Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2

The World Health Organization declared the infection named COVID-19 as a Public Health Emergency of International Concern on January 30, 2020, caused by the RNA virus called Coronavirus, causing more than 800 thousand deaths worldwide.(1) According to research carried out by Piera Valenti, they desc...

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Autores:
Cerquera Muñoz, Carmen Alicia
Urrutia Rivas, Yaney Yuliana
Bryan Lopera, Crishnaisha
Arias Vivas, Flor María
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2021
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/6542
Acceso en línea:
http://repositorio.uan.edu.co/handle/123456789/6542
Palabra clave:
SARS-CoV-2
Receptores ACE2
Proteasa TMPRSS2
Susceptibilidad
Patologías oculares
617.7
SARS-CoV-2
ACE2 receptors
TMPRSS2 protease
Susceptibility
Ocular pathologies
Rights
closedAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
id UAntonioN2_717308124e838c2383d559c8f6435ca6
oai_identifier_str oai:repositorio.uan.edu.co:123456789/6542
network_acronym_str UAntonioN2
network_name_str Repositorio UAN
repository_id_str
dc.title.es_ES.fl_str_mv Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
title Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
spellingShingle Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
SARS-CoV-2
Receptores ACE2
Proteasa TMPRSS2
Susceptibilidad
Patologías oculares
617.7
SARS-CoV-2
ACE2 receptors
TMPRSS2 protease
Susceptibility
Ocular pathologies
title_short Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
title_full Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
title_fullStr Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
title_full_unstemmed Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
title_sort Receptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2
dc.creator.fl_str_mv Cerquera Muñoz, Carmen Alicia
Urrutia Rivas, Yaney Yuliana
Bryan Lopera, Crishnaisha
Arias Vivas, Flor María
dc.contributor.advisor.spa.fl_str_mv Garzón Parra, Johanna
Hernández, César Augusto
dc.contributor.author.spa.fl_str_mv Cerquera Muñoz, Carmen Alicia
Urrutia Rivas, Yaney Yuliana
Bryan Lopera, Crishnaisha
Arias Vivas, Flor María
dc.subject.es_ES.fl_str_mv SARS-CoV-2
Receptores ACE2
Proteasa TMPRSS2
Susceptibilidad
Patologías oculares
topic SARS-CoV-2
Receptores ACE2
Proteasa TMPRSS2
Susceptibilidad
Patologías oculares
617.7
SARS-CoV-2
ACE2 receptors
TMPRSS2 protease
Susceptibility
Ocular pathologies
dc.subject.ddc.es_ES.fl_str_mv 617.7
dc.subject.keyword.es_ES.fl_str_mv SARS-CoV-2
ACE2 receptors
TMPRSS2 protease
Susceptibility
Ocular pathologies
description The World Health Organization declared the infection named COVID-19 as a Public Health Emergency of International Concern on January 30, 2020, caused by the RNA virus called Coronavirus, causing more than 800 thousand deaths worldwide.(1) According to research carried out by Piera Valenti, they describe: “Coronavirus belongs to the Coronaviridae family, specifically of the Delta genus. coronavirus and its name is SARS-CoV-2” (2); This virus is similar to the SARS-CoV at the nucleotide level, and possesses a sense single-stranded RNA genome positive with predisposition to epithelial cells and the respiratory system; this virus contains an encapsulated form that has a spike glycoprotein interacting with the receptor binding domain. The purpose of this bibliographical study is to understand and analyze that the virus does not It only affects the heart, lungs, kidneys, liver, digestive tract, and liver. blood vessels, but there is also growing clinical and scientific evidence of that the human ocular surface may represent an additional route of entry. In the evidence has shown that some respiratory viruses, including SARS CoV cause eye complications such as conjunctivitis in infected people and in they do establish a respiratory infection after ocular exposure.
publishDate 2021
dc.date.issued.spa.fl_str_mv 2021-11-11
dc.date.accessioned.none.fl_str_mv 2022-05-14T14:20:03Z
dc.date.available.none.fl_str_mv 2022-05-14T14:20:03Z
dc.type.spa.fl_str_mv Trabajo de grado (Pregrado y/o Especialización)
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format http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv http://repositorio.uan.edu.co/handle/123456789/6542
dc.identifier.bibliographicCitation.spa.fl_str_mv Zhang C, Chen Y, Li L, Yang Y, He J, Chen C, et al. Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. Mol Biomed [Internet]. 2020 Dec 20 [cited 2020 Aug 27]; 1(1):5. Available from: http://link.springer.com/10.1186/s43556-020-00005-0
Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, et al. Coexpression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. Ocul Surf. 2020 Jun 3;
Al-Qahtani AA. Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2): Emergence, history, basic and clinical aspects. Saudi Journal of Biological Sciences. Elsevier B.V.; 2020.
Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, et al. Structure of the SARS-CoV2 spike receptor-binding domain bound to the ACE2 receptor. Nature [Internet]. 2020 May 14 [cited 2020 Sep 16]; 581(7807):215–20. Available from: https://doi.org/10.1038/s41586-020-2180-5
Coronavirus (CoV) GLOBAL [Internet]. [cited 2020 Oct 20]. Available from: https://www.who.int/es/health-topics/coronavirus
Zhang C, Chen Y, Li L, Yang Y, He J, Chen C, et al. Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. Mol Biomed [Internet]. 2020 Dec 20 [cited 2020 Aug 27]; 1(1):5. Available from: http://link.springer.com/10.1186/s43556-020-00005-0
Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD, et al. The Natural History, Pathobiology, and Clinical Manifestations of SARSCoV-2 Infections [Internet]. Journal of Neuroimmune Pharmacology. Springer; 2020 [cited 2020 Aug 28]. p. 1. Available from: /pmc/articles/PMC7373339/?report=abstract
Liu Z, Zheng H, Lin H, Li M, Yuan R, Peng J, et al. Identification of common deletions in the spike protein of SARS-CoV-2. J Virol [Internet]. 2020 Jun 22 [cited 2020 Aug 27]; 94(17):790–810. Available from: /pmc/articles/PMC7431800/? Report=abstract.
Da Silva PG, Mesquita JR, de São José Nascimento M, Ferreira VAM. Viral, host and environmental factors that favor anthropozoonotic spillover of coronaviruses: An opinionated review, focusing on SARS-CoV, MERS-CoV and SARS-CoV-2. Sci Total Environ. 2020 Aug 1; 750:141483.
Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, et al. Coexpression of SARS-CoV-2 entry genes in the superficial adult humanconjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. Ocul Surf. 2020 Jun 3; Campione E, Cosio T, Rosa L, Lanna C, Girolamo S Di, Gaziano R, et al
dc.identifier.instname.spa.fl_str_mv instname:Universidad Antonio Nariño
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UAN
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url http://repositorio.uan.edu.co/handle/123456789/6542
identifier_str_mv Zhang C, Chen Y, Li L, Yang Y, He J, Chen C, et al. Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. Mol Biomed [Internet]. 2020 Dec 20 [cited 2020 Aug 27]; 1(1):5. Available from: http://link.springer.com/10.1186/s43556-020-00005-0
Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, et al. Coexpression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. Ocul Surf. 2020 Jun 3;
Al-Qahtani AA. Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2): Emergence, history, basic and clinical aspects. Saudi Journal of Biological Sciences. Elsevier B.V.; 2020.
Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, et al. Structure of the SARS-CoV2 spike receptor-binding domain bound to the ACE2 receptor. Nature [Internet]. 2020 May 14 [cited 2020 Sep 16]; 581(7807):215–20. Available from: https://doi.org/10.1038/s41586-020-2180-5
Coronavirus (CoV) GLOBAL [Internet]. [cited 2020 Oct 20]. Available from: https://www.who.int/es/health-topics/coronavirus
Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD, et al. The Natural History, Pathobiology, and Clinical Manifestations of SARSCoV-2 Infections [Internet]. Journal of Neuroimmune Pharmacology. Springer; 2020 [cited 2020 Aug 28]. p. 1. Available from: /pmc/articles/PMC7373339/?report=abstract
Liu Z, Zheng H, Lin H, Li M, Yuan R, Peng J, et al. Identification of common deletions in the spike protein of SARS-CoV-2. J Virol [Internet]. 2020 Jun 22 [cited 2020 Aug 27]; 94(17):790–810. Available from: /pmc/articles/PMC7431800/? Report=abstract.
Da Silva PG, Mesquita JR, de São José Nascimento M, Ferreira VAM. Viral, host and environmental factors that favor anthropozoonotic spillover of coronaviruses: An opinionated review, focusing on SARS-CoV, MERS-CoV and SARS-CoV-2. Sci Total Environ. 2020 Aug 1; 750:141483.
Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, et al. Coexpression of SARS-CoV-2 entry genes in the superficial adult humanconjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. Ocul Surf. 2020 Jun 3; Campione E, Cosio T, Rosa L, Lanna C, Girolamo S Di, Gaziano R, et al
instname:Universidad Antonio Nariño
reponame:Repositorio Institucional UAN
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dc.publisher.spa.fl_str_mv Universidad Antonio Nariño
dc.publisher.program.spa.fl_str_mv Optometría
dc.publisher.faculty.spa.fl_str_mv Facultad de Optometría
dc.publisher.campus.spa.fl_str_mv Medellín
institution Universidad Antonio Nariño
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spelling Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso a solo metadatoshttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbGarzón Parra, JohannaHernández, César AugustoCerquera Muñoz, Carmen AliciaUrrutia Rivas, Yaney YulianaBryan Lopera, CrishnaishaArias Vivas, Flor María202717157382027162371120271626533102720287182022-05-14T14:20:03Z2022-05-14T14:20:03Z2021-11-11http://repositorio.uan.edu.co/handle/123456789/6542Zhang C, Chen Y, Li L, Yang Y, He J, Chen C, et al. Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. Mol Biomed [Internet]. 2020 Dec 20 [cited 2020 Aug 27]; 1(1):5. Available from: http://link.springer.com/10.1186/s43556-020-00005-0Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, et al. Coexpression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. Ocul Surf. 2020 Jun 3;Al-Qahtani AA. Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2): Emergence, history, basic and clinical aspects. Saudi Journal of Biological Sciences. Elsevier B.V.; 2020.Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, et al. Structure of the SARS-CoV2 spike receptor-binding domain bound to the ACE2 receptor. Nature [Internet]. 2020 May 14 [cited 2020 Sep 16]; 581(7807):215–20. Available from: https://doi.org/10.1038/s41586-020-2180-5Coronavirus (CoV) GLOBAL [Internet]. [cited 2020 Oct 20]. Available from: https://www.who.int/es/health-topics/coronavirusZhang C, Chen Y, Li L, Yang Y, He J, Chen C, et al. Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. Mol Biomed [Internet]. 2020 Dec 20 [cited 2020 Aug 27]; 1(1):5. Available from: http://link.springer.com/10.1186/s43556-020-00005-0Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD, et al. The Natural History, Pathobiology, and Clinical Manifestations of SARSCoV-2 Infections [Internet]. Journal of Neuroimmune Pharmacology. Springer; 2020 [cited 2020 Aug 28]. p. 1. Available from: /pmc/articles/PMC7373339/?report=abstractLiu Z, Zheng H, Lin H, Li M, Yuan R, Peng J, et al. Identification of common deletions in the spike protein of SARS-CoV-2. J Virol [Internet]. 2020 Jun 22 [cited 2020 Aug 27]; 94(17):790–810. Available from: /pmc/articles/PMC7431800/? Report=abstract.Da Silva PG, Mesquita JR, de São José Nascimento M, Ferreira VAM. Viral, host and environmental factors that favor anthropozoonotic spillover of coronaviruses: An opinionated review, focusing on SARS-CoV, MERS-CoV and SARS-CoV-2. Sci Total Environ. 2020 Aug 1; 750:141483.Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, et al. Coexpression of SARS-CoV-2 entry genes in the superficial adult humanconjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface. Ocul Surf. 2020 Jun 3; Campione E, Cosio T, Rosa L, Lanna C, Girolamo S Di, Gaziano R, et alinstname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/The World Health Organization declared the infection named COVID-19 as a Public Health Emergency of International Concern on January 30, 2020, caused by the RNA virus called Coronavirus, causing more than 800 thousand deaths worldwide.(1) According to research carried out by Piera Valenti, they describe: “Coronavirus belongs to the Coronaviridae family, specifically of the Delta genus. coronavirus and its name is SARS-CoV-2” (2); This virus is similar to the SARS-CoV at the nucleotide level, and possesses a sense single-stranded RNA genome positive with predisposition to epithelial cells and the respiratory system; this virus contains an encapsulated form that has a spike glycoprotein interacting with the receptor binding domain. The purpose of this bibliographical study is to understand and analyze that the virus does not It only affects the heart, lungs, kidneys, liver, digestive tract, and liver. blood vessels, but there is also growing clinical and scientific evidence of that the human ocular surface may represent an additional route of entry. In the evidence has shown that some respiratory viruses, including SARS CoV cause eye complications such as conjunctivitis in infected people and in they do establish a respiratory infection after ocular exposure.La Organización mundial de la Salud declaró la infección denominada COVID-19 como una emergencia de salud pública de preocupación internacional el 30 de enero de 2020, causada por el virus ARN denominado Coronavirus, causante de más de 800 mil muertes a nivel mundial.(1) Según investigaciones realizadas por Piera Valenti describe: “Coronavirus pertenece a la familia Coronaviridae, específicamente del género Delta coronavirus y su denominación es SARS-CoV-2” (2); este virus presenta similitud con el SARS-CoV a nivel de nucleótidos, y posee un genoma de ARN monocatenario de sentido positivo con predisposición a las células epiteliales y al sistema respiratorio; éste virus contiene una forma encapsulada que tiene una glicoproteína espiga interactuando con el dominio de unión al receptor. La finalidad de este estudio bibliográfico es comprender y analizar que el virus no solamente afecta al corazón, al pulmón, los riñones, el hígado, el tracto digestivo y los vasos sanguíneos, sino que también existe una creciente evidencia clínica y científica de que la superficie ocular humana puede representar una ruta adicional de entrada. En las evidencias se ha demostrado que algunos virus respiratorios por lo que se incluye el SARS CoV provocan complicaciones oculares como la conjuntivitis en personas infectadas y en sí establecen una infección respiratoria tras la exposición ocular.OptómetraPregradoPresencialMonografíaspaUniversidad Antonio NariñoOptometríaFacultad de OptometríaMedellínSARS-CoV-2Receptores ACE2Proteasa TMPRSS2SusceptibilidadPatologías oculares617.7SARS-CoV-2ACE2 receptorsTMPRSS2 proteaseSusceptibilityOcular pathologiesReceptores ACE-2 en superficie ocular y susceptibilidad con SARS CoV-2Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85EspecializadaORIGINAL2022_CarmenAliciaCerqueraMuñoz.pdf2022_CarmenAliciaCerqueraMuñoz.pdfapplication/pdf586284https://repositorio.uan.edu.co/bitstreams/3744e248-20ed-4d6c-9db8-0a4acea74019/download45c5d731c46cb3d5620d71f2049e50e3MD522022_CarmenAliciaCerqueraMuñoz_Autorizacion.pdf2022_CarmenAliciaCerqueraMuñoz_Autorizacion.pdfapplication/pdf2920280https://repositorio.uan.edu.co/bitstreams/572965c5-ad2b-481f-8955-3b14f4e229f9/download796d83c254f1cffd2960e4f0c94e9619MD512022_CarmenAliciaCerqueraMuñoz_Acta.pdf2022_CarmenAliciaCerqueraMuñoz_Acta.pdfapplication/pdf266656https://repositorio.uan.edu.co/bitstreams/5fb40ab0-aa38-4f54-9d05-4a69b04f74b1/download592b757123fb7c007a7abd932f946051MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.uan.edu.co/bitstreams/b91dba41-8c6e-48d6-9c5c-0866605641a3/download9868ccc48a14c8d591352b6eaf7f6239MD54123456789/6542oai:repositorio.uan.edu.co:123456789/65422024-10-09 23:35:32.11https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso a solo metadatosrestrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co

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