Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis

The present work is a review of the state of the art on the antiparasitic potential of extracts and / or metabolites from plants, propolis and chitosan, as therapy for Leishmaniasis and Chagas disease. Products of natural origin capable of attacking the causative agents of these pathologies were ide...

Full description

Autores:: Ramón González, Solangie

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2021

Institución:: Universidad Antonio Nariño

Repositorio:: Repositorio UAN

Idioma:: spa

id	UAntonioN2_852c297e3dd8b6fe3ba07a50e75e8a79
oai_identifier_str	oai:repositorio.uan.edu.co:123456789/6379
network_acronym_str	UAntonioN2
network_name_str	Repositorio UAN
repository_id_str
dc.title.es_ES.fl_str_mv	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
title	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
spellingShingle	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis Plantas Propóleo Quitosano Trypanosoma cruzi Leishmania spp 540 Plants Propolis Chitosan Trypanosoma cruzi Leishmania spp
title_short	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
title_full	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
title_fullStr	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
title_full_unstemmed	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
title_sort	Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis
dc.creator.fl_str_mv	Ramón González, Solangie
dc.contributor.advisor.spa.fl_str_mv	Bernal Rosas, Yuly Elien Torres García, Orlando Alfredo
dc.contributor.author.spa.fl_str_mv	Ramón González, Solangie
dc.subject.es_ES.fl_str_mv	Plantas Propóleo Quitosano Trypanosoma cruzi Leishmania spp
topic	Plantas Propóleo Quitosano Trypanosoma cruzi Leishmania spp 540 Plants Propolis Chitosan Trypanosoma cruzi Leishmania spp
dc.subject.ddc.es_ES.fl_str_mv	540
dc.subject.keyword.es_ES.fl_str_mv	Plants Propolis Chitosan Trypanosoma cruzi Leishmania spp
description	The present work is a review of the state of the art on the antiparasitic potential of extracts and / or metabolites from plants, propolis and chitosan, as therapy for Leishmaniasis and Chagas disease. Products of natural origin capable of attacking the causative agents of these pathologies were identified Trypanosoma cruzi and Leishmania spp. Based on this, a study was proposed as an alternative in the treatment of these conditions. In order to develop this project, a descriptive literature review of the last six years (2015-2021) was carried out in the main scientific databases. The results do not describe relevant cellular toxicity, but they do describe high antiparasitic activity of plant extracts, propolis, chitosan and chitosan nanoparticles, which present various phytochemical compounds. These act directly on parasites or on host cells, activating immune response signaling pathways.
publishDate	2021
dc.date.issued.spa.fl_str_mv	2021-11-25
dc.date.accessioned.none.fl_str_mv	2022-04-30T14:42:28Z
dc.date.available.none.fl_str_mv	2022-04-30T14:42:28Z
dc.type.spa.fl_str_mv	Trabajo de grado (Pregrado y/o Especialización)
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
format	http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv	http://repositorio.uan.edu.co/handle/123456789/6379
dc.identifier.bibliographicCitation.spa.fl_str_mv	Abadías-Granado I., Diago, A., Cerro, P. A., Palma-Ruiz, A.M., & Gilaberte, Y. (2021). Cutaneous and mucocutaneous leishmaniasis. Actas Dermo-Sifiliograficas. https://doi.org/10.1016/j.ad.2021.02.008 Akhoundi, M., Kuhls, K., Cannet, A., Votypka, J., Marty, P., Delaunay, P., & Sereno, D. (2016). A historical overview of the classification, evolution and dispersion of leishmania parasites and sandflies. PLoS Neglected Tropical Diseases, 10(3), e0004349. https://doi.org/10.1371/journal.pntd.0004349 Aksoy, T., Sivcan, E., Dogan, F., Cetin, S., & Yar, T. M. (2020). (Investigation of Anti-Leishmanial Effects of Bee Products (Honey Propolis), on Leishmania Tropica Promastigotes). Mikrobyoloji Bulteni, 54(3) 479-489. https://doi.org/10.5578/mb.69632 Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A. M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2019). European propolis is highly active against trypanosomatids including Crithidia fasciculata. Scientific Reports, 9(1), 11364. https://doi.org/10.1038/s41598-019-47840-y Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alfayez, I. A., Natto, M. J., Alenezi, S., Siheri, W., AlQarni, M., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2021). Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules (Basel Switzerland), 26(13). https://doi.org/10.3390/molecules26133912 Alves, D. R., Maia de Morais, S., Tomiotto-Pellissier, F., Miranda-Sapla, M. M., Vasconcelos, F, R., da Silva, I. N. G., Araujo de Sousa, H., Assolini, J. P., Conchon-Costa, I., Pavanelli, W. R., & Freire, F. das C. O. (2017). Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga biome. Evidence-Based Complementary and Alternative Medicine, 2017, 6834218. https://doi.org/10.1155/2017/6834218 Andrade, M. A., Azevedo, C. D. S., Motta, F. N., Santos, M. L. D., Silva, C. L., Santana, J. M., de & Bastos, I. M. D. (2016). Essentials oils: in vitro activity against Leishmania amazonensis, cytotoxity and chemical composition. BMC Complementary and Alternative Medicine, 16(1), 444. https://doi.org/10.1186/s12906-016-1401-9 Aquino, A. B., de, Cavalcante-Silva, L. H. A., Matta, C, B. B., da, Epifanio, W. A. do N., Aquino, P. G. V., Santana, A. E. G., Alexandre-Moreira, M. S., & de Araújo-Júnior, J. X. (2013). The antinociceptive and anti-inflammatory activities of Aspidosperma tomentosum (Apocynaceae). Thescientificworldjournal, 2013, 218627. https://doi.org/10.1155/2013/218627 Arias-Giraldo, L. M., Muñoz, M., Hernández, C., Herrera, G., Velásquez-Ortiz, N., Cantillo-Barraza, O., Urbano, P., & Ramírez, J. D. (2020). Species-dependent variation of the gut bacterial communities across Trypanosoma cruzi insect vectors. Plos One 15(11), e0240916. https://doi.org/10.1371/journal.pone.0240916 Arrúa, E. C., Seremeta, K. P., Bedogni, G. R., Okulik., N. B., & Salomon, C. J. (2019). Nanocarriers for effective delivery of benznidazole and nifurtimux in the treatment of chagas disease. A review. Acta Tropica, 198. 105080. https://doi.org/10.1016/j.actatropica.2019.105080
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Antonio Nariño
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional UAN
dc.identifier.repourl.spa.fl_str_mv	repourl:https://repositorio.uan.edu.co/
url	http://repositorio.uan.edu.co/handle/123456789/6379
identifier_str_mv	Abadías-Granado I., Diago, A., Cerro, P. A., Palma-Ruiz, A.M., & Gilaberte, Y. (2021). Cutaneous and mucocutaneous leishmaniasis. Actas Dermo-Sifiliograficas. https://doi.org/10.1016/j.ad.2021.02.008 Akhoundi, M., Kuhls, K., Cannet, A., Votypka, J., Marty, P., Delaunay, P., & Sereno, D. (2016). A historical overview of the classification, evolution and dispersion of leishmania parasites and sandflies. PLoS Neglected Tropical Diseases, 10(3), e0004349. https://doi.org/10.1371/journal.pntd.0004349 Aksoy, T., Sivcan, E., Dogan, F., Cetin, S., & Yar, T. M. (2020). (Investigation of Anti-Leishmanial Effects of Bee Products (Honey Propolis), on Leishmania Tropica Promastigotes). Mikrobyoloji Bulteni, 54(3) 479-489. https://doi.org/10.5578/mb.69632 Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A. M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2019). European propolis is highly active against trypanosomatids including Crithidia fasciculata. Scientific Reports, 9(1), 11364. https://doi.org/10.1038/s41598-019-47840-y Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alfayez, I. A., Natto, M. J., Alenezi, S., Siheri, W., AlQarni, M., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2021). Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules (Basel Switzerland), 26(13). https://doi.org/10.3390/molecules26133912 Alves, D. R., Maia de Morais, S., Tomiotto-Pellissier, F., Miranda-Sapla, M. M., Vasconcelos, F, R., da Silva, I. N. G., Araujo de Sousa, H., Assolini, J. P., Conchon-Costa, I., Pavanelli, W. R., & Freire, F. das C. O. (2017). Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga biome. Evidence-Based Complementary and Alternative Medicine, 2017, 6834218. https://doi.org/10.1155/2017/6834218 Andrade, M. A., Azevedo, C. D. S., Motta, F. N., Santos, M. L. D., Silva, C. L., Santana, J. M., de & Bastos, I. M. D. (2016). Essentials oils: in vitro activity against Leishmania amazonensis, cytotoxity and chemical composition. BMC Complementary and Alternative Medicine, 16(1), 444. https://doi.org/10.1186/s12906-016-1401-9 Aquino, A. B., de, Cavalcante-Silva, L. H. A., Matta, C, B. B., da, Epifanio, W. A. do N., Aquino, P. G. V., Santana, A. E. G., Alexandre-Moreira, M. S., & de Araújo-Júnior, J. X. (2013). The antinociceptive and anti-inflammatory activities of Aspidosperma tomentosum (Apocynaceae). Thescientificworldjournal, 2013, 218627. https://doi.org/10.1155/2013/218627 Arias-Giraldo, L. M., Muñoz, M., Hernández, C., Herrera, G., Velásquez-Ortiz, N., Cantillo-Barraza, O., Urbano, P., & Ramírez, J. D. (2020). Species-dependent variation of the gut bacterial communities across Trypanosoma cruzi insect vectors. Plos One 15(11), e0240916. https://doi.org/10.1371/journal.pone.0240916 Arrúa, E. C., Seremeta, K. P., Bedogni, G. R., Okulik., N. B., & Salomon, C. J. (2019). Nanocarriers for effective delivery of benznidazole and nifurtimux in the treatment of chagas disease. A review. Acta Tropica, 198. 105080. https://doi.org/10.1016/j.actatropica.2019.105080 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.rights.none.fl_str_mv	Acceso abierto
dc.rights.license.spa.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.uri.spa.fl_str_mv	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv	http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Acceso abierto https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.publisher.spa.fl_str_mv	Universidad Antonio Nariño
dc.publisher.program.spa.fl_str_mv	Bioquímica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.campus.spa.fl_str_mv	Bogotá - Circunvalar
institution	Universidad Antonio Nariño
bitstream.url.fl_str_mv	https://repositorio.uan.edu.co/bitstreams/4c68a6e5-6afd-42e0-9ad0-dc3a60245b6d/download https://repositorio.uan.edu.co/bitstreams/c45037cb-c77f-4ae9-b694-4683bd8714be/download https://repositorio.uan.edu.co/bitstreams/63dd6558-c36d-4930-ae54-2a08d75a6386/download https://repositorio.uan.edu.co/bitstreams/46a592a2-bf99-42b4-a942-c074fb1ca2de/download
bitstream.checksum.fl_str_mv	f23c1ea14d3307c3af56db9e8b60e2e3 723230e5ff0a64e5726e28a032c54cc3 07953061327ee0816a75e28bb16776fa 9868ccc48a14c8d591352b6eaf7f6239
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional UAN
repository.mail.fl_str_mv	alertas.repositorio@uan.edu.co
_version_	1812928336618323968
spelling	Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Bernal Rosas, Yuly ElienTorres García, Orlando AlfredoRamón González, Solangie118217187422022-04-30T14:42:28Z2022-04-30T14:42:28Z2021-11-25http://repositorio.uan.edu.co/handle/123456789/6379Abadías-Granado I., Diago, A., Cerro, P. A., Palma-Ruiz, A.M., & Gilaberte, Y. (2021). Cutaneous and mucocutaneous leishmaniasis. Actas Dermo-Sifiliograficas. https://doi.org/10.1016/j.ad.2021.02.008Akhoundi, M., Kuhls, K., Cannet, A., Votypka, J., Marty, P., Delaunay, P., & Sereno, D. (2016). A historical overview of the classification, evolution and dispersion of leishmania parasites and sandflies. PLoS Neglected Tropical Diseases, 10(3), e0004349. https://doi.org/10.1371/journal.pntd.0004349Aksoy, T., Sivcan, E., Dogan, F., Cetin, S., & Yar, T. M. (2020). (Investigation of Anti-Leishmanial Effects of Bee Products (Honey Propolis), on Leishmania Tropica Promastigotes). Mikrobyoloji Bulteni, 54(3) 479-489. https://doi.org/10.5578/mb.69632Alotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A. M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2019). European propolis is highly active against trypanosomatids including Crithidia fasciculata. Scientific Reports, 9(1), 11364. https://doi.org/10.1038/s41598-019-47840-yAlotaibi, Abdullah, Ebiloma, G. U., Williams, R., Alfayez, I. A., Natto, M. J., Alenezi, S., Siheri, W., AlQarni, M., Igoli, J. O., Fearnley, J., de Koning, H. P., & Watson, D. G. (2021). Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules (Basel Switzerland), 26(13). https://doi.org/10.3390/molecules26133912Alves, D. R., Maia de Morais, S., Tomiotto-Pellissier, F., Miranda-Sapla, M. M., Vasconcelos, F, R., da Silva, I. N. G., Araujo de Sousa, H., Assolini, J. P., Conchon-Costa, I., Pavanelli, W. R., & Freire, F. das C. O. (2017). Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga biome. Evidence-Based Complementary and Alternative Medicine, 2017, 6834218. https://doi.org/10.1155/2017/6834218Andrade, M. A., Azevedo, C. D. S., Motta, F. N., Santos, M. L. D., Silva, C. L., Santana, J. M., de & Bastos, I. M. D. (2016). Essentials oils: in vitro activity against Leishmania amazonensis, cytotoxity and chemical composition. BMC Complementary and Alternative Medicine, 16(1), 444. https://doi.org/10.1186/s12906-016-1401-9Aquino, A. B., de, Cavalcante-Silva, L. H. A., Matta, C, B. B., da, Epifanio, W. A. do N., Aquino, P. G. V., Santana, A. E. G., Alexandre-Moreira, M. S., & de Araújo-Júnior, J. X. (2013). The antinociceptive and anti-inflammatory activities of Aspidosperma tomentosum (Apocynaceae). Thescientificworldjournal, 2013, 218627. https://doi.org/10.1155/2013/218627Arias-Giraldo, L. M., Muñoz, M., Hernández, C., Herrera, G., Velásquez-Ortiz, N., Cantillo-Barraza, O., Urbano, P., & Ramírez, J. D. (2020). Species-dependent variation of the gut bacterial communities across Trypanosoma cruzi insect vectors. Plos One 15(11), e0240916. https://doi.org/10.1371/journal.pone.0240916Arrúa, E. C., Seremeta, K. P., Bedogni, G. R., Okulik., N. B., & Salomon, C. J. (2019). Nanocarriers for effective delivery of benznidazole and nifurtimux in the treatment of chagas disease. A review. Acta Tropica, 198. 105080. https://doi.org/10.1016/j.actatropica.2019.105080instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/The present work is a review of the state of the art on the antiparasitic potential of extracts and / or metabolites from plants, propolis and chitosan, as therapy for Leishmaniasis and Chagas disease. Products of natural origin capable of attacking the causative agents of these pathologies were identified Trypanosoma cruzi and Leishmania spp. Based on this, a study was proposed as an alternative in the treatment of these conditions. In order to develop this project, a descriptive literature review of the last six years (2015-2021) was carried out in the main scientific databases. The results do not describe relevant cellular toxicity, but they do describe high antiparasitic activity of plant extracts, propolis, chitosan and chitosan nanoparticles, which present various phytochemical compounds. These act directly on parasites or on host cells, activating immune response signaling pathways.El presente trabajo es una revisión del estado del arte sobre el potencial antiparasitario de extractos y/o metabolitos provenientes de plantas, propóleos y quitosano, como terapia para Leishmaniasis y enfermedad de Chagas. Se identificaron productos de origen natural capaces de atacar los agentes causales de dichas patologías Trypanosoma cruzi y Leishmania spp. A partir de ello se planteó un estudio como alternativa en el tratamiento de estas afecciones. En aras de desarrollar este proyecto se realizó una revisión de literatura descriptiva de los últimos seis años (2015-2021), en las principales bases de datos científicas. Los resultados no describen toxicidad celular relevante, pero sí alta actividad antiparasitaria de extractos vegetales, propóleos, quitosano y nanopartículas de quitosano, que presentan diversos compuestos fitoquímicos. Estos ejercen acción directamente en los parásitos o en las células del huésped, activando vías de señalización de respuesta inmune.Bioquímico(a)PregradoPresencialMonografíaspaUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - CircunvalarPlantasPropóleoQuitosanoTrypanosoma cruziLeishmania spp540PlantsPropolisChitosanTrypanosoma cruziLeishmania sppTratamientos alternativos de origen natural para las enfermedades de Chagas y LeishmaniasisTrabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85EspecializadaORIGINAL2021_SolangieRamónGonzález_Acta.pdf2021_SolangieRamónGonzález_Acta.pdfActa de sustentaciónapplication/pdf415551https://repositorio.uan.edu.co/bitstreams/4c68a6e5-6afd-42e0-9ad0-dc3a60245b6d/downloadf23c1ea14d3307c3af56db9e8b60e2e3MD512021_SolangieRamónGonzález_Autorización.pdf2021_SolangieRamónGonzález_Autorización.pdfFormato de autorización de autoresapplication/pdf662486https://repositorio.uan.edu.co/bitstreams/c45037cb-c77f-4ae9-b694-4683bd8714be/download723230e5ff0a64e5726e28a032c54cc3MD522021_SolangieRamónGonzález.pdf2021_SolangieRamónGonzález.pdfTrabajo de gradoapplication/pdf2029416https://repositorio.uan.edu.co/bitstreams/63dd6558-c36d-4930-ae54-2a08d75a6386/download07953061327ee0816a75e28bb16776faMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.uan.edu.co/bitstreams/46a592a2-bf99-42b4-a942-c074fb1ca2de/download9868ccc48a14c8d591352b6eaf7f6239MD54123456789/6379oai:repositorio.uan.edu.co:123456789/63792024-10-09 22:58:23.905https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertorestrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co

Tratamientos alternativos de origen natural para las enfermedades de Chagas y Leishmaniasis

Publicaciones similares