función de las subunidades del receptor a glutamato tipo NMDA. 27(5), 301–310. https://doi.org/10.1016/j.nrl.2011.10.014 |
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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso restringidohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/restrictedAccesshttp://purl.org/coar/access_right/c_16ecReyes Guzman, Edwin AlfredoForero Vivas , Maria ElisaForero Vivas, Maria ElisaAguilar Niño, Johann Sebastian2024-10-07T21:22:28Z2024-10-07T21:22:28Z0024-06-112024-10-04https://repositorio.uan.edu.co/handle/123456789/10295PropiaThe NMDA receptor is involved in various physiological processes such as memory, synaptic plasticity, and signal transmission. It has been proven that dysfunction, inhibition, or overactivation of the NMDA receptor leads to various pathologies including Alzheimer's, cerebral ischemias, depression, and schizophrenia, among others. Experimental and clinical research suggests that peptides found in the venom of certain animals can modulate NMDA receptor activity and could be effective in treating these diseases. In this work, we conducted an exhaustive literature review on peptides that have been demonstrated through electrophysiology to modulate receptor activityUAN Proyectos de ciencia, tecnología, innovación y creación artísticaEl receptor NMDA está involucrado en diversos procesos fisiológicos como memoria, plasticidad sináptica y transmisión de señales. Se ha comprobado que la disfunción, inhibición o sobreactivación del NMDA genera diversas patologías en donde se pueden encontrar alzheimer, isquemias cerebrales, depresión, esquizofrenia entre otras. Investigaciones experimentales y clínicas sugieren que en el veneno de algunos animales se encuentran péptidos que modulan la actividad del receptor NMDA y podrían ser efectivas para tratar estas enfermedades. En este trabajo se realizó la búsqueda exhaustiva de la literatura sobre péptidos demostrados mediante electrofisiología como moduladores de la actividad del receptorfinalBioquímico(a)PregradoPresencialMonografíareponame:Repositorio Institucional UANAndrade, C. (2017). Memantine as an Augmentation Treatment for Schizophrenia: Limitations of MetaAnalysis for Evidence-Based Evaluation of Research. The Journal of Clinical Psychiatry, 78(9), 11569. https://doi.org/10.4088/JCP.17F11998Bermudez, S and Reyes-Guzman EA. (2020). Tesis de pregrado. Evaluation of the effect of the Pb53a, a synthetic peptide obtained from toxins of the spider Phoneutria boliviensis on the cell viability of the HEK-293 line.Bleich, S., Römer, K., Wiltfang, J., & Kornhuber, J. (2003). Glutamate and the glutamate receptor system: a target for drug action. International Journal of Geriatric Psychiatry, 18(S1), S33–S40. https://doi.org/10.1002/GPS.933Bogin, O. (2005). Venom Peptides and their Mimetics as Potential Drugs | Alomone Labs. Modulator. https://www.alomone.com/article/venom-peptides-mimetics-potential-drugsCarvajal, J and Reyes-Guzman EA. (2020). Tesis de pregrado. In silico analysis of the interactión of peptides derived from the Ctenitoxin-Pb48 and Ctenitoxin-Pb53 toxins of the Colombian spider Phoneutria boliviensis with the NMDA receptorChang, C. H., Lane, H. Y., Tseng, P. T., Chen, S. J., Liu, C. Y., & Lin, C. H. (2019). Effect of N-methyl-Daspartate-receptor-enhancing agents on cognition in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials. Https://Doi.Org/10.1177/0269881118822157, 33(4), 436–448. https://doi.org/10.1177/0269881118822157Chen, R., Robinson, A., & Chung, S. H. (2012). Binding of Hanatoxin to the Voltage Sensor of Kv2.1. Toxins 2012, Vol. 4, Pages 1552-1564, 4(12), 1552–1564. https://doi.org/10.3390/TOXINS4121552Cristina, D. I., & Madera, P. (2014). Epidemiología de las enfermedades cerebrovasculares de origen extracraneal Epidemiology of the cerebrovascular diseases of extracranial origin. Revista Cubana de Angiología y Cirugía Vascular, 15(2), 66–74. http://scielo.sld.cuhttp://scielo.sld.cuFeigin, V. L., Brainin, M., Norrving, B., Martins, S., Sacco, R. L., Hacke, W., Fisher, M., Pandian, J., & Lindsay, P. (2022). World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. International Journal of Stroke, 17(1), 18–29. https://doi.org/10.1177/17474930211065917Flores-Soto, M. E., Chaparro-Huerta, V., Escoto-Delgadillo, M., Vazquez-Valls, E., González-Castañeda, R. E., & Beas-Zarate, C. (2012). NEUROLOGÍA Estructura y función de las subunidades del receptor a glutamato tipo NMDA. 27(5), 301–310. https://doi.org/10.1016/j.nrl.2011.10.014Recepctores NMDAPeptidosElectrofisiologíaAntagonistasAgonistasNMDA receptorPeptidesElectrophysiologyAntagonistsAgonistsPéptidos derivados de toxinas animales como moduladores de la actividad del receptor NMDABioquímicaFacultad de CienciasBogotá - CircunvalarEspecializadaEstudio exploratorioVersión original del autor, Borrador, Manuscritohttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/redcol/resource_type/PIDhttp://purl.org/coar/version/c_b1a7d7d4d402bcceTesis/Trabajo de grado - Monografía - PregradospaORIGINAL2024_Johann Sebastian Aguilar Niño_Autorización2024_Johann Sebastian Aguilar Niño_AutorizaciónAutorizaciónapplication/pdf1040729https://repositorio.uan.edu.co/bitstreams/97fb4f01-b2f8-4b92-8f83-0305fda99c66/download4d0c325f3c49bcc069b5fa155cd60b6fMD512024_Johann Sebastian Aguilar Niño_Acta2024_Johann Sebastian Aguilar Niño_ActaActaapplication/pdf1763669https://repositorio.uan.edu.co/bitstreams/4e8407d1-206c-4bbc-b745-955d109aa04c/download19cc5581b7e1bb24eec588b1ba07f075MD522024_Johann Sebastian Aguilar Niño2024_Johann Sebastian Aguilar NiñoTrabajo de gradoapplication/pdf1097193https://repositorio.uan.edu.co/bitstreams/ed12481e-1024-4752-bbcd-1440d96922ed/download48ee3525a697c54b3dd5ff6d50bef25eMD53123456789/10295oai:repositorio.uan.edu.co:123456789/102952024-10-09 23:38:55.56https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso restringidorestrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co |