Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.

Interna

Autores:
Lota Mendoza, Camila Alejandra
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2020
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/1492
Acceso en línea:
http://repositorio.uan.edu.co/handle/123456789/1492
Palabra clave:
Nanocompuesto magnético de plata, biocida, bacteriostático, bacterias multirresistentes, antibióticos.
Magnetic silver nanocomposite, biocide, bacteriostatic, multi-resistant bacteria, antibiotics.
Rights
openAccess
License
Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
id UAntonioN2_66371aa697ca60ed8331b4cf414c5544
oai_identifier_str oai:repositorio.uan.edu.co:123456789/1492
network_acronym_str UAntonioN2
network_name_str Repositorio UAN
repository_id_str
dc.title.es_ES.fl_str_mv Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
title Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
spellingShingle Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
Nanocompuesto magnético de plata, biocida, bacteriostático, bacterias multirresistentes, antibióticos.
Magnetic silver nanocomposite, biocide, bacteriostatic, multi-resistant bacteria, antibiotics.
title_short Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
title_full Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
title_fullStr Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
title_full_unstemmed Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
title_sort Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.
dc.creator.fl_str_mv Lota Mendoza, Camila Alejandra
dc.contributor.advisor.spa.fl_str_mv Murillo, Gladys Angélica
Rincón, Rolando Javier
dc.contributor.author.spa.fl_str_mv Lota Mendoza, Camila Alejandra
dc.subject.es_ES.fl_str_mv Nanocompuesto magnético de plata, biocida, bacteriostático, bacterias multirresistentes, antibióticos.
topic Nanocompuesto magnético de plata, biocida, bacteriostático, bacterias multirresistentes, antibióticos.
Magnetic silver nanocomposite, biocide, bacteriostatic, multi-resistant bacteria, antibiotics.
dc.subject.keyword.es_ES.fl_str_mv Magnetic silver nanocomposite, biocide, bacteriostatic, multi-resistant bacteria, antibiotics.
description Interna
publishDate 2020
dc.date.issued.spa.fl_str_mv 2020-11-17
dc.date.accessioned.none.fl_str_mv 2021-02-18T17:53:11Z
dc.date.available.none.fl_str_mv 2021-02-18T17:53:11Z
dc.type.spa.fl_str_mv Trabajo de grado (Pregrado y/o Especialización)
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv http://repositorio.uan.edu.co/handle/123456789/1492
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dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional UAN
dc.identifier.repourl.spa.fl_str_mv repourl:https://repositorio.uan.edu.co/
url http://repositorio.uan.edu.co/handle/123456789/1492
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Polymers, 12(1). https://doi.org/10.3390/polym12010197instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/InternaSilver nanoparticles are a novel treatment against bacterial infections that exhibit resistance against traditional antibiotic agents resulting in infectious diseases of complex evolution. However, this type of nanoparticles exhibit cytotoxicity on eukaryotic cells, as well as are a substance that generates contamination in the water where it has been used, due to lack of a mechanism for its removal from the environment. As a solution alternative to these problems, it is proposed to develop a nanocomposite consisting of a magnetic core of iron oxide, coated with silica, and decorated with silver nanoparticles. The capacity of the nanostructured compound produced as a bactericidal agent, was evaluated on Gram positive strains and Gram Negatives. The characterization was carried out through by scanning electron microscopy and scanning transmission electron microscopy to determine its morphology, its chemical composition was determined semi-qualitatively by dispersed energy X-ray spectroscopy and its magnetic properties by vibrant sample magnetometry. The study showed that developed nanocomposites can be applied as bactericidal and/or bacteriostatic agents, being an alternative in disinfection processes for microbial control. Finally, by their magnetic property they would facilitate their removal from the environment in which they have been applied, thus allowing to perform a disinfection process without adding additional contaminants to the environment, preventing the accumulation of these in the environment.Las nanopartículas de plata se han ido constituyendo como un tratamiento novedoso contra infecciones bacterianas que presentan resistencia contra los agentes antibióticos tradicionales generando como consecuencia enfermedades infecciosas de evolución compleja. Sin embargo, este tipo de nanopartículas exhiben citotoxicidad sobre células eucariotas, así como generan contaminación en el agua donde han sido empleadas, por falta de un mecanismo para su remoción del medio. Como una alternativa de solución a estas problemáticas, se propone el desarrollo de un nanocompuesto constituido por un núcleo magnético de óxido de hierro, recubierto con sílica y decorado con nanopartículas de plata. La capacidad del compuesto nanoestructurado producido como agente bactericida, fue evaluado sobre cepas Gram positivas y Gram Negativas. La caracterización se realizó a través de microscopia electrónica de barrido y microscopía electrónica de transmisión de barrido para determinar su morfología, su composición química fue determinada de forma semicuantitativa por espectroscopía de rayos X de energía dispersa y las propiedades magnéticas por magnetometría de muestra vibrante. El estudio evidenció que los nanocompuestos desarrollados pueden aplicarse como agentes bactericidas y/o bacteriostáticos, siendo una alternativa en los procesos de desinfección para el control microbiano. Finalmente, por su propiedad magnética facilitarían su remoción del medio en el que han sido aplicadas, permitiendo así realizar un proceso de desinfección sin adicionar agentes contaminantes adicionales al medio, previniendo la acumulación de estos en el ambiente.UAN Proyectos de ciencia, tecnología, innovación y creación artísticaBioquímico(a)PregradoEl trabajo de grado fue financiado por el proyecto de la convocatoria interna de la Universidad Antonio Nariño No. 2019204PresencialspaUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - CircunvalarNanocompuesto magnético de plata, biocida, bacteriostático, bacterias multirresistentes, antibióticos.Magnetic silver nanocomposite, biocide, bacteriostatic, multi-resistant bacteria, antibiotics.Síntesis y actividad antibacterial de un nanocompuesto NPIO@SiO2/Ag, evaluando su citotoxicidad en células eucariotas.Trabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINAL2020AutorizacióndeAutores.pdf2020AutorizacióndeAutores.pdfAutorización de Autoresapplication/pdf376624https://repositorio.uan.edu.co/bitstreams/57f0499a-a3f4-4504-b632-09f053d935cb/downloadac967afaec419d19f33d2690305b5270MD512020CamilaAlejandraLotaMendoza.pdf2020CamilaAlejandraLotaMendoza.pdfTrabajo de Gradoapplication/pdf2052013https://repositorio.uan.edu.co/bitstreams/d3beae42-7591-4d9e-a157-a4988c70d47f/download427d0c35fa656ede9305737333ddc205MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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