Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo
Retinitis pigmentosa and diabetic retinopathy are neurodegenerative eye diseases. Molecules such as LEP, ET-1, and CLU are described as present in these pathologies, their expression in biological fluids could be considered useful in supporting the diagnosis of the two pathologies.
- Autores:
-
Narváez Rumié, Olivia Margarita
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2021
- Institución:
- Universidad Antonio Nariño
- Repositorio:
- Repositorio UAN
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uan.edu.co:123456789/5091
- Acceso en línea:
- http://repositorio.uan.edu.co/handle/123456789/5091
- Palabra clave:
- Retinitis pigmentaria
Retinopatía diabética
Leptina
Endotelina-1
Clusterina
Retinitis pigmentosa
Diabetic retinopathy
Leptin
Endothelin-1
Clusterin
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
| id |
UAntonioN2_415c04499385eafa1f53f014705352af |
|---|---|
| oai_identifier_str |
oai:repositorio.uan.edu.co:123456789/5091 |
| network_acronym_str |
UAntonioN2 |
| network_name_str |
Repositorio UAN |
| repository_id_str |
|
| dc.title.es_ES.fl_str_mv |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| title |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| spellingShingle |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo Retinitis pigmentaria Retinopatía diabética Leptina Endotelina-1 Clusterina Retinitis pigmentosa Diabetic retinopathy Leptin Endothelin-1 Clusterin |
| title_short |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| title_full |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| title_fullStr |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| title_full_unstemmed |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| title_sort |
Niveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgo |
| dc.creator.fl_str_mv |
Narváez Rumié, Olivia Margarita |
| dc.contributor.advisor.spa.fl_str_mv |
Trujillo Güiza, Martha Liliana Escobar Martinez, Magally |
| dc.contributor.author.spa.fl_str_mv |
Narváez Rumié, Olivia Margarita |
| dc.subject.es_ES.fl_str_mv |
Retinitis pigmentaria Retinopatía diabética Leptina Endotelina-1 Clusterina |
| topic |
Retinitis pigmentaria Retinopatía diabética Leptina Endotelina-1 Clusterina Retinitis pigmentosa Diabetic retinopathy Leptin Endothelin-1 Clusterin |
| dc.subject.keyword.es_ES.fl_str_mv |
Retinitis pigmentosa Diabetic retinopathy Leptin Endothelin-1 Clusterin |
| description |
Retinitis pigmentosa and diabetic retinopathy are neurodegenerative eye diseases. Molecules such as LEP, ET-1, and CLU are described as present in these pathologies, their expression in biological fluids could be considered useful in supporting the diagnosis of the two pathologies. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2021-10-26T21:43:33Z |
| dc.date.available.none.fl_str_mv |
2021-10-26T21:43:33Z |
| dc.date.issued.spa.fl_str_mv |
2021-07-02 |
| dc.type.spa.fl_str_mv |
Tesis y disertaciones (Maestría y/o Doctorado) |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
| dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.local.spa.fl_str_mv |
Tesis/Trabajo de grado - Monografía - Doctorado |
| format |
http://purl.org/coar/resource_type/c_db06 |
| dc.identifier.uri.none.fl_str_mv |
http://repositorio.uan.edu.co/handle/123456789/5091 |
| dc.identifier.bibliographicCitation.spa.fl_str_mv |
Misnaza S. Informe del evento de vigilancia de enfermedades huérfanas-raras hasta el período epidemiológico seis, Colombia, 2017. 2017. [Internet]. Available from: www.ins.gov.co/...Vigilancia/Informe de Evento Epidemiolgico/ENFERM...%0A OMS. Informe mundial sobre la diabetes [Internet]. [cited 2017 Nov 2]; Available from: http://apps.who.int/iris/bitstream/10665/204877/1/WHO_NMH_NVI_16.3_spa.pdf? ua=1 Gariano R, Nath A, D´amico D, Lee T, Sierra-Honigman R. Elevation of vitreous leptin in diabetic retinopathy and retinal detachment. Investig Ophthalmol Vis Sci [Internet]. 2000; 41 (11): 3576–81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11006255 Bauskar A, Mack W, Mauris J, Argüeso P, Heur M, Nagel B, et al. Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results. Ocul Surf [Internet]. 2018;10 (4): 1–24. Available from: https://doi.org/10.1016/j.jtos.2018.08.001 Chang W, Lajko M, Fawzi A. Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. PLoS One [Internet]. 2018; 13(1): 1–15. Available from: doi: 10.1371/journal.pone.0191285 Daiger S, Bowne S, Sullivan L. Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa. Cold Spring Harb Perspect Med. [Internet]. 2015; 5 (10): 1– 13. Available from: https://pubmed.ncbi.nlm.nih.gov/25304133/ Delgado-Pelayo S. Retinosis. Rev Med MD [Internet]. 2012 [cited 2017 Oct 8];3(3):163–6. Available from: http://www.medigraphic.com/pdfs/revmed/md2012/md123f.pdf Gili P, Carracedo G. Retinitis pigmentosa. Revisión bibliográfica. Gac Optom y Óptica Oftálmica [Internet]. 2013; 481: 7. Available from: www.cnoo.es/download.asp?file=media/gaceta/gaceta481/cientifico1.pdf Verbakel S, Van Huet R, Boon C, Hollander A, Collin R, Klaver C, et al. Nonsyndromic retinitis pigmentosa. Prog Retin Eye Res [Internet]. 2018; 66 (March):1– 30. Available from: https://doi.org/10.1016/j.preteyeres.2018.03.005 Milam AH, De Castro EB, Smith JE, Tang W-X, John SK, Gorin MB, et al. Concentric Retinitis Pigmentosa: Clinicopathologic correlations. Exp Eye Res [Internet]. 2001; 73 (4): 493–508. Available from: doi: 10.1111/aos.13475 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Universidad Antonio Nariño |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional UAN |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repositorio.uan.edu.co/ |
| url |
http://repositorio.uan.edu.co/handle/123456789/5091 |
| identifier_str_mv |
Misnaza S. Informe del evento de vigilancia de enfermedades huérfanas-raras hasta el período epidemiológico seis, Colombia, 2017. 2017. [Internet]. Available from: www.ins.gov.co/...Vigilancia/Informe de Evento Epidemiolgico/ENFERM...%0A OMS. Informe mundial sobre la diabetes [Internet]. [cited 2017 Nov 2]; Available from: http://apps.who.int/iris/bitstream/10665/204877/1/WHO_NMH_NVI_16.3_spa.pdf? ua=1 Gariano R, Nath A, D´amico D, Lee T, Sierra-Honigman R. Elevation of vitreous leptin in diabetic retinopathy and retinal detachment. Investig Ophthalmol Vis Sci [Internet]. 2000; 41 (11): 3576–81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11006255 Bauskar A, Mack W, Mauris J, Argüeso P, Heur M, Nagel B, et al. Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results. Ocul Surf [Internet]. 2018;10 (4): 1–24. Available from: https://doi.org/10.1016/j.jtos.2018.08.001 Chang W, Lajko M, Fawzi A. Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. PLoS One [Internet]. 2018; 13(1): 1–15. Available from: doi: 10.1371/journal.pone.0191285 Daiger S, Bowne S, Sullivan L. Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa. Cold Spring Harb Perspect Med. [Internet]. 2015; 5 (10): 1– 13. Available from: https://pubmed.ncbi.nlm.nih.gov/25304133/ Delgado-Pelayo S. Retinosis. Rev Med MD [Internet]. 2012 [cited 2017 Oct 8];3(3):163–6. Available from: http://www.medigraphic.com/pdfs/revmed/md2012/md123f.pdf Gili P, Carracedo G. Retinitis pigmentosa. Revisión bibliográfica. Gac Optom y Óptica Oftálmica [Internet]. 2013; 481: 7. Available from: www.cnoo.es/download.asp?file=media/gaceta/gaceta481/cientifico1.pdf Verbakel S, Van Huet R, Boon C, Hollander A, Collin R, Klaver C, et al. Nonsyndromic retinitis pigmentosa. Prog Retin Eye Res [Internet]. 2018; 66 (March):1– 30. Available from: https://doi.org/10.1016/j.preteyeres.2018.03.005 Milam AH, De Castro EB, Smith JE, Tang W-X, John SK, Gorin MB, et al. Concentric Retinitis Pigmentosa: Clinicopathologic correlations. Exp Eye Res [Internet]. 2001; 73 (4): 493–508. Available from: doi: 10.1111/aos.13475 instname:Universidad Antonio Nariño reponame:Repositorio Institucional UAN repourl:https://repositorio.uan.edu.co/ |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.rights.none.fl_str_mv |
Acceso abierto |
| dc.rights.license.spa.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Acceso abierto https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.publisher.spa.fl_str_mv |
Universidad Antonio Nariño |
| dc.publisher.program.spa.fl_str_mv |
Doctorado en Ciencias de la salud |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Medicina |
| dc.publisher.campus.spa.fl_str_mv |
Bogotá - Circunvalar |
| institution |
Universidad Antonio Nariño |
| bitstream.url.fl_str_mv |
https://repositorio.uan.edu.co/bitstreams/ce3dd337-6ce3-4460-887f-ba1d440ec690/download https://repositorio.uan.edu.co/bitstreams/8c0d261f-b855-4bac-9072-73732a8a205e/download https://repositorio.uan.edu.co/bitstreams/e1f940c8-3a91-474d-9723-2c4d8cc93d1b/download https://repositorio.uan.edu.co/bitstreams/c5683d68-854d-40d3-9cd8-fb089ea18d30/download https://repositorio.uan.edu.co/bitstreams/a8b3e6a7-4209-4014-9fea-82606f23eebe/download https://repositorio.uan.edu.co/bitstreams/661bd4a9-6fdf-404b-8cbd-64a579154526/download https://repositorio.uan.edu.co/bitstreams/678188e3-1899-43c4-a99b-c130e2e5033e/download https://repositorio.uan.edu.co/bitstreams/d5d717b5-ee4e-4e43-b18d-2b3349af135b/download https://repositorio.uan.edu.co/bitstreams/ade34ba7-4748-4384-a3e7-af7616128387/download https://repositorio.uan.edu.co/bitstreams/06fb7395-f880-4097-80ad-637a21a769a9/download |
| bitstream.checksum.fl_str_mv |
3ca7c12b20bc845f3c17e400366e0e83 1e0498a84f0f128e553d168e1932b256 47caf276605a7f4dd742bcc7b7d24af0 c3b2cdca800aa01c6175488b1291697a a20bd95964551e0f5d2f833c84cfb68b 0a5d06c8aba08d27eeb373984c2a6eae e1c06d85ae7b8b032bef47e42e4c08f9 7bff754d3fddcd2edb85ab591a252da2 7b6d2c451d8772b9003c241afe68be70 daa588ee20abbca69eb7fdf78a938abb |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional UAN |
| repository.mail.fl_str_mv |
alertas.repositorio@uan.edu.co |
| _version_ |
1814300333262766080 |
| spelling |
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)Acceso abiertohttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Trujillo Güiza, Martha LilianaEscobar Martinez, MagallyNarváez Rumié, Olivia Margarita0000-0001-8792-36810000-0002-8082-3407https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001410980https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000194255https://scholar.google.es/citations?user=Fv7Kb8IAAAAJ&hl=es129717113852021-10-26T21:43:33Z2021-10-26T21:43:33Z2021-07-02http://repositorio.uan.edu.co/handle/123456789/5091Misnaza S. Informe del evento de vigilancia de enfermedades huérfanas-raras hasta el período epidemiológico seis, Colombia, 2017. 2017. [Internet]. Available from: www.ins.gov.co/...Vigilancia/Informe de Evento Epidemiolgico/ENFERM...%0AOMS. Informe mundial sobre la diabetes [Internet]. [cited 2017 Nov 2]; Available from: http://apps.who.int/iris/bitstream/10665/204877/1/WHO_NMH_NVI_16.3_spa.pdf? ua=1Gariano R, Nath A, D´amico D, Lee T, Sierra-Honigman R. Elevation of vitreous leptin in diabetic retinopathy and retinal detachment. Investig Ophthalmol Vis Sci [Internet]. 2000; 41 (11): 3576–81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11006255Bauskar A, Mack W, Mauris J, Argüeso P, Heur M, Nagel B, et al. Clusterin from human clinical tear samples: Positive correlation between tear concentration and Schirmer strip test results. Ocul Surf [Internet]. 2018;10 (4): 1–24. Available from: https://doi.org/10.1016/j.jtos.2018.08.001Chang W, Lajko M, Fawzi A. Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. PLoS One [Internet]. 2018; 13(1): 1–15. Available from: doi: 10.1371/journal.pone.0191285Daiger S, Bowne S, Sullivan L. Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa. Cold Spring Harb Perspect Med. [Internet]. 2015; 5 (10): 1– 13. Available from: https://pubmed.ncbi.nlm.nih.gov/25304133/Delgado-Pelayo S. Retinosis. Rev Med MD [Internet]. 2012 [cited 2017 Oct 8];3(3):163–6. Available from: http://www.medigraphic.com/pdfs/revmed/md2012/md123f.pdfGili P, Carracedo G. Retinitis pigmentosa. Revisión bibliográfica. Gac Optom y Óptica Oftálmica [Internet]. 2013; 481: 7. Available from: www.cnoo.es/download.asp?file=media/gaceta/gaceta481/cientifico1.pdfVerbakel S, Van Huet R, Boon C, Hollander A, Collin R, Klaver C, et al. Nonsyndromic retinitis pigmentosa. Prog Retin Eye Res [Internet]. 2018; 66 (March):1– 30. Available from: https://doi.org/10.1016/j.preteyeres.2018.03.005Milam AH, De Castro EB, Smith JE, Tang W-X, John SK, Gorin MB, et al. Concentric Retinitis Pigmentosa: Clinicopathologic correlations. Exp Eye Res [Internet]. 2001; 73 (4): 493–508. Available from: doi: 10.1111/aos.13475instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/Retinitis pigmentosa and diabetic retinopathy are neurodegenerative eye diseases. Molecules such as LEP, ET-1, and CLU are described as present in these pathologies, their expression in biological fluids could be considered useful in supporting the diagnosis of the two pathologies.La retinosis pigmentaria (RP) y la retinopatía diabética (RD) son enfermedades oculares neurodegenerativas. Moléculas como la leptina (LEP), endotelina-1 (ET-1) y clusterina (CLU) están descritas como presentes en estas patologías, su expresión en fluidos biológicos podría considerarse útil en el apoyo del diagnóstico de estas dos patologías.Doctor(a) en Ciencias de la saludDoctoradoPresencialspaUniversidad Antonio NariñoDoctorado en Ciencias de la saludFacultad de MedicinaBogotá - CircunvalarRetinitis pigmentariaRetinopatía diabéticaLeptinaEndotelina-1ClusterinaRetinitis pigmentosaDiabetic retinopathyLeptinEndothelin-1ClusterinNiveles lagrimales y plasmáticos de leptina, endotelina-1 y clusterina, correlación con diagnósticos de retinosis pigmentaria y retinopatía diabética y factores de riesgoTesis y disertaciones (Maestría y/o Doctorado)http://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85Tesis/Trabajo de grado - Monografía - DoctoradoEspecializadaORIGINAL2021Olivia MargaritaNarváez Rumié.pdf2021Olivia MargaritaNarváez Rumié.pdfTesis Doctoralapplication/pdf4176919https://repositorio.uan.edu.co/bitstreams/ce3dd337-6ce3-4460-887f-ba1d440ec690/download3ca7c12b20bc845f3c17e400366e0e83MD512021ActadeSustentacion.pdf2021ActadeSustentacion.pdfActa Sustentaciónapplication/pdf214876https://repositorio.uan.edu.co/bitstreams/8c0d261f-b855-4bac-9072-73732a8a205e/download1e0498a84f0f128e553d168e1932b256MD532021AutorizacióndeAutorespdf2021AutorizacióndeAutorespdfAutorización autoresapplication/pdf611088https://repositorio.uan.edu.co/bitstreams/e1f940c8-3a91-474d-9723-2c4d8cc93d1b/download47caf276605a7f4dd742bcc7b7d24af0MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-83747https://repositorio.uan.edu.co/bitstreams/c5683d68-854d-40d3-9cd8-fb089ea18d30/downloadc3b2cdca800aa01c6175488b1291697aMD55TEXT2021Olivia MargaritaNarváez Rumié.pdf.txt2021Olivia MargaritaNarváez Rumié.pdf.txtExtracted texttext/plain101859https://repositorio.uan.edu.co/bitstreams/a8b3e6a7-4209-4014-9fea-82606f23eebe/downloada20bd95964551e0f5d2f833c84cfb68bMD562021ActadeSustentacion.pdf.txt2021ActadeSustentacion.pdf.txtExtracted texttext/plain2317https://repositorio.uan.edu.co/bitstreams/661bd4a9-6fdf-404b-8cbd-64a579154526/download0a5d06c8aba08d27eeb373984c2a6eaeMD582021AutorizacióndeAutorespdf.txt2021AutorizacióndeAutorespdf.txtExtracted texttext/plain2https://repositorio.uan.edu.co/bitstreams/678188e3-1899-43c4-a99b-c130e2e5033e/downloade1c06d85ae7b8b032bef47e42e4c08f9MD510THUMBNAIL2021Olivia MargaritaNarváez Rumié.pdf.jpg2021Olivia MargaritaNarváez Rumié.pdf.jpgGenerated Thumbnailimage/jpeg7400https://repositorio.uan.edu.co/bitstreams/d5d717b5-ee4e-4e43-b18d-2b3349af135b/download7bff754d3fddcd2edb85ab591a252da2MD572021ActadeSustentacion.pdf.jpg2021ActadeSustentacion.pdf.jpgGenerated Thumbnailimage/jpeg19920https://repositorio.uan.edu.co/bitstreams/ade34ba7-4748-4384-a3e7-af7616128387/download7b6d2c451d8772b9003c241afe68be70MD592021AutorizacióndeAutorespdf.jpg2021AutorizacióndeAutorespdf.jpgGenerated Thumbnailimage/jpeg16999https://repositorio.uan.edu.co/bitstreams/06fb7395-f880-4097-80ad-637a21a769a9/downloaddaa588ee20abbca69eb7fdf78a938abbMD511123456789/5091oai:repositorio.uan.edu.co:123456789/50912024-10-09 22:47:06.499https://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertoopen.accesshttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.coQWwgaW5jbHVpciBpbmZvcm1hY2nDs24gZW4gZWwgUmVwb3NpdG9yaW8gSW5zdGl0dWNpb25hbCwgZWwgYXV0b3IoZXMpLCBjcmVhZG9yIChlcyksIGludmVudG9yIChlcykgYXV0b3JpemFuIGEgbGEgVU5JVkVSU0lEQUQgQU5UT05JTyBOQVJJw5FPIHBhcmEgcXVlIGRlIGFjdWVyZG8gY29uIGxvcyB0w6lybWlub3MgZXN0YWJsZWNpZG9zIGVuIGxhIExleSAyMyBkZSAxOTgyLCBMZXkgNDQgZGUgMTk5MywgTGV5IDE0NTAgZGUgMjAxMSwgRGVjaXNpw7NuIEFuZGluYSAzNTEgZGUgMTk5MywgRGVjcmV0byA0NjAgZGUgMTk5NSwgbGEgQ2lyY3VsYXIgTm8uIDYgZGUgbGEgRGlyZWNjacOzbiBOYWNpb25hbCBkZSBEZXJlY2hvcyBkZSBBdXRvciB5IGRlbcOhcyBub3JtYXMgZ2VuZXJhbGVzIHNvYnJlIGxhIG1hdGVyaWEsIGNvbiBmaW5lcyBhY2Fkw6ltaWNvcywgbm8gY29tZXJjaWFsZXMgeSBkZSBtYW5lcmEgZ3JhdHVpdGEsIHV0aWxpY2UsIHB1YmxpcXVlIGRpZ2l0YWxtZW50ZSwgcmVwcm9kdXpjYSB5IHBlcm1pdGEgbGEgZGlmdXNpw7NuIHkgY29uc3VsdGEgZGUgbG9zIGNvbnRlbmlkb3MgZW4gcmVmZXJlbmNpYSBhIHRyYXbDqXMgZGUgbGEgdmlzaWJpbGlkYWQsIHNpZW1wcmUgZW4gY3VtcGxpbWllbnRvIGRlIGxhcyBzaWd1aWVudGVzIGRpc3Bvc2ljaW9uZXM6CgoxLglFbCBpbnRlcmVzYWRvIHBvZHLDoSBjb25zdWx0YXIgZWwgY29udGVuaWRvIGVuIGxvcyBzaXRpb3Mgd2ViIHF1ZSBhZG1pbmlzdHJhIGxhIFVuaXZlcnNpZGFkIEFudG9uaW8gTmFyacOxbywgZW4gbGFzIEJhc2VzIGRlIERhdG9zLCBlbiBvdHJvcyBDYXTDoWxvZ29zIHkgZW4gb3Ryb3Mgc2l0aW9zIFdlYiwgUmVkZXMgeSBTaXN0ZW1hcyBkZSBJbmZvcm1hY2nDs24gbmFjaW9uYWxlcyBlIGludGVybmFjaW9uYWxlcyDigJxBY2Nlc28gQWJpZXJ0byAoT3BlbiBBY2Nlc3Mp4oCdIHkgZW4gbGFzIHJlZGVzIGRlIGluZm9ybWFjacOzbiBkZWwgcGHDrXMgeSBkZWwgZXh0ZXJpb3IsIGNvbiBsYXMgY3VhbGVzIHRlbmdhIGNvbnZlbmlvIGxhIFVuaXZlcnNpZGFkIEFudG9uaW8gTmFyacOxby4KCjIuCVNlIHBlcm1pdGlyw6EgbGEgY29uc3VsdGEgYSBsb3MgdXN1YXJpb3MgaW50ZXJlc2Fkb3MgZW4gZWwgY29udGVuaWRvIGRlIGVzdGUgZG9jdW1lbnRvIHkvbyByZWN1cnNvcywgY29uIGZpbmFsaWRhZCBhY2Fkw6ltaWNhLCBudW5jYSBwYXJhIHVzb3MgY29tZXJjaWFsZXMsIHNpZW1wcmUgeSBjdWFuZG8gbWVkaWFudGUgbGEgY29ycmVzcG9uZGllbnRlIGNpdGEgYmlibGlvZ3LDoWZpY2Egc2UgbGUgZMOpIGNyw6lkaXRvIGFsIGRvY3VtZW50byB5L28gcmVjdXJzbyB5IGEgc3UgYXV0b3IgKGVzKSwgY3JlYWRvcihlcykgbyBpbnZlbnRvcihlcykuIEVzdG8gaW5jbHV5ZSBjdWFscXVpZXIgZm9ybWF0byBkaXNwb25pYmxlIGNvbm9jaWRvIG8gcG9yIGNvbm9jZXIgbyBjdWFscXVpZXIgdGlwbyBkZSByZXByb2R1Y2Npw7NuIGbDrXNpY2EsIGRpZ2l0YWwgbyBmb3JtYXRvIGRpZ2l0YWwgY29ub2NpZG8gbyBwb3IgY29ub2Nlci4KCjMuCUVsKGxvcykgYXV0b3IoZXMpLCBkZWNsYXJhKG4pIHF1ZSBjb250aW7DumEobikgY29uc2VydmFuZG8gbG9zIGNvcnJlc3BvbmRpZW50ZXMgZGVyZWNob3MgbW9yYWxlcyB5IHBhdHJpbW9uaWFsZXMgc29icmUgbGEgb2JyYSByZWxhY2lvbmFkYSwgc2luIG1vZGlmaWNhY2nDs24gbyByZXN0cmljY2nDs24gYWxndW5hIHB1ZXN0byBxdWUsIGRlIGFjdWVyZG8gY29uIGxhIGxlZ2lzbGFjacOzbiBjb2xvbWJpYW5hIGFwbGljYWJsZSwgZWwgcHJlc2VudGUgZXMgdW4gYWN1ZXJkbyBqdXLDrWRpY28gZW5jYW1pbmFkbyBhIGxhIGNvbnN1bHRhIHF1ZSwgZW4gbmluZ8O6biBjYXNvIGNvbmxsZXZhIGxhIGVuYWplbmFjacOzbiBkZWwgZGVyZWNobyBkZSBhdXRvciB5IHN1cyBkZXJlY2hvcyBjb25leG9zLiBTZSBnYXJhbnRpemEgcXVlIGVsIChsb3MpIGF1dG9yKGVzKSBjb25zZXJ2YW4gbG9zIGRlcmVjaG9zIHBhdHJpbW9uaWFsZXMgZGUgbGEgb2JyYSwgc2Fsdm8gZW4gbG9zIGNhc29zIGVuIGxvcyBxdWUgbG9zIGF1dG9yZXMgdGVuZ2FuIHVuYSByZWxhY2nDs24gY29udHJhY3R1YWwgY29uIGxhIFVuaXZlcnNpZGFkLCBkZSBsYSBxdWUgc2UgZGVyaXZhIGxhIGNlc2nDs24gZGUgbG9zIGRlcmVjaG9zIHBhdHJpbW9uaWFsZXMgZGUgbGFzIG9icmFzIGRpcmVjdGFtZW50ZSBhIGZhdm9yIGRlIGxhIGluc3RpdHVjacOzbiwgc2llbXByZSB5IGN1YW5kbywgZXN0YXMgb2JyYXMgc2VhbiBlbGFib3JhZGFzIGVuIGVsIGRlc2Fycm9sbG8geSBlamVyY2ljaW8gZGUgbGFzIGFjdGl2aWRhZGVzIGNvbnRyYXRhZGFzCgo0LglRdWUgZWwgU2lzdGVtYSBOYWNpb25hbCBkZSBCaWJsaW90ZWNhcyBkZSBsYSBVbml2ZXJzaWRhZCBBbnRvbmlvIE5hcmnDsW8gcHVlZGEgY29udmVydGlyIGVsIGRvY3VtZW50byB5L28gcmVjdXJzbyBhIGN1YWxxdWllciBtZWRpbyBvIGZvcm1hdG8gcGFyYSBwcm9ww7NzaXRvcyBkZSBwcmVzZXJ2YWNpw7NuIGRpZ2l0YWwuIERlIGNvbmZvcm1pZGFkIGNvbiBsbyBlc3RhYmxlY2lkbyBlbiBsYSBMZXkgMjMgZGUgMTk4MiwgTGV5IDQ0IGRlIDE5OTMsIERlY2lzacOzbiBBbmRpbmEgMzUxIGRlIDE5OTMsIERlY3JldG8gNDYwIGRlIDE5OTUgYXPDrSBjb21vIGxhIERlY2lzacOzbiBBbmRpbmEgNDg2IGRlIDIwMDAgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIGluZHVzdHJpYWwgeSBkZW3DoXMgbm9ybWFzIGdlbmVyYWxlcyBzb2JyZSBsYSBtYXRlcmlhLCB1dGlsaWNlIHkgdXNlIGVuIHRvZGFzIHN1cyBmb3JtYXMsIGxvcyBkZXJlY2hvcyBwYXRyaW1vbmlhbGVzIGRlIHJlcHJvZHVjY2nDs24sIGNvbXVuaWNhY2nDs24gcMO6YmxpY2EsIHRyYW5zZm9ybWFjacOzbiAoZW4gZGVyZWNob3MgZGUgYXV0b3IpIGNvbW8gcHJvcGllZGFkIGluZHVzdHJpYWwgZnJlbnRlIGEgbGEgZGlzdHJpYnVjacOzbiBkZSBsYSBpbmZvcm1hY2nDs24gaW5jbHVpZGEgZW4gZXN0ZSByZXBvc2l0b3Jpby4KCjUuCUVsKGxvcykgYXV0b3IoZXMpLCBkZWNsYXJhKG4pIHF1ZSBsYSBvYnJhIHNvYnJlIGxhIGN1YWwgYXV0b3JpemFuIGxhIHB1YmxpY2FjacOzbiBlcyB0b3RhbG1lbnRlIG9yaWdpbmFsIHkgZGUgc3UgZXhjbHVzaXZhIGF1dG9yw61hLCBQb3IgdGFudG8sIGVuIGNhc28gZGUgcHJlc2VudGFyc2UgYWxndW5hIHJlY2xhbWFjacOzbiBwb3IgcGFydGUgZGUgdGVyY2Vyb3MsIGVsIChsb3MpIGF1dG9yKGVzKSBtYW50ZW5kcsOhKG4pIGluZGVtbmUgYSBsYSBVbml2ZXJzaWRhZCBkZSBjdWFscXVpZXIgcmVjbGFtYWNpw7NuIG8gcGVyanVpY2lvLCB5IHNhbGRyw6EobikgZW4gZGVmZW5zYSBkZSBsb3MgZGVyZWNob3MgYXF1w60gYXV0b3JpemFkb3MgYXN1bWllbmRvIHRvZGEgbGEgcmVzcG9uc2FiaWxpZGFkLCBpbmNsdXllbmRvIGN1YWxxdWllciBjb3N0byBxdWUgc2UgZ2VuZXJlIGVuIGxhIHJlc29sdWNpw7NuIGRlbCBjb25mbGljdG8gZ2VuZXJhZG8uCgo2LglFbChsb3MpIGF1dG9yZXMocykgYXV0b3JpemEobikgYSBsYSBVTklWRVJTSURBRCBwYXJhIHJlY29sZWN0YXIsIGFsbWFjZW5hciB5IHVzYXIgbG9zIGRhdG9zIHBlcnNvbmFsZXMgY29uZm9ybWUgYSBsbyBlc3RhYmxlY2lkbyBlbiBsYSBMZXkgMTU4MSBkZSAyMDEyLCBwYXJhIGxhcyBmaW5hbGlkYWRlcyByZXF1ZXJpZGFzIGVuIHZpcnR1ZCBkZSBsYSBwcmVzZW50ZSBhdXRvcml6YWNpw7NuIGRlIHB1YmxpY2FjacOzbi4K |