Protein fibrillation: the good, the bad and the ugly
Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays...
- Autores:
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad Antonio Nariño
- Repositorio:
- Repositorio UAN
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uan.edu.co:123456789/11090
- Acceso en línea:
- https://revistas.uan.edu.co/index.php/saywa/article/view/674
https://repositorio.uan.edu.co/handle/123456789/11090
- Palabra clave:
- Rights
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0
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2020-03-202024-10-10T02:54:54Z2024-10-10T02:54:54Zhttps://revistas.uan.edu.co/index.php/saywa/article/view/674https://repositorio.uan.edu.co/handle/123456789/11090Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins.Los procesos de fibrilación de proteínas se refieren a la unión de cadenas ligeramente modificadas en su estructura nativa, formando pequeñas fibras. Se conoce poco acerca del mecanismo que conduce a estas conformaciones, una hipótesis difundida y aceptada es la del cono entrópico, según la cual una estructura pre-desplegada es crucial en el crecimiento de fibras. La fibrilación puede presentar ventajas en cuanto a que las proteínas así conformadas tienen cualidades aprovechables tecnológicamente. Por otra parte, si el proceso ocurre en tejidos podría generar enfermedades conocidas como amiloidosis. En la Universidad Antonio Nariño se han estudiado moléculas macrocíclicas tipo resorcinareno capaces de inhibir la fibrilación de algunas proteínas.application/pdfspaUNIVERSIDAD ANTONIO NARIÑOhttps://revistas.uan.edu.co/index.php/saywa/article/view/674/574https://creativecommons.org/licenses/by-nc-sa/4.0http://purl.org/coar/access_right/c_abf2REVISTA SAYWA; Vol. 1 Núm. 1 (2019)2744-85762711-1571Protein fibrillation: the good, the bad and the uglyFibrilación de proteínas: Lo bueno, lo malo y lo feoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionDivulgación científicahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Segura, KarenMalagón, Edwin Andres123456789/11090oai:repositorio.uan.edu.co:123456789/110902024-10-14 03:46:03.677metadata.onlyhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co |
| dc.title.en-US.fl_str_mv |
Protein fibrillation: the good, the bad and the ugly |
| dc.title.es-ES.fl_str_mv |
Fibrilación de proteínas: Lo bueno, lo malo y lo feo |
| title |
Protein fibrillation: the good, the bad and the ugly |
| spellingShingle |
Protein fibrillation: the good, the bad and the ugly |
| title_short |
Protein fibrillation: the good, the bad and the ugly |
| title_full |
Protein fibrillation: the good, the bad and the ugly |
| title_fullStr |
Protein fibrillation: the good, the bad and the ugly |
| title_full_unstemmed |
Protein fibrillation: the good, the bad and the ugly |
| title_sort |
Protein fibrillation: the good, the bad and the ugly |
| description |
Protein fibrillation is a process in which the peptide chains are slightly modified form native structure to yield fibers. The mechanism that leads to this fiber conformations is little known. An accepted hypothesis is the “entropic cone”, according to this hypothesis a pre-unfolded structure plays a crucial role in the fiber growth. Fibrillation can offer certain advantages, since the new structure offers technological possibilities. On the other hand, when the process occurs inside tissues could be responsible to generate a series of illness known as “amyloidosis”. At the University Antonio Nariño a family of macrocyclic molecules, the resorcinarenes, is been studied. Preliminary results indicate that thismacrocycles are able to inhibit the fibrillation of certain proteins. |
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2020 |
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2024-10-10T02:54:54Z |
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2024-10-10T02:54:54Z |
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2020-03-20 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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Divulgación científica |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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publishedVersion |
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https://revistas.uan.edu.co/index.php/saywa/article/view/674 |
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https://repositorio.uan.edu.co/handle/123456789/11090 |
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https://revistas.uan.edu.co/index.php/saywa/article/view/674 https://repositorio.uan.edu.co/handle/123456789/11090 |
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spa |
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spa |
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https://revistas.uan.edu.co/index.php/saywa/article/view/674/574 |
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https://creativecommons.org/licenses/by-nc-sa/4.0 |
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application/pdf |
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UNIVERSIDAD ANTONIO NARIÑO |
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REVISTA SAYWA; Vol. 1 Núm. 1 (2019) |
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2744-8576 2711-1571 |
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Universidad Antonio Nariño |
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Repositorio Institucional UAN |
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