Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas

Interna

Autores:: Medina Castillo, Yehidi Julieth

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2020

Institución:: Universidad Antonio Nariño

Repositorio:: Repositorio UAN

Idioma:: spa

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network_acronym_str	UAntonioN2
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repository_id_str
dc.title.es_ES.fl_str_mv	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
title	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
spellingShingle	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas Neuroinflamación, barrera hematoencefálica, nanopartículas superparamagnéticas, péptido biomarcador, proteínas blanco, cultivos in vitro. Neuroinflammation, blood-brain barrier, superparamagnetic nanoparticles, biomarker peptide, target proteins, in vitro cultures.
title_short	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
title_full	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
title_fullStr	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
title_full_unstemmed	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
title_sort	Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas
dc.creator.fl_str_mv	Medina Castillo, Yehidi Julieth
dc.contributor.advisor.spa.fl_str_mv	Losada Barragán, Mónica Llamosa Pérez, Daniel
dc.contributor.author.spa.fl_str_mv	Medina Castillo, Yehidi Julieth
dc.subject.es_ES.fl_str_mv	Neuroinflamación, barrera hematoencefálica, nanopartículas superparamagnéticas, péptido biomarcador, proteínas blanco, cultivos in vitro.
topic	Neuroinflamación, barrera hematoencefálica, nanopartículas superparamagnéticas, péptido biomarcador, proteínas blanco, cultivos in vitro. Neuroinflammation, blood-brain barrier, superparamagnetic nanoparticles, biomarker peptide, target proteins, in vitro cultures.
dc.subject.keyword.es_ES.fl_str_mv	Neuroinflammation, blood-brain barrier, superparamagnetic nanoparticles, biomarker peptide, target proteins, in vitro cultures.
description	Interna
publishDate	2020
dc.date.issued.spa.fl_str_mv	2020-11-18
dc.date.accessioned.none.fl_str_mv	2021-02-18T18:33:52Z
dc.date.available.none.fl_str_mv	2021-02-18T18:33:52Z
dc.type.spa.fl_str_mv	Trabajo de grado (Pregrado y/o Especialización)
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
format	http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv	http://repositorio.uan.edu.co/handle/123456789/1494
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dc.identifier.instname.spa.fl_str_mv	instname:Universidad Antonio Nariño
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional UAN
dc.identifier.repourl.spa.fl_str_mv	repourl:https://repositorio.uan.edu.co/
url	http://repositorio.uan.edu.co/handle/123456789/1494
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American Journal of Neuroradiology, 28(10), 1850–1858. https://doi.org/10.3174/ajnr.A0831instname:Universidad Antonio Nariñoreponame:Repositorio Institucional UANrepourl:https://repositorio.uan.edu.co/InternaNeuroinflammation is characterized by presenting alterations in the blood-brain barrier, and activation of glial cells, leading to brain tissue alterations generating a pathology, this has led to the need to improve the magnetic resonance imaging technique that allows understanding the development and progression of alterations of the blood-brain barrier in real time, under neuroinflammatory conditions. As an alternative to this solution, it is proposed to establish the binding of a neuroinflammation marker peptide with its target protein and its conjugation with superparamagnetic nanoparticles. The results show that the magnetic nanoparticles have a spherical shape with a size of 54 ± 10 nm, the chemical composition Fe @ SiO2 and a magnetic hysteresis curve indicating a superparamagnetic behavior; The evaluation of the binding of peptide-88 with its possible receptor protein showed a greater binding between peptide-88 with laminin β1, likewise the binding of peptide-88 with the nanoparticles was studied, demonstrating a greater binding unlike the target. The present study showed that by establishing the functionalization of superparamagnetic nanoparticles conjugated to a neuroinflammation biomarker peptide, they can be used for early diagnosis and real-time evolution of the mechanisms triggered under neuroinflammatory conditions.La neuroinflamación es caracterizada por presentar alteraciones en la barrera hematoencefálica, y activación de las células glía, conduciendo a eventos patológicos, esto ha llevado a la necesidad de mejorar la técnica de imagen por resonancia magnética que permitan comprender el desarrollo y progresión de las alteraciones de la barrera hematoencefálica en tiempo real, bajo condiciones neuroinflamatorias. Como una alternativa a esta solución, se propone establecer la unión de un péptido marcador de neuroinflamación con su proteína blanco y su conjugación con nanopartículas superparamagnéticas. Los resultados muestran que las nanopartículas magnéticas presentan una forma esférica con un tamaño 54 ± 10 nm, la composición química Fe@SiO2 y una curva de histéresis magnética indicando un comportamiento superparamagnético; la evaluación de la unión del péptido-88 con su posible proteína receptora mostró una mayor unión entre el peptido-88 con laminina β1, igualmente se estudió la unión del péptido-88 con las nanopartículas demostrando una mayor unión a diferencia del blanco. El presente estudio evidenció que al establecer la funcionalización de nanopartículas superparamagnéticas conjugadas a un péptido biomarcador de neuroinflamación, pueden ser utilizadas para el diagnóstico temprano y evolución en tiempo real de los mecanismos desencadenados bajo condiciones neuroinflamatorias.UAN Proyectos de ciencia, tecnología, innovación y creación artísticaBioquímico(a)PregradoCT-672-2018, código 123377757091PresencialspaUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - CircunvalarNeuroinflamación, barrera hematoencefálica, nanopartículas superparamagnéticas, péptido biomarcador, proteínas blanco, cultivos in vitro.Neuroinflammation, blood-brain barrier, superparamagnetic nanoparticles, biomarker peptide, target proteins, in vitro cultures.Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticasTrabajo de grado (Pregrado y/o Especialización)http://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINAL2020YehidiJuliethMedinaCastillo.pdf2020YehidiJuliethMedinaCastillo.pdfTrabajo de gradoapplication/pdf1255928https://repositorio.uan.edu.co/bitstreams/a76079ee-bcee-49b3-814d-4949dfa01f94/downloadc6346eaff178d3c866defdfdecdb412bMD512020AutorizaciondeAutores.pdf2020AutorizaciondeAutores.pdfFormato de autorización de autoresapplication/pdf282321https://repositorio.uan.edu.co/bitstreams/5e6b5a25-d0c5-4104-a608-e707c09dca6a/downloadf3dd3e5e8c6a50c3ab77dfbb2f87911bMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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Evaluación de la unión de un péptido marcador de neuroinflamación con diferentes proteínas blanco y su conjugación con nanopartículas superparamagnéticas

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